Mohamed Mutocheluh
Department of Clinical MicrobiologyHealth SciencesLife Sciences

Mohamed Mutocheluh

50 Publications29 Research Themes41 Open Access
Research Overview & Focus

The researcher has focused on a diverse range of infectious diseases and medical interventions, including cervical human papillomavirus (HPV) infection and squamous intraepithelial lesions among HIV-infected and uninfected Ghanaian women, viral-associated cancers, hepatitis B virus studies, HIV/AIDS research, and more. Their work encompasses both direct medical research, such as the identification of Caspase-mediated decay of interferon regulatory factor-3 through a Kaposi Sarcoma-associated herpesvirus immunoregulatory protein, and indirect areas like cytokine signaling pathways where future experimental work may be prioritized. The researcher's broader focus includes developing new diagnostic tools for viral diseases like SARS-CoV-2 and COVID-19, as well as enhancing immunomodulation strategies to combat various health conditions. Their research also explores emerging viruses such as Kaposi’s sarcoma-associated herpesvirus and the role of cryptolepine in cancer treatment, while addressing complex issues like sexual health, respiratory infections, and infectious disease management.

Faculty Biography

Mohamed Mutocheluh is a Professor in the Department of Clinical Microbiology of the School of Medical Sciences of the Kwame Nkrumah University of Science and Technology (KNUST). He was head of department from 2020 - 2024. He served as a visiting scholar (2024/25 academicy year) at Weill Cornell Medical College in New York City, USA. His mission is to turn research into impact. As a clinical virologist and immunologist, he worked at the intersection of laboratory discovery and public health, from reducing HIV and HBV viral loads in patients to developing promising new drug candidates based on his extensive work on the antiviral type I interferon response signalling pathway. His journey has taken him from Ghana through London to New York City, forging collaborations that cross borders and disciplines. Beyond the science, he is committed to mentoring the next generation of African researchers and building the infrastructure that will make our continent a leader in global health innovation. Click on this link to learn more about his work. https://www.youtube.com/watch?v=cNdlvMiZtf4His new promising antiviral candidate drug code named LT500MM was confirmed to inhibit HIV and HBV replication in vitro during his research visit to Weill Corneil Medical College in New York City. His team had previously shown that LT500MM reduced HIV load among some people living with HIV in clinical case studies in Ghana. Since 2012 he has generated resources worth at least $600,000 USD to promote teaching and learning in KNUST. His key collaborators are the West African Centre for Cell Biology of Infectious Pathogens (WACCBIP) and the Department of Microbial and Cellular Sciences of the University of Surrey, UK and Dr Robert Schwartz Lab at Weill Cornell Medicine in New York City.Professor Mutocheluh was born in Yendi in the Northern Region of Ghana. He attended the SakaSaka Primary School and later on spent one year at the Northern School of Business. In 1987 he won a national award to study in Cuba were attended secondary school and university.He did his national service at the Tamale Regional Hospital and later on worked there as a laboratory technologist between 1995 -1999. He joined KNUST in the year 2000 as a Medical Laboratory Technologist/teaching assistant.In 2002, he won a scholarship to the University of Nottingham UK, to study a Masters degree programme in Molecular Medical Microbiology. He went to the University of Birmingham, UK to pursue MPhil and PhD in Immunology and infection (2006 -2011).He is married to Dr Alimatu Salam and they have four beautiful daughters.

Key Research Themes (29)
Health Sciences

Adolescent Sexual and Reproductive Health

Life Sciences

Antibiotic Use and Resistance

Life Sciences

Bacterial Infections and Vaccines

Health Sciences

Cervical Cancer and HPV Research

Health Sciences

COVID-19 diagnosis using AI

Health Sciences

Cytokine Signaling Pathways and Interactions

Health Sciences

Cytomegalovirus and herpesvirus research

Health Sciences

Diverse Scientific Research Studies

Health Sciences

Gestational Diabetes Research and Management

Life Sciences

Glycosylation and Glycoproteins Research

Health Sciences

Hepatitis B Virus Studies

Health Sciences

Hepatitis Viruses Studies and Epidemiology

Health Sciences

HIV/AIDS Research and Interventions

Health Sciences

Human Health and Disease

Life Sciences

interferon and immune responses

Health Sciences

Malaria Research and Control

Life Sciences

Medicinal Plant Research

Health Sciences

Mosquito-borne diseases and control

Life Sciences

Mycotoxins in Agriculture and Food

Health Sciences

Natural Antidiabetic Agents Studies

Life Sciences

Parasitic Infections and Diagnostics

Health Sciences

Respiratory viral infections research

Health Sciences

SARS-CoV-2 and COVID-19 Research

Health Sciences

SARS-CoV-2 detection and testing

Life Sciences

Synthesis and bioactivity of alkaloids

Life Sciences

Toxin Mechanisms and Immunotoxins

Health Sciences

Viral gastroenteritis research and epidemiology

Health Sciences

Viral-associated cancers and disorders

Health Sciences

Xenotransplantation and immune response

Publications (50)

A CRYPTOLEPIS SANGUINOLENTA-BASED PREPARATION REDUCED HOSPITAL STAY AND MORTALITY OF COVID-19 PATIENTS DURING THE PANDEMI

Open Access
2025Synthesis and bioactivity of alkaloidsDOI: 10.21010/ajtcamv21i1.1

Effect of Ochratoxin A (OTA) on the Immune System: A Systematic Review

Open Access
2025Mycotoxins in Agriculture and FoodDOI: 10.3390/toxins17050256

In vitro cytotoxic activity of five Ghanaian plants on human cancer cell lines

Open Access
2024Natural Antidiabetic Agents StudiesDOI: 10.1016/j.sciaf.2024.e02477

Prevalence and Predictors of Gestational Diabetes Mellitus in <scp>Sub‐Saharan</scp> Africa: A 10‐Year Systematic Review

Open Access
2024Gestational Diabetes Research and ManagementDOI: 10.1002/edm2.478

In Vitro Cytotoxic Activity of Five Ghanaian Plants on Human Cancer Cell Lines

Open Access
2024Diverse Scientific Research StudiesDOI: 10.2139/ssrn.4880373

Comparative Analysis of SARS-Cov-2 Detection Using Viral Swab in Viral Transport Medium Against Cotton Swab in 0.9% Normal Saline

Open Access
2023COVID-19 diagnosis using AIDOI: 10.36108/gjoboh/3202.20.0240

Cryptolepine, a plant-derived alkaloid, differentially regulates signal transduction pathways in human embryonic kidney (HEK293) cells

2023Synthesis and bioactivity of alkaloidsDOI: 10.4314/just.v41i3.4

Microbial Organisms in the Lower Respiratory Tract Associated with SARS-CoV-2 Infection: A Cross-Sectional Study in Northern Ghana

Open Access
2023Antibiotic Use and ResistanceDOI: 10.3390/covid3040033

Genetic diversity of rotavirus infection among young children with diarrhoea in the Kasena-Nankana Districts of Northern Ghana: a seasonal cross-sectional survey

Open Access
2023Viral gastroenteritis research and epidemiologyDOI: 10.11604/pamj.2023.44.148.36783

Phased Multi-Country Seroepidemiology Study of Over 20000 Individuals&amp;nbsp;In West Africa Reveals the Dynamics of SARS-CoV-2 Exposure Driven by Delta, Omicron and Omicron Waves

Open Access
2023SARS-CoV-2 and COVID-19 ResearchDOI: 10.2139/ssrn.4593226

Aflatoxin B<sub>1</sub>: An Immunomodulator and Cancer Agent

Open Access
2022Mycotoxins in Agriculture and FoodDOI: 10.5772/intechopen.106833

Evaluation of inflammatory and liver injury biomarkers among drug-naive viral hepatitis B patients: A study in a referral laboratory, Ghana

Open Access
2022Hepatitis B Virus StudiesDOI: 10.21608/ajgh.2023.183024.1025

The Pharmacologically Active Alkaloid Cryptolepine Activates a Type 1 Interferon Response That Is Independent of MAVS and STING Pathways

Open Access
2022Toxin Mechanisms and ImmunotoxinsDOI: 10.1155/2022/8873536

Comparable Detection of SARS-CoV-2 in Sputum and Oropharyngeal Swab Samples of Suspected COVID-19 Patients

Open Access
2022SARS-CoV-2 detection and testingDOI: 10.3390/covid2070062

Occurrence of Cryptosporidium Infection and Associated Risk Factors among HIV-Infected Patients Attending ART Clinics in the Central Region of Ghana

Open Access
2021Parasitic Infections and DiagnosticsDOI: 10.3390/tropicalmed6040210

Immunosurveillance and molecular detection of hepatitis B virus infection amongst vaccinated children in the West Gonja District in Savanna Region of Ghana

Open Access
2021Hepatitis B Virus StudiesDOI: 10.1371/journal.pone.0257103

Cryptolepine and Nibima inhibit hepatitis B virus replication

Open Access
2021Hepatitis B Virus StudiesDOI: 10.1016/j.sciaf.2021.e00942

Evidence of chikungunya virus infections among febrile patients at three secondary health facilities in the Ashanti and the Bono Regions of Ghana

Open Access
2021Mosquito-borne diseases and controlDOI: 10.1371/journal.pntd.0009735

Cryptolepine inhibits hepatocellular carcinoma growth through inhibiting interleukin-6/STAT3 signalling

Open Access
2021Synthesis and bioactivity of alkaloidsDOI: 10.1186/s12906-021-03326-x

Low risk of SARS-CoV-2 in blood transfusion

Open Access
2021SARS-CoV-2 and COVID-19 ResearchDOI: 10.1371/journal.pone.0249069

Cryptosporidium Infection and Associated Risk Factors among Cattle in the Central Region of Ghana

Open Access
2021Parasitic Infections and DiagnosticsDOI: 10.1155/2021/6625117

Cryptolepine consolidates its anticancer potential by increasing the anti-cancer pathway genes and decreasing that of pro-cancer pathway genes

Open Access
2021Synthesis and bioactivity of alkaloidsDOI: 10.21203/rs.3.rs-133186/v3

Cryptolepine consolidates its anticancer potential by increasing the anti-cancer pathway genes and decreasing that of pro-cancer pathway genes

Open Access
2021Synthesis and bioactivity of alkaloidsDOI: 10.21203/rs.3.rs-133186/v2

Cryptolepine consolidates its anticancer property by increasing the anti-cancer pathway genes and decreasing that of pro-cancer pathway genes

Open Access
2020Synthesis and bioactivity of alkaloidsDOI: 10.21203/rs.3.rs-133186/v1

Prevalence and attitude towards hepatitis B vaccination among healthcare workers in a tertiary hospital in Ghana

Open Access
2020Hepatitis B Virus StudiesDOI: 10.11604/pamj.2020.36.244.24085

Molecular detection of enterovirus D68 among children with acute respiratory tract infection in Ghana

Open Access
2019Respiratory viral infections researchDOI: 10.4102/ajlm.v8i1.732

Sero-prevalence of Hepatitis B and C viral co-infections among HIV-1 infected ART-naïve individuals in Kumasi, Ghana

Open Access
2019Hepatitis B Virus StudiesDOI: 10.1371/journal.pone.0215377

Prevalence of HIV, Hepatitis B, Hepatitis C and Syphilis Infections among Patients in a Psychiatric Hospital in Ghana

Open Access
2019Adolescent Sexual and Reproductive HealthDOI: 10.23937/2469-567x/1510050

Aetiology of viral hepatitis among jaundiced patients presenting to a tertiary hospital in Ghana

Open Access
2018Hepatitis Viruses Studies and EpidemiologyDOI: 10.1371/journal.pone.0203699

USING A GLYCAN MICROARRAY TO IDENTIFY DOMINANT ANTI-GLYCAN IGE RESPONSES IN GHANAIAN SCHOOL-CHILDREN LIVING IN A HELMINTH-ENDEMIC AREA

2018Human Health and Disease

Identification of dominant anti-glycan IgE responses in school children by glycan microarray

Open Access
2017Xenotransplantation and immune responseDOI: 10.1016/j.jaci.2017.09.040

Epidemiology of cervical human papillomavirus (HPV) infection and squamous intraepithelial lesions (SIL) among a cohort of HIV-infected and uninfected Ghanaian women

Open Access
2017Cervical Cancer and HPV ResearchDOI: 10.1186/s12885-017-3682-x

Iconography : Identification of dominant anti-glycan IgE responses in school children by glycan microarray

2017Glycosylation and Glycoproteins Research

Supplementary material : Identification of dominant anti-glycan IgE responses in school children by glycan microarray

2017Glycosylation and Glycoproteins Research

Microbial pathogens associated with acute childhood diarrhoea in Kumasi, Ghana

Open Access
2017Viral gastroenteritis research and epidemiologyDOI: 10.1186/s13104-017-2578-9

Antifungal and Anti-Proliferative Effects of Zeolites A and X on Yeast Pathogenic and Cancer Cells <i>In Vitro</i>

2017Medicinal Plant ResearchDOI: 10.1166/jbt.2017.1602

Aflatoxin B1 inhibits the type 1 interferon response pathway via STAT1 suggesting another mechanism of hepatocellular carcinoma

Open Access
2017Cytokine Signaling Pathways and InteractionsDOI: 10.1186/s13027-017-0127-8

PREVALENCE AND RISK FACTORS OF VIROLOGICAL FAILURE AMONG CHILDREN ON ANTIRETROVIRAL THERAPY

Open Access
2017HIV/AIDS Research and InterventionsDOI: 10.1136/bmjgh-2016-000260.20

Performance of First Response® and CareStart™ Malaria Rapid Diagnostic Tests for the Detection of Plasmodium falciparum in a Tertiary Hospital in Ghana

2017Malaria Research and ControlDOI: 10.9734/bjmmr/2017/30892

Dengue virus exposure among blood donors in Ghana

Open Access
2016Mosquito-borne diseases and controlDOI: 10.4314/jmbs.v5i2.5

Seroprevalence of Rubella Virus, Cytomegalovirus and Herpes Simplex Virus–2 among Pregnant Women at the Komfo Anokye Teaching Hospital, Ghana

2015Cytomegalovirus and herpesvirus research

Pattern and predictors of immunologic recovery in HIV infected patients

Open Access
2015HIV/AIDS Research and InterventionsDOI: 10.1186/s13104-015-1406-3

Behavioural Practices Associated with Occurrence of HIV among University Students in Ghana

2015Adolescent Sexual and Reproductive HealthDOI: 10.9734/bjmmr/2015/18827

Knowledge and occupational hazards of barbers in the transmission of hepatitis B and C was low in Kumasi, Ghana

Open Access
2015Hepatitis B Virus StudiesDOI: 10.11604/pamj.2015.20.260.4138

Risk factors associated with hepatitis B exposure and the reliability of five rapid kits commonly used for screening blood donors in Ghana

Open Access
2014Hepatitis B Virus StudiesDOI: 10.1186/1756-0500-7-873

The prevalence of hepatitis B virus E antigen among Ghanaian blood donors

Open Access
2014Hepatitis B Virus StudiesDOI: 10.11604/pamj.2014.17.53.3390

HIV co-infection and mortality pattern of purulent meningitis: A 5 year retrospective autopsy study at the Korle-Bu Teaching Hospital

Open Access
2012Bacterial Infections and Vaccines

Understanding KSHV vIRF-2-cell interactions

Open Access
2011interferon and immune responses

Kaposi’s sarcoma-associated herpesvirus viral interferon regulatory factor-2 inhibits type 1 interferon signalling by targeting interferon-stimulated gene factor-3

2011Viral-associated cancers and disordersDOI: 10.1099/vir.0.034322-0

Identification of Caspase-mediated Decay of Interferon Regulatory Factor-3, Exploited by a Kaposi Sarcoma-associated Herpesvirus Immunoregulatory Protein

Open Access
2009interferon and immune responsesDOI: 10.1074/jbc.m109.033290
Academic Metrics
DepartmentDepartment of Clinical Microbiology
Total Publications50
Research Themes29
Open Access Papers41

Department of Clinical Microbiology

Kwame Nkrumah University of Science and Technology

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