Lawrence Sheringham Borquaye
The researcher's research focuses on integrating computational methods into drug discovery and development, particularly addressing public health issues such as infectious diseases, toxic environments, traditional medicine, and plant biochemistry. Their work encompasses a wide range of topics, including computational chemistry, mathematical modeling, molecular dynamics simulations, toxicity assessment, and the application of advanced analytical techniques across various biological systems. The researcher's contributions span themes like heavy metals, traditional Ghanaian medicines, malaria research, traditional use of Annonaceae plants, merozotetunia, traditional herbal extracts, toxic metal residues, plant biochemistry, enzymatic studies, marine sponges, organometallic compounds, phytochemistry, ginger and zingiberaceae research, Leishmania control, mathematical modeling for toxicity, mine management, water quality assessment, child nutrition, biofuel production, plant biochemistry, algal biology, chemical synthesis, genetic and molecular insights into infectious diseases, distributed computing systems, mycobacterium research, and genomics. Their research integrates computational approaches with biological and chemical methods to develop innovative solutions for public health challenges.
Faculty Biography
Lawrence Sheringham Borquaye is an alumni of St. Mary’s Seminary Senior High School (SMASCO), Lolobi – VR, Ghana where he graduated in 2000. He received his B. Sc. in Chemistry from the University of Cape Coast, Ghana in 2006, working with Dr. Victor Y. Atsu - Barko in investigating the mosquito repellency properties of the leaves of Hyptis suaveleons. He proceeded to the University of Massachusetts Amherst, USA and graduated in 2013 with a Ph.D. in Chemistry working under the mentorship of Professor Nathan A. Schnarr in developing new tools for engineering polyketide synthases (PKSs), the gigantic biosynthetic machinery responsible for the assembly of the class of natural product called polyketides. This work was partly supported by the UMASS Amherst Chemistry-Biology Interface Trainee Fellowship. After graduate studies, Lawrence joined the Kwame Nkrumah University of Science and Technology (KNUST), Kumasi where he is a lecturer in the Department of Chemistry. He also doubles as the Assistant Laboratory Manager of the KNUST Central Laboratory, a state-of-the-art research facility that is home to modern analytical instruments for research in the basic and applied sciences. The research works of Lawrence Sheringham Borquaye has been funded by research grants from the International Foundation for Science, the Building Stronger Universities II (BSU II) project which is a DANIDA funded program between KNUST and some Danish universities, The World Academy of Sciences (TWAS) and the KNUST Research Fund (KReF).Lawrence has supervised thesis at the undergraduate, Master's and Doctoral levels.
Algal biology and biofuel production
Alkaloids: synthesis and pharmacology
Antibiotics Pharmacokinetics and Efficacy
Antimicrobial Peptides and Activities
Bacterial biofilms and quorum sensing
Biodiesel Production and Applications
Chemical synthesis and alkaloids
Child Nutrition and Water Access
Computational Drug Discovery Methods
Distributed and Parallel Computing Systems
Enzyme Production and Characterization
Essential Oils and Antimicrobial Activity
Ethnobotanical and Medicinal Plants Studies
Genomics and Rare Diseases
Ginger and Zingiberaceae research
Heavy metals in environment
Heavy Metals in Plants
HIV/AIDS drug development and treatment
Insect and Pesticide Research
Insect Pest Control Strategies
Malaria Research and Control
Marine Sponges and Natural Products
Mercury impact and mitigation studies
Mining and Resource Management
Moringa oleifera research and applications
Mycobacterium research and diagnosis
Ocular Infections and Treatments
Organometallic Compounds Synthesis and Characterization
Pesticide Exposure and Toxicity
Pharmaceutical and Antibiotic Environmental Impacts
Phytochemistry and Bioactivity Studies
Phytochemistry and Biological Activities
Phytochemistry and biological activity of medicinal plants
Plant biochemistry and biosynthesis
Protein Hydrolysis and Bioactive Peptides
Research on Leishmaniasis Studies
Reservoir Engineering and Simulation Methods
Synthesis and bioactivity of alkaloids
Toxic Organic Pollutants Impact
Traditional and Medicinal Uses of Annonaceae
Trypanosoma species research and implications
Water Quality and Pollution Assessment
Source Apportionment of Potentially Toxic Elements in Topsoils Across Some Mining-Impacted Communities in Ghana Using the Positive Matrix Factorization Model
Pharmaceutical Waste Disposal: A Cross‐Sectional Survey of Disposal Practices and Awareness in Sefwi Wiawso Municipality, Ghana
Open AccessPharmacogenomics in Orofacial Clefts Care: Insights from Whole-Genome Sequencing of Case-Parents Trios
Open AccessDescriptive analysis of pharmaceutical disposal practices in Sekondi-Takoradi: implications for environmental and public health safety in Ghana
Open AccessA CRYPTOLEPIS SANGUINOLENTA-BASED PREPARATION REDUCED HOSPITAL STAY AND MORTALITY OF COVID-19 PATIENTS DURING THE PANDEMI
Open AccessEssential Oil Emulsions from Xylopia Villosa and Hyparrhena Rufa as Potent Antimicrobial and Antibiofilm Agents
Computational elucidation of Plasmodium falciparum enoyl-ACP reductase inhibition by Salacia debilis compounds: adaptive ligand binding drives antimalarial activity
Synergistic action of phytoconstituents drives the anthelmintic potential of Croton penduliflorus stem bark extracts
Open AccessChemical characterization, biological activities, and molecular docking studies of essential oils from <i>Annona reticulata</i> L (Annonaceae)
Open AccessCrude alkaloids from Phyllanthus fraternus, Webster: Antibacterial, time-kill kinetics and resistance modulation studies
Occurrence and ecological risk assessment of commonly used pharmaceuticals in water and soil of Sefwi Wiawso, Ghana
Open AccessPharmaceutical residues in environment matrices in the Sekondi-Takoradi metropolis of Ghana present potential ecotoxicological risks
Receptor modeling, ecological risks, and human health impacts of mercury in some Ghanaian topsoils due to mining and commercial activities
Open AccessCrude Alkaloids form Phyllanthus fraternus, Webster: Antibacterial, Time-Kill Kinetics and Resistance Modulation Studies
Open AccessIn Silico Investigation of Phytochemicals From Clinically Tested Herbal Extracts as Potential Dihydrofolate Reductase Inhibitors for Buruli Ulcer
Open AccessEcological risk assessment of selected pharmaceuticals in major rivers within Kumasi, Ghana
Open AccessMolecular insights into the inhibition of Leishmania donovani O-acetylserine sulfhydrylase by cyclopropane carboxylic acid derivatives: a computational study
Open AccessEnvironmental impact of pharmaceutical contaminants in dumpsites: a study from Ejisu-Juaben municipality, Ghana
Open AccessAntimicrobial resistance modifying effects and molecular docking studies of Affinine, derived from Tabernaemontana crassa
Open AccessAntileishmanial natural products as potential inhibitors of the Leishmania pteridine reductase: insights from molecular docking and molecular dynamics simulations
Open AccessSpatial distribution, bioaccessibility, and human health implications of potentially toxic elements in mining-impacted topsoils in Obuasi Municipality of Ghana
Peptide Extract from Red Kidney Beans, Phaseolus vulgaris (Fabaceae), Shows Promising Antimicrobial, Antibiofilm, and Quorum Sensing Inhibitory Effects
Open AccessAbstract 2266 Amaryllidaceae Alkaloids as Potential Inhibitors of the Trypanosoma cruzi Trans-sialidase Enzyme: Unique Insights from Computational Studies
Open AccessMarine-Derived Furanones Targeting Quorum-Sensing Receptors in <i>Pseudomonas aeruginosa</i>: Molecular Insights and Potential Mechanisms of Inhibition
Open AccessTargeting Quorum Sensing in <i>Pseudomonas aeruginosa</i> Using Marine‐Derived Metabolites—An <i>In Silico</i> Approach
Open AccessHealth risks of potentially toxic metals in cereal-based breakfast meals in the Kumasi Metropolis, Ghana
Open AccessMolecular insights into the differential membrane targeting of maximin 1 in prokaryotic and eukaryotic cells
Distribution and in-vitro bioaccessibility of potentially toxic metals in surface soils from a mining and a non-mining community in Ghana: implications for human health
The Amaryllidaceae alkaloid, montanine, is a potential inhibitor of the <i>Trypanosoma cruzi</i> trans-sialidase enzyme
Antimalarial compounds from the climbing stems of <i>salacia debilis</i>
Human health risk assessment of potentially toxic elements in soil and air particulate matter of automobile hub environments in Kumasi, Ghana
Open AccessDe novo peptides as potential antimicrobial agents
Open Access<i>In silico</i> identification of α-bisabolol and letestuianin C as potential inhibitors of <i>Trypanosoma brucei</i> trypanothione reductase
Antioxidant, antimicrobial, and antibiofilm properties of essential oils extracted from <i>Dialium guineense</i>
Open AccessOccurrence and Ecological Risk Assessment of Pharmaceutical Residues in Effluents from Pharmaceutical Manufacturing Facilities in Kumasi, Ghana
Oplodiol and nitidine as potential inhibitors of <i>Plasmodium falciparum</i> dihydrofolate reductase: insights from a computational study
Chemical Composition, Antioxidant, and Antimicrobial Activities of the Leaf and Fruit Essential Oils of the West African Plum, Vitex doniana
Open AccessChemical Characterization, Antioxidant, Antimicrobial, and Antibiofilm Activities of Essential Oils of Plumeria alba (Forget-Me-Not)
Open AccessApplications of molecular docking in natural products-based drug discovery
Open AccessComputational studies on potential small molecule inhibitors of <i>Leishmania</i> pteridine reductase 1
Computational Studies Provide a Molecular Basis for the Quorum Sensing Inhibitory Action of Compounds from <i>Dioon spinulosum</i> Dyer Ex Eichler
N-benzylimidazoles as potential antimicrobial and antibiofilm agents – syntheses, bioactivity and molecular docking studies
Open AccessN-alkylimidazole derivatives as potential inhibitors of quorum sensing in Pseudomonas aeruginosa
Open AccessHuman exposure to mercury in the atmosphere and soils in Konongo: an age-old mining centre in the Ashanti Region of Ghana
In vitro antileishmanial activity and molecular docking studies of lupeol and monostearin, isolated from Parkia biglobosa
Open AccessComputer-aided design of proline-rich antimicrobial peptides based on the chemophysical properties of a peptide isolated from <i>Olivancillaria hiatula</i>
Open AccessEssential Oils from the Fruits and Leaves of Spondias mombin Linn.: Chemical Composition, Biological Activity, and Molecular Docking Study
Open AccessAllosteric Modulation of the Main Protease (MPro) of SARS-CoV-2 by Casticin—Insights from Molecular Dynamics Simulations
Open AccessClinical characteristics of external bacterial ocular and periocular infections and their antimicrobial treatment patterns among a Ghanaian ophthalmic population
Open AccessAn In Silico Study of the Interactions of Alkaloids from Cryptolepis sanguinolenta with Plasmodium falciparum Dihydrofolate Reductase and Dihydroorotate Dehydrogenase
Open AccessOccurrence of Pharmaceutical Residues and Antibiotic-Resistant Bacteria in Water and Sediments from Major Reservoirs (Owabi and Barekese Dams) in Ghana
Open AccessAssessment of some quality parameters and chemometric-assisted FTIR spectral analysis of commercial powdered ginger products on the Ghanaian market
Open AccessClinical Characteristics of External Ocular and Periocular Infections and Their Antimicrobial Treatment Patterns Among a Ghanaian Ophthalmic Population; A Multicenter Study
Open AccessConversion of cassava peels into bioethanol using the OSTEP approach
Disposal of Unused and Expired Medicines within the Sunyani Municipality of Ghana: A Cross‐Sectional Survey
Open AccessAntibiotic and analgesic residues in the environment – Occurrence and ecological risk study from the Sunyani municipality, Ghana
Open AccessUrbanizing with or without nature: pollution effects of human activities on water quality of major rivers that drain the Kumasi Metropolis of Ghana
Synthesis, molecular docking studies and ADME prediction of some new triazoles as potential antimalarial agents
Open AccessIn Vivo Antiplasmodial Activity and Toxicological Analyses of the Ethanolic Leaf and Twig Extract of Faurea speciosa Welw. (Proteaceae)
Open AccessOptimization of hydrolases production from cassava peels by Trametes polyzona BKW001
Open AccessAntimicrobial properties of metal piperidine dithiocarbamate complexes against Staphylococcus aureus and Candida albicans
Open AccessAntimalarial, Antioxidant, and Toxicological Evaluation of Extracts of Celtis africana, Grosseria vignei, Physalis micrantha, and Stachytarpheta angustifolia
Open AccessEssential Oils from Averrhoa carambola L. (Oxalidaceae): Chemical Composition, Antioxidant, Antimicrobial and Anti-biofilm Potential
Chemical Composition and Biological Activities of the Essential Oils of Chrysophyllum albidum G. Don (African Star Apple)
Open AccessAntiplasmodial potential and safety evaluation of the ethanolic stem bark extract of Distemonanthus benthamianus Baill. (Leguminosae)
Open AccessVeterinary Drug Residues in Beef, Chicken, and Egg from Ghana
Distribution, bioaccessibility and human health risks of toxic metals in peri-urban topsoils of the Kumasi Metropolis
Open AccessQuality Assessment and Chemometric-Assisted FTIR Spectral Analysis of Commercial Powdered Ginger Products on the Ghanaian Market
Open AccessPatterns in protein consumption in Ghanaian cities
Open AccessAnti-inflammatory and antioxidant activities of the root and bark extracts of Vitex grandifolia (Verbanaceae)
Open AccessDistribution of heavy metals in soils from abandoned dump sites in Kumasi, Ghana
Open AccessBiological Efficacy and Toxicological Evaluation of Ethanolic Extract of <i>Cassia nodosa</i> Buch.-Ham<i>.</i> (Leguminosae)
Open AccessAccumulation and bioaccessibility of toxic metals in root tubers and soils from gold mining and farming communities in the Ashanti region of Ghana
Anti-inflammatory and antioxidant activities of extracts of<i>Reissantia indica, Cissus cornifolia</i>and<i>Grosseria vignei</i>
Open AccessAlkaloids from <i>Cryptolepis sanguinolenta</i> as Potential Inhibitors of SARS‐CoV‐2 Viral Proteins: An <i>In Silico</i> Study
Open AccessAnti-inflammatory and anti-oxidant activities of ethanolic extracts of <i>Tamarindus indica</i> L. (Fabaceae)
Open AccessOptimization of Hydrolase Production (Dataset).pdf
Open AccessOptimization of Hydrolase Production (Dataset).pdf
Open AccessOptimization of Hydrolases Production (Dataset).pdf
Open AccessOptimization of Hydrolase Production (Dataset).pdf
Open AccessOptimization of Hydrolase Production (Dataset).pdf
Open AccessOptimization of Hydrolase Production (Dataset).pdf
Open AccessPeptide Mix from <i>Olivancillaria hiatula</i> Interferes with Cell-to-Cell Communication in <i>Pseudomonas aeruginosa</i>
Open AccessChemical Composition, Total Phenolic Content, and Antioxidant Activities of the Essential Oils of the Leaves and Fruit Pulp of<i>Annona muricata</i>L. (Soursop) from Ghana
Open AccessAntimalarial Efficacy and Toxicological Assessment of Extracts of Some Ghanaian Medicinal Plants
Open AccessOccurrence of Antibiotics and Antibiotic-Resistant Bacteria in Landfill Sites in Kumasi, Ghana
Open AccessEthanolic leaf extract from <i>Strophanthus gratus</i> (Hook.) Franch. (Apocynaceae) exhibits anti-inflammatory and antioxidant activities
Open AccessPeptide Extract from<i> Olivancillaria hiatula</i> Exhibits Broad-Spectrum Antibacterial Activity
Open AccessRisk Of Human Dietary Exposure To Organochlorine Pesticide Residues In Fruits From Ghana
Open AccessHuman Risk Assessment of Organochlorine Pesticide Residues in Vegetables from Kumasi, Ghana
Open AccessAssessment of the quality of the Owabi reservoir and its tributaries
Open AccessDistribution and ecological risks of toxic metals in the topsoils in the Kumasi metropolis, Ghana
Open AccessPesticide Residues in Honey from the Major Honey Producing Forest Belts in Ghana
Open AccessNutritional and anti-nutrient profiles of some Ghanaian spices
Open AccessAnti-inflammatory activities of extracts from<i>Oliva sp., Patella rustica</i>, and<i>Littorina littorea</i>collected from Ghana’s coastal shorelines
Open AccessVeterinary antibiotics in dairy products from Kumasi, Ghana
Open AccessHeavy metal contents of some medicinal herbs from Kumasi, Ghana
Open AccessAntimicrobial and antioxidant activities of ethyl acetate and methanol extracts of<i>Littorina littorea</i>and<i>Galatea paradoxa</i>
Open AccessORGANIC CHEMISTRY | RESEARCH ARTICLE Antimicrobial and antioxidant activities of ethyl acetate and methanol extracts of Littorina littorea and Galatea paradoxa
Antimicrobial and antioxidant properties of the crude peptide extracts of Galatea paradoxa and Patella rustica
Open AccessDepartment of Chemistry
Kwame Nkrumah University of Science and Technology