Paul Poku Sampene Ossei
Department of PathologyLife SciencesHealth SciencesPhysical SciencesSocial Sciences

Paul Poku Sampene Ossei

43 Publications36 Research Themes38 Open Access
Research Overview & Focus

The researcher has conducted extensive research across diverse domains, focusing on integrating plant extracts for anti-inflammatory effects with neuroinflammation mechanisms, examining toxicological impacts on animals and plants, studying cellular repair mechanisms such as autophagy, and exploring bioactive compounds' natural defense mechanisms against diseases. Their work extends to broader societal health contexts, particularly in addressing chronic conditions like heart disease and alcohol use among Ghanaian residents, while also contributing to environmental impact assessments. This comprehensive approach underscores their commitment to advancing health sciences through interdisciplinary studies.

Faculty Biography

Dr. Paul Poku Sampene Ossei is a Consultant Histo- and Forensic Pathologist and had his medical training at Kharkov Medical Academy from 1989 to 1995 in Ukraine, USSR. He obtained his Fellowship in Pathology at the UniKlinikum, Muenster, Germany in 2009. He is a Senior Lecturer and currently the Head of Department of Pathology, SMD, KNUST. He is the author of more than 30 scientific papers in high-quality peer-reviewed journals.

Key Research Themes (36)
Life Sciences

African Botany and Ecology Studies

Health Sciences

Andrographolide Research and Applications

Health Sciences

Anorectal Disease Treatments and Outcomes

Health Sciences

Autophagy in Disease and Therapy

Health Sciences

Berberine and alkaloids research

Physical Sciences

Chemical synthesis and alkaloids

Health Sciences

Chemotherapy-induced organ toxicity mitigation

Health Sciences

Complementary and Alternative Medicine Studies

Health Sciences

Congenital Heart Disease Studies

Social Sciences

COVID-19 and Mental Health

Health Sciences

Diabetes, Cardiovascular Risks, and Lipoproteins

Life Sciences

Drug-Induced Hepatotoxicity and Protection

Health Sciences

Enhanced Recovery After Surgery

Life Sciences

Essential Oils and Antimicrobial Activity

Life Sciences

Ethnobotanical and Medicinal Plants Studies

Life Sciences

Glycosylation and Glycoproteins Research

Social Sciences

Gun Ownership and Violence Research

Health Sciences

Influenza Virus Research Studies

Health Sciences

Injury Epidemiology and Prevention

Health Sciences

Medical Coding and Health Information

Health Sciences

Medicinal Plants and Neuroprotection

Life Sciences

Neuroinflammation and Neurodegeneration Mechanisms

Life Sciences

Phytochemical Studies and Bioactivities

Life Sciences

Phytochemistry and Bioactivity Studies

Life Sciences

Phytochemistry and Biological Activities

Health Sciences

Prostate Cancer Diagnosis and Treatment

Life Sciences

Reproductive tract infections research

Life Sciences

Seed and Plant Biochemistry

Social Sciences

Suicide and Self-Harm Studies

Physical Sciences

Traffic and Road Safety

Health Sciences

Urinary Bladder and Prostate Research

Health Sciences

Uterine Myomas and Treatments

Social Sciences

Vaccine Coverage and Hesitancy

Health Sciences

Venous Thromboembolism Diagnosis and Management

Health Sciences

Viral Infections and Outbreaks Research

Health Sciences

Wound Healing and Treatments

Publications (43)

Diosgenin ameliorates silica‐induced tuberculosis in rats

Open Access
2025Phytochemical Studies and BioactivitiesDOI: 10.1002/ame2.70055

Suicidal Behavior in Police Custody: a Ten Year (2011-2021) Study in the Northern Part of Ghana

Open Access
2025COVID-19 and Mental HealthDOI: 10.20471/jan.2025.61.08

Protective effect of hydroethanolic leaves extract of Solanum macrocarpon on Cisplatin-induced kidney injury in rats

Open Access
2024Chemotherapy-induced organ toxicity mitigationDOI: 10.31183/imcp.2024.00100

Health and Toxicity Effects of Solanum torvum and Solanum nigrum Berries Extract on Rats

Open Access
2024Medicinal Plants and NeuroprotectionDOI: 10.3923/ajbs.2024.482.495

Hydroethanolic Leaves Extract of Amaranthus Cruentus Protects Against Lead-Induced Hepatorenal Toxicity in Rats

Open Access
2024Seed and Plant BiochemistryDOI: 10.15419/bmrat.v11i5.892

Nephroprotective Activity of Dialium guineense Aqueous Extract Against Cisplatin-Induced Kidney Damage in Rats

Open Access
2024Chemotherapy-induced organ toxicity mitigationDOI: 10.33425/2639-9458.1185

An acute and sub-acute toxicological assessment of Reissantia indica plant extract in male Sprague-Dawley rats: Hematological, serum biochemical and histopathology

Open Access
2024Ethnobotanical and Medicinal Plants StudiesDOI: 10.1016/j.sciaf.2024.e02089

Determinants of Hospital Stay Duration Post-Colorectal Surgery

Open Access
2024Enhanced Recovery After SurgeryDOI: 10.18502/jbe.v9i2.14627

Beyond survival: unraveling the dynamics of Ebola virus resurgence in Sub-Saharan Africa and the remarkable journey of survivors

Open Access
2023Viral Infections and Outbreaks ResearchDOI: 10.3389/fviro.2023.1227314

<i>Lantana camara</i> leaf extract ameliorates memory deficit and the neuroinflammation associated with scopolamine-induced Alzheimer’s-like cognitive impairment in zebrafish and mice

Open Access
2023Neuroinflammation and Neurodegeneration MechanismsDOI: 10.1080/13880209.2023.2209130

Preliminary health risk assessment of two exudate gums as pharmaceutical excipients

Open Access
2023African Botany and Ecology StudiesDOI: 10.1016/j.sciaf.2023.e01648

Non-HDL Cholesterol and Remnant Cholesterol Predict Different Components of the Metabolic Syndrome in Type 2 Diabetes Mellitus Patients in a Regional Hospital

Open Access
2023Diabetes, Cardiovascular Risks, and LipoproteinsDOI: 10.21203/rs.3.rs-2696463/v1

An Acute Toxicological Assessment of Reissantia Indica Plant Extract in Male Sprague-Dawley Rats: Hematological and Serum Biochemical

Open Access
2023Drug-Induced Hepatotoxicity and ProtectionDOI: 10.2139/ssrn.4628100

The hydroethanolic root extract of Psydrax subcordata (DC.) Bridson exhibits antinociceptive and anti-inflammatory effects in animal models

Open Access
2022Ethnobotanical and Medicinal Plants StudiesDOI: 10.1016/j.sciaf.2022.e01342

Anti-Arthritic Effect of the Hydroethanolic Root Extract of Psydrax subcordata in Rats

Open Access
2022Phytochemistry and Biological ActivitiesDOI: 10.1155/2022/9748382

Evaluation of Dermal Toxicity and Wound Healing Activity of Cnestis ferruginea Vahl ex DC

Open Access
2022Essential Oils and Antimicrobial ActivityDOI: 10.1155/2022/5268613

Antitubercular activities of Crinum asiaticum bulb extract using aeroso-linduced Mycobacterium smegmatis in mice model

Open Access
2022Chemical synthesis and alkaloidsDOI: 10.7324/japs.2022.120513

Palmatine Attenuates Metastatic Lung Colonization of Triple Negative Breast Cancer Cells

Open Access
2022Berberine and alkaloids researchDOI: 10.3389/fphar.2022.853230

Profile of suicide within the northern part of Ghana: A decade under review

Open Access
2022Suicide and Self-Harm StudiesDOI: 10.4102/sajpsychiatry.v28i0.1620

Anti-arthritic activity of solvent extracts of the bulbs of Crinum pedunculatum R.Br.

Open Access
2022Chemical synthesis and alkaloidsDOI: 10.29090/psa.2022.06.22.138

Acute and sub-acute toxicity studies of the chloroform extract of Crinum asiaticum bulbs in mice.

Open Access
2021Chemical synthesis and alkaloidsDOI: 10.1016/j.sajb.2021.07.047

Protective effects of andrographolide against diclofenac-induced gastric damage

Open Access
2021Andrographolide Research and ApplicationsDOI: 10.1016/j.sciaf.2021.e00944

Reporting a Case with Literature Review on Enucleation of a Giant Prostatic Hyperplasia in Ghana

2021Urinary Bladder and Prostate ResearchDOI: 10.9734/bpi/cdhr/v6/6421d

Formulation of Suppositories of Alum Produced from Bauxite Waste in Ghana for the Treatment of Hemorrhoid

Open Access
2021Anorectal Disease Treatments and OutcomesDOI: 10.1155/2021/6667562

Latent Medical Conditions of Drivers Involved in Road Traffic Collisions in Ghana: Implication from Autopsy Findings

Open Access
2021Traffic and Road SafetyDOI: 10.1177/2632010x211043871

COVID-19 Impact on Medical Practice in Sub-Saharan Africa; The Need to Guard Against Medical Negligence: A Case Report in a Health Care Facility in Kumasi, Ghana

Open Access
2021Vaccine Coverage and HesitancyDOI: 10.1177/2632010x211025308

Wound healing, antimicrobial and antioxidant properties of the leaf and stem bark of Entada africana Guill. &amp; Perr.

Open Access
2020Wound Healing and TreatmentsDOI: 10.1016/j.sajb.2020.09.037

The Culture of Herbal Preparations Among Pregnant Women: A Remedy or a Suicide Potion? A Case Report and Mini Review

Open Access
2020Complementary and Alternative Medicine StudiesDOI: 10.1155/2020/6186147

Iron-deficiency anaemia in children with congenital heart diseases at a teaching hospital in Ghana

Open Access
2020Congenital Heart Disease StudiesDOI: 10.1016/j.heliyon.2020.e03408

Prevalence of Venous Thromboembolism in Kumasi: A Postmortem-Based Study in a Tertiary Hospital in Ghana

Open Access
2020Venous Thromboembolism Diagnosis and ManagementDOI: 10.1177/1179548420956364

Trend analysis and economic effect of RTA deaths on dependency ratio in Ghana

Open Access
2019Traffic and Road SafetyDOI: 10.5897/jeif2019.0997

Review of gunshot fatalities in the Northern part of Ghana; a 6 year forensic autopsy based study

2019Gun Ownership and Violence ResearchDOI: 10.1016/j.jflm.2019.101889

Outbreak of influenza a viral infection in Ghana: A consideration of autopsy findings and a mini-review of the literature

Open Access
2019Influenza Virus Research StudiesDOI: 10.1016/j.fsir.2019.100032

Profile of unnatural mortalities in Northern part of Ghana; a forensic-based autopsy study

2019Injury Epidemiology and PreventionDOI: 10.1016/j.jflm.2019.05.012

Detecting Ureaplasma urealyticum among HIV-infected women with or without human papillomavirus using real-time PCR with the ANYPLEX™ II STI-7 assay system

Open Access
2019Reproductive tract infections researchDOI: 10.1016/j.jtumed.2019.04.001

Patterns and Presentation of Prostate Cancer in the Brong Ahafo Region of Ghana: A 6-Year Single Center Retrospective Study

Open Access
2019Prostate Cancer Diagnosis and TreatmentDOI: 10.4236/health.2019.114031

Total abdominal hysterectomy in a Tertiary Hospital in Kumasi: Indication, Histopathological Findings and Clinicopathological Correlation

Open Access
2018Uterine Myomas and TreatmentsDOI: 10.4314/jmbs.v7i1.3

Nuclear Localisation of Autophagic p62 and Associated Cytoplasmic Beclin-1 and Bcl-2 Expressions in Adenomas and Adenocarcinomas of the Colorectal Regions

2018Autophagy in Disease and TherapyDOI: 10.4172/2157-2518.1000314

Enucleation of a Giant Prostatic Hyperplasia in Ghana: A Case Report and Mini Literature Review

Open Access
2018Urinary Bladder and Prostate ResearchDOI: 10.4236/crcm.2018.712053

Death certificates errors in academic hospital; Review of 617 cases at Komfo Anokye Teaching Hospital (KATH), Kumasi

Open Access
2017Medical Coding and Health InformationDOI: 10.5897/ijmms2017.1296

Mucin expression patterns in histological grades of colonic cancers in Ghanaian population

Open Access
2017Glycosylation and Glycoproteins ResearchDOI: 10.11604/pamj.2017.27.267.9793

Anti-inflammatory activity of aqueous leaf extract of Phyllanthus muellerianus (Kuntze) Exell. and its major constituent, geraniin

2016Phytochemistry and Bioactivity StudiesDOI: 10.1016/j.jep.2016.04.020

Antioxidant and in vivo Wound Healing Activities of Clausena anisata

Open Access
2015Essential Oils and Antimicrobial ActivityDOI: 10.9734/ejmp/2015/19792
Academic Metrics
DepartmentDepartment of Pathology
Total Publications43
Research Themes36
Open Access Papers38

Department of Pathology

Kwame Nkrumah University of Science and Technology

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