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Obed Brew
Department of PharmacologyLife SciencesHealth Sciences

Obed Brew

13 Publications5 Research Themes3 Open Access
KNUST Profile
Research Overview & Focus

The researcher's work centers on the intricate relationship between maternal histamine levels and pregnancy outcomes, particularly in pre-eclampsia scenarios. Their research encompasses several key areas: systematic reviews of histidine decarboxylase activity and diamine oxidase isoforms in placental genes, molecular mechanisms using RNA analysis techniques, experimental models to study histamine effects, and discussions on the interplay between histamine receptors and fetal development. This research aims to elucidate how maternal histamine influences pregnancy, with a focus on understanding its role in pre-eclampsia and fetal gene expression changes.

Key Research Themes (5)
Life Sciences

Mast cells and histamine

Life Sciences

Molecular Biology Techniques and Applications

Health Sciences

Pregnancy and Medication Impact

Health Sciences

Pregnancy and preeclampsia studies

Life Sciences

Reproductive System and Pregnancy

Publications (13)

Gestational Week 13 – a Critical Window for Pre-Eclampsia Pathogenesis: A Cell-Free RNA Gene Expression Study

2025Pregnancy and preeclampsia studiesDOI: 10.12688/verixiv.2024.1

Community Perspectives on Hypertensive Disorders of Pregnancy: A Qualitative Study

2025Pregnancy and preeclampsia studiesDOI: 10.12688/verixiv.1869.1

Diamine Oxidase isoforms in placenta - structural analysis and implication in pre-eclampsia

2021Pregnancy and preeclampsia studiesDOI: 10.1016/j.placenta.2021.07.280

Placental genomics : regulatory roles of histamine in pre-eclampsia

2018Reproductive System and Pregnancy

Elevated Histamine Model: A Protocol for an ex vivo model for in vitro study of histamine effect on placenta v2

Open Access
2017Pregnancy and Medication ImpactDOI: 10.17504/protocols.io.jigckbw

Elevated Histamine Model: A Protocol for an ex vivo model for in vitro study of histamine effect on placenta v1

Open Access
2017Pregnancy and Medication ImpactDOI: 10.17504/protocols.io.i6uchew

Oxygen and tissue culture affect placental gene expression

2017Pregnancy and preeclampsia studiesDOI: 10.1016/j.placenta.2017.04.024

Placental gene expression in response to histamine and oxygen

2016Mast cells and histamine

Quality of placental RNA: Effects of explant size and culture duration

2016Molecular Biology Techniques and ApplicationsDOI: 10.1016/j.placenta.2016.08.083

Comparison of Normal and Pre-Eclamptic Placental Gene Expression: A Systematic Review with Meta-Analysis

Open Access
2016Pregnancy and preeclampsia studiesDOI: 10.1371/journal.pone.0161504

The links between maternal histamine levels and complications of human pregnancy

2006Reproductive System and PregnancyDOI: 10.1016/j.jri.2006.04.002

Differential Activity of Histidine Decarboxylase in Normal and Pre-eclamptic Placentae

2006Pregnancy and preeclampsia studiesDOI: 10.1016/j.placenta.2006.05.003

Localisation of mRNAs for diamine oxidase and histamine receptors H1 and H2, at the feto-maternal interface of human pregnancy

2001Mast cells and histamineDOI: 10.1007/pl00000269
Academic Metrics
DepartmentDepartment of Pharmacology
Total Publications13
Research Themes5
Open Access Papers3

Department of Pharmacology

Kwame Nkrumah University of Science and Technology

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