Charles Ansah
The researcher has conducted extensive work in pharmacological studies focusing on gastrointestinal diseases, particularly related to helicobacter pylori, inflammatory bowel disease, alkaloid synthesis, toxicological effects of natural compounds, and plant-based extracts. Their findings include the development of novel antiviral agents, insights into gut microbiota-herbal interactions, exploration of alkaloid bioactivity, understanding of toxicity mechanisms in mammals, and contributions to reproductive health interventions.
Faculty Biography
I have considerable experience as a university professor and administrator. I have been a university administrator as a Head of Department, Dean and acted as Provost on several occasions. I have also served as a former Pro Vice-Chancellor. I have served on several non-statutory and statutory committees of KNUST including the Academic Board. I have been in attendance at the Governing Council of KNUST as a Pro Vice-Chancellor. I have served as an assessor of the defunct NAB for new programmes at both public and private universities.I have travelled extensively to other universities and I am familiar with the processes and procedures in university management and how universities should brace themselves to face future challenges in the face of dwindling public funding.I have also served on several state boards including the Agogo Presbyterian College of Education, Pharmacy Council, Food and Drugs Authority and the Centre for Plant Medicine Research, Mampong Akuapem. Presently, I am presently a member of the Ministry of Health Research Committee on Herbal medicines for the possible management of Covid-19 and serve on the Ad Hoc committee charged to develop basic procedures for assessing the efficacy and safety of herbal products. I am an astute researcher in the area of toxicology, pharmacy, pharmacology and herbal medicine and have published extensively in reputable journals in the area of toxicology and pharmacology Am also a member of the KNUST research team on Covid-19. Currently, I serve as an Expert/ Consultant of traditional medicine for the West African Health Organization (WAHO).
Antioxidant Activity and Oxidative Stress
ATP Synthase and ATPases Research
Cancer-related Molecular Pathways
Chemical synthesis and alkaloids
Diabetes Management and Education
Drug-Induced Hepatotoxicity and Protection
Essential Oils and Antimicrobial Activity
Ethnobotanical and Medicinal Plants Studies
Heavy Metal Exposure and Toxicity
Helicobacter pylori-related gastroenterology studies
Hermeneutics and Narrative Identity
Hypothalamic control of reproductive hormones
Inflammatory Bowel Disease
Malaria Research and Control
Monoclonal and Polyclonal Antibodies Research
Natural Antidiabetic Agents Studies
Natural Compound Pharmacology Studies
Natural product bioactivities and synthesis
Pain Mechanisms and Treatments
Papaya Research and Applications
Pharmacological Effects of Natural Compounds
Pharmacology and Obesity Treatment
Pharmacovigilance and Adverse Drug Reactions
Phytochemical compounds biological activities
Phytochemical Studies and Bioactivities
Phytochemistry and Biological Activities
Phytochemistry and biological activity of medicinal plants
Polar Research and Ecology
Pregnancy and Medication Impact
Reproductive Biology and Fertility
Reproductive Health and Technologies
Synthesis and bioactivity of alkaloids
Toxin Mechanisms and Immunotoxins
Uterine Myomas and Treatments
Pharmacovigilance of herbal medicines in Ghana- Knowledge, perception and practice
Open AccessCoping strategies of Ghanaian couples after unsuccessful infertility treatment: An exploratory qualitative study
Open AccessPharmacological Evaluation Of A Popular Polyherbal Preparation, Femitol, Used For The Management Of Uterine Fibroids
Open AccessMultimerization approach to improve a cell surface plectin binding cancer stem cell targeted peptoid drug-lead
Open AccessPolyherbal renal tea extract shows anti-inflammatory and antioxidant effects against gentamicin-induced nephrotoxicity in guinea pigs
Open AccessPsychological distress of Ghanaian couples after unsuccessful treatment for infertility
Open AccessEffects of prenatal antibiotic treatment on early infant health: a retrospective study in a rural health facility in Ghana
Open AccessPharmacotherapy for Infertility in Ghana: A Prospective Study on Prescription Patterns and Treatment Outcomes among Women undergoing Fertility Treatment
Open AccessPharmacotherapy of infertility in Ghana: Why do infertile patients discontinue their fertility treatment?
Open AccessIn vivo inhibition of gastric acid secretions and H+/K+- ATPase activity, and enhancement of mucin activity by Dissotis rotundifolia plant extract
Open AccessThe Pharmacologically Active Alkaloid Cryptolepine Activates a Type 1 Interferon Response That Is Independent of MAVS and STING Pathways
Open AccessCryptolepine inhibits hepatocellular carcinoma growth through inhibiting interleukin-6/STAT3 signalling
Open AccessCryptolepine, the major alkaloid of Cryptolepis sanguinolenta (Lindl.) Schlechter (Apocynaceae), attenuates early and late-phase symptoms of asthma
Open AccessAntiplasmodial and Antipyretic Activity and Safety Evaluation of the Methanolic Leaf Extract of <i>Murraya exotica (L.)</i>
Open AccessEthanolic stem bark extract of Terminalia ivorensis A. Chev. protects against potassium dichromate–induced nephrotoxicity in rats
Open AccessSynthesis and <i>In Vitro</i> Antimicrobial and Anthelminthic Evaluation of Naphtholic and Phenolic <i>Azo</i> Dyes
Open AccessFlavonoid-Rich Extract of <i>Dissotis rotundifolia</i> Whole Plant Protects against Ethanol-Induced Gastric Mucosal Damage
Open AccessAcetic Acid-Induced Ulcerative Colitis in Sprague Dawley Rats Is Suppressed by Hydroethanolic Extract of<i>Cordia vignei</i>Leaves through Reduced Serum Levels of TNF-<i>α</i>and IL-6
Open AccessPharmacotherapy of infertility in Ghana: retrospective study at the cape coast teaching hospital
Open AccessCryptolepine, the Main Alkaloid of the Antimalarial <i>Cryptolepis sanguinolenta</i> (Lindl.) Schlechter, Induces Malformations in Zebrafish Embryos
Open AccessIsolation of<i> Helicobacter pylori</i> from Gastric Biopsy of Dyspeptic Patients in Ghana and<i> In Vitro</i> Preliminary Assessment of the Effect of<i> Dissotis rotundifolia</i> Extract on Its Growth
Open AccessDNA damage protecting activity and antioxidant potential of Launaea taraxacifolia leaves extract
Open AccessIn vitro H<sup>+</sup>/K<sup>+</sup>-ATPase Inhibition, Antiradical effects of a flavonoid-rich fraction of Dissotis rotundifolia, and In silico PASS Prediction of its isolated compounds
Open AccessIdentification of cryptolepine metabolites in rat and human hepatocytes and metabolism and pharmacokinetics of cryptolepine in Sprague Dawley rats
Open AccessIn vitro anti-malarial interaction and gametocytocidal activity of cryptolepine
Open AccessAntibiotic use during pregnancy: a retrospective study of prescription patterns and birth outcomes at an antenatal clinic in rural Ghana
Open AccessToxicological evaluation and protective effect of ethanolic leaf extract of Launaea taraxacifolia on gentamicin induced rat kidney injury
Open AccessIn vitro antimalarial interaction and transmission-blocking activity of cryptolepine
Irrational use of antibiotics and the risk of diabetes in Ghana
Open AccessIn vivo assessment of the toxic potential of Dissotis rotundifolia whole plant extract in Sprague–Dawley rats
Open AccessErratum to: Synergistic anti-malarial action of cryptolepine and artemisinins
Open AccessSynergistic anti-malarial action of cryptolepine and artemisinins
Open AccessAQUEOUS LEAF EXTRACT OF CARICA PAPAYA (CARICACEAE) LINN. CAUSES LIVER INJURY AND REDUCED FERTILITY IN RATS
Open AccessTerminalia ivorensis A. Chev. Ethanolic Stem Bark Extract Protects Against Gentamicin-Induced Renal and Hepatic Damage in Rats
Open AccessEffect of an ethanolic seed extract of Picralima nitida ((Stapf) Th. and H. Durand) on reproductive abilities and developmental indices in rodents
Assessment of an ethanolic seed extract of Picralima nitida ((Stapf) Th. and H. Durand) on reproductive hormones and its safety for use
Open AccessSPATHODEA CAMPANULATA EXTRACT ATTENUATES ACETAMINOPHEN-INDUCED HEPATIC INJURY IN MICE
Open AccessA review of the anticancer potential of the antimalarial herbal cryptolepis sanguinolenta and its major alkaloid cryptolepine.
Open Access<i>In Vivo</i>Models Used for Evaluation of Potential Antigastroduodenal Ulcer Agents
Open AccessUntitled
Open AccessEffect of Aqueous Extract of Euphorbia hirta on Haematological and Biochemical Parameters of Sprague Dawley Rats
Subacute Oral Toxicity Assessment of <i>Alchornea cordifolia</i> (Schumach and Thonn) Müll Arg (Euphorbiaceae) Extract in Rats
Open Access<i>Trichilia monadelpha</i> Bark Extracts Inhibit Carrageenan-Induced Foot-Oedema in the 7-Day Old Chick and the Oedema Associated with Adjuvant-Induced Arthritis in Rats
Open AccessAnti-inflammatory and Antipyretic Effects of an Ethanolic Extract of Capparis erythrocarpos Isert Roots
Open AccessReproductive and Developmental Toxicity of Cryptolepis sanguinolenta in Mice
Anxiolytic and Antidepressant Effects of a Leaf Extract of Palisota hirsuta K. Schum. (Commelinaceae) in Mice
Antinociceptive Effects of an Ethanolic Extract of Capparis erythrocarpos Isert Roots in the Mice Formalin Test
Open AccessToxicity studies on <i> Alchornea cordifolia</i> leaf extract in mince
Open AccessCharacterization and Treatment of Severe Malaria in Hospitalized Children at a Ghanaian District Hospital
Open AccessToxicological assessment of Cryptolepis sanguinolenta for possible use in veterinary medicine
Open AccessAnti-Arthritic Effects of Palisota hirsuta K. Schum. Leaf Extract in Freund’s Adjuvant-Induced Arthritis in Rats
Cryptolepine Provokes Changes in the Expression of Cell Cycle Proteins in Growing Cells
Anxiogenic-like Effects of a Root Extract of Sphenocentrum jollyanum Pierre in Murine Behavioural Models
Open AccessAnti-Nociceptive Effects and the Mechanism of Palisota hirsuta K. Schum. Leaf Extract in Murine Models
Alchornea Cordifolia (Euphorbiaceae), the Major Constituent of Antiasthmatic Herbal Formulations in Ghana, Stimulates β- adrenoceptors.
Antidepressant-Like Effects of an Ethanolic Extract of Sphenocentrum jollyanum Pierre Roots in Mice
Open AccessAnti-Nociceptive Effects of an Ethanolic Extract of the Whole Plant of Synedrella nodiflora (L.) Gaertn in Mice: Involvement of Adenosinergic Mechanisms
Open AccessAnti-Inflammatory and antipyretic effects of an ethanolic extract of Palisota hirsuta K. Schum roots
Open AccessAntinociceptive activity of the ethanolic extract of the root bark of <i>Cassia sieberiana</i> (Fam. Caesalpinaceae)
Anti-arthritic and antioxidant properties of the ethanolic stem bark extract of Newbouldia laevis (P. Beauv.) Seaman ex Bureau (Bignoniaceae)
Open AccessToxicological Evaluation of the Anti-Malarial Herb Cryptolepis sanguinolenta in Rodents
Effects of Tetrapleura Tetraptera (Taub) Fruit Extract On Some Isolated Tissues: Possible Mechanism(S) of Antihypertensive Action
Open AccessThe Mechanism of Cryptolepine-Induced Cell Death
Open AccessAnti-inflammatory and antioxidant properties of the root extract of <i>Carissa edulis</i> (forsk.) Vahl (apocynaceae)
Open AccessAnxiogenic Effects of an Aqueous Crude Extract of Cryptolepis sanguinolenta (Periplocaceae) in Mice
Toxicological assessment of <i>Parquetina nigrescens</i> extracts in rats
Open AccessReactive oxygen species is associated with cryptolepine cytotoxicity
Open AccessResponses of genes involved in cell cycle control to diverse DNA damaging chemicals in human lung adenocarcinoma A549 cells.
Open AccessIn vitro genotoxicity of the West African anti-malarial herbal Cryptolepis sanguinolenta and its major alkaloid cryptolepine
The molecular toxicology of Cryptolepis sanguinolenta, a West African anti-malarial herbal medicine.
Open AccessThe Popular Herbal Antimalarial, Extract of Cryptolepis sanguinolenta, Is Potently Cytotoxic
Open AccessDepartment of Pharmacology
Kwame Nkrumah University of Science and Technology