Daniel Ansong
100 Publications41 Research Themes86 Open Access
Research Overview & Focus
The researcher has made significant contributions to the field of infectious diseases through extensive research on malaria vaccines in Ghana, covering themes from clinical efficacy and safety to public health strategies and ethical considerations. The work highlights vaccine co-administration effects on maternal and child health, the impact of vaccination subsidies, and challenges in equitable healthcare. It also delves into issues such as childhood bacterial meningitis prevention and global collaborations in maternal care.
Faculty Biography
I have had the opportunity to serve as the Study Coordinator as well as the Principal Investigator in major clinical trials that have taken place in my institution. I am currently a trained Clinical Trial Monitor for the Tropical Disease Research (TDR)-World Health Organization (WHO). I have also served as a Senior Investigator on National Institutes of Health (NIH) funded research projects in my institution. I participated as Co-Principal Investigator on the pivotal phase III RTS,S vaccine trial programme and currently the Principal Investigator on the Safety Arm of the Malaria Vaccine Implementation Programme in Ghana. I am the Principal Investigator of World Health Organization (WHO) Hemophilus Influenzae Type B and Streptococcus Pneumoniae Invasive Disease Surveillance since 2004 and Rotavirus Diarrhoea Disease in Children since 2010 in Komfo Another Teaching Hospital, Ghana. I have been a study clinician in the Sickle Cell Center of the Komfo Anokye Teaching Hospital for over two decades. I served as a senior investigator to the Organ Damage in Sickle Cell Disease Study (ORDISS) in 2017 and currently serving as a consultant pediatrician to the Center and providing clinical and technical support to the Sickle Cell Pan-African Consortium (SPARCO) study. My rich experience in clinical trials and infectious disease surveillance in Ghana places me in a stronger position to support mentors students interest in research.
Key Research Themes (41)
Health Sciences
Acute Ischemic Stroke Management
Life Sciences
Antibiotic Resistance in Bacteria
Life Sciences
Antibiotic Use and Resistance
Life Sciences
Bacterial Infections and Vaccines
Health Sciences
Blood Coagulation and Thrombosis Mechanisms
Health Sciences
Blood Pressure and Hypertension Studies
Life Sciences
BRCA gene mutations in cancer
Health Sciences
Breastfeeding Practices and Influences
Health Sciences
Cancer Risks and Factors
Health Sciences
Cervical Cancer and HPV Research
Health Sciences
Child Nutrition and Water Access
Health Sciences
Chronic Kidney Disease and Diabetes
Life Sciences
Complement system in diseases
Health Sciences
Diabetes, Cardiovascular Risks, and Lipoproteins
Physical Sciences
Effects and risks of endocrine disrupting chemicals
Physical Sciences
Energy and Environment Impacts
Health Sciences
Erythrocyte Function and Pathophysiology
Health Sciences
Global Cancer Incidence and Screening
Health Sciences
Global Health and Surgery
Health Sciences
Global Maternal and Child Health
Social Sciences
Global Public Health Policies and Epidemiology
Life Sciences
Gut microbiota and health
Health Sciences
Health Policy Implementation Science
Health Sciences
Hemoglobinopathies and Related Disorders
Life Sciences
HIV Research and Treatment
Health Sciences
HIV/AIDS Research and Interventions
Health Sciences
Infant Development and Preterm Care
Health Sciences
Innovations in Medical Education
Health Sciences
Malaria Research and Control
Health Sciences
Mobile Health and mHealth Applications
Health Sciences
Mosquito-borne diseases and control
Social Sciences
Pharmaceutical Economics and Policy
Health Sciences
Pneumonia and Respiratory Infections
Health Sciences
Poisoning and overdose treatments
Health Sciences
SARS-CoV-2 and COVID-19 Research
Health Sciences
Sepsis Diagnosis and Treatment
Health Sciences
Tuberculosis Research and Epidemiology
Social Sciences
Vaccine Coverage and Hesitancy
Life Sciences
Vestibular and auditory disorders
Health Sciences
Viral gastroenteritis research and epidemiology
Health Sciences
Viral Infections and Outbreaks Research
Publications (100)
Knowledge, uptake and therapeutic effectiveness of sulfadoxine-pyrimethamine (IPTp-SP) among pregnant women attending the antenatal clinic at ayeduase Health Centre in Oforikrom Municipality in the Ashanti-region, Ghana
Open AccessGene expression signatures in blood from a West African sepsis cohort define host response phenotypes
Open AccessGenotypic analysis of RTS,S/AS01E malaria vaccine efficacy against parasite infection as a function of dosage regimen and baseline malaria infection status in children aged 5–17 months in Ghana and Kenya: a longitudinal phase 2b randomised controlled trial
Open AccessFeasibility, safety, and impact of the RTS,S/AS01E malaria vaccine when implemented through national immunisation programmes: evaluation of cluster-randomised introduction of the vaccine in Ghana, Kenya, and Malawi
Open AccessCould Less Be More? Accounting for Fractional-Dose Regimens and Different Number of Vaccine Doses When Measuring the Impact of the RTS,S/AS01E Malaria Vaccine
Open AccessMalaria
Hospitalizations among children with sickle cell disease enrolled in the Kumasi Sickle Cell Pan African Consortium (SPARCo) database: A cross sectional study
Open AccessAssociations of Circulating Estrogens and Estrogen Metabolites with Fecal and Oral Microbiome in Postmenopausal Women in the Ghana Breast Health Study
Open AccessScreening tools for predicting mortality of adults with suspected sepsis: an international sepsis cohort validation study
Open AccessComparing Patterns in Antimicrobial Use During Global Point Prevalence Study at a Single Tertiary Hospital in Ghana: Implications for Antimicrobial Stewardship Programme
Open AccessEfficacy of RTS,S/AS01E malaria vaccine administered according to different full, fractional, and delayed third or early fourth dose regimens in children aged 5–17 months in Ghana and Kenya: an open-label, phase 2b, randomised controlled trial
Open AccessThe oral microbiome and breast cancer and nonmalignant breast disease, and its relationship with the fecal microbiome in the Ghana Breast Health Study
Open AccessBreast Cancer Risk in Women from Ghana Carrying Rare Germline Pathogenic Mutations
Open AccessEstablishing a Sickle Cell Disease Registry in Africa: Experience From the Sickle Pan-African Research Consortium, Kumasi-Ghana
Open AccessMeasured body size and serum estrogen metabolism in postmenopausal women: the Ghana Breast Health Study
Open AccessBurden of hypertension in Ghana – Analysis of awareness and screening campaign in the Ashanti Region of Ghana
Open AccessPrevalence of Hypertension in Ghana: Analysis of an Awareness and Screening Campaign in 2019
Open AccessHuman genetic variant E756del in the ion channel PIEZO1 not associated with protection from severe malaria in a large Ghanaian study
Open AccessImmediate “Kangaroo Mother Care” and Survival of Infants with Low Birth Weight
Open AccessGlobal Health Education Amidst COVID-19: Disruptions and Opportunities
Open AccessAssociations of fecal microbial profiles with breast cancer and nonmalignant breast disease in the Ghana Breast Health Study
Open AccessHealthcare services utilisation among patients with hypertension and diabetes in rural Ghana
Open AccessPoint prevalence of asymptomatic Plasmodium infection and the comparison of microscopy, rapid diagnostic test and nested PCR for the diagnosis of asymptomatic malaria among children under 5 years in Ghana
Open AccessEtiology of Pediatric Meningitis in West Africa Using Molecular Methods in the Era of Conjugate Vaccines against Pneumococcus, Meningococcus, and Haemophilus influenzae Type b
Open AccessLongitudinal control of blood pressure among a cohort of Ghanaians with hypertension: A multicenter, hospital‐based study
Open AccessCentral Nervous System Virus Infection in African Children with Cerebral Malaria
Open AccessImmunogenicity and safety of the RTS,S/AS01 malaria vaccine co-administered with measles, rubella and yellow fever vaccines in Ghanaian children: A phase IIIb, multi-center, non-inferiority, randomized, open, controlled trial
Open AccessReproductive factors and risk of breast cancer by tumor subtypes among Ghanaian women: A population‐based case–control study
Open AccessInsights into malaria susceptibility using genome-wide data on 17,000 individuals from Africa, Asia and Oceania
Open AccessDeterminants of post-malarial anemia in African children treated with parenteral artesunate
Open AccessSafety and immunogenicity of the RTS,S/AS01 malaria vaccine in infants and children identified as HIV-infected during a randomized trial in sub-Saharan Africa
Open AccessA randomized crossover trial comparing the Nifty cup to a medicine cup in preterm infants who have difficulty breastfeeding at Komfo Anokye Teaching Hospital (KATH) in Kumasi, Ghana
Open AccessHospital-based Surveillance for Pediatric Bacterial Meningitis in the Era of the 13-Valent Pneumococcal Conjugate Vaccine in Ghana
Open AccessSafety profile of the RTS,S/AS01 malaria vaccine in infants and children: additional data from a phase III randomized controlled trial in sub-Saharan Africa
Open AccessRecruiting population controls for case-control studies in sub-Saharan Africa: The Ghana Breast Health Study
Open AccessDeterminants of paying national health insurance premium with mobile phone in Ghana: a cross-sectional prospective study
Open AccessEstimated glomerular filtration rate predicts incident stroke among Ghanaians with diabetes and hypertension
Open AccessIncident stroke among Ghanaians with hypertension and diabetes: A multicenter, prospective cohort study
Open AccessPredictors of glycemic control in type-2 diabetes mellitus: Evidence from a multicenter study in Ghana
Open AccessHuman candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study
Open AccessSustained impact of rotavirus vaccine introduction on rotavirus gastroenteritis hospitalizations in children <5 years of age, Ghana, 2009–2016
Open AccessA multi-center prospective cohort study to evaluate the effect of differential pricing and health systems strengthening on access to medicines and management of hypertension and diabetes in Ghana: A study protocol
Open AccessEvaluation of Intussusception after Monovalent Rotavirus Vaccination in Africa
Open AccessHost-mediated selection impacts the diversity of Plasmodium falciparum antigens within infections
Open AccessImmune response to the hepatitis B antigen in the RTS,S/AS01 malaria vaccine, and co-administration with pneumococcal conjugate and rotavirus vaccines in African children: A randomized controlled trial
Open AccessFactors associated with uncontrolled blood pressure among Ghanaians: Evidence from a multicenter hospital-based study
Open AccessA multi-center prospective cohort study to evaluate the effect of differential pricing and health systems strengthening on access to medicines and management of hypertension and diabetes in Ghana: A study protocol
Open AccessRotavirus strain distribution in Ghana pre- and post- rotavirus vaccine introduction
Open AccessSkin lighteners and hair relaxers as risk factors for breast cancer: results from the Ghana breast health study
Open AccessLongitudinal estimation of Plasmodium falciparum prevalence in relation to malaria prevention measures in six sub-Saharan African countries
Open AccessDesign considerations for identifying breast cancer risk factors in a population‐based study in Africa
Open AccessFactors contributing to delays in diagnosis of breast cancers in Ghana, West Africa
Open AccessPharmacokinetics of the First-Line Antituberculosis Drugs in Ghanaian Children with Tuberculosis with or without HIV Coinfection
Open AccessThe effect of power outages on in-facility mortality in healthcare facilities: Evidence from Ghana
Impact and Effectiveness of Monovalent Rotavirus Vaccine Against Severe Rotavirus Diarrhea in Ghana
Open AccessEpidemiology of paediatric poisoning reporting to a tertiary hospital in Ghana
Open AccessChallenges with implementing malaria rapid diagnostic tests at primary care facilities in a Ghanaian district: a qualitative study
Open AccessIntramuscular Artesunate for Severe Malaria in African Children: A Multicenter Randomized Controlled Trial
Open AccessblaCTX-M-15 carried by IncF-type plasmids is the dominant ESBL gene in Escherichia coli and Klebsiella pneumoniae at a hospital in Ghana
Genetic Diversity and Protective Efficacy of the RTS,S/AS01 Malaria Vaccine
Open AccessImmunogenicity of the RTS,S/AS01 malaria vaccine and implications for duration of vaccine efficacy: secondary analysis of data from a phase 3 randomised controlled trial
Open AccessSevere malaria in children leads to a significant impairment of transitory otoacoustic emissions - a prospective multicenter cohort study
Open AccessPharmacokinetics of First-Line Antituberculosis Drugs Using WHO Revised Dosage in Children With Tuberculosis With and Without HIV Coinfection
Open AccessAvailability and price of malaria rapid diagnostic tests in the public and private health sectors in 2011: results from 10 nationally representative cross‐sectional retail surveys
Open AccessEndothelial Protein C Receptor Gene Variants Not Associated with Severe Malaria in Ghanaian Children
Open AccessImproving Access To Malaria Medicine Through Private-Sector Subsidies In Seven African Countries
A combined analysis of immunogenicity, antibody kinetics and vaccine efficacy from phase 2 trials of the RTS,S malaria vaccine
Open AccessCancer incidence in Ghana, 2012: evidence from a population-based cancer registry
Open AccessBreast cancer in Sub-Saharan Africa: opportunities for prevention
Open AccessCommunicating the AMFm message: exploring the effect of communication and training interventions on private for-profit provider awareness and knowledge related to a multi-country anti-malarial subsidy intervention
Open AccessCervical Cancer Screening in Ghana, West Africa
Delayed Hemolysis After Treatment With Parenteral Artesunate in African Children With Severe Malaria—A Double-center Prospective Study
Open AccessSickle Cell Disease: Management options and challenges in developing countries
Open AccessThe burden and correlates of hypertension in rural Ghana: A cross-sectional study
Drinking water quality and source reliability in rural Ashanti region, Ghana
Open AccessA Phase 3 Trial of RTS,S/AS01 Malaria Vaccine in African Infants
Open AccessEffect of the Affordable Medicines Facility—malaria (AMFm) on the availability, price, and market share of quality-assured artemisinin-based combination therapies in seven countries: a before-and-after analysis of outlet survey data
Genome-wide association study indicates two novel resistance loci for severe malaria
Cardiac function in Ghanaian children with severe malaria
Prevalence of hypertension and diabetes mellitus in adults from a rural community in Ghana.
2012Blood Pressure and Hypertension Studies
Family planning in a sub-district near Kumasi, Ghana: side effect fears, unintended pregnancies and misuse of a medication as emergency contraception.
2011Global Maternal and Child Health
Assessment of severe malaria in a multicenter, phase III, RTS, S/AS01 malaria candidate vaccine trial: case definition, standardization of data collection and patient care
Open AccessA −436C>A Polymorphism in the Human FAS Gene Promoter Associated with Severe Childhood Malaria
Open AccessVerbal autopsy: an analysis of the common causes of childhood death in the Barekese sub-district of Ghana
Open AccessT Cell Responses to the RTS,S/AS01E and RTS,S/AS02D Malaria Candidate Vaccines Administered According to Different Schedules to Ghanaian Children
Open AccessIndicators of sustainable capacity building for health research: analysis of four African case studies
Open AccessPattern of AST and ALT changes in Relation to Hemolysis in sickle cell Disease
Open AccessAdherence to antiretroviral therapy, virologic failure and workload at the Rustenburg Provincial Hospital
Open AccessExploring the relationship between chronic undernutrition and asymptomatic malaria in Ghanaian children
Open Access<i>FCGR2A</i> functional genetic variant associated with susceptibility to severe malarial anaemia in Ghanaian children
Open AccessEvaluating International Collaboration: Differential Perceptions of Partnership in a CBPR Project in Ghana
Randomized Controlled Trial of RTS,S/AS02D and RTS,S/AS01E Malaria Candidate Vaccines Given According to Different Schedules in Ghanaian Children
Open AccessA randomized trial on effectiveness of artemether-lumefantrine versus artesunate plus amodiaquine for unsupervised treatment of uncomplicated Plasmodium falciparum malaria in Ghanaian children
Open AccessEvaluation of a learner-designed course for teaching health research skills in Ghana
Open AccessCapillary refill time as an independent prognostic indicator in severe and complicated malaria
Evaluating Health Research Capacity Building: An Evidence-Based Tool
Open AccessRoutine lumbar puncture in children with febrile seizures in Ghana: should it continue?
Open AccessRoutine lumbar puncture in children with febrile seizures in Ghana: should it continue?
Open AccessA Prospective Comparison of Malaria with Other Severe Diseases in African Children: Prognosis and Optimization of Management
Open AccessPopulation Kinetics, Efficacy, and Safety of Dichloroacetate for Lactic Acidosis Due to Severe Malaria in Children
Academic Metrics
DepartmentDepartment of Child Health
Total Publications100
Research Themes41
Open Access Papers86
Department of Child Health
Kwame Nkrumah University of Science and Technology