Ishmael Kyei
84 Publications29 Research Themes62 Open Access
Research Overview & Focus
The cancer genomics and diagnostics theme focuses on the interplay between African ancestry and its effects on cancer biology and treatment. Key research highlights include increased expression of specific tumor suppressor genes (e.g., EGFR and FGFR1) in triple-negative breast cancer, which are influenced by African-derived alleles such as the FANCC pathway. Studies show that African descent correlates with altered tumor microenvironmental factors and poorer clinical outcomes, suggesting a shared genetic basis for these associations.
Faculty Biography
He is a practicing General Surgeon and Breast Surgeon and a researcher with interest in surgical oncology especially breast cancer . He aims to better understand Breast cancer in Africans and other ethnic minorities in the bid to improve outcomes in the management of breast cancer in these populations. He is a Co investigator with the International Center for the Study of Breast Cancer Subtypes(ICSBCS).He also works as a Senior Lecturer with the Department of Surgery, School of Medicine and Dentistry, College of Health Sciences, KNUST. He holds Fellowship in both the Ghana College of Surgeons and the West African College of Surgeons and a Post graduate Diploma in Project Design and Management from the Lieverpool School of Tropical Medicine
Key Research Themes (29)
Health Sciences
Advances in Oncology and Radiotherapy
Health Sciences
Appendicitis Diagnosis and Management
Life Sciences
BRCA gene mutations in cancer
Life Sciences
Breast Cancer Treatment Studies
Health Sciences
Breast Implant and Reconstruction
Health Sciences
Cancer Cells and Metastasis
Life Sciences
Cancer Genomics and Diagnostics
Life Sciences
Cancer-related molecular mechanisms research
Health Sciences
Cancer-related Molecular Pathways
Health Sciences
Chemokine receptors and signaling
Health Sciences
Chronic Disease Management Strategies
Health Sciences
Congenital Diaphragmatic Hernia Studies
Life Sciences
CRISPR and Genetic Engineering
Health Sciences
Diabetes Treatment and Management
Health Sciences
Diabetic Foot Ulcer Assessment and Management
Health Sciences
Drug Transport and Resistance Mechanisms
Life Sciences
Epigenetics and DNA Methylation
Health Sciences
Esophageal and GI Pathology
Health Sciences
Gastrointestinal Tumor Research and Treatment
Life Sciences
Genomic variations and chromosomal abnormalities
Health Sciences
Global Cancer Incidence and Screening
Health Sciences
Global Health and Surgery
Health Sciences
Head and Neck Anomalies
Social Sciences
Health Systems, Economic Evaluations, Quality of Life
Health Sciences
Hernia repair and management
Health Sciences
PARP inhibition in cancer therapy
Health Sciences
Soft tissue tumor case studies
Health Sciences
Thyroid Disorders and Treatments
Health Sciences
Urinary and Genital Oncology Studies
Publications (84)
Pathogenic FANCC Variants Are Associated with Accessory Breasts in a Sub-Saharan African Multiplex Family
Open AccessPathogenic FANCC Variants are Associated with Accessory Breasts in a Sub-Saharan African Multiplex Family
Open AccessA Preliminary Comparative Study on Clinical and Pathologic Response Patterns of Breast Cancer in Ghanaian Women Undergoing Neoadjuvant Chemotherapy and Hormonal Therapy
Open AccessOncologic Anthropology and the African Diaspora: Twenty-Year Anniversary Report, International Center for the Study of Breast Cancer Subtypes (ICSBCS)
Health Comes First: A Qualitative Study of Empowerment in Women Facing Breast Cancer in Ghana and Ethiopia
Open AccessEvaluating the efficacy of dilute povidone-iodine versus normal saline for preventing surgical site infections following appendectomy: a prospective observational study in Ghanaian tertiary hospital
Open AccessPatients’ Perspectives on Breast Reconstruction in Sub-Saharan Africa
Open AccessUrachal cyst: a rare cause of an abdominal mass in a Ghanaian adult female: a case report
Open AccessAssessing Breast Cancer Diagnosis and Management in Ghana per the Global Breast Cancer Initiative Key Performance Indicators
Open AccessTable S4 from Kinome-Focused CRISPR-Cas9 Screens in African Ancestry Patient-Derived Breast Cancer Organoids Identify Essential Kinases and Synergy of EGFR and FGFR1 Inhibition
Open AccessTable S1 from Kinome-Focused CRISPR-Cas9 Screens in African Ancestry Patient-Derived Breast Cancer Organoids Identify Essential Kinases and Synergy of EGFR and FGFR1 Inhibition
Open AccessTable S3 from Kinome-Focused CRISPR-Cas9 Screens in African Ancestry Patient-Derived Breast Cancer Organoids Identify Essential Kinases and Synergy of EGFR and FGFR1 Inhibition
Open AccessTable S5 from Kinome-Focused CRISPR-Cas9 Screens in African Ancestry Patient-Derived Breast Cancer Organoids Identify Essential Kinases and Synergy of EGFR and FGFR1 Inhibition
Open AccessKinome-Focused CRISPR-Cas9 Screens in African Ancestry Patient-Derived Breast Cancer Organoids Identify Essential Kinases and Synergy of EGFR and FGFR1 Inhibition
Supplementary Figures from Kinome-Focused CRISPR-Cas9 Screens in African Ancestry Patient-Derived Breast Cancer Organoids Identify Essential Kinases and Synergy of EGFR and FGFR1 Inhibition
Open AccessTable S2 from Kinome-Focused CRISPR-Cas9 Screens in African Ancestry Patient-Derived Breast Cancer Organoids Identify Essential Kinases and Synergy of EGFR and FGFR1 Inhibition
Open AccessTable S6 from Kinome-Focused CRISPR-Cas9 Screens in African Ancestry Patient-Derived Breast Cancer Organoids Identify Essential Kinases and Synergy of EGFR and FGFR1 Inhibition
Open AccessTable S7 from Kinome-Focused CRISPR-Cas9 Screens in African Ancestry Patient-Derived Breast Cancer Organoids Identify Essential Kinases and Synergy of EGFR and FGFR1 Inhibition
Open AccessData from Kinome-Focused CRISPR-Cas9 Screens in African Ancestry Patient-Derived Breast Cancer Organoids Identify Essential Kinases and Synergy of EGFR and FGFR1 Inhibition
Open AccessASO Visual Abstract: Developing a Surgical Oncology Workforce in West Africa: A Needs Assessment and Environmental Scan
Patterns of breast cancer locoregional relapse, metastasis, and subtypes in Ghana
Open AccessDeveloping a Surgical Oncology Workforce in West Africa: A Needs Assessment and Environmental Scan
18. “Who Am I Trying to Fool, God or Myself?”: A Qualitative Analysis of Sociocultural Attitudes and Perceptions about Breast Reconstruction in Sub-Saharan Africa
Open AccessParticipant Evaluation of a Multi-disciplinary Oncology Preceptorship Training Program for Oncology Health Professionals from Kumasi, Ghana
Open AccessComparative analysis of breast cancer characteristics in young premenopausal and postmenopausal women in Ghana
Open AccessKinome focused CRISPR-Cas9 screens in African ancestry patient-derived breast cancer organoids identify essential kinases and synergy of EGFR and FGFR1 inhibition
Open AccessPatient-derived tumor organoids with p53 mutations, and not wild-type p53, are sensitive to synergistic combination PARP inhibitor treatment
Open AccessKinome focused CRISPR-Cas9 screens in African ancestry patient-derived breast cancer organoids identifies essential kinases and synergy of EGFR and FGFR1 inhibition
Open AccessAbstract C047: Multiomics approaches to identify African-ancestry specific phenotypes of triple negative breast cancer
A gist on an obscure neoplasm in Ghana: gastrointestinal stromal tumours
Open AccessPatient-derived tumor organoids with p53 mutations, and not wild-type p53, are sensitive to synergistic combination PARP inhibitor treatment
Open AccessA Gist of an Obscure Neoplasm in Ghana: Gastrointestinal stromal tumours
Open AccessSupplementary Figure from African Ancestry–Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent
Open AccessAbstract NG03: Multiomics in disparities research: Identifying African ancestry-specific mechanisms in the triple negative breast cancer tumor microenvironment
Supplementary Table from African Ancestry–Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent
Open AccessSupplementary Data from African Ancestry–Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent
Open AccessSupplementary Table from African Ancestry–Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent
Open AccessSupplementary Table from African Ancestry–Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent
Open AccessSupplementary Table from African Ancestry–Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent
Open AccessSupplementary Table from African Ancestry–Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent
Open AccessSupplementary Figure from African Ancestry–Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent
Open AccessAbstract 2247: Evaluation of multidrug resistant genes among breast cancer patients in Ghana
Supplementary Table from African Ancestry–Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent
Open AccessData from African Ancestry–Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent
Open AccessSupplementary Data from African Ancestry–Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent
Open AccessData from African Ancestry–Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent
Open AccessC‐kit‐negative transmural gastrointestinal stromal tumor in the stomach: A rare case of upper GI bleeding in Ghana
Open AccessAbstract C010: Genes with African ancestry-specific expression in TNBC tumors also show population-specific baseline differences in normal mammary tissue
Innovative Methodology for Strengthening a Multidisciplinary Team Approach in Cities in Low- and Middle-Income Countries
Open AccessAfrican Ancestry–Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent
Open AccessAbstract 6037: Kinome crispr cas9 screening in breast cancer organoids derived from Ghanaian patients
African-Ancestry Associated Gene Expression Signatures and Pathways in Triple Negative Breast Cancer, a Comparison across Women of African Descent
Open AccessAbstract PO-139: BRCA sequence variants in breast cancer patients with African ancestry
Surgical management of traumatic diaphragmaticrupture: ten-year experience in a Teaching Hospitalin Ghana
Open AccessAbstract PO-141: The role of African Duffy-null allele related inflammation on the tumor microenvironment
Abstract 78: Breast Cancer in Kumasi: Recent Progress
Investigation of triple-negative breast cancer risk alleles in an International African-enriched cohort
Open AccessMultiethnic PDX models predict a possible immune signature associated with TNBC of African ancestry
Investigation of Triple-Negative Breast Cancer Risk Alleles in An International African-Enriched Cohort
Open AccessSeeking healthcare at their ‘right’ time; the iterative decision process for women with breast cancer
Open AccessSeeking healthcare at their 'right' time; the iterative decision process for women with breast cancer
Open AccessEvaluation of External Abdominal Wall Hernia Surgery in a Secondary Level Facility in Kumasi, Ghana
Open AccessSeeking Healthcare at Their 'Right' Time: The Iterative Decision Process for Women with Breast Cancer
Open AccessTable of Contents
Brief report: Global health initiatives and breast oncology capacity-building in Africa
Hereditary Susceptibility for Triple Negative Breast Cancer Associated With Western Sub-Saharan African Ancestry
Causes and predictors of mortality among Ghanaians hospitalised with endocrine disorders
Open AccessIncidence and determinants of diabetes-related lower limb amputations in Ghana, 2010–2015- a retrospective cohort study
Open AccessAfrican Clinicians’ Prioritization of Needs in International Breast Cancer Partnerships
Open AccessCreating Models to Identify New Therapeutic Options for Aggressive African Breast Cancers
Open AccessBiologic diversity of breast cancers in women with African ancestry.
Graves Disease in Central Ghana: Clinical Characteristics and Associated Factors
Open AccessThe Effect of Thyroid Dysfunction on the Cardiovascular Risk of Type 2 Diabetes Mellitus Patients in Ghana
Open AccessDiabetes-related foot disorders among adult Ghanaians
Open AccessThyroid Disorders in Central Ghana: The Influence of 20 Years of Iodization
Open AccessSpectrum of Endocrine Disorders in Central Ghana
Open AccessComparative Analysis of Breast Cancer Phenotypes in African American, White American, and West Versus East African patients: Correlation Between African Ancestry and Triple-Negative Breast Cancer
Breast Cancer and African Ancestry: Lessons Learned at the 10-Year Anniversary of the Ghana-Michigan Research Partnership and International Breast Registry
Open AccessExtra gonadal sclerosing stromal tumour in the transverse mesocolon
Open AccessAbstract P6-12-14: Comparative analysis of breast cancer phenotypes in African American, White American, and African patients- Correlation between African ancestry and triple negative breast cancer
Characterizing Breast Cancer in a Population with Increased Prevalence of Triple-Negative Breast Cancer: Androgen Receptor and ALDH1 Expression in Ghanaian Women
Open AccessSociety News
Changing Epidemiology of Intestinal Obstruction in Ghana: Signs of Increasing Surgical Capacity and an Aging Population
Incidence of breast developmental anomalies: A study at Sogakope, Ghana
Academic Metrics
DepartmentDepartment of Surgery
Total Publications84
Research Themes29
Open Access Papers62
Department of Surgery
Kwame Nkrumah University of Science and Technology