Aaron Opoku Antwi
The researcher's work is centered on the study of asthma and related inflammatory conditions, focusing particularly on the modulation of allergic and inflammatory responses through compounds like Stigmasterol. Their research integrates multiple domains such as immunology, pharmacology, phytochemistry, and traditional medicine applications. Key themes include the use of Stigmasterol in modulating airway inflammation in guinea pigs induced by ovalbumin, its therapeutic potential in asthma treatment, and its broader relevance to inflammatory diseases across various biological systems. The researcher also explores the biological mechanisms underlying these effects, applying findings to both animal models and human conditions, highlighting a holistic approach to understanding and addressing respiratory health challenges.
Faculty Biography
Dr. Aaron Opoku Antwi is a lecturer at the Department of Pharmacology, KNUST, Kumasi, Ghana. He obtained both his Bachelor of Pharmacy (BPharm) and PhD (Pharmacology) degrees in Kwame Nkrumah University of Science and Technology (KNUST), in 2011 and 2018 respectively. Dr. Antwi’s research interest is mainly the immunopharmacology of medicinal plants and plant-derived compounds. His research focuses on investigating the effect of these compounds on modulatory pathways, cytokine profiles and inflammatory cell involvement in allergy and inflammation.Dr. Antwi is currently a member of the Pharmaceutical Society of Ghana (PSGH) and the Society for Medicinal Plants and Natural Product Research.
Allergic Rhinitis and Sensitization
Asthma and respiratory diseases
Cannabis and Cannabinoid Research
Computational Drug Discovery Methods
Dermatology and Skin Diseases
Echinoderm biology and ecology
Essential Oils and Antimicrobial Activity
Food Allergy and Anaphylaxis Research
Gastrointestinal motility and disorders
Immune Response and Inflammation
Inflammatory Bowel Disease
Malaria Research and Control
Mast cells and histamine
Mitochondrial Function and Pathology
Moringa oleifera research and applications
Olfactory and Sensory Function Studies
Pharmacological Effects of Natural Compounds
Pharmacovigilance and Adverse Drug Reactions
Phytochemistry and Bioactive Compounds
Stress Responses and Cortisol
Synthesis and bioactivity of alkaloids
Traditional and Medicinal Uses of Annonaceae
Tryptophan and brain disorders
Exploring the antidepressant-like effect of stigmasterol using network pharmacology with molecular docking and in vivo experimental validation
Open AccessAntiangiogenic effects of the hydroethanolic root extract of Croton membranaceus in chick chorioallantoic membrane
Open AccessPharmacovigilance of herbal medicines in Ghana- Knowledge, perception and practice
Open AccessExploring the antidepressant-like effects of stigmasterol using network pharmacology with molecular docking and in vivo experimental validation: Involvement of serotonin modulation
Open AccessAnti-IBD activity of Eleusine indica through inhibition of TNF-alpha and p38 MAPK expression
Evaluating the potential of stigmasterol as a scaffold for novel antidepressants
Antidepressant-like potential of stigmasterol against lipopolysaccharide-induced depression-like behaviors in mice
Acetic acid-induced ulcerative colitis alleviation by Xylopia aethiopica (Dunal) A. Rich in Sprague Dawley rats
Aurantio‐Obtusin Suppresses Airway Inflammation and Serum ICAM‐1 Expression in Guinea Pig Allergic Asthma Model
Open AccessVoacanga africana-artesunate and Voacanga africana-amodiaquine combinations as effective anti-plasmodial agents in mice
Open AccessEleusine indica inhibits airway inflammation and ICAM-1 expression in ovalbumin-induced asthma in guinea pigs
In vivo anti-plasmodial activity of alpha-onocerin and artesunate combination against Plasmodium berghei infected mice
Open AccessAurantio-obtusin alleviates allergic responses in ovalbumin-induced rhinitis
Open AccessCoadministration of Stigmasterol and Dexamethasone (STIG+DEX) Modulates Steroid-Resistant Asthma
Open AccessHydro-ethanol extract of Holarrhena floribunda stem bark exhibits anti-anaphylactic and anti-oedematogenic effects in murine models of acute inflammation
Open AccessPseudocedrela kotschyi limits airway inflammation in ovalbumin-induced asthma in guinea pigs
Open AccessMethanolic Leaf Extract of Dissotis Rotundifolia Alleviates Acetic Acid-Induced Ulcerative Colitis in Rats
Open AccessCutaneous and systemic anti-allergic potential of xylopic acid in rodents
Endocannabinoid system and its modulation of brain, gut, joint and skin inflammation
Xylopic Acid Suppresses Adjuvant-induced Arthritis in Sprague DawleyRats via Reduction in Serum Levels of IL-6 and TNF-alpha
Hydro ethanol extract of Holarrhena floribunda stem bark exhibits anti-anaphylactic and anti-oedematogenic effects in murine models of acute inflammation
Open AccessCannabinoid Receptor and Inflammation
Open AccessCryptolepine, the major alkaloid of Cryptolepis sanguinolenta (Lindl.) Schlechter (Apocynaceae), attenuates early and late-phase symptoms of asthma
Open AccessAntiplasmodial and Antipyretic Activity and Safety Evaluation of the Methanolic Leaf Extract of <i>Murraya exotica (L.)</i>
Open AccessAcetic Acid-Induced Ulcerative Colitis in Sprague Dawley Rats Is Suppressed by Hydroethanolic Extract of<i>Cordia vignei</i>Leaves through Reduced Serum Levels of TNF-<i>α</i>and IL-6
Open AccessPotential effects of xylopic acid on acetic acid-induced ulcerative colitis in rats
Open AccessAllergic Airway-Induced Hypersensitivity Is Attenuated by Bergapten in Murine Models of Inflammation
Open AccessThe acute anti-inflammatory action of xylopic acid isolated from <i>Xylopia aethiopica</i>
Stigmasterol Alleviates Cutaneous Allergic Responses in Rodents
Open AccessOxidative Stress and Neurodegeneration
Effect of xylopic acid isolated from <i>Xylopia aethiopica</i> on acetic acid‐induced ulcerative colitis in rats
Stigmasterol inhibits lipopolysaccharide-induced innate immune responses in murine models
The Ethanolic Stem-Bark Extract of<i>Antrocaryon micraster</i>Inhibits Carrageenan-Induced Pleurisy and Pedal Oedema in Murine Models of Inflammation
Open AccessStigmasterol Modulates Allergic Airway Inflammation in Guinea Pig Model of Ovalbumin-Induced Asthma
Open AccessEffects of a Hydro-ethanolic Extract of Scoparia dulcis on Systemic Inflammation and Cachexia in an Allergic Asthma Model
Open AccessXylopia aethiopica (Annonaceae) fruit extract suppresses Freund׳s adjuvant-induced arthritis in Sprague-Dawley rats
Department of Pharmacology
Kwame Nkrumah University of Science and Technology