Patrick Williams Narkwa
The researcher's work spans multiple domains within health sciences, with a central focus on the interplay between alkaloids like cryptolepine and their biological roles. This includes its role in anti-cancer mechanisms by modulating pathways such as STAT3 and interleukin signaling, particularly in the context of hepatocellular carcinoma growth. The study also explores its pathobiology, highlighting how it consolidates anticancer properties while counteracting anti-cancer pathways. Additionally, the researcher investigates emerging challenges in environmental hazards affecting health sciences through studies on viral gastroenteritis, mycotoxins, and SARS-CoV-2. This work integrates diverse themes to advance understanding of alkaloid-derived compounds' pharmacological versatility across cancer prevention, food safety, and global health crises.
Faculty Biography
Patrick Williams Narkwa is a lecturer in Virology, Immunology and Molecular Techniques at the Department of Clinical Microbiology at the Kwame Nkrumah University of Science and Technology (KNUST), Kumasi-Ghana. Patrick's research focuses on the 'interaction between aflatoxin B1 and hepatitis B virus: effects on type I interferon signalling pathway". Patrick received his PhD in Clinical Microbiology from KNUST where he worked on understanding the role of aflatoxin B1 in modulating the type I interferon response. Prior to being appointed as a lecturer, Patrick was a Leverhulme Royal Society Africa Postdoctoral Fellow at the Department of Clinical Microbiology.
Cytokine Signaling Pathways and Interactions
Cytomegalovirus and herpesvirus research
Diverse Scientific Research Studies
Hepatitis B Virus Studies
Malaria Research and Control
Medicinal Plant Research
Mosquito-borne diseases and control
Mycotoxins in Agriculture and Food
Natural Antidiabetic Agents Studies
SARS-CoV-2 and COVID-19 Research
Synthesis and bioactivity of alkaloids
Toxin Mechanisms and Immunotoxins
Viral gastroenteritis research and epidemiology
The Burden of Atherosclerotic Cardiovascular Disease Risk Factors Among Adults Living With HIV in the Ashanti Region: A Cross-Sectional Study in Kumasi
Open AccessIn vitro cytotoxic activity of five Ghanaian plants on human cancer cell lines
Open AccessIn Vitro Cytotoxic Activity of Five Ghanaian Plants on Human Cancer Cell Lines
Open AccessCryptolepine, a plant-derived alkaloid, differentially regulates signal transduction pathways in human embryonic kidney (HEK293) cells
Phased Multi-Country Seroepidemiology Study of Over 20000 Individuals In West Africa Reveals the Dynamics of SARS-CoV-2 Exposure Driven by Delta, Omicron and Omicron Waves
Open AccessAflatoxin B<sub>1</sub>: An Immunomodulator and Cancer Agent
Open AccessEvaluation of inflammatory and liver injury biomarkers among drug-naive viral hepatitis B patients: A study in a referral laboratory, Ghana
Open AccessThe Pharmacologically Active Alkaloid Cryptolepine Activates a Type 1 Interferon Response That Is Independent of MAVS and STING Pathways
Open AccessImmunosurveillance and molecular detection of hepatitis B virus infection amongst vaccinated children in the West Gonja District in Savanna Region of Ghana
Open AccessCryptolepine and Nibima inhibit hepatitis B virus replication
Open AccessEvidence of chikungunya virus infections among febrile patients at three secondary health facilities in the Ashanti and the Bono Regions of Ghana
Open AccessCryptolepine inhibits hepatocellular carcinoma growth through inhibiting interleukin-6/STAT3 signalling
Open AccessCryptolepine consolidates its anticancer potential by increasing the anti-cancer pathway genes and decreasing that of pro-cancer pathway genes
Open AccessCryptolepine consolidates its anticancer potential by increasing the anti-cancer pathway genes and decreasing that of pro-cancer pathway genes
Open AccessCryptolepine consolidates its anticancer property by increasing the anti-cancer pathway genes and decreasing that of pro-cancer pathway genes
Open AccessSero-prevalence of Hepatitis B and C viral co-infections among HIV-1 infected ART-naïve individuals in Kumasi, Ghana
Open AccessMicrobial pathogens associated with acute childhood diarrhoea in Kumasi, Ghana
Open AccessAntifungal and Anti-Proliferative Effects of Zeolites A and X on Yeast Pathogenic and Cancer Cells <i>In Vitro</i>
Aflatoxin B1 inhibits the type 1 interferon response pathway via STAT1 suggesting another mechanism of hepatocellular carcinoma
Open AccessPerformance of First Response® and CareStart™ Malaria Rapid Diagnostic Tests for the Detection of Plasmodium falciparum in a Tertiary Hospital in Ghana
Dengue virus exposure among blood donors in Ghana
Open AccessSeroprevalence of Rubella Virus, Cytomegalovirus and Herpes Simplex Virus–2 among Pregnant Women at the Komfo Anokye Teaching Hospital, Ghana
Risk factors associated with hepatitis B exposure and the reliability of five rapid kits commonly used for screening blood donors in Ghana
Open AccessDepartment of Clinical Microbiology
Kwame Nkrumah University of Science and Technology