Charles Ansah
Department of PharmacologyHealth SciencesLife SciencesPhysical SciencesSocial Sciences

Charles Ansah

71 Publications34 Research Themes58 Open Access
Research Overview & Focus

The researcher has conducted extensive work in pharmacological studies focusing on gastrointestinal diseases, particularly related to helicobacter pylori, inflammatory bowel disease, alkaloid synthesis, toxicological effects of natural compounds, and plant-based extracts. Their findings include the development of novel antiviral agents, insights into gut microbiota-herbal interactions, exploration of alkaloid bioactivity, understanding of toxicity mechanisms in mammals, and contributions to reproductive health interventions.

Faculty Biography

I have considerable experience as a university professor and administrator.  I have been a university administrator as a Head of Department, Dean and acted as Provost on several occasions.  I have also served as a former Pro Vice-Chancellor.  I have served on several non-statutory and statutory committees of KNUST including the Academic Board. I have been   in attendance at the Governing Council of KNUST as a Pro Vice-Chancellor.  I have served as an assessor of the defunct NAB for new programmes at both public and private universities.I have travelled extensively to other universities and I am familiar with the processes and procedures in university management and how universities should brace themselves to face future challenges in the face of dwindling public funding.I have also served on several state boards including the Agogo Presbyterian College of Education, Pharmacy Council, Food and Drugs Authority and the Centre for Plant Medicine Research, Mampong Akuapem. Presently, I am presently a member of the Ministry of Health Research Committee on Herbal medicines for the possible management of Covid-19 and serve on the Ad Hoc committee charged to develop basic procedures for assessing the efficacy and safety of herbal products. I am an astute researcher in the area of toxicology, pharmacy, pharmacology and herbal medicine and have published extensively in reputable journals in the area of toxicology and pharmacology  Am also a member of the KNUST research team on Covid-19.  Currently, I serve as an Expert/ Consultant of traditional medicine for the West African Health Organization (WAHO).

Key Research Themes (34)
Health Sciences

Antioxidant Activity and Oxidative Stress

Life Sciences

ATP Synthase and ATPases Research

Health Sciences

Cancer-related Molecular Pathways

Physical Sciences

Chemical synthesis and alkaloids

Health Sciences

Diabetes Management and Education

Life Sciences

Drug-Induced Hepatotoxicity and Protection

Life Sciences

Essential Oils and Antimicrobial Activity

Life Sciences

Ethnobotanical and Medicinal Plants Studies

Physical Sciences

Heavy Metal Exposure and Toxicity

Health Sciences

Helicobacter pylori-related gastroenterology studies

Social Sciences

Hermeneutics and Narrative Identity

Health Sciences

Hypothalamic control of reproductive hormones

Life Sciences

Inflammatory Bowel Disease

Health Sciences

Malaria Research and Control

Health Sciences

Monoclonal and Polyclonal Antibodies Research

Health Sciences

Natural Antidiabetic Agents Studies

Life Sciences

Natural Compound Pharmacology Studies

Life Sciences

Natural product bioactivities and synthesis

Health Sciences

Pain Mechanisms and Treatments

Health Sciences

Papaya Research and Applications

Life Sciences

Pharmacological Effects of Natural Compounds

Health Sciences

Pharmacology and Obesity Treatment

Life Sciences

Pharmacovigilance and Adverse Drug Reactions

Life Sciences

Phytochemical compounds biological activities

Life Sciences

Phytochemical Studies and Bioactivities

Life Sciences

Phytochemistry and Biological Activities

Life Sciences

Phytochemistry and biological activity of medicinal plants

Physical Sciences

Polar Research and Ecology

Health Sciences

Pregnancy and Medication Impact

Health Sciences

Reproductive Biology and Fertility

Health Sciences

Reproductive Health and Technologies

Life Sciences

Synthesis and bioactivity of alkaloids

Life Sciences

Toxin Mechanisms and Immunotoxins

Health Sciences

Uterine Myomas and Treatments

Publications (71)

Pharmacovigilance of herbal medicines in Ghana- Knowledge, perception and practice

Open Access
2025Pharmacovigilance and Adverse Drug ReactionsDOI: 10.1016/j.sciaf.2025.e02917

Coping strategies of Ghanaian couples after unsuccessful infertility treatment: An exploratory qualitative study

Open Access
2025Reproductive Health and TechnologiesDOI: 10.1371/journal.pone.0326923

Pharmacological Evaluation Of A Popular Polyherbal Preparation, Femitol, Used For The Management Of Uterine Fibroids

Open Access
2025Uterine Myomas and TreatmentsDOI: 10.53555/ajbr.v28i1s.1148

Multimerization approach to improve a cell surface plectin binding cancer stem cell targeted peptoid drug-lead

Open Access
2025Monoclonal and Polyclonal Antibodies ResearchDOI: 10.2139/ssrn.5526924

Polyherbal renal tea extract shows anti-inflammatory and antioxidant effects against gentamicin-induced nephrotoxicity in guinea pigs

Open Access
2024Drug-Induced Hepatotoxicity and ProtectionDOI: 10.1080/2314808x.2024.2447123

Psychological distress of Ghanaian couples after unsuccessful treatment for infertility

Open Access
2023Reproductive Health and TechnologiesDOI: 10.4314/gmj.v57i4.4

Effects of prenatal antibiotic treatment on early infant health: a retrospective study in a rural health facility in Ghana

Open Access
2023Pregnancy and Medication ImpactDOI: 10.4314/ahs.v23i1.44

Pharmacotherapy for Infertility in Ghana: A Prospective Study on Prescription Patterns and Treatment Outcomes among Women undergoing Fertility Treatment

Open Access
2023Reproductive Health and TechnologiesDOI: 10.1016/j.curtheres.2023.100711

Pharmacotherapy of infertility in Ghana: Why do infertile patients discontinue their fertility treatment?

Open Access
2022Reproductive Health and TechnologiesDOI: 10.1371/journal.pone.0274635

In vivo inhibition of gastric acid secretions and H+/K+- ATPase activity, and enhancement of mucin activity by Dissotis rotundifolia plant extract

Open Access
2022Helicobacter pylori-related gastroenterology studiesDOI: 10.1016/j.sciaf.2022.e01317

The Pharmacologically Active Alkaloid Cryptolepine Activates a Type 1 Interferon Response That Is Independent of MAVS and STING Pathways

Open Access
2022Toxin Mechanisms and ImmunotoxinsDOI: 10.1155/2022/8873536

Cryptolepine inhibits hepatocellular carcinoma growth through inhibiting interleukin-6/STAT3 signalling

Open Access
2021Synthesis and bioactivity of alkaloidsDOI: 10.1186/s12906-021-03326-x

Cryptolepine, the major alkaloid of Cryptolepis sanguinolenta (Lindl.) Schlechter (Apocynaceae), attenuates early and late-phase symptoms of asthma

Open Access
2020Synthesis and bioactivity of alkaloidsDOI: 10.1016/j.sciaf.2020.e00540

Antiplasmodial and Antipyretic Activity and Safety Evaluation of the Methanolic Leaf Extract of <i>Murraya exotica (L.)</i>

Open Access
2020Essential Oils and Antimicrobial ActivityDOI: 10.1155/2020/1308541

Ethanolic stem bark extract of Terminalia ivorensis A. Chev. protects against potassium dichromate–induced nephrotoxicity in rats

Open Access
2020Heavy Metal Exposure and ToxicityDOI: 10.1016/j.sciaf.2020.e00410

Synthesis and <i>In Vitro</i> Antimicrobial and Anthelminthic Evaluation of Naphtholic and Phenolic <i>Azo</i> Dyes

Open Access
2020Essential Oils and Antimicrobial ActivityDOI: 10.1155/2020/4850492

Flavonoid-Rich Extract of <i>Dissotis rotundifolia</i> Whole Plant Protects against Ethanol-Induced Gastric Mucosal Damage

Open Access
2020Phytochemical Studies and BioactivitiesDOI: 10.1155/2020/7656127

Acetic Acid-Induced Ulcerative Colitis in Sprague Dawley Rats Is Suppressed by Hydroethanolic Extract of<i>Cordia vignei</i>Leaves through Reduced Serum Levels of TNF-<i>α</i>and IL-6

Open Access
2020Inflammatory Bowel DiseaseDOI: 10.1155/2020/8785497

Pharmacotherapy of infertility in Ghana: retrospective study at the cape coast teaching hospital

Open Access
2019Reproductive Health and TechnologiesDOI: 10.1186/s40545-019-0191-0

Cryptolepine, the Main Alkaloid of the Antimalarial <i>Cryptolepis sanguinolenta</i> (Lindl.) Schlechter, Induces Malformations in Zebrafish Embryos

Open Access
2019Synthesis and bioactivity of alkaloidsDOI: 10.1155/2019/7076986

Isolation of<i> Helicobacter pylori</i> from Gastric Biopsy of Dyspeptic Patients in Ghana and<i> In Vitro</i> Preliminary Assessment of the Effect of<i> Dissotis rotundifolia</i> Extract on Its Growth

Open Access
2018Helicobacter pylori-related gastroenterology studiesDOI: 10.1155/2018/8071081

DNA damage protecting activity and antioxidant potential of Launaea taraxacifolia leaves extract

Open Access
2018Antioxidant Activity and Oxidative StressDOI: 10.4103/jnsbm.jnsbm_22_17

In vitro H<sup>+</sup>/K<sup>+</sup>-ATPase Inhibition, Antiradical effects of a flavonoid-rich fraction of Dissotis rotundifolia, and In silico PASS Prediction of its isolated compounds

Open Access
2018ATP Synthase and ATPases ResearchDOI: 10.4103/jnsbm.jnsbm_104_17

Identification of cryptolepine metabolites in rat and human hepatocytes and metabolism and pharmacokinetics of cryptolepine in Sprague Dawley rats

Open Access
2017Synthesis and bioactivity of alkaloidsDOI: 10.1186/s40360-017-0188-8

In vitro anti-malarial interaction and gametocytocidal activity of cryptolepine

Open Access
2017Synthesis and bioactivity of alkaloidsDOI: 10.1186/s12936-017-2142-z

Antibiotic use during pregnancy: a retrospective study of prescription patterns and birth outcomes at an antenatal clinic in rural Ghana

Open Access
2017Pregnancy and Medication ImpactDOI: 10.1186/s40545-017-0111-0

Toxicological evaluation and protective effect of ethanolic leaf extract of Launaea taraxacifolia on gentamicin induced rat kidney injury

Open Access
2017Drug-Induced Hepatotoxicity and ProtectionDOI: 10.1016/j.apjtb.2017.06.011

In vitro antimalarial interaction and transmission-blocking activity of cryptolepine

2016Synthesis and bioactivity of alkaloidsDOI: 10.1055/s-0036-1596329

Irrational use of antibiotics and the risk of diabetes in Ghana

Open Access
2016Diabetes Management and EducationDOI: 10.4314/gmj.v50i2.9

In vivo assessment of the toxic potential of Dissotis rotundifolia whole plant extract in Sprague–Dawley rats

Open Access
2016Chemical synthesis and alkaloidsDOI: 10.1016/j.apjtb.2016.04.010

Erratum to: Synergistic anti-malarial action of cryptolepine and artemisinins

Open Access
2016Synthesis and bioactivity of alkaloidsDOI: 10.1186/s12936-016-1223-8

Synergistic anti-malarial action of cryptolepine and artemisinins

Open Access
2016Synthesis and bioactivity of alkaloidsDOI: 10.1186/s12936-016-1137-5

AQUEOUS LEAF EXTRACT OF CARICA PAPAYA (CARICACEAE) LINN. CAUSES LIVER INJURY AND REDUCED FERTILITY IN RATS

Open Access
2016Papaya Research and Applications

Terminalia ivorensis A. Chev. Ethanolic Stem Bark Extract Protects Against Gentamicin-Induced Renal and Hepatic Damage in Rats

Open Access
2016Drug-Induced Hepatotoxicity and ProtectionDOI: 10.7324/japs.2016.60425

Effect of an ethanolic seed extract of Picralima nitida ((Stapf) Th. and H. Durand) on reproductive abilities and developmental indices in rodents

2015Reproductive Biology and FertilityDOI: 10.5455/jeim.051115.or.137

Assessment of an ethanolic seed extract of Picralima nitida ((Stapf) Th. and H. Durand) on reproductive hormones and its safety for use

Open Access
2015Hypothalamic control of reproductive hormonesDOI: 10.5455/jice.20151030085004

SPATHODEA CAMPANULATA EXTRACT ATTENUATES ACETAMINOPHEN-INDUCED HEPATIC INJURY IN MICE

Open Access
2013Hermeneutics and Narrative IdentityDOI: 10.25004/ijpsdr.2013.050405

A review of the anticancer potential of the antimalarial herbal cryptolepis sanguinolenta and its major alkaloid cryptolepine.

Open Access
2013Synthesis and bioactivity of alkaloids

<i>In Vivo</i>Models Used for Evaluation of Potential Antigastroduodenal Ulcer Agents

Open Access
2013Helicobacter pylori-related gastroenterology studiesDOI: 10.1155/2013/796405

Untitled

Open Access
2013Synthesis and bioactivity of alkaloidsDOI: 10.13040/ijpsr.0975-8232.4(4).1442-48

Effect of Aqueous Extract of Euphorbia hirta on Haematological and Biochemical Parameters of Sprague Dawley Rats

2013Drug-Induced Hepatotoxicity and Protection

Subacute Oral Toxicity Assessment of &lt;i&gt;Alchornea cordifolia&lt;/i&gt; (Schumach and Thonn) Müll Arg (Euphorbiaceae) Extract in Rats

Open Access
2011Drug-Induced Hepatotoxicity and ProtectionDOI: 10.4314/tjpr.v10i5.7

&lt;i&gt;Trichilia monadelpha&lt;/i&gt; Bark Extracts Inhibit Carrageenan-Induced Foot-Oedema in the 7-Day Old Chick and the Oedema Associated with Adjuvant-Induced Arthritis in Rats

Open Access
2011Phytochemical compounds biological activitiesDOI: 10.4314/ajtcam.v9i1.2

Anti-inflammatory and Antipyretic Effects of an Ethanolic Extract of Capparis erythrocarpos Isert Roots

Open Access
2011Phytochemistry and Biological ActivitiesDOI: 10.3923/rjmp.2011.158.168

Reproductive and Developmental Toxicity of Cryptolepis sanguinolenta in Mice

2010Synthesis and bioactivity of alkaloidsDOI: 10.3923/rjpharm.2010.9.14

Anxiolytic and Antidepressant Effects of a Leaf Extract of Palisota hirsuta K. Schum. (Commelinaceae) in Mice

2009Chemical synthesis and alkaloidsDOI: 10.3923/ijp.2010.1.17

Antinociceptive Effects of an Ethanolic Extract of Capparis erythrocarpos Isert Roots in the Mice Formalin Test

Open Access
2009Pharmacological Effects of Natural CompoundsDOI: 10.3923/ijp.2009.354.361

Toxicity studies on &lt;i&gt; Alchornea cordifolia&lt;/i&gt; leaf extract in mince

Open Access
2009Drug-Induced Hepatotoxicity and ProtectionDOI: 10.4314/just.v29i1.46424

Characterization and Treatment of Severe Malaria in Hospitalized Children at a Ghanaian District Hospital

Open Access
2009Malaria Research and ControlDOI: 10.2174/1874315300902010039

Toxicological assessment of Cryptolepis sanguinolenta for possible use in veterinary medicine

Open Access
2009Synthesis and bioactivity of alkaloidsDOI: 10.5897/jvmah.9000030

Anti-Arthritic Effects of Palisota hirsuta K. Schum. Leaf Extract in Freund’s Adjuvant-Induced Arthritis in Rats

2009Natural product bioactivities and synthesisDOI: 10.3923/ijp.2009.181.190

Cryptolepine Provokes Changes in the Expression of Cell Cycle Proteins in Growing Cells

2009Synthesis and bioactivity of alkaloidsDOI: 10.3844/ajptsp.2009.177.185

Anxiogenic-like Effects of a Root Extract of Sphenocentrum jollyanum Pierre in Murine Behavioural Models

Open Access
2009Polar Research and EcologyDOI: 10.3923/jpt.2009.91.106

Anti-Nociceptive Effects and the Mechanism of Palisota hirsuta K. Schum. Leaf Extract in Murine Models

2009Phytochemistry and Biological ActivitiesDOI: 10.3923/ijp.2009.101.113

Alchornea Cordifolia (Euphorbiaceae), the Major Constituent of Antiasthmatic Herbal Formulations in Ghana, Stimulates β- adrenoceptors.

2009Pharmacology and Obesity TreatmentDOI: 10.4314/jgsa.v10i2.18025

Antidepressant-Like Effects of an Ethanolic Extract of Sphenocentrum jollyanum Pierre Roots in Mice

Open Access
2008Natural Compound Pharmacology StudiesDOI: 10.3923/ijp.2009.22.29

Anti-Nociceptive Effects of an Ethanolic Extract of the Whole Plant of Synedrella nodiflora (L.) Gaertn in Mice: Involvement of Adenosinergic Mechanisms

Open Access
2008Pain Mechanisms and TreatmentsDOI: 10.3923/jpt.2009.17.29

Anti-Inflammatory and antipyretic effects of an ethanolic extract of Palisota hirsuta K. Schum roots

Open Access
2008Phytochemistry and Biological ActivitiesDOI: 10.5897/ajpp.9000033

Antinociceptive activity of the ethanolic extract of the root bark of &lt;i&gt;Cassia sieberiana&lt;/i&gt; (Fam. Caesalpinaceae)

2008Phytochemistry and biological activity of medicinal plantsDOI: 10.4314/jpb.v4i1.32110

Anti-arthritic and antioxidant properties of the ethanolic stem bark extract of Newbouldia laevis (P. Beauv.) Seaman ex Bureau (Bignoniaceae)

Open Access
2008Ethnobotanical and Medicinal Plants Studies

Toxicological Evaluation of the Anti-Malarial Herb Cryptolepis sanguinolenta in Rodents

2008Synthesis and bioactivity of alkaloidsDOI: 10.3923/jpt.2008.335.343

Effects of Tetrapleura Tetraptera (Taub) Fruit Extract On Some Isolated Tissues: Possible Mechanism(S) of Antihypertensive Action

Open Access
2008Pharmacology and Obesity TreatmentDOI: 10.4314/just.v28i1.33075

The Mechanism of Cryptolepine-Induced Cell Death

Open Access
2008Synthesis and bioactivity of alkaloidsDOI: 10.3923/jpt.2008.291.301

Anti-inflammatory and antioxidant properties of the root extract of &lt;i&gt;Carissa edulis&lt;/i&gt; (forsk.) Vahl (apocynaceae)

Open Access
2008Natural Antidiabetic Agents StudiesDOI: 10.4314/just.v27i3.33054

Anxiogenic Effects of an Aqueous Crude Extract of Cryptolepis sanguinolenta (Periplocaceae) in Mice

2007Pharmacological Effects of Natural CompoundsDOI: 10.3923/ijp.2008.20.26

Toxicological assessment of &lt;i&gt;Parquetina nigrescens&lt;/i&gt; extracts in rats

Open Access
2007Drug-Induced Hepatotoxicity and ProtectionDOI: 10.4314/just.v26i3.33001

Reactive oxygen species is associated with cryptolepine cytotoxicity

Open Access
2005Synthesis and bioactivity of alkaloidsDOI: 10.4314/just.v25i1.32926

Responses of genes involved in cell cycle control to diverse DNA damaging chemicals in human lung adenocarcinoma A549 cells.

Open Access
2005Cancer-related Molecular PathwaysDOI: 10.1186/1475-2867-5-28

In vitro genotoxicity of the West African anti-malarial herbal Cryptolepis sanguinolenta and its major alkaloid cryptolepine

2004Synthesis and bioactivity of alkaloidsDOI: 10.1016/j.tox.2004.11.026

The molecular toxicology of Cryptolepis sanguinolenta, a West African anti-malarial herbal medicine.

Open Access
2004Synthesis and bioactivity of alkaloids

The Popular Herbal Antimalarial, Extract of Cryptolepis sanguinolenta, Is Potently Cytotoxic

Open Access
2002Synthesis and bioactivity of alkaloidsDOI: 10.1093/toxsci/70.2.245
Academic Metrics
DepartmentDepartment of Pharmacology
Total Publications71
Research Themes34
Open Access Papers58

Department of Pharmacology

Kwame Nkrumah University of Science and Technology

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