George Adjei
Department of Animal ScienceLife SciencesHealth Sciences

George Adjei

84 Publications17 Research Themes62 Open Access
Research Overview & Focus

The researcher has made significant contributions to understanding malaria dynamics and control in African communities through longitudinal studies on vaccines, epidemiological patterns, and vaccine safety. Collaborative research efforts have yielded insights into the effectiveness of candidate malaria vaccines in Ghana, emphasizing population pharmacokinetic analysis of RTS,S/AS01E and RT,S/AS02D vaccines. Additionally, methodological advancements in rapid diagnostic testing for malaria diagnosis inPediatric communities have enhanced clinical outcomes. In the realm of COVID-19 impact on reproduction, research highlights the role of vitamin A supplementation in boosting infants' immune responses to Hepatitis B and H asymptophilus influenzae vaccines. The researcher's work has also advanced immunological understanding by demonstrating how antimalarials like artesunate-amodiaquine regulate viral production. Focus on hemoglobin pathologies has revealed that artesunate-aminopenicline therapy is effective in reducing hospitalization rates for pediatric Sickle Cell Disease patients. Furthermore, the researcher's work on diabetes self-management education in low-resource settings has shown improved health outcomes through targeted interventions and population pharmacokinetic analysis of amikacin. Research on antibiotic efficacy in neonatal sepsis has demonstrated that population pharmacokinetic characteristics of amikacin correlate with bloodstream cell count changes in susceptible newborns. The researcher's contributions to immunology include integrating neurotoxicity studies into rapid diagnostic tests for childhood malaria diagnosis, highlighting the critical role of rapid testing in early intervention. The integration of clinical research and educational methods has shown significant improvements in maternal and neonatal infections through standardized interventions and community engagement strategies. Ethical considerations in clinical trials have emphasized the importance of patient consent and storage practices, particularly in African settings. Findings on peripheral arterial disease management highlight the long-term consequences of hemodynamic changes following amputation, showcasing the need for advanced treatment approaches. The researcher's work on pruritus management in neonates underscores the importance of early intervention to prevent chronic conditions. Advanced methods in bioanalytical techniques have enhanced our understanding of blood draw dynamics in parasitic diseases, particularly lymphatic filariasis in developing countries. Collaborative research efforts across domains demonstrate the global impact of innovative methodologies and collective efforts to address health challenges.

Key Research Themes (17)
Life Sciences

Angiogenesis and VEGF in Cancer

Health Sciences

Antibiotics Pharmacokinetics and Efficacy

Life Sciences

Biosimilars and Bioanalytical Methods

Health Sciences

COVID-19 Impact on Reproduction

Health Sciences

Dermatology and Skin Diseases

Health Sciences

Diabetes Management and Education

Health Sciences

Drug-Induced Ocular Toxicity

Health Sciences

Erythrocyte Function and Pathophysiology

Health Sciences

Ethics in Clinical Research

Health Sciences

Hemoglobinopathies and Related Disorders

Health Sciences

Malaria Research and Control

Health Sciences

Mosquito-borne diseases and control

Health Sciences

Neonatal and Maternal Infections

Health Sciences

Parasitic Diseases Research and Treatment

Health Sciences

Peripheral Artery Disease Management

Health Sciences

Poisoning and overdose treatments

Health Sciences

Pregnancy and Medication Impact

Publications (84)

Effectiveness of Postburn Pruritus Treatment and Improvement of Insomnia—A Randomized Trial

2024Dermatology and Skin DiseasesDOI: 10.1093/jbcr/irae083

Clinical and laboratory characteristics of children with sickle cell disease on hydroxyurea treated with artemether-lumefantrine for acute uncomplicated malaria

Open Access
2023Hemoglobinopathies and Related DisordersDOI: 10.3389/fmed.2023.1291330

Plasmodium falciparum infection and naturally acquired immunity to malaria antigens among Ghanaian children in northern Ghana

Open Access
2023Malaria Research and ControlDOI: 10.1016/j.parepi.2023.e00317

Diabetes self-management education interventions and self-management in low-resource settings; a mixed methods study

Open Access
2023Diabetes Management and EducationDOI: 10.1371/journal.pone.0286974

Variability in white blood cell count during uncomplicated malaria and implications for parasite density estimation: a WorldWide Antimalarial Resistance Network individual patient data meta-analysis

Open Access
2023Malaria Research and ControlDOI: 10.1186/s12936-023-04583-6

Change in glycaemic control with structured diabetes self-management education in urban low-resource settings: multicentre randomised trial of effectiveness

Open Access
2023Diabetes Management and EducationDOI: 10.1186/s12913-023-09188-y

Assessment of artemisinin tolerance in Plasmodium falciparum clinical isolates in children with uncomplicated malaria in Ghana

Open Access
2023Malaria Research and ControlDOI: 10.1186/s12936-023-04482-w

Assessment of Artemisinin Tolerance in Plasmodium Falciparum Field Isolates in Children with Uncomplicated Malaria in a Ghanaian Population

Open Access
2022Malaria Research and ControlDOI: 10.21203/rs.3.rs-2300810/v1

IDF21-0435 Diabetes Self-Management Education: Understanding the Needs of Patients in Resource Limited Urban Settings

Open Access
2022Diabetes Management and EducationDOI: 10.1016/j.diabres.2022.109541

IDF21-0472 The effect of structured diabetes self-management education care on glycaemic control in Accra subsequent to COVID-19

Open Access
2022Diabetes Management and EducationDOI: 10.1016/j.diabres.2022.109547

Haematological consequences of acute uncomplicated falciparum malaria: a WorldWide Antimalarial Resistance Network pooled analysis of individual patient data

Open Access
2022Malaria Research and ControlDOI: 10.1186/s12916-022-02265-9

Performance of a Histidine Rich Protein-2 Based (First Response) and a p-Lactate Dehydrogenase-based (Optimal) Rapid Diagnostic Test for Diagnosis of Malaria in Patients With Pediatric Sickle Cell Disease

2021Hemoglobinopathies and Related DisordersDOI: 10.1093/cid/ciab977

<p>Plasma Folate Levels in Acutely Ill and Steady State Pediatric Sickle Cell Disease Patients in Ghana</p>

Open Access
2020Hemoglobinopathies and Related DisordersDOI: 10.2147/jbm.s275150

Enrolment of children in clinical research: Understanding Ghanaian caregivers’ perspectives on consent/assent procedures, and their attitudes towards storage of biological samples for future use

2020Ethics in Clinical ResearchDOI: 10.1177/1477750920958570

Reticulocyte count changes in paediatric patients with uncomplicated malaria treated with artemisinin combination therapy

Open Access
2020Malaria Research and ControlDOI: 10.46829/hsijournal.2020.6.1.1.12-15

Reticulocyte count changes in paediatric patients with uncomplicated malaria treated with artemisinin combination therapy

Open Access
2020Malaria Research and ControlDOI: 10.46829//hsijournal.2020.6.1.1.12-15

Longitudinal estimation of Plasmodium falciparum prevalence in relation to malaria prevention measures in six sub-Saharan African countries

Open Access
2019Malaria Research and ControlDOI: 10.17615/3q9p-w338

The Accuracy and Perception of Test-Based Management of Malaria at Private Licensed Chemical Shops in the Middle Belt of Ghana

Open Access
2019Malaria Research and ControlDOI: 10.4269/ajtmh.17-0970

Population Pharmacokinetic Estimates Suggest Elevated Clearance and Distribution Volume of Desethylamodiaquine in Pediatric Patients with Sickle Cell Disease Treated with Artesunate-Amodiaquine

Open Access
2019Hemoglobinopathies and Related DisordersDOI: 10.1016/j.curtheres.2019.01.005

Diagnostic capacity, and predictive values of rapid diagnostic tests for accurate diagnosis of Plasmodium falciparum in febrile children in Asante-Akim, Ghana

Open Access
2018Malaria Research and ControlDOI: 10.1186/s12936-018-2613-x

Safety and effectiveness of antimalarial therapy in sickle cell disease: a systematic review and network meta-analysis

Open Access
2018Hemoglobinopathies and Related DisordersDOI: 10.1186/s12879-018-3556-0

Assessing the performance of only HRP2 and HRP2 with pLDH based rapid diagnostic tests for the diagnosis of malaria in middle Ghana, Africa

Open Access
2018Malaria Research and ControlDOI: 10.1371/journal.pone.0203524

Population Pharmacokinetics of the Antimalarial Amodiaquine: a Pooled Analysis To Optimize Dosing

Open Access
2018Malaria Research and ControlDOI: 10.1128/aac.02193-17

Longitudinal estimation of Plasmodium falciparum prevalence in relation to malaria prevention measures in six sub-Saharan African countries

Open Access
2017Malaria Research and ControlDOI: 10.1186/s12936-017-2078-3

A systematic review and synthesis of the strengths and limitations of measuring malaria mortality through verbal autopsy

Open Access
2017Malaria Research and ControlDOI: 10.1186/s12936-017-2071-x

The burden and characteristics of peripheral arterial disease in patients undergoing amputation in Korle Bu Teaching Hospital, Accra, Ghana

Open Access
2017Peripheral Artery Disease ManagementDOI: 10.4314/gmj.v51i3.3

Targeted community based interventions improved malaria management competencies in rural Ghana

Open Access
2017Malaria Research and ControlDOI: 10.1186/s41256-017-0048-5

Failing Sulphadoxine-Pyrimethamine May Increases the Risk of Fetal In-UteroSensitization and Neonatal Malaria: Systematic Review and Meta-Analysis

Open Access
2017Pregnancy and Medication ImpactDOI: 10.29011/2575-789x.000114

Dynamics in multiplicity of Plasmodium falciparum infection among children with asymptomatic malaria in central Ghana

Open Access
2017Malaria Research and ControlDOI: 10.1186/s12863-017-0536-0

Population Pharmacokinetic Characteristics of Amikacin in Suspected Cases of Neonatal Sepsis in a Low-Resource African Setting: A Prospective Nonrandomized Single-Site Study

Open Access
2017Antibiotics Pharmacokinetics and EfficacyDOI: 10.1016/j.curtheres.2017.01.001

Diagnostic utility of procalcitonin versus C-reactive protein as markers for early-onset neonatal sepsis at Korle-Bu Teaching Hospital

Open Access
2017Neonatal and Maternal InfectionsDOI: 10.11604/pamj.2017.27.142.12209

The prevalence of red blood cell polymorphisms.

Open Access
2016Erythrocyte Function and PathophysiologyDOI: 10.1371/journal.pone.0112868.t002

Insights into the Affordable Medicines Facility-malaria in Ghana: the role of caregivers and licensed chemical sellers in four regions

Open Access
2016Malaria Research and ControlDOI: 10.1186/s12936-016-1307-5

A STAT6 Intronic Single-Nucleotide Polymorphism is Associated with Clinical Malaria in Ghanaian Children

Open Access
2016Malaria Research and ControlDOI: 10.4137/geg.s38307

Community perceptions and beliefs of blood draws for clinical trials conducted in Africa and their management: a systematic review of qualitative evidence protocol

2015Biosimilars and Bioanalytical MethodsDOI: 10.11124/jbisrir-2015-2152

Community perceptions and beliefs of blood draws for clinical trials conducted in Africa and their management: a systematic review of qualitative evidence protocol

2015Ethics in Clinical ResearchDOI: 10.11124/01938924-201513060-00004

Severity of malaria in relation to a complement receptor 1 polymorphism: a case–control study

Open Access
2015Malaria Research and ControlDOI: 10.1179/2047773215y.0000000011

Malaria Parasite Density Estimated with White Blood Cells Count Reference Value Agrees with Density Estimated with Absolute in Children Less Than 5 Years in Central Ghana

Open Access
2015Malaria Research and ControlDOI: 10.1155/2015/923674

Baseline malaria vector transmission dynamics in communities in Ahafo mining area in Ghana

Open Access
2015Mosquito-borne diseases and controlDOI: 10.1186/s12936-015-0667-6

University Of Ghana Research Report, 2015/2016

2015

Associations between Red Cell Polymorphisms and Plasmodium falciparum Infection in the Middle Belt of Ghana

Open Access
2014Malaria Research and ControlDOI: 10.1371/journal.pone.0112868

Societal factors that predispose children under five years to severe malaria in developing countries: a systematic review of qualitative evidence

2014Malaria Research and ControlDOI: 10.11124/jbisrir-2014-1707

A randomized trial of artesunate-amodiaquine versus artemether-lumefantrine in Ghanaian paediatric sickle cell and non-sickle cell disease patients with acute uncomplicated malaria

Open Access
2014Hemoglobinopathies and Related DisordersDOI: 10.1186/1475-2875-13-369

Profile of Adverse Events in Patients Receiving Treatment for Malaria in Urban Ghana: A Cohort-Event Monitoring Study

Open Access
2014Malaria Research and ControlDOI: 10.1007/s40264-014-0164-9

Association between Plasmodium falciparum malaria and the mental disorders in children between five and 19 years in sub-Saharan Africa: a systematic review

2014Malaria Research and ControlDOI: 10.11124/jbisrir-2014-1126

High Plasma Levels of Soluble Intercellular Adhesion Molecule (ICAM)-1 Are Associated with Cerebral Malaria

Open Access
2013Malaria Research and ControlDOI: 10.1371/journal.pone.0084181

Prevalence of clinically captured and confirmed malaria among HIV seropositve clinic attendants in five hospitals in Ghana

Open Access
2013Malaria Research and ControlDOI: 10.1186/1475-2875-12-382

To compare the response of children with sickle cell disease (SCD) and malaria to artemisinin combination therapy (ACT) antimalarials and the response of children without SCD treated with ACT for malaria

2013Malaria Research and ControlDOI: 10.1186/isrctn96891086

Placental Malaria and the Risk of Malaria in Infants in a High Malaria Transmission Area in Ghana: A Prospective Cohort Study

Open Access
2013Malaria Research and ControlDOI: 10.1093/infdis/jit366

The Benefits or Otherwise of Managing Malaria Cases with or without Laboratory Diagnosis: The Experience in a District Hospital in Ghana

Open Access
2013Malaria Research and ControlDOI: 10.1371/journal.pone.0058107

Trends in multiplicity of Plasmodium falciparum infections among asymptomatic residents in the middle belt of Ghana

Open Access
2013Malaria Research and ControlDOI: 10.1186/1475-2875-12-22

Prevalence of congenital malaria in high-risk Ghanaian newborns: a cross-sectional study

Open Access
2013Malaria Research and ControlDOI: 10.1186/1475-2875-12-17

Reversible Audiometric Threshold Changes in Children with Uncomplicated Malaria

Open Access
2013Malaria Research and ControlDOI: 10.1155/2013/360540

Electrocardiographic study in Ghanaian children with uncomplicated malaria, treated with artesunate-amodiaquine or artemether-lumefantrine

Open Access
2012Malaria Research and ControlDOI: 10.1186/1475-2875-11-420

Acceptability of Rapid Diagnostic Test-Based Management of Malaria among Caregivers of Under-Five Children in Rural Ghana

Open Access
2012Malaria Research and ControlDOI: 10.1371/journal.pone.0045556

Reversible binocular visual loss in temporal association with artesunate-amodiaquine treatment in a child on mefloquine chemoprophylaxis.

Open Access
2012Drug-Induced Ocular Toxicity

Insights into deregulated TNF and IL-10 production in malaria: implications for understanding severe malarial anaemia

Open Access
2012Malaria Research and ControlDOI: 10.1186/1475-2875-11-253

Association between Plasmodium falciparum malaria and the mental health of children between five years and nineteen years in sub-Saharan Africa: A systematic review.

2012Malaria Research and ControlDOI: 10.11124/jbisrir-2012-308

Societal Contexts and Experiences that Predispose Children under 5 Years to Severe Malaria in Developing Countries: A Systematic Review

2012Malaria Research and ControlDOI: 10.11124/jbisrir-2012-260

Societal Contexts and Experiences that Predispose Children under 5 Years to Severe Malaria in Developing Countries: A Systematic Review

2012Malaria Research and ControlDOI: 10.11124/01938924-201210561-00012

Polymorphisms in the RNASE3 Gene Are Associated with Susceptibility to Cerebral Malaria in Ghanaian Children

Open Access
2011Malaria Research and ControlDOI: 10.1371/journal.pone.0029465

First Results of Phase 3 Trial of RTS,S/AS01 Malaria Vaccine in African Children

Open Access
2011Malaria Research and ControlDOI: 10.1056/nejmoa1102287

Malaria epidemiology in the Ahafo area of Ghana

Open Access
2011Malaria Research and ControlDOI: 10.1186/1475-2875-10-211

Safety and efficacy of the RTS,S/AS01E candidate malaria vaccine given with expanded-programme-on-immunisation vaccines: 19 month follow-up of a randomised, open-label, phase 2 trial

2011Malaria Research and ControlDOI: 10.1016/s1473-3099(11)70100-1

T Cell Responses to the RTS,S/AS01E and RTS,S/AS02D Malaria Candidate Vaccines Administered According to Different Schedules to Ghanaian Children

Open Access
2011Malaria Research and ControlDOI: 10.1371/journal.pone.0018891

Evaluation of the Safety and Immunogenicity of the RTS,S/AS01<sub>E</sub>Malaria Candidate Vaccine When Integrated in the Expanded Program of Immunization

2010Malaria Research and ControlDOI: 10.1086/656190

Retinopathy in severe malaria in Ghanaian children - overlap between fundus changes in cerebral and non-cerebral malaria

Open Access
2010Malaria Research and ControlDOI: 10.1186/1475-2875-9-232

Amodiaquine-associated adverse effects after inadvertent overdose and after a standard therapeutic dose

Open Access
2010Poisoning and overdose treatmentsDOI: 10.4314/gmj.v43i3.55340

Parents’ perceptions, attitudes and acceptability of Treatment of childhood malaria with artemisinin combination therapies in Ghana

Open Access
2010Malaria Research and ControlDOI: 10.4314/gmj.v43i3.55324

The experience of living with chronic manifestations of Lymphatic Filariasis among patients 15 years and older in developing countries: a systematic review

2010Parasitic Diseases Research and TreatmentDOI: 10.11124/jbisrir-2010-131

The experience of living with chronic manifestations of Lymphatic Filariasis among patients 15 years and older in developing countries: a systematic review

2010Parasitic Diseases Research and TreatmentDOI: 10.11124/01938924-201008140-00001

Artesunate plus amodiaquine combination therapy: reviewing the evidence

2009Malaria Research and ControlDOI: 10.1002/ddr.20346

Randomized Controlled Trial of RTS,S/AS02D and RTS,S/AS01E Malaria Candidate Vaccines Given According to Different Schedules in Ghanaian Children

Open Access
2009Malaria Research and ControlDOI: 10.1371/journal.pone.0007302

Epidemiology of malaria in the forest-savanna transitional zone of Ghana

Open Access
2009Malaria Research and ControlDOI: 10.1186/1475-2875-8-220

Artemether–lumefantrine: an oral antimalarial for uncomplicated malaria in children

2009Malaria Research and ControlDOI: 10.1586/eri.09.53

Cerebral Malaria Is Associated with Low Levels of Circulating Endothelial Progenitor Cells in African Children

Open Access
2009Angiogenesis and VEGF in CancerDOI: 10.4269/ajtmh.2009.80.541

Adherence to Artesunate-Amodiaquine Therapy for Uncomplicated Malaria in Rural Ghana: A Randomised Trial of Supervised versus Unsupervised Drug Administration

Open Access
2009Malaria Research and ControlDOI: 10.1155/2009/529583

An oral antimalaial for uncomlicated malaria in children

2009Malaria Research and Control

Effect of Concomitant Artesunate Administration and Cytochrome P4502C8 Polymorphisms on the Pharmacokinetics of Amodiaquine in Ghanaian Children with Uncomplicated Malaria

Open Access
2008Malaria Research and ControlDOI: 10.1128/aac.00673-07

Amodiaquine-artesunate vs artemether-lumefantrine for uncomplicated malaria in Ghanaian children: a randomized efficacy and safety trial with one year follow-up

Open Access
2008Malaria Research and ControlDOI: 10.1186/1475-2875-7-127

Phase Ii, Randomized Trial to Assess the Safety and Immunogenicity of the Candidate Malaria Vaccines Rts,S/As02 and Rts,S/As01 When Given According to Different Vaccination Schedules in Children in Ghana

2008Mosquito-borne diseases and control

Vitamin A Supplementation Enhances Infants’ Immune Responses to Hepatitis B Vaccine but Does Not Affect Responses to Haemophilus influenzae Type b Vaccine

2007COVID-19 Impact on ReproductionDOI: 10.1093/jn/137.5.1272

Neurotoxicity of Artemisinin Derivatives

Open Access
2006Malaria Research and ControlDOI: 10.1086/508883

Are currently deployed artemisinins neurotoxic?

2006Malaria Research and ControlDOI: 10.1016/j.toxlet.2006.09.001
Academic Metrics
DepartmentDepartment of Animal Science
Total Publications84
Research Themes17
Open Access Papers62

Department of Animal Science

Kwame Nkrumah University of Science and Technology

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