Michael Ntim
Department of PhysiologyHealth SciencesLife SciencesSocial Sciences

Michael Ntim

40 Publications26 Research Themes27 Open Access
Research Overview & Focus

The researcher's work is centered on integrating biological biomarkers across various domains to develop effective strategies for cancer immunotherapy, health disparities, and chronic disease management. Their research spans multiple fields, including immunology, neuroscience, pharmacology, and public health, with a focus on understanding the role of biological markers in disease diagnosis, treatment, and prevention. Key themes include: 1. **Cancer Immunotherapy and Biomarkers**: Development of models like the immune score to predict prognosis using biomarkers. 2. **Biology and Health Disparities**: Investigating interactions between chronic diseases (e.g., hypertension) and factors affecting brain development. 3. **Neurogenesis and Ageing**: Exploring the role of neural connections in cognitive decline, supported by neurovascular insights. 4. **Global Health Policies and Public Health**: Considering interventions like task-shifting strategies to reduce hypertension. 5. **Autophagy and Pancreatic Cancer**: Addressing both promising benefits and potential controversies regarding autophagy's role in cancer. 6. **Neuroscience and Sleep Disorders**: Linking sleep patterns with brain health, influencing long-term cognitive outcomes. The researcher employs a holistic approach, using biomarkers as tools to enhance understanding and improve treatment options across these interconnected fields, aiming to contribute significantly to global health solutions.

Key Research Themes (26)
Health Sciences

Alzheimer's disease research and treatments

Health Sciences

Autophagy in Disease and Therapy

Health Sciences

Blood Pressure and Hypertension Studies

Health Sciences

Cancer Immunotherapy and Biomarkers

Life Sciences

Cancer-related molecular mechanisms research

Health Sciences

Chemokine receptors and signaling

Life Sciences

Epigenetics and DNA Methylation

Life Sciences

Genetics, Aging, and Longevity in Model Organisms

Health Sciences

Global Maternal and Child Health

Social Sciences

Global Public Health Policies and Epidemiology

Life Sciences

Gut microbiota and health

Social Sciences

Health disparities and outcomes

Social Sciences

Health Systems, Economic Evaluations, Quality of Life

Life Sciences

Ion Transport and Channel Regulation

Health Sciences

Maternal Mental Health During Pregnancy and Postpartum

Life Sciences

Metabolism, Diabetes, and Cancer

Health Sciences

Nausea and vomiting management

Health Sciences

Neonatal and Maternal Infections

Life Sciences

Neurogenesis and neuroplasticity mechanisms

Life Sciences

Neurological Disease Mechanisms and Treatments

Life Sciences

Neuroscience and Neuropharmacology Research

Health Sciences

Pancreatic and Hepatic Oncology Research

Health Sciences

Pancreatitis Pathology and Treatment

Life Sciences

Proteoglycans and glycosaminoglycans research

Life Sciences

Receptor Mechanisms and Signaling

Life Sciences

Stress Responses and Cortisol

Publications (40)

DNA methylation as a new frontier in treating fear-related disorders: A need for careful evaluation

Open Access

Predictors of postpartum depression among new mothers in Kumasi, Ghana: A multicenter study using Bayesian analysis

Open Access
2025Maternal Mental Health During Pregnancy and PostpartumDOI: 10.1177/17455057251343953

Triglyceride-glucose index in predicting gastric cancer prognosis: A need for caution

Open Access
2025Metabolism, Diabetes, and CancerDOI: 10.3748/wjg.v31.i18.104525

Editorial: Neurovascular health insights: a powerful tool to understand and prognose neurocognitive decline

Open Access
2025Neurological Disease Mechanisms and TreatmentsDOI: 10.3389/fnagi.2025.1584895

Phospholipase D2: A biomarker for stratifying disease severity in acute pancreatitis?

Open Access
2025Pancreatitis Pathology and TreatmentDOI: 10.3748/wjg.v31.i11.104033

Cell-type-specific expression of Nav1.6 in the developing brain of mice and its involvement in glial activation in Alzheimer’s disease

2025Neuroscience and Neuropharmacology ResearchDOI: 10.1093/cercor/bhaf038

Review of: "Auditing the Cost of Treating Hypertension in a Tertiary Health Facility in Yobe State, North-Eastern Nigeria"

Open Access
2024Health Systems, Economic Evaluations, Quality of LifeDOI: 10.32388/kr1xso

Developing Culturally Salient Assessment Tools and Interventions for Underserved and High-Risk Populations in the United States and Africa

2024Health disparities and outcomesDOI: 10.1007/978-3-031-61160-5_14

TIP60 mediates stress-induced hypertension via promoting glutamate <sup>dmPFC-</sup> <sup>to-</sup> <sup>vCA1</sup> release

Open Access
2023Genetics, Aging, and Longevity in Model OrganismsDOI: 10.1080/10641963.2023.2259130

AQP4-A25Q Point Mutation in Mice Depolymerizes Orthogonal Arrays of Particles and Decreases Polarized Expression of AQP4 Protein in Astrocytic Endfeet at the Blood–Brain Barrier

Open Access
2022Ion Transport and Channel RegulationDOI: 10.1523/jneurosci.0401-22.2022

Bacteriological Profile and Predictors of Death Among Neonates With Blood Culture-Proven Sepsis in a National Hospital in Tanzania—A Retrospective Cohort Study

Open Access
2022Neonatal and Maternal InfectionsDOI: 10.3389/fped.2022.797208

Reducing Nav1.6 expression attenuates the pathogenesis of Alzheimer's disease by suppressing BACE1 transcription

Open Access
2022Alzheimer's disease research and treatmentsDOI: 10.1111/acel.13593

Long-Term Social Isolation-Induced Autophagy Inhibition and Cell Senescence Aggravate Cognitive Impairment in D(+)Galactose-Treated Male Mice

Open Access
2022Autophagy in Disease and TherapyDOI: 10.3389/fnagi.2022.777700

Two-hour acute restraint stress facilitates escape behavior and learning outcomes through the activation of the Cdk5/GR P S211 pathway in male mice

2022Stress Responses and CortisolDOI: 10.1016/j.expneurol.2022.114023

TIP60 buffers acute stress response and depressive behaviour by controlling PPARγ-mediated transcription

2022Neuroscience and Neuropharmacology ResearchDOI: 10.1016/j.bbi.2022.01.022

Prediction of Survival Rate and Chemotherapy Effect by an Immune Score Model in Colorectal Cancer

Open Access
2022Cancer Immunotherapy and BiomarkersDOI: 10.1155/2022/8219701

SRC-1 Deficiency Increases Susceptibility of Mice to Depressive-Like Behavior After Exposure to CUMS

2021Stress Responses and CortisolDOI: 10.1007/s11064-021-03316-y

The Role of KDM2B and EZH2 in Regulating the Stemness in Colorectal Cancer Through the PI3K/AKT Pathway

Open Access
2021Epigenetics and DNA MethylationDOI: 10.3389/fonc.2021.637298

Effect of emodin on long non‐coding RNA‐mRNA networks in rats with severe acute pancreatitis‐induced acute lung injury

Open Access
2021Cancer-related molecular mechanisms researchDOI: 10.1111/jcmm.15525

Treatment with <i>Bifidobacteria</i> can suppress Aβ accumulation and neuroinflammation in APP/PS1 mice

Open Access
2020Gut microbiota and healthDOI: 10.7717/peerj.10262

GPR50 Distribution in the Mouse Cortex and Hippocampus

2020Receptor Mechanisms and SignalingDOI: 10.1007/s11064-020-03089-w

SRC-1 Knockout Exerts No Effect on Amyloid β Deposition in APP/PS1 Mice

Open Access
2020Alzheimer's disease research and treatmentsDOI: 10.3389/fnagi.2020.00145

The landscape of immune cell infiltration and its clinical implications of pancreatic ductal adenocarcinoma

Open Access
2020Pancreatic and Hepatic Oncology ResearchDOI: 10.1016/j.jare.2020.03.009

TRIM32 Deficiency Impairs Synaptic Plasticity by Excitatory-Inhibitory Imbalance via Notch Pathway

2020Neurogenesis and neuroplasticity mechanismsDOI: 10.1093/cercor/bhaa064

Application of the Consolidated Framework for Implementation Research to examine nurses’ perception of the task shifting strategy for hypertension control trial in Ghana

Open Access
2020Blood Pressure and Hypertension StudiesDOI: 10.1186/s12913-020-4912-5

An immune cell infiltration-based immune score model predicts prognosis and chemotherapy effects in breast cancer

Open Access
2020Cancer Immunotherapy and BiomarkersDOI: 10.7150/thno.49451

Sub-hypnotic dose of propofol as antiemetic prophylaxis attenuates intrathecal morphine-induced postoperative nausea and vomiting, and pruritus in parturient undergoing cesarean section — a randomized control trial

Open Access
2019Nausea and vomiting managementDOI: 10.1186/s12871-019-0847-y

Impaired Cognitive Function and Altered Hippocampal Synaptic Plasticity in Mice Lacking Dermatan Sulfotransferase Chst14/D4st1

Open Access
2019Proteoglycans and glycosaminoglycans researchDOI: 10.3389/fnmol.2019.00026

Long-term social isolation inhibits autophagy activation, induces postsynaptic dysfunctions and impairs spatial memory

2018Autophagy in Disease and TherapyDOI: 10.1016/j.expneurol.2018.09.009

IL-8 analogue CXCL8 (3-72) K11R/G31P, modulates LPS-induced inflammation via AKT1-NF-kβ and ERK1/2-AP-1 pathways in THP-1 monocytes

2018Chemokine receptors and signalingDOI: 10.1016/j.humimm.2018.08.007

Health insurance coverage with or without a nurse-led task shifting strategy for hypertension control: A pragmatic cluster randomized trial in Ghana

Open Access
2018Blood Pressure and Hypertension StudiesDOI: 10.1371/journal.pmed.1002561

Issue Information ‐ TOC

Open Access

[LB.03.07] COMPARATIVE EFFECTIVENESS CLUSTER-RANDOMIZED TRIAL OF A NURSE-LED TASK-SHIFTING STRATEGY FOR HYPERTENSION CONTROL VERSUS PROVISION OF HEALTH INSURANCE COVERAGE IN CHCS IN GHANA

2017Global Public Health Policies and EpidemiologyDOI: 10.1097/01.hjh.0000523178.88436.3d

‘I believe high blood pressure can kill me:’ using the PEN-3 Cultural Model to understand patients’ perceptions of an intervention to control hypertension in Ghana

2017Global Maternal and Child HealthDOI: 10.1080/13557858.2017.1346178

Sustaining Nurse‐Led Task‐Shifting Strategies for Hypertension Control: A Concept Mapping Study to Inform Evidence‐Based Practice

2017Global Maternal and Child HealthDOI: 10.1111/wvn.12230

Erratum to: Training nurses in task-shifting strategies for the management and control of hypertension in Ghana: a mixed-methods study

Open Access
2017Global Public Health Policies and EpidemiologyDOI: 10.1186/s12913-017-2161-z

Exploring stakeholders’ perceptions of a task-shifting strategy for hypertension control in Ghana: a qualitative study

Open Access
2017Blood Pressure and Hypertension StudiesDOI: 10.1186/s12889-017-4127-9

Training nurses in task-shifting strategies for the management and control of hypertension in Ghana: a mixed-methods study

Open Access
2017Blood Pressure and Hypertension StudiesDOI: 10.1186/s12913-017-2026-5

OC05_01 Task-Shifting for the Management of Hypertension: Lessons From the Global Alliance for Chronic Diseases

2016Global Maternal and Child HealthDOI: 10.1016/j.gheart.2016.03.016

A cluster-randomized trial of task shifting and blood pressure control in Ghana: study protocol

Open Access
2014Blood Pressure and Hypertension StudiesDOI: 10.1186/1748-5908-9-73
Academic Metrics
DepartmentDepartment of Physiology
Total Publications40
Research Themes26
Open Access Papers27

Department of Physiology

Kwame Nkrumah University of Science and Technology

View Department Directory