Seth Agyei Domfeh

Seth Agyei Domfeh

21 Publications13 Research Themes19 Open Access
Research Overview & Focus

The researcher has conducted extensive research focusing on infectious diseases, with a particular emphasis on mosquito-borne infections (such as chikungunya virus and hepatitis B virus) and the natural science domain, utilizing plant-based agents like Cryptolepine.

Faculty Biography

Seth is a Lecturer in the Department of Biochemistry and Biotechnology at Kwame Nkrumah University of Science and Technology (KNUST), Kumasi. He is a certified Medical Laboratory Scientist, as recognised by the Allied Health Professions Council in Ghana, with over a decade of experience in clinical laboratory practice before joining KNUST.Seth holds a BSc in Medical Laboratory Technology, an MPhil in Immunology, and an MEd in Educational Planning and Administration from KNUST, as well as a PGDip in Teaching and Learning in Higher Education from the University of Education, Winneba. Seth was a PhD Fellow at the West African Centre for Cell Biology of Infectious Pathogens (WACCBIP) in Ghana, under the esteemed Wellcome Trust - Developing Excellence in Leadership, Training, and Science in Africa (DELTAS) programme. He afterwards graduated with a PhD in Molecular Cell Biology of Infectious Diseases from the University of Ghana, Legon.His research focuses on elucidating how toxins interact with the hepatitis B virus to promote liver cancer, discovering anticancer agents from medicinal plants, and identifying drugs that block the transmission of the malaria parasite. To advance his expertise in malaria research, he received the prestigious Africa Research Excellence Fund (AREF) Research Development Fellowship, which enabled him to receive training at the London School of Hygiene and Tropical Medicine. He was also a Visiting Researcher at the Africa Microscopy Initiative Imaging Centre in South Africa, where he gained advanced bioimaging skills.His professional services include reviewing for reputable journals such as Cancer Reports, Health Science Reports, and the Journal of Ethnopharmacology, as well as serving as an Academic Editor for PLOS One. Through his work, Seth aims to advance the discovery of innovative therapies and empower the next generation of African scientists.

Key Research Themes (13)
Health Sciences

Diet and metabolism studies

Health Sciences

Diverse Scientific Research Studies

Life Sciences

Ethnobotanical and Medicinal Plants Studies

Health Sciences

Hepatitis B Virus Studies

Health Sciences

Malaria Research and Control

Health Sciences

Medicinal Plants and Neuroprotection

Health Sciences

Mosquito-borne diseases and control

Health Sciences

Natural Antidiabetic Agents Studies

Health Sciences

PARP inhibition in cancer therapy

Life Sciences

Synthesis and bioactivity of alkaloids

Life Sciences

Toxin Mechanisms and Immunotoxins

Health Sciences

Urinary Tract Infections Management

Health Sciences

Viral gastroenteritis research and epidemiology

Publications (21)

A CRYPTOLEPIS SANGUINOLENTA-BASED PREPARATION REDUCED HOSPITAL STAY AND MORTALITY OF COVID-19 PATIENTS DURING THE PANDEMI

Open Access
2025Synthesis and bioactivity of alkaloidsDOI: 10.21010/ajtcamv21i1.1

A bioactive fraction from the leaves of Ceiba pentandra (L.) Gaertn. exhibits antiproliferative activity via cell cycle arrest at the G1/S checkpoint and initiation of apoptosis via poly [ADP-ribose] polymerase 1 (PARP1) cleavage in HeLa cells.

2025PARP inhibition in cancer therapyDOI: 10.1016/j.jep.2025.119363

In vitro cytotoxic activity of five Ghanaian plants on human cancer cell lines

Open Access
2024Natural Antidiabetic Agents StudiesDOI: 10.1016/j.sciaf.2024.e02477

In vitro antiproliferative activities of some Ghanaian medicinal plants

Open Access
2024Ethnobotanical and Medicinal Plants StudiesDOI: 10.1186/s40816-024-00383-w

Bacteriuria Among Type 2 Diabetes Mellitus Patients Attending Ejisu Government Hospital in the Ashanti Region, Ghana

Open Access
2024Urinary Tract Infections ManagementDOI: 10.1155/2024/1120083

In Vitro Cytotoxic Activity of Five Ghanaian Plants on Human Cancer Cell Lines

Open Access
2024Diverse Scientific Research StudiesDOI: 10.2139/ssrn.4880373

Cryptolepine, a plant-derived alkaloid, differentially regulates signal transduction pathways in human embryonic kidney (HEK293) cells

2023Synthesis and bioactivity of alkaloidsDOI: 10.4314/just.v41i3.4

Evaluation of Four Malaria Rapid Diagnostic Test Kits Used at the Enyiresi Government Hospital in the Eastern Region of Ghana

Open Access
2023Malaria Research and ControlDOI: 10.1155/2023/4226020

Comparative study of Widal test to stool culture for the diagnosis of suspected typhoid fever: a study in a primary health centre, Ghana

Open Access
2023Viral gastroenteritis research and epidemiologyDOI: 10.21608/mid.2023.191532.1460

Evaluation of Anti‐<i>Candida albicans</i> Activities of Herbal Preparations Sold at the Kumasi Central Market in the Ashanti Region of Ghana

Open Access
2023Medicinal Plants and NeuroprotectionDOI: 10.1155/2023/6162532

Evaluation of inflammatory and liver injury biomarkers among drug-naive viral hepatitis B patients: A study in a referral laboratory, Ghana

Open Access
2022Hepatitis B Virus StudiesDOI: 10.21608/ajgh.2023.183024.1025

The Pharmacologically Active Alkaloid Cryptolepine Activates a Type 1 Interferon Response That Is Independent of MAVS and STING Pathways

Open Access
2022Toxin Mechanisms and ImmunotoxinsDOI: 10.1155/2022/8873536

Immunosurveillance and molecular detection of hepatitis B virus infection amongst vaccinated children in the West Gonja District in Savanna Region of Ghana

Open Access
2021Hepatitis B Virus StudiesDOI: 10.1371/journal.pone.0257103

Cryptolepine and Nibima inhibit hepatitis B virus replication

Open Access
2021Hepatitis B Virus StudiesDOI: 10.1016/j.sciaf.2021.e00942

Evidence of chikungunya virus infections among febrile patients at three secondary health facilities in the Ashanti and the Bono Regions of Ghana

Open Access
2021Mosquito-borne diseases and controlDOI: 10.1371/journal.pntd.0009735

Cryptolepine inhibits hepatocellular carcinoma growth through inhibiting interleukin-6/STAT3 signalling

Open Access
2021Synthesis and bioactivity of alkaloidsDOI: 10.1186/s12906-021-03326-x

Cryptolepine consolidates its anticancer potential by increasing the anti-cancer pathway genes and decreasing that of pro-cancer pathway genes

Open Access
2021Synthesis and bioactivity of alkaloidsDOI: 10.21203/rs.3.rs-133186/v2

Cryptolepine consolidates its anticancer potential by increasing the anti-cancer pathway genes and decreasing that of pro-cancer pathway genes

Open Access
2021Synthesis and bioactivity of alkaloidsDOI: 10.21203/rs.3.rs-133186/v3

Cryptolepine consolidates its anticancer property by increasing the anti-cancer pathway genes and decreasing that of pro-cancer pathway genes

Open Access
2020Synthesis and bioactivity of alkaloidsDOI: 10.21203/rs.3.rs-133186/v1

Postprandial glycemic responses of four common Ghanaian meals

Open Access
2019Diet and metabolism studies

Asymptomatic Bacteriuria and Anti-Microbial Susceptibility Patterns among Women of Reproductive Age. A Cross-Sectional Study in Primary Care, Ghana

Open Access
2018Urinary Tract Infections ManagementDOI: 10.3390/medsci6040118
Academic Metrics
DepartmentDepartment of Biochemistry and Biotechnology
Total Publications21
Research Themes13
Open Access Papers19

Department of Biochemistry and Biotechnology

Kwame Nkrumah University of Science and Technology

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