Isaac Ayensu
The researcher has a diverse research focus centered around innovative approaches in drug delivery systems and biochemical analysis techniques. Their work encompasses the development of chitosan-based films for protein delivery via both buccal and wafers, as well as the functional characterization of lyophilized materials like thiolated chitosan wafers. The researcher employs computational methods and bioactive compound studies to evaluate their efficacy and biological properties. Their research also extends into health sciences, particularly in treatments related to malaria, wound healing, hemp-based interventions, and natural antidiabetic agents. This work highlights a comprehensive exploration of delivery mechanisms, biochemical characterization, and computational tools, aiming to advance therapeutic applications in various domains.
Faculty Biography
Profile of Professor Isaac AyensuProfessor Isaac Ayensu, a distinguished alumnus of Mfantsipim School (Cape Coast), has been appointed as a Full Professor in Pharmaceutical Chemistry at the Kwame Nkrumah University of Science and Technology (KNUST), marking the first such promotion since 1988. This prestigiousnappointment, effective August 1, 2023, was formally communicated in a letter dated June 24, 2024, signed by the Registrar of KNUST.Professor Ayensu holds a Bachelor of Pharmacy degree (First Class Honors, 2000) and a Master of Science in Pharmaceutical Analysis and Quality Control (2003) from KNUST. He began his academic career as a lecturer in the Department of Pharmaceutical Chemistry at KNUST in 2003. He furthered his education through a Commonwealth Scholarship, earning a PhD from the University of Greenwich, UK, between 2009 and 2013. Additionally, he holds a Commonwealth Executive Masters in Public Administration (CEMPA) from the Institute of Distance Learning (IDL), KNUST, which he completed in 2015. Professor Ayensu is a fellow of the Ghana College of Pharmacist and has held several leadership roles, including three terms as Head of the Department of Pharmaceutical Chemistry (2014-2017), and most recently, as Head of the Department of Herbal Medicine (2020-2022). He currently serves as the Head of the Department of Pharmaceutical Chemistry. His leadership extends beyond academia; he is the immediate past Chairman of the Academic, Social, and Research Pharmacists Association (ASRPA) and served on the Governing Board of the Pharmaceutical Society of Ghana from 2019 to 2023. He was also a member of the Governing Board of the Traditional Medicine Practice Council.With a robust research portfolio, Professor Ayensu has published extensively and presented at numerous national and international conferences. He is a respected reviewer for several peer-reviewed international journals. His research interests include pharmacokinetics, bioavailability, stability evaluation of allopathic and plant medicines, pharmaceutical analysis, drug regulation, quality control, and the development of novel drug formulations. Since returning to Ghana after his PhD, Professor Ayensu has been instrumental in bridging academia and industry, significantly enhancing the quality of training for PharmD, Human Biology, Dental Surgery, Veterinary Medicine, MPhil, and PhD students. He has trained countless pharmacists, doctors, dentists, physician assistants, veterinary doctors, medical herbalists, pharmacologists, and pharmaceutical analysts in Ghana, Nigeria, and China. Since 2019, he has supervised and graduated seven (7) PhD candidates who are now academics and leaders in various institutions globally. He is also a visiting professor at Madonna University (Nigeria) and China Pharmaceutical University (Nanjing, China). Professor Ayensu is a Commonwealth Fellow (2017) and a recipient of the Seeding Labs Instrumental Access Award (2018). His expertise is pivotal in advancing the Ghanaian Pharmaceutical Industry's research and development (R&D) capabilities, fostering strong collaborations between academia and industry. His work in medicine quality control has significantly improved the quality of herbal products on the Ghanaian market, addressing the critical issue of substandard medicines that pose risks to vulnerable populations such as children and pregnant women.Professor Ayensu is married to Mrs. Olivia Ayensu, and they are blessed with four children.
Advanced Drug Delivery Systems
African Botany and Ecology Studies
Agricultural pest management studies
Analytical Methods in Pharmaceuticals
Bioactive Compounds in Plants
Biochemical Acid Research Studies
Biochemical Analysis and Sensing Techniques
Biochemical and biochemical processes
Cannabis and Cannabinoid Research
Computational Drug Discovery Methods
Crystallization and Solubility Studies
Effects and risks of endocrine disrupting chemicals
Heavy metals in environment
Malaria Research and Control
Natural Antidiabetic Agents Studies
Papaya Research and Applications
Pharmaceutical studies and practices
Phytochemistry and Bioactivity Studies
Potato Plant Research
Sensory Analysis and Statistical Methods
Synthesis and biological activity
Traditional and Medicinal Uses of Annonaceae
Wound Healing and Treatments
A proteomics–metabolomics approach and mineral content analysis reveal inherent differences in the quality of <scp>Bambara</scp> groundnuts from two geographic regions
Low-temperature Heat Capacity and Other Thermodynamic Characteristics of Xylopic Acid Crystals
Phytochemical constituents from corn silk and antimicrobial activity of the isolates
Open AccessThe Effect of Storage Time on the Levels of Phthalates in Extemporaneous Preparations in Ghana
Open AccessAntiplasmodial activity and toxicity of the leaves, stem and roots of Parinari robusta Oliv [CHRYSOBALANACEAE] in animal model
The Editor-in-Chief May 31, 2024 the Journal of Chemical Thermodynamicslow-Temperature Heat Capacity and Other Thermodynamic Characteristics of Xylopic Acid Crystals
Open AccessForced Degradation Studies, Elucidation of Degradation Pathways and Degradation Kinetics of Xylopic Acid via LC and LC-MS/MS Analyses
Pharmacokinetics and in vitro liver microsomal enzyme metabolism of Xylopic acid
Trace Metals in Cannabis Seized by Law Enforcement in Ghana and Multivariate Analysis to Distinguish among Different Cannabis Farms
Open AccessAcid-Base Indicator Properties of Synthesized Phenylhydrazones: 4-(2-(2,4-Dinitrophenyl) Hydrazono) Methyl)-2 Methoxy Phenol and 4-(2-(2,4-Dinitrophenylhydrazono) Methyl) Benzene-1,3-diol
Open AccessPharmacokinetics and in Vitro Liver Microsomal Enzyme Metabolism of Xylopic Acid
Open AccessForced Degradation Studies, Elucidation of Degradation Pathways and Degradation Kinetics of Xylopic Acid via LC and LC-MS/MS Analyses
Open AccessUltraviolet-Visible Spectroscopy and Chemometric Strategy Enable the Classification and Detection of Expired Antimalarial Herbal Medicinal Product in Ghana
Open AccessIn-vivo anti-inflammatory activity of different parts of Adansonia Digitata
Open AccessSynthesis and Antimicrobial Resistant Modulatory Activity of 2,4-Dinitrophenylhydrazone Derivatives as Agents against Some ESKAPE Human Pathogens
Open AccessHydroethanolic stem bark extract of Vernonia amygdalina Del. (Asteraceae) suppresses yeast-induced pyrexia and Plasmodium berghei malaria in murine models
Open AccessEvaluation of acid neutralizing and buffering capacities of selected antacids in Ghana
Open AccessCHARACTERIZATION AND RP-HPLC METHOD DEVELOPMENT OF A BIOMARKER (BERGENIN) FROM THE ROOTS OF Securinega virosa
Assessing metal contaminants in milled maize products available on the Ghanaian market with Atomic Absorption Spectrometry and Instrumental Neutron Activation Analyser techniques
Oral Thin Films As a Remedy for Noncompliance in Pediatric and Geriatric Patients
The Challenges and Knowledge Gaps in Malaria Therapy: A Stakeholder Approach to Improving Oral Quinine Use in the Treatment of Childhood Malaria in Ghana
Open AccessSynergistic in-vitro anthelmintic potentials of Vernonia amygdalina Delile stem and Carica papaya Lin. seeds
Preliminary Phytochemical Screening and Scientific Validation of the Anti-Diabetic Effect of the Dried Husk of Zea mays L. (Corn, Poaceae)
Open AccessPhytochemical screening and antimicrobial activities of the stem bark of Allanblackia parviflora Chev. (Clusiaceae)
Open AccessDetermination of the antimicrobial and antitussive activities of the leaves of Solanum torvum
Assessment of bioequivalence profile of locally produced flucloxacillin sodium capsules via urinary excretory rates
Open AccessFunctional Characterisation and Permeation Studies of Lyophilised Thiolated Chitosan Xerogels for Buccal Delivery of Insulin
Chitosan
Multifunctional Medicated Lyophilised Wafer Dressing for Effective Chronic Wound Healing
Preparation and characterization of laminated thiolated chitosan-based freeze-dried wafers for potential buccal delivery of macromolecules
An integrated buccal delivery system combining chitosan films impregnated with peptide loaded PEG-b-PLA nanoparticles
Development and physico-mechanical characterization of carrageenan and poloxamer-based lyophilized matrix as a potential buccal drug delivery system
Development of novel formulations for mucosal delivery of protein based drugs
Open AccessDevelopment and Evaluation of Lyophilized Thiolated-Chitosan Wafers for Buccal Delivery of Protein
Open AccessIn vitro characterisation of chitosan based xerogels for potential buccal delivery of proteins
Development and characterisation of chitosan films impregnated with insulin loaded PEG-b-PLA nanoparticles (NPs): A potential approach for buccal delivery of macromolecules
Effect of membrane dialysis on characteristics of lyophilised chitosan wafers for potential buccal delivery of proteins
Development and physico-mechanical characterisation of lyophilised chitosan wafers as potential protein drug delivery systems via the buccal mucosa
Novel lyophilization cycle development of chitosan based formulation for buccal delivery using paracetamol as a model drug
Bioavailability studies on a locally manufactured paracetamol tablet.
Department of Pharmaceutical Chemistry
Kwame Nkrumah University of Science and Technology