JY
Jibira Yakubu
57 Publications30 Research Themes49 Open Access
Research Overview & Focus
The researcher's work focuses on synthesizing and studying natural compounds to address a wide range of health issues, including inflammation, pain, cardiovascular disease, prostate cancer, heart disease, hyperinflammation, mental health, and bone health. The approach integrates chemical synthesis, in vitro experiments, and therapeutic activities across diverse biological pathways, leveraging natural products like curcumin and ethylene glycol for anti-prostatic activity and anti-inflammatory effects.
Key Research Themes (30)
Life Sciences
African Botany and Ecology Studies
Health Sciences
Berberine and alkaloids research
Life Sciences
Bioactive Compounds and Antitumor Agents
Life Sciences
Bioactive natural compounds
Physical Sciences
Chemical synthesis and alkaloids
Health Sciences
Complementary and Alternative Medicine Studies
Life Sciences
Curcumin's Biomedical Applications
Life Sciences
Drug-Induced Hepatotoxicity and Protection
Life Sciences
Essential Oils and Antimicrobial Activity
Life Sciences
Estrogen and related hormone effects
Life Sciences
Ethnobotanical and Medicinal Plants Studies
Health Sciences
Hormonal and reproductive studies
Health Sciences
Hormonal Regulation and Hypertension
Social Sciences
Islamic Finance and Banking Studies
Health Sciences
Malaria Research and Control
Life Sciences
Moringa oleifera research and applications
Health Sciences
Natural Antidiabetic Agents Studies
Life Sciences
Natural product bioactivities and synthesis
Life Sciences
Neuroinflammation and Neurodegeneration Mechanisms
Physical Sciences
Organic Chemistry Cycloaddition Reactions
Health Sciences
Pain Mechanisms and Treatments
Life Sciences
Pharmacological Effects of Natural Compounds
Life Sciences
Phytochemistry and biological activity of medicinal plants
Health Sciences
Prostate Cancer Treatment and Research
Life Sciences
Protein Hydrolysis and Bioactive Peptides
Life Sciences
Seed and Plant Biochemistry
Physical Sciences
Synthesis and biological activity
Life Sciences
Tannin, Tannase and Anticancer Activities
Life Sciences
Traditional and Medicinal Uses of Annonaceae
Health Sciences
Wound Healing and Treatments
Publications (57)
Clinical Hurdles for Curcumin and Piperine Nanoparticles for Treatment of Prostate Cancer
Open AccessSAT-317 Design and Evaluation of novel CYP17A1 Inhibitors: Potential Therapeutic Agents for Castration-Resistant Prostate Cancer
Open AccessAnti-Prostatic Carcinoma Activity of Entandrophragma angolense and Methyl Angolensate: In Vitro and In Silico Analyses
Open AccessNeuro-therapeutic effect of ursolic acid in a murine model of vincristine-induced neuropathic pain
Steroidogenesis and CYP17A1 inhibition: development of potent inhibitors for adrenal and gonadal steroid biosynthesis
Nanoparticles with curcumin and piperine modulate steroid biosynthesis in prostate cancer
Open AccessDesign and Evaluation of Novel CYP17A1 Inhibitors: Potential Therapeutic Agents for Castration-Resistant Prostate Cancer (Abstract ID: 190110)
Pyridine indole hybrids as novel potent CYP17A1 inhibitors
Open AccessIn vitro antioxidant and antiarthritic effects of Persicaria lanigera R. Br. Soják (Polygonaceae) leaf extract in complete Freund’s Adjuvant-induced rheumatoid arthritis model via immunomodulatory regulation of NF-κB, IL-1β, TNF-α, and COX-2 signaling pathways
“Hydroethanol extract and triterpenoids of Senegalia ataxacantha show antiplasmodial activity and the compounds are predicted to inhibit parasite lactate dehydrogenase (pfLDH) as indicated by molecular docking studies”
Open AccessCurcumin and Piperine Nanoparticles inhibit CYP17A1 activity to Regulate Steroid Biosynthesis in Prostate Cancer
Open AccessNanoparticles with Curcumin and Piperine Modulate Steroid Biosynthesis in Prostate Cancer
Open AccessNanoparticles with Curcumin and Piperine Modulate Steroid Biosynthesis in Prostate Cancer
Open Access7906 Nanoencapsulated Curcumin-Piperine Complex: A Breakthrough in Targeting CYP17A1 for Castration Resistant Prostate Cancer Therapy
Open Access7906 Nanoencapsulated Curcumin-Piperine Complex: A Breakthrough In Targeting CYP17A1 For Castration Resistant Prostate Cancer Therapy
Open AccessNanoencapsulation of Curcumin-Piperine Complex for Targeting CYP17A1 in Castration-Resistant Prostate Cancer
Innovative Delivery Systems for Curcumin: Exploring Nanosized and Conventional Formulations
Open AccessNano‐Delivery Systems for Curcumin
Open AccessEffect of Essential Oil Components on the Activity of Steroidogenic Cytochrome P450
Open AccessEffect of Essential oil Components on the Activity of Steroidogenic Cytochromes P450
Open AccessReview of: "In-Vitro Antibacterial Activity of some Ganoderma Species: A Review"
Open AccessEssential oil terpenes may inhibit steroidogenic cytochrome P450 activities
Open AccessEssential Oil Components May Act as Antiandrogen Compounds in Prostate Cancer by Inhibition of Steroidogenic Cytochrome P450 Activities
Open AccessExploring the Potential of Sulfur Moieties in Compounds Inhibiting Steroidogenesis
Open AccessReview of: "Toxicity of Olea africana in Artemia Salina and Mice"
Open Access<i>Lantana camara</i> leaf extract ameliorates memory deficit and the neuroinflammation associated with scopolamine-induced Alzheimer’s-like cognitive impairment in zebrafish and mice
Open AccessNon-steroidal CYP17A1 Inhibitors: Discovery and Assessment
Open AccessPharmacognostic study, anti-inflammatory and, antioxidant activities of Loeseneriella africana
Open AccessAnti-microbial, anti-inflammatory and anti-oxidant bioactivities of the methanolic extract of Alafia zambesiaca (stem-bark)
Open AccessEvaluation of the anti-inflammatory and antioxidant potential of the stem bark extract and some constituents of Aidia genipiflora (DC.) dandy (rubiaceae)
Open AccessAntimicrobial, Antioxidant, and Anti-inflammatory Evaluation of Synthesised Azo Compounds based on β-naphthol, Catechol and Quinol Nucleus
Open AccessMethanolic extract of Nauclea diderrichii (stem-bark) show anti-microbial, anti-oxidant and anti-inflammatory bioactivities
Open AccessAntinociceptive effects of a hydroethanolic stem bark extract of Burkea africana
Open AccessEvaluation of the Anti-Inflammatory and Antioxidant Potential of the Stem Bark Extract and Some Constituents of <i>Aidia Genipiflora</i> (Dc.) Dandy (Rubiaceae)
Open AccessAnti-arthritic activity of solvent extracts of the bulbs of Crinum pedunculatum R.Br.
Open AccessAntimicrobial, antioxidant and wound healing activities of methanol leaf extract of Bridelia micrantha (Hochst.) Baill.
Open AccessAmphimas pterocarpoides harms.: An Evaluation of flavonoid and phenolic contents, wound healing, anthelmintic and antioxidant activities of the leaves and stem bark
Open AccessPharmacological Role of Biosynthetic Products
Open AccessPurchase of Aphrodisiacs; A Descriptive Cross-sectional Study in the Kumasi Metropolis of Ghana
Open AccessWound Management Property of a Hydroethanolic Leaf Extract of Cnestis ferruginea DC
Open AccessIn-vivo anti-inflammatory activity of different parts of Adansonia Digitata
Open AccessSensory Perception of Bioactive Peptides and Debittering Techniques Employed for Taste Improvement
<i>Amphimas pterocarpoides</i> Harms: An Evaluation of Flavonoid and Phenolic Contents, Wound Healing, Anthelmintic and Antioxidant Activities of the Leaves and Stem Bark
Open AccessThe Effectiveness of Varying Combination Ratios of A. cordifolia and M. indica against Field and Laboratory Strains of P. falciparum In Vitro
Open AccessPhysicochemical, Phytochemical, Heavy Metal and Microbiological Analysis of Moringa oleifera Lam. Leaves
Open AccessAntioxidant and Hepatoprotective properties of Helianthus annuus seed extract against paracetamol-induced liver toxicity
Open AccessHydroethanolic stem bark extract of Vernonia amygdalina Del. (Asteraceae) suppresses yeast-induced pyrexia and Plasmodium berghei malaria in murine models
Open AccessHydroethanolic Stem Bark Extract of <i>Burkea africana</i> Attenuates Vincristine-Induced Peripheral Neuropathy in Rats
Open AccessHypotensive and Antihypertensive Properties and Safety for Use of <i>Annona muricata</i> and <i>Persea americana</i> and Their Combination Products
Open AccessCo-extract mixture from Strophanthus hispidus (roots) and Aframomum meleguta (seeds) show phytochemical synergy in its anti-inflammatory activity
Open AccessResistance Modulation Action, Time-Kill Kinetics Assay, and Inhibition of Biofilm Formation Effects of Plumbagin from <i>Plumbago zeylanica</i> Linn
Open AccessPhytochemistry, proximate and antioxidant properties of some indigenous leafy vegetables
Open AccessPhytochemistry, proximate and antioxidant properties of some indigenous leafy vegetables
Open AccessMacaranga barteri stem bark extract exerts anti-inflammatory and anti-hyperalgesia activity in murine models
Open AccessEvaluation of the Anti-inflammatory, Antimicrobial and Antioxidant activities of the stem bark extract of Croton penduliflorus Hutch (Euphorbiaceae)
2017Essential Oils and Antimicrobial Activity
Pharmacognostic studies of the leaves and seeds of Cassia occidentalis (Linn.) (Leguminosae)
2016Phytochemistry and biological activity of medicinal plants
Antimicrobial Qualities of Senna Alata
Open AccessAcademic Metrics
DepartmentDepartment of Pharmacology
Total Publications57
Research Themes30
Open Access Papers49
Department of Pharmacology
Kwame Nkrumah University of Science and Technology