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Ishmael Kyei

Surgery

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About

He is a practicing General Surgeon and Breast Surgeon and a researcher with interest in surgical oncology especially breast cancer . He aims to better understand Breast cancer in Africans and other ethnic minorities in the bid to improve outcomes in the management of breast cancer in these populations. He is a Co investigator with the International Center for the Study of Breast Cancer Subtypes(ICSBCS).He also works as a Senior Lecturer with the Department of Surgery, School of Medicine and Dentistry, College of Health Sciences, KNUST. He holds  Fellowship in both the Ghana College of Surgeons and the West African College of Surgeons and a Post graduate Diploma in Project Design and Management from the Lieverpool School of Tropical Medicine

Research Summary

(inferred from publications by AI)

The cancer genomics and diagnostics theme focuses on the interplay between African ancestry and its effects on cancer biology and treatment. Key research highlights include increased expression of specific tumor suppressor genes (e.g., EGFR and FGFR1) in triple-negative breast cancer, which are influenced by African-derived alleles such as the FANCC pathway. Studies show that African descent correlates with altered tumor microenvironmental factors and poorer clinical outcomes, suggesting a shared genetic basis for these associations.

Research Themes

All Papers

African Ancestry–Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent(2022)
Comparative Analysis of Breast Cancer Phenotypes in African American, White American, and West Versus East African patients: Correlation Between African Ancestry and Triple-Negative Breast Cancer(2016)
African-Ancestry Associated Gene Expression Signatures and Pathways in Triple Negative Breast Cancer, a Comparison across Women of African Descent(2022)
Kinome focused CRISPR-Cas9 screens in African ancestry patient-derived breast cancer organoids identifies essential kinases and synergy of EGFR and FGFR1 inhibition(2023)
Kinome focused CRISPR-Cas9 screens in African ancestry patient-derived breast cancer organoids identify essential kinases and synergy of EGFR and FGFR1 inhibition(2024)
Creating Models to Identify New Therapeutic Options for Aggressive African Breast Cancers(2018)
Biologic diversity of breast cancers in women with African ancestry.(2018)
Abstract 6037: Kinome crispr cas9 screening in breast cancer organoids derived from Ghanaian patients(2022)
Data from African Ancestry–Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent(2023)
Supplementary Data from African Ancestry–Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent(2023)
Supplementary Figure from African Ancestry–Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent(2023)
Supplementary Figure from African Ancestry–Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent(2023)
Supplementary Table from African Ancestry–Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent(2023)
Supplementary Table from African Ancestry–Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent(2023)
Supplementary Table from African Ancestry–Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent(2023)
Data from African Ancestry–Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent(2023)
Supplementary Data from African Ancestry–Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent(2023)
Supplementary Table from African Ancestry–Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent(2023)
Supplementary Table from African Ancestry–Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent(2023)
Supplementary Table from African Ancestry–Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent(2023)
Abstract NG03: Multiomics in disparities research: Identifying African ancestry-specific mechanisms in the triple negative breast cancer tumor microenvironment(2023)
Abstract C047: Multiomics approaches to identify African-ancestry specific phenotypes of triple negative breast cancer(2023)
Table S5 from Kinome-Focused CRISPR-Cas9 Screens in African Ancestry Patient-Derived Breast Cancer Organoids Identify Essential Kinases and Synergy of EGFR and FGFR1 Inhibition(2025)
Table S7 from Kinome-Focused CRISPR-Cas9 Screens in African Ancestry Patient-Derived Breast Cancer Organoids Identify Essential Kinases and Synergy of EGFR and FGFR1 Inhibition(2025)
Table S6 from Kinome-Focused CRISPR-Cas9 Screens in African Ancestry Patient-Derived Breast Cancer Organoids Identify Essential Kinases and Synergy of EGFR and FGFR1 Inhibition(2025)
Table S2 from Kinome-Focused CRISPR-Cas9 Screens in African Ancestry Patient-Derived Breast Cancer Organoids Identify Essential Kinases and Synergy of EGFR and FGFR1 Inhibition(2025)
Table S3 from Kinome-Focused CRISPR-Cas9 Screens in African Ancestry Patient-Derived Breast Cancer Organoids Identify Essential Kinases and Synergy of EGFR and FGFR1 Inhibition(2025)
Table S1 from Kinome-Focused CRISPR-Cas9 Screens in African Ancestry Patient-Derived Breast Cancer Organoids Identify Essential Kinases and Synergy of EGFR and FGFR1 Inhibition(2025)
Table S4 from Kinome-Focused CRISPR-Cas9 Screens in African Ancestry Patient-Derived Breast Cancer Organoids Identify Essential Kinases and Synergy of EGFR and FGFR1 Inhibition(2025)
Data from Kinome-Focused CRISPR-Cas9 Screens in African Ancestry Patient-Derived Breast Cancer Organoids Identify Essential Kinases and Synergy of EGFR and FGFR1 Inhibition(2025)
Supplementary Figures from Kinome-Focused CRISPR-Cas9 Screens in African Ancestry Patient-Derived Breast Cancer Organoids Identify Essential Kinases and Synergy of EGFR and FGFR1 Inhibition(2025)
Hereditary Susceptibility for Triple Negative Breast Cancer Associated With Western Sub-Saharan African Ancestry(2019)
Abstract PO-139: BRCA sequence variants in breast cancer patients with African ancestry(2022)
Investigation of Triple-Negative Breast Cancer Risk Alleles in An International African-Enriched Cohort(2020)
Incidence and determinants of diabetes-related lower limb amputations in Ghana, 2010–2015- a retrospective cohort study(2019)
Diabetes-related foot disorders among adult Ghanaians(2018)
Breast Cancer and African Ancestry: Lessons Learned at the 10-Year Anniversary of the Ghana-Michigan Research Partnership and International Breast Registry(2016)
Seeking healthcare at their ‘right’ time; the iterative decision process for women with breast cancer(2020)
Assessing Breast Cancer Diagnosis and Management in Ghana per the Global Breast Cancer Initiative Key Performance Indicators(2025)
Seeking healthcare at their 'right' time; the iterative decision process for women with breast cancer(2020)
African Clinicians’ Prioritization of Needs in International Breast Cancer Partnerships(2018)
Abstract P6-12-14: Comparative analysis of breast cancer phenotypes in African American, White American, and African patients- Correlation between African ancestry and triple negative breast cancer(2016)
Abstract 78: Breast Cancer in Kumasi: Recent Progress(2021)
Seeking Healthcare at Their 'Right' Time: The Iterative Decision Process for Women with Breast Cancer(2020)
18. “Who Am I Trying to Fool, God or Myself?”: A Qualitative Analysis of Sociocultural Attitudes and Perceptions about Breast Reconstruction in Sub-Saharan Africa(2024)
Oncologic Anthropology and the African Diaspora: Twenty-Year Anniversary Report, International Center for the Study of Breast Cancer Subtypes (ICSBCS)(2025)
Health Comes First: A Qualitative Study of Empowerment in Women Facing Breast Cancer in Ghana and Ethiopia(2025)
Investigation of triple-negative breast cancer risk alleles in an International African-enriched cohort(2021)
Multiethnic PDX models predict a possible immune signature associated with TNBC of African ancestry(2021)
Patient-derived tumor organoids with p53 mutations, and not wild-type p53, are sensitive to synergistic combination PARP inhibitor treatment(2024)
Kinome-Focused CRISPR-Cas9 Screens in African Ancestry Patient-Derived Breast Cancer Organoids Identify Essential Kinases and Synergy of EGFR and FGFR1 Inhibition(2025)
Thyroid Disorders in Central Ghana: The Influence of 20 Years of Iodization(2017)
The Effect of Thyroid Dysfunction on the Cardiovascular Risk of Type 2 Diabetes Mellitus Patients in Ghana(2018)
Graves Disease in Central Ghana: Clinical Characteristics and Associated Factors(2018)
Comparative analysis of breast cancer characteristics in young premenopausal and postmenopausal women in Ghana(2024)
Characterizing Breast Cancer in a Population with Increased Prevalence of Triple-Negative Breast Cancer: Androgen Receptor and ALDH1 Expression in Ghanaian Women(2015)
Patterns of breast cancer locoregional relapse, metastasis, and subtypes in Ghana(2024)
A Preliminary Comparative Study on Clinical and Pathologic Response Patterns of Breast Cancer in Ghanaian Women Undergoing Neoadjuvant Chemotherapy and Hormonal Therapy(2025)
Changing Epidemiology of Intestinal Obstruction in Ghana: Signs of Increasing Surgical Capacity and an Aging Population(2015)
Spectrum of Endocrine Disorders in Central Ghana(2017)
Causes and predictors of mortality among Ghanaians hospitalised with endocrine disorders(2019)
Brief report: Global health initiatives and breast oncology capacity-building in Africa(2020)
Developing a Surgical Oncology Workforce in West Africa: A Needs Assessment and Environmental Scan(2024)
ASO Visual Abstract: Developing a Surgical Oncology Workforce in West Africa: A Needs Assessment and Environmental Scan(2024)
Innovative Methodology for Strengthening a Multidisciplinary Team Approach in Cities in Low- and Middle-Income Countries(2022)
Surgical management of traumatic diaphragmaticrupture: ten-year experience in a Teaching Hospitalin Ghana(2022)
Participant Evaluation of a Multi-disciplinary Oncology Preceptorship Training Program for Oncology Health Professionals from Kumasi, Ghana(2024)
Extra gonadal sclerosing stromal tumour in the transverse mesocolon(2016)
Patient-derived tumor organoids with p53 mutations, and not wild-type p53, are sensitive to synergistic combination PARP inhibitor treatment(2023)
Urachal cyst: a rare cause of an abdominal mass in a Ghanaian adult female: a case report(2025)
Incidence of breast developmental anomalies: A study at Sogakope, Ghana(2010)
Patients’ Perspectives on Breast Reconstruction in Sub-Saharan Africa(2025)
Evaluation of External Abdominal Wall Hernia Surgery in a Secondary Level Facility in Kumasi, Ghana(2020)
C‐kit‐negative transmural gastrointestinal stromal tumor in the stomach: A rare case of upper GI bleeding in Ghana(2023)
A Gist of an Obscure Neoplasm in Ghana: Gastrointestinal stromal tumours(2023)
A gist on an obscure neoplasm in Ghana: gastrointestinal stromal tumours(2023)
Abstract PO-141: The role of African Duffy-null allele related inflammation on the tumor microenvironment(2022)
Abstract C010: Genes with African ancestry-specific expression in TNBC tumors also show population-specific baseline differences in normal mammary tissue(2023)
Abstract 2247: Evaluation of multidrug resistant genes among breast cancer patients in Ghana(2023)
Evaluating the efficacy of dilute povidone-iodine versus normal saline for preventing surgical site infections following appendectomy: a prospective observational study in Ghanaian tertiary hospital(2025)
Pathogenic FANCC Variants are Associated with Accessory Breasts in a Sub-Saharan African Multiplex Family(2025)
Pathogenic FANCC Variants Are Associated with Accessory Breasts in a Sub-Saharan African Multiplex Family(2025)

Collaboration Network

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About This Profile

This profile is generated from publicly available publication metadata and is intended for research discovery purposes. Themes, summaries, and trajectories are inferred computationally and may not capture the full scope of the lecturer's work. For authoritative information, please refer to the official KNUST profile.