Caleb Kesse Firempong

Biochemistry and Biotechnology

About

Caleb Kesse Firempong is a PhD holder in Medical Science and Clinical Laboratory Diagnostics from Jiangsu University, China. He doubles as a lecturer and laboratory manager at Department of Biochemistry and Biotechnology, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi-Ghana, and Clinical Analysis Laboratory (CAn-Lab), KNUST, respectively. Currently, he is also the Head of Department of Biochemistry and Biotechnology, KNUST-Kumasi. He is an expert in Medicinal Plant Biochemistry with special emphasis on the discovery, formulation and bioavailability of drugs from natural sources which can be used to treat non-communicable diseases (Cancers, Liver disorders and Hypertension). By dint of hard work he has contributed immensely to the progress of society and the knowledge of Natural Product Science both locally and at the international level. His professional mission is to improve health and well-being in Ghana and the international community as a whole, through biomedical research, education, clinical services and consulting.

Research Summary

(inferred from publications by AI)

The researcher's work is concentrated across multiple thematic areas within health sciences, with a focus on bioavailability, nanotechnology applications, and systemic effects without significant overlap with other domains. Their research includes capsaicin derivatives via liposomal nanoformulation, ergosterol loading for antitumor activity, lipid nanoparticles in biocharaction studies, and the effects of chemicals like CCl4 and Hura crepitans on liver injury. However, these areas are distinct and not directly linked to other domains such as thermal therapy or systemic drugs.

Research Themes

All (55 Papers)

Life Sciences (31 Papers)

Health Sciences (14 Papers)

Physical Sciences (10 Papers)

All Papers

Improved oral bioavailability of capsaicin via liposomal nanoformulation: preparation, in vitro drug release and pharmacokinetics in rats(2014)

In vitro and in vivo evaluation of capsaicin‐loaded microemulsion for enhanced oral bioavailability(2014)

Enhanced Solubility and Bioavailability of Naringenin via Liposomal Nanoformulation: Preparation and In Vitro and In Vivo Evaluations(2016)

Enhanced oral bioavailability and in vivo antioxidant activity of chlorogenic acid via liposomal formulation(2016)

Enhanced oral bioavailability of capsaicin in mixed polymeric micelles: Preparation, in vitro and in vivo evaluation(2014)

Development and in vitro/in vivo evaluation of famotidine hydrochloride bioadhesive sustained release suspension.(2024)

Ergosterol-loaded poly(lactide-co-glycolide) nanoparticles with enhanced in vitro antitumor activity and oral bioavailability(2016)

Cytotoxic effect of novel Flammulina velutipes sterols and its oral bioavailability via mixed micellar nanoformulation(2013)

Hypolipidemic potential of perillaldehyde-loaded self-nanoemulsifying delivery system in high-fat diet induced hyperlipidemic mice: Formulation, in vitro and in vivo evaluation(2016)

Tissue distribution and enhanced in vivo anti-hyperlipidemic-antioxidant effects of perillaldehyde-loaded liposomal nanoformulation against Poloxamer 407-induced hyperlipidemia(2016)

Enhanced oral bioavailability and anti-gout activity of [6]-shogaol-loaded solid lipid nanoparticles(2018)

Enhanced oral bioavailability of [6]-Gingerol-SMEDDS: Preparation, in vitro and in vivo evaluation(2016)

Preparation and in vitro/in vivo evaluation of 6-Gingerol TPGS/PEG-PCL polymeric micelles(2018)

Anti-hyperuricemic property of 6-shogaol via self-micro emulsifying drug delivery system in model rats: formulation design, in vitro and in vivo evaluation(2019)

Preparation, characterization and pharmacokinetic studies of linalool-loaded nanostructured lipid carriers(2016)

Chemical characteristics of toilet soap prepared from neem (Azadirachta indica A. Juss) seed oil(2011)

Enhanced Oral Bioavailability and Tissue Distribution of a New Potential Anticancer Agent, Flammulina velutipes Sterols, through Liposomal Encapsulation(2013)

Preparation, characterization, and pharmacokinetics study of capsaicin via hydroxypropyl-beta-cyclodextrin encapsulation(2015)

Self-microemulsifying Drug Delivery System for Improved Oral Delivery of Limonene: Preparation, Characterization, in vitro and in vivo Evaluation(2019)

Novel cuminaldehyde self-emulsified nanoemulsion for enhanced antihepatotoxicity in carbon tetrachloride-treated mice(2019)

Preparation and in vitro/in vivo evaluation of a clonidine hydrochloride drug–resin suspension as a sustained-release formulation(2021)

Development, optimization, and in vitro/in vivo evaluation of ranitidine hydrochloride resinate sustained release suspension(2023)

Construction and in vitro / in vivo evaluation of menantine hydrochloride oral liquid sustained-release drug delivery system(2024)

Enhanced oral bioavailability, reduced irritation and increased hypolipidemic activity of self-assembled capsaicin prodrug nanoparticles(2018)

Preparation, optimization, and pharmacokinetic study of nanoliposomes loaded with triacylglycerol‐bound punicic acid for increased antihepatotoxic activity(2018)

Preparation and evaluation of sustained release pirfenidone-loaded microsphere dry powder inhalation for treatment of idiopathic pulmonary fibrosis(2023)

Glycemic index of different varieties of yam as influenced by boiling, frying and roasting(2020)

Modulation of Oxidative Stress and Inflammatory Cytokines as Therapeutic Mechanisms ofOcimum americanumL Extract in Carbon Tetrachloride and Acetaminophen-Induced Toxicity in Rats(2020)

Hura crepitans stem bark extract: A potential remedy to sub-acute liver damage(2021)

Extracts of Hura crepitans L. stem bark attenuate liver injury and inflammation induced by CCl4 in rats(2020)

Production and evaluation of monovalent anti-snake immunoglobulins from chicken egg yolk using Ghanaian puff adder (Bitis arietans) Venom: Isolation, purification, and neutralization efficacy(2023)

Lipid Raft Stationary Phase Chromatography for Screening Anti-tumor Components from Galla chinensis(2014)

Simultaneous Measurement of Titratable Acidity and Fermentation Index in Cocoa Beans by Electronic Tongue Together with Linear and Non-linear Multivariate Technique(2014)

Segetoside I, a plant-derived bisdesmosidic saponin, induces apoptosis in human hepatoma cells in vitro and inhibits tumor growth in vivo(2016)

Development and thermodynamic evaluation of novel lipid raft stationary phase chromatography for screening potential antitumor agents(2014)

Construction and Evaluation of Traceable rhES-QDs-M-MS Protein Delivery System: Sustained-Release Properties, Targeted Effect, and Antitumor Activity(2022)

Prospects for multitarget lipid-raft-coated silica beads: a remarkable online biomaterial for discovering multitarget antitumor lead compounds(2015)

In vitro antiproliferative activities of some Ghanaian medicinal plants(2024)

Ethnobotanical study of medicinal plants used to treat HIV, cancer and diabetes in some communities of Ashanti Region, Ghana(2023)

Polycyclic Aromatic Hydrocarbons Burden of Meats Singed with Different Fuel Sources from Abattoirs in Ghana and Associated Cancer Risk Assessment(2025)

A bioactive fraction from the leaves of Ceiba pentandra (L.) Gaertn. exhibits antiproliferative activity via cell cycle arrest at the G1/S checkpoint and initiation of apoptosis via poly [ADP-ribose] polymerase 1 (PARP1) cleavage in HeLa cells.(2025)

Simultaneous HPLC determination of ergosterol and 22,23‐dihydroergosterol in Flammulina velutipes sterol‐loaded microemulsion(2013)

In Vitro Metabolic Profiling of Periplogenin in Rat Liver Microsomes and its Associated Enzyme-kinetic Evaluation(2019)

Hepatoprotective Potential of Hura crepitans L.: A Review of Ethnomedical, Phytochemical and Pharmacological Studies(2020)

Phytochemical, Antioxidant and Safety Evaluation of Hura crepitans (L.) Stem Bark Hydroethanolic Extract in Animals(2020)

In vitro cytotoxic activity of five Ghanaian plants on human cancer cell lines(2024)

Lipid raft biomaterial as a mass screening affinity tool for rapid identification of potential antitumor Chinese herbal medicine(2015)

Preparation and Evaluation of rhINF-α-2b Sodium Hyaluronate Cross-Linked Porous Microspheres: Characterization, Sustained-Release Properties, and Antitumor Activity(2021)

Fabrication of core-shell quantum dots microbeads with high stability, enhanced sensitivity and potential application in C-reactive protein (CRP) and procalcitonin (PCT) immunochromatography in vitro diagnostic reagents(2024)

Some Anthropometric, Biochemical and Haematogical Studies of Rats Fed on Different Composite Diets Prepared from Maize, Groundnut and Soybean(2010)

Fabrication of ticagrelor bioadhesive solid dispersion based on coaxial electrostatic spray to improve drug release and enhance oral bioavailability.(2023)

A review of preclinical evidence of Cryptolepis nigrescens (Wennberg) L. Joubert. and Bruyns., Prosopsis africana (Guill. and Perr.) Taub. and Pterygota macrocarpa K. Schum. traditionally used to manage tumours in Ghana(2023)

Improving the Oral Absorption of Celecoxib via Solid Self-Microemulsion Drug Delivery System: Preparation and In Vitro/In Vivo Evaluation(2023)

In Vitro Cytotoxic Activity of Five Ghanaian Plants on Human Cancer Cell Lines(2024)

Health risk assessment of arsenic and metals (Cd, Cu, Fe, Ni, and Pb) consumed in meat singed with different fuel types from some selected cities in Ghana(2025)

Collaboration Network

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Research Collaboration Map

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About This Profile

This profile is generated from publicly available publication metadata and is intended for research discovery purposes. Themes, summaries, and trajectories are inferred computationally and may not capture the full scope of the lecturer's work. For authoritative information, please refer to the official KNUST profile.