George Adjei
The researcher has made significant contributions to understanding malaria dynamics and control in African communities through longitudinal studies on vaccines, epidemiological patterns, and vaccine safety. Collaborative research efforts have yielded insights into the effectiveness of candidate malaria vaccines in Ghana, emphasizing population pharmacokinetic analysis of RTS,S/AS01E and RT,S/AS02D vaccines. Additionally, methodological advancements in rapid diagnostic testing for malaria diagnosis inPediatric communities have enhanced clinical outcomes. In the realm of COVID-19 impact on reproduction, research highlights the role of vitamin A supplementation in boosting infants' immune responses to Hepatitis B and H asymptophilus influenzae vaccines. The researcher's work has also advanced immunological understanding by demonstrating how antimalarials like artesunate-amodiaquine regulate viral production. Focus on hemoglobin pathologies has revealed that artesunate-aminopenicline therapy is effective in reducing hospitalization rates for pediatric Sickle Cell Disease patients. Furthermore, the researcher's work on diabetes self-management education in low-resource settings has shown improved health outcomes through targeted interventions and population pharmacokinetic analysis of amikacin. Research on antibiotic efficacy in neonatal sepsis has demonstrated that population pharmacokinetic characteristics of amikacin correlate with bloodstream cell count changes in susceptible newborns. The researcher's contributions to immunology include integrating neurotoxicity studies into rapid diagnostic tests for childhood malaria diagnosis, highlighting the critical role of rapid testing in early intervention. The integration of clinical research and educational methods has shown significant improvements in maternal and neonatal infections through standardized interventions and community engagement strategies. Ethical considerations in clinical trials have emphasized the importance of patient consent and storage practices, particularly in African settings. Findings on peripheral arterial disease management highlight the long-term consequences of hemodynamic changes following amputation, showcasing the need for advanced treatment approaches. The researcher's work on pruritus management in neonates underscores the importance of early intervention to prevent chronic conditions. Advanced methods in bioanalytical techniques have enhanced our understanding of blood draw dynamics in parasitic diseases, particularly lymphatic filariasis in developing countries. Collaborative research efforts across domains demonstrate the global impact of innovative methodologies and collective efforts to address health challenges.
Angiogenesis and VEGF in Cancer
Antibiotics Pharmacokinetics and Efficacy
Biosimilars and Bioanalytical Methods
COVID-19 Impact on Reproduction
Dermatology and Skin Diseases
Diabetes Management and Education
Drug-Induced Ocular Toxicity
Erythrocyte Function and Pathophysiology
Ethics in Clinical Research
Hemoglobinopathies and Related Disorders
Malaria Research and Control
Mosquito-borne diseases and control
Neonatal and Maternal Infections
Parasitic Diseases Research and Treatment
Peripheral Artery Disease Management
Poisoning and overdose treatments
Pregnancy and Medication Impact
Effectiveness of Postburn Pruritus Treatment and Improvement of Insomnia—A Randomized Trial
Clinical and laboratory characteristics of children with sickle cell disease on hydroxyurea treated with artemether-lumefantrine for acute uncomplicated malaria
Open AccessPlasmodium falciparum infection and naturally acquired immunity to malaria antigens among Ghanaian children in northern Ghana
Open AccessDiabetes self-management education interventions and self-management in low-resource settings; a mixed methods study
Open AccessVariability in white blood cell count during uncomplicated malaria and implications for parasite density estimation: a WorldWide Antimalarial Resistance Network individual patient data meta-analysis
Open AccessChange in glycaemic control with structured diabetes self-management education in urban low-resource settings: multicentre randomised trial of effectiveness
Open AccessAssessment of artemisinin tolerance in Plasmodium falciparum clinical isolates in children with uncomplicated malaria in Ghana
Open AccessAssessment of Artemisinin Tolerance in Plasmodium Falciparum Field Isolates in Children with Uncomplicated Malaria in a Ghanaian Population
Open AccessIDF21-0435 Diabetes Self-Management Education: Understanding the Needs of Patients in Resource Limited Urban Settings
Open AccessIDF21-0472 The effect of structured diabetes self-management education care on glycaemic control in Accra subsequent to COVID-19
Open AccessHaematological consequences of acute uncomplicated falciparum malaria: a WorldWide Antimalarial Resistance Network pooled analysis of individual patient data
Open AccessPerformance of a Histidine Rich Protein-2 Based (First Response) and a p-Lactate Dehydrogenase-based (Optimal) Rapid Diagnostic Test for Diagnosis of Malaria in Patients With Pediatric Sickle Cell Disease
<p>Plasma Folate Levels in Acutely Ill and Steady State Pediatric Sickle Cell Disease Patients in Ghana</p>
Open AccessEnrolment of children in clinical research: Understanding Ghanaian caregivers’ perspectives on consent/assent procedures, and their attitudes towards storage of biological samples for future use
Reticulocyte count changes in paediatric patients with uncomplicated malaria treated with artemisinin combination therapy
Open AccessReticulocyte count changes in paediatric patients with uncomplicated malaria treated with artemisinin combination therapy
Open AccessLongitudinal estimation of Plasmodium falciparum prevalence in relation to malaria prevention measures in six sub-Saharan African countries
Open AccessThe Accuracy and Perception of Test-Based Management of Malaria at Private Licensed Chemical Shops in the Middle Belt of Ghana
Open AccessPopulation Pharmacokinetic Estimates Suggest Elevated Clearance and Distribution Volume of Desethylamodiaquine in Pediatric Patients with Sickle Cell Disease Treated with Artesunate-Amodiaquine
Open AccessDiagnostic capacity, and predictive values of rapid diagnostic tests for accurate diagnosis of Plasmodium falciparum in febrile children in Asante-Akim, Ghana
Open AccessSafety and effectiveness of antimalarial therapy in sickle cell disease: a systematic review and network meta-analysis
Open AccessAssessing the performance of only HRP2 and HRP2 with pLDH based rapid diagnostic tests for the diagnosis of malaria in middle Ghana, Africa
Open AccessPopulation Pharmacokinetics of the Antimalarial Amodiaquine: a Pooled Analysis To Optimize Dosing
Open AccessLongitudinal estimation of Plasmodium falciparum prevalence in relation to malaria prevention measures in six sub-Saharan African countries
Open AccessA systematic review and synthesis of the strengths and limitations of measuring malaria mortality through verbal autopsy
Open AccessThe burden and characteristics of peripheral arterial disease in patients undergoing amputation in Korle Bu Teaching Hospital, Accra, Ghana
Open AccessTargeted community based interventions improved malaria management competencies in rural Ghana
Open AccessFailing Sulphadoxine-Pyrimethamine May Increases the Risk of Fetal In-UteroSensitization and Neonatal Malaria: Systematic Review and Meta-Analysis
Open AccessDynamics in multiplicity of Plasmodium falciparum infection among children with asymptomatic malaria in central Ghana
Open AccessPopulation Pharmacokinetic Characteristics of Amikacin in Suspected Cases of Neonatal Sepsis in a Low-Resource African Setting: A Prospective Nonrandomized Single-Site Study
Open AccessDiagnostic utility of procalcitonin versus C-reactive protein as markers for early-onset neonatal sepsis at Korle-Bu Teaching Hospital
Open AccessThe prevalence of red blood cell polymorphisms.
Open AccessInsights into the Affordable Medicines Facility-malaria in Ghana: the role of caregivers and licensed chemical sellers in four regions
Open AccessA STAT6 Intronic Single-Nucleotide Polymorphism is Associated with Clinical Malaria in Ghanaian Children
Open AccessCommunity perceptions and beliefs of blood draws for clinical trials conducted in Africa and their management: a systematic review of qualitative evidence protocol
Community perceptions and beliefs of blood draws for clinical trials conducted in Africa and their management: a systematic review of qualitative evidence protocol
Severity of malaria in relation to a complement receptor 1 polymorphism: a case–control study
Open AccessMalaria Parasite Density Estimated with White Blood Cells Count Reference Value Agrees with Density Estimated with Absolute in Children Less Than 5 Years in Central Ghana
Open AccessBaseline malaria vector transmission dynamics in communities in Ahafo mining area in Ghana
Open AccessUniversity Of Ghana Research Report, 2015/2016
Associations between Red Cell Polymorphisms and Plasmodium falciparum Infection in the Middle Belt of Ghana
Open AccessSocietal factors that predispose children under five years to severe malaria in developing countries: a systematic review of qualitative evidence
A randomized trial of artesunate-amodiaquine versus artemether-lumefantrine in Ghanaian paediatric sickle cell and non-sickle cell disease patients with acute uncomplicated malaria
Open AccessProfile of Adverse Events in Patients Receiving Treatment for Malaria in Urban Ghana: A Cohort-Event Monitoring Study
Open AccessAssociation between Plasmodium falciparum malaria and the mental disorders in children between five and 19 years in sub-Saharan Africa: a systematic review
High Plasma Levels of Soluble Intercellular Adhesion Molecule (ICAM)-1 Are Associated with Cerebral Malaria
Open AccessPrevalence of clinically captured and confirmed malaria among HIV seropositve clinic attendants in five hospitals in Ghana
Open AccessTo compare the response of children with sickle cell disease (SCD) and malaria to artemisinin combination therapy (ACT) antimalarials and the response of children without SCD treated with ACT for malaria
Placental Malaria and the Risk of Malaria in Infants in a High Malaria Transmission Area in Ghana: A Prospective Cohort Study
Open AccessThe Benefits or Otherwise of Managing Malaria Cases with or without Laboratory Diagnosis: The Experience in a District Hospital in Ghana
Open AccessTrends in multiplicity of Plasmodium falciparum infections among asymptomatic residents in the middle belt of Ghana
Open AccessPrevalence of congenital malaria in high-risk Ghanaian newborns: a cross-sectional study
Open AccessReversible Audiometric Threshold Changes in Children with Uncomplicated Malaria
Open AccessElectrocardiographic study in Ghanaian children with uncomplicated malaria, treated with artesunate-amodiaquine or artemether-lumefantrine
Open AccessAcceptability of Rapid Diagnostic Test-Based Management of Malaria among Caregivers of Under-Five Children in Rural Ghana
Open AccessReversible binocular visual loss in temporal association with artesunate-amodiaquine treatment in a child on mefloquine chemoprophylaxis.
Open AccessInsights into deregulated TNF and IL-10 production in malaria: implications for understanding severe malarial anaemia
Open AccessAssociation between Plasmodium falciparum malaria and the mental health of children between five years and nineteen years in sub-Saharan Africa: A systematic review.
Societal Contexts and Experiences that Predispose Children under 5 Years to Severe Malaria in Developing Countries: A Systematic Review
Societal Contexts and Experiences that Predispose Children under 5 Years to Severe Malaria in Developing Countries: A Systematic Review
Polymorphisms in the RNASE3 Gene Are Associated with Susceptibility to Cerebral Malaria in Ghanaian Children
Open AccessFirst Results of Phase 3 Trial of RTS,S/AS01 Malaria Vaccine in African Children
Open AccessMalaria epidemiology in the Ahafo area of Ghana
Open AccessSafety and efficacy of the RTS,S/AS01E candidate malaria vaccine given with expanded-programme-on-immunisation vaccines: 19 month follow-up of a randomised, open-label, phase 2 trial
T Cell Responses to the RTS,S/AS01E and RTS,S/AS02D Malaria Candidate Vaccines Administered According to Different Schedules to Ghanaian Children
Open AccessEvaluation of the Safety and Immunogenicity of the RTS,S/AS01<sub>E</sub>Malaria Candidate Vaccine When Integrated in the Expanded Program of Immunization
Retinopathy in severe malaria in Ghanaian children - overlap between fundus changes in cerebral and non-cerebral malaria
Open AccessAmodiaquine-associated adverse effects after inadvertent overdose and after a standard therapeutic dose
Open AccessParents’ perceptions, attitudes and acceptability of Treatment of childhood malaria with artemisinin combination therapies in Ghana
Open AccessThe experience of living with chronic manifestations of Lymphatic Filariasis among patients 15 years and older in developing countries: a systematic review
The experience of living with chronic manifestations of Lymphatic Filariasis among patients 15 years and older in developing countries: a systematic review
Artesunate plus amodiaquine combination therapy: reviewing the evidence
Randomized Controlled Trial of RTS,S/AS02D and RTS,S/AS01E Malaria Candidate Vaccines Given According to Different Schedules in Ghanaian Children
Open AccessEpidemiology of malaria in the forest-savanna transitional zone of Ghana
Open AccessArtemether–lumefantrine: an oral antimalarial for uncomplicated malaria in children
Cerebral Malaria Is Associated with Low Levels of Circulating Endothelial Progenitor Cells in African Children
Open AccessAdherence to Artesunate-Amodiaquine Therapy for Uncomplicated Malaria in Rural Ghana: A Randomised Trial of Supervised versus Unsupervised Drug Administration
Open AccessAn oral antimalaial for uncomlicated malaria in children
Effect of Concomitant Artesunate Administration and Cytochrome P4502C8 Polymorphisms on the Pharmacokinetics of Amodiaquine in Ghanaian Children with Uncomplicated Malaria
Open AccessAmodiaquine-artesunate vs artemether-lumefantrine for uncomplicated malaria in Ghanaian children: a randomized efficacy and safety trial with one year follow-up
Open AccessPhase Ii, Randomized Trial to Assess the Safety and Immunogenicity of the Candidate Malaria Vaccines Rts,S/As02 and Rts,S/As01 When Given According to Different Vaccination Schedules in Children in Ghana
Vitamin A Supplementation Enhances Infants’ Immune Responses to Hepatitis B Vaccine but Does Not Affect Responses to Haemophilus influenzae Type b Vaccine
Neurotoxicity of Artemisinin Derivatives
Open AccessAre currently deployed artemisinins neurotoxic?
Department of Animal Science
Kwame Nkrumah University of Science and Technology