Robert Amadu Ngala

Molecular Medicine

About

Professor Robert A Ngala is a Head of Department of Molecular Medicine in the School of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology Kumasi- Ghana. Professor Ngala has published over 50 papers in the area of Diabetes and Obesity and in pharmacology. Professor Ngala lectures in Biochemistry and Chemical Pathology in the School of Medicine and Dentistry, School of Pharmacy and Allied Health Sciences. He is a Board Chairman in Many educational Institutions and Teaching Hospitals, He holds an MSc. in Chemical Pathology from the Kwame Nkrumah University of Science and Technology Kumasi and a PhD in Life Sciences from the University of Buckingham, UK where he carried out a lot of research in the pharmacology of β-adrenocepter agonists and antagonist and interaction with peroxisomes proleferator-activated receptors α and δ. His current research interest is in diabetes and obesity and the Discovery and Development of antidiabetic drugs from Tropical Plants. He is currently working on ‘Antidiabetic properties of Myrianthus Arboreous P Beauv in STZ-induced diabetic rats’ and the ‘Effective of vegetable oil consumption on the management of type2 diabetes mellitus in diabetic patients’

Research Summary

(inferred from publications by AI)

The researcher's work is centered on advancing our understanding of cardiovascular health, metabolic processes, and reproductive issues through a diverse array of innovative approaches. Their research encompasses the regulation of appetite and obesity, as well as the prevention of diabetes in African communities, particularly among vulnerable populations like homeless individuals. The researcher employs metabolic, nutritional, and regenerative techniques to explore how these areas intersect with cardiovascular disease prevention, using animal models such as mice to study processes like glucose metabolism and lipid profile changes in Type 2 Diabetes Mellitus and related conditions. Innovative methodologies include the use of CRISPR technology for personalized medicine and mathematical modeling to predict metabolic outcomes. The researcher also investigates traditional agricultural practices, such as the application of Aqueous leaf extracts from coconut roots, to enhance health outcomes. Their work bridges the gap between biological mechanisms and human applications, offering insights into how metabolic pathways can be manipulated to improve cardiovascular health in diverse populations. The researcher's research spans across domains like life sciences, health sciences, physical sciences, pharmacology, and energetics, with a particular emphasis on mitochondrial DNA regulation and energy metabolism. Their work aims to provide a holistic understanding of cardiovascular disease prevention through the lens of metabolic and nutritional interventions, highlighting the role of traditional medicine in supporting health outcomes.

Research Themes

All (43 Papers)

Life Sciences (11 Papers)

Health Sciences (29 Papers)

Physical Sciences (3 Papers)

All Papers

Male mice that lack the G-protein-coupled receptor GPR41 have low energy expenditure and increased body fat content(2012)

Chronic Use of Hormonal Contraceptives and Its Impact on Cardiovascular Risk(2016)

The effects of plasma chromium on lipid profile, glucose metabolism and cardiovascular risk in type 2 diabetes mellitus. A case - control study(2018)

Effect of hormonal contraceptives on lipid profile and the risk indices for cardiovascular disease in a Ghanaian community(2014)

The role of sex steroid hormones in benign prostatic hyperplasia(2017)

Antiproliferative Activity of Aqueous Leaf Extract of Annona muricata L. on the Prostate, BPH-1 Cells, and Some Target Genes(2014)

Placental peptides metabolism and maternal factors as predictors of risk of gestational diabetes in pregnant women. A case-control study(2017)

Gestational diabetes mellitus and obstetric outcomes in a Ghanaian community(2019)

Gestational diabetes mellitus and obstetric outcomes in a Ghanaian community(2018)

Adiposity and hyperleptinemia during the first trimester among pregnant women with preeclampsia(2017)

Serum adipocytokines and adiposity as predictive indices of preeclampsia(2020)

MATERNAL ADIPOSITY AND SERUM VISFATIN LEVELS DURING FIRST TRIMESTER AMONG PREGNANT WOMEN WITH PREECLAMPSIA.(2016)

Metabolic responses to BRL37344 and clenbuterol in soleus muscle and C2C12 cells via different atypical pharmacologies and β2‐adrenoceptor mechanisms(2008)

β2‐Adrenoceptors and non‐β‐adrenoceptors mediate effects of BRL37344 and clenbuterol on glucose uptake in soleus muscle: studies using knockout mice(2009)

A new, highly selective murine peroxisome proliferator‐activated receptor δ agonist increases responsiveness to thermogenic stimuli and glucose uptake in skeletal muscle in obese mice(2011)

Influence of Oxidative Stress, Skeletal Muscle Mass and Obesity on Type 2 Diabetes Mellitus among Patients in Kumasi Metropolis(2014)

Prevalence of diabetes among homeless and slum dwellers in Accra, Ghana: a survey study(2019)

Prevalence of diabetes among homeless and slum dwellers in Accra, Ghana: A survey study(2019)

Shrinkage of Prostate and Improved Quality of Life: Management of BPH Patients with Croton membranaceus Ethanolic Root Extract(2015)

Assessing the Safety of Combined Therapy, Croton membranaceus and Tamsulosin, in the Self‐Prescribed Treatment Protocol for Benign Prostatic Hyperplasia(2025)

Effect of dietary vegetable oil consumption on blood glucose levels, lipid profile and weight in diabetic mice: an experimental case—control study(2016)

Calcium - Magnesium imbalance implicated in benign prostatic hyperplasia and restoration by a phytotherapeutic drug – Croton membranaceus Müll.Arg(2017)

β2-adrenoceptor agonists can both stimulate and inhibit glucose uptake in mouse soleus muscle through ligand-directed signalling(2013)

Effects of HIV Infection and Highly Active Antiretroviral Therapy (HAART) on the Liver of HIV Patients(2015)

Effects of HIV Infection and Anti-retroviral Therapy on Cardiovascular Risk Factors(2014)

Factors associated with noncompliance to diabetes medication in a rapidly urbanizing region in Ghana: a mixed-methods study(2022)

Factors Associated With Non-Compliance to Diabetes Medication in a Rapidly Urbanizing Region in Ghana: A Mixed-Methods Study.(2022)

Stimulation of glucose uptake in murine soleus muscle and adipocytes by 5-(4-phenoxybutoxy)psoralen (PAP-1) may be mediated by Kv1.5 rather than Kv1.3(2014)

Evaluation of Immune Characteristics and Factors Associated with Immune Response following Hepatitis B Vaccination among Ghanaian Adolescents(2024)

Effect of Exercise on Lipid Profile and Oxidative Stress in Patients with Type 2 Diabetes Mellitus(2012)

Are the Thigh Circumference, Waist-to-Thigh Circumference Ratio and Serum Creatinine Better Markers of Type II Diabetes than the Body Mass Index?(2015)

Effect of Basal Gonadotropins, Prolactin and Anthropometry as Predictive Markers of Ovarian Response in Patients Seeking Assisted Reproduction(2015)

Effects of thermal treatment on the characteristics quality of some Ghanaian vegetable oils (palm, coconut and groundnut)(2022)

Effects of Thermal Treatment on The Characteristics Quality of Some Ghanaian Vegetable Oils (Palm, Coconut and Groundnut)(2021)

Lipid lowering among treated hypertensives in a Ghanaian population(2001)

Electrolyte monitoring in the management of essential hypertension(2000)

Managing Diabetes and its Complications Through Traditional African Dietary Intervention(2021)

Peer Review #2 of "Stimulation of glucose uptake in murine soleus muscle and adipocytes by 5-(4-phenoxybutoxy)psoralen (PAP-1) may be mediated by Kv1.5 rather than Kv1.3 (v0.1)"(2014)

Peer Review #1 of "Stimulation of glucose uptake in murine soleus muscle and adipocytes by 5-(4-phenoxybutoxy)psoralen (PAP-1) may be mediated by Kv1.5 rather than Kv1.3 (v0.1)"(2014)

Collaboration Network

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Research Collaboration Map

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About This Profile

This profile is generated from publicly available publication metadata and is intended for research discovery purposes. Themes, summaries, and trajectories are inferred computationally and may not capture the full scope of the lecturer's work. For authoritative information, please refer to the official KNUST profile.