Michael Konney Laryea
The researcher's research is centered around the exploration of natural products derived from plants used in traditional medicine, with a primary focus on understanding their biological activities, potential applications in disease control, and their ethical implications. Their work spans multiple themes, including the chemical synthesis of alkaloids, the study of biofilms and quorum sensing mechanisms in bacteria, and the investigation of essential oils for antimicrobial properties. The researcher employs computational methods and molecular biology approaches to analyze these natural products, examining their effectiveness in preventing vector-borne diseases such as malaria and leishmaniasis. Their research also delves into plant biochemistry and synthesizes compounds that could inhibit or enhance processes like trans-sialidase enzymes. Additionally, they address environmental impacts of pharmaceuticals, the role of essential oils in health, and the ethical considerations surrounding natural product use. This integrated approach underscores a multidisciplinary study that bridges natural products, their chemical properties, and their health applications, aiming to inform both therapeutic strategies and sustainable practices in public health.
Faculty Biography
Michael Konney Laryea is a dedicated and innovative chemist with a profound interest in exploring Africa's rich biodiversity for novel therapeutics. Currently serving as a Lecturer in the Department of Chemistry at Kwame Nkrumah University of Science and Technology (KNUST) in Kumasi, Ghana, Michael has made significant contributions to the field of organic and natural products chemistry. Michael's academic journey began with a B.Sc. in Chemistry from KNUST, where he investigated the contamination of herbal medicines with formaldehyde and pathogens. He continued his studies at KNUST, earning an MPhil in Organic and Natural Products Chemistry, focusing on the in vitro anti-plasmodial activity of selected Ghanaian plants. His PhD research further delved into the isolation and characterization of anti-plasmodial agents from Ghanaian medicinal plants, under the guidance of Dr. Edmund Ekuadzi and Dr. Lawrence Sheringham Borquaye. Throughout his career, Michael has been actively involved in various research projects and has presented his findings at numerous conferences and workshops. His work has been published in reputable journals, showcasing his expertise in the field. Notable publications include studies on the antimicrobial and antibiofilm properties of plant extracts, as well as the antimalarial efficacy and toxicological assessment of Ghanaian medicinal plants. Michael's professional experience extends beyond academia. He has participated in the Next Generation Scientist Program by Novartis, where he received training in drug discovery and development, leadership, and professional communication. He has also attended the Phytochemistry Summer School at Egerton University in Kenya, gaining invaluable skills in the separation and structural elucidation of plant-derived compounds. In addition to his research and teaching responsibilities, Michael is committed to mentoring undergraduate and MPhil students, helping them navigate their research challenges. He is an active member of several professional organizations, including the Ghana Chemical Society and the Ghana Science Association, where he contributes to various initiatives aimed at advancing scientific research and education in Ghana. Michael's dedication to his field is further demonstrated by his involvement in developing and maintaining websites for research groups and projects, as well as his role in organizing and moderating journal club meetings and other academic events. With a strong foundation in chemistry and a passion for scientific discovery, Michael Konney Laryea continues to strive for excellence in his research, teaching, and professional endeavors, aiming to make a lasting impact on the scientific community and contribute to the development of a self-sustaining science base in Africa.
Alkaloids: synthesis and pharmacology
Antimicrobial Peptides and Activities
Bacterial biofilms and quorum sensing
Chemical synthesis and alkaloids
Child Nutrition and Water Access
Essential Oils and Antimicrobial Activity
Ethnobotanical and Medicinal Plants Studies
Insect Pest Control Strategies
Malaria Research and Control
Marine Sponges and Natural Products
Moringa oleifera research and applications
Pharmaceutical and Antibiotic Environmental Impacts
Phytochemistry and biological activity of medicinal plants
Plant biochemistry and biosynthesis
Research on Leishmaniasis Studies
Traditional and Medicinal Uses of Annonaceae
Antifungal potential of Salacia debilis extracts and compounds against Candida albicans: Biofilm inhibition, synergistic effects and computational studies
Nanoemulsion encapsulation improves the stability and antibacterial efficacy of orange (Citrus x sinensis) peel essential oil
Open AccessPharmaceutical Waste Disposal: A Cross‐Sectional Survey of Disposal Practices and Awareness in Sefwi Wiawso Municipality, Ghana
Open AccessDescriptive analysis of pharmaceutical disposal practices in Sekondi-Takoradi: implications for environmental and public health safety in Ghana
Open AccessEssential Oil Emulsions from Xylopia Villosa and Hyparrhena Rufa as Potent Antimicrobial and Antibiofilm Agents
Computational elucidation of Plasmodium falciparum enoyl-ACP reductase inhibition by Salacia debilis compounds: adaptive ligand binding drives antimalarial activity
Synergistic action of phytoconstituents drives the anthelmintic potential of Croton penduliflorus stem bark extracts
Open AccessChemical characterization, biological activities, and molecular docking studies of essential oils from <i>Annona reticulata</i> L (Annonaceae)
Open AccessOccurrence and ecological risk assessment of commonly used pharmaceuticals in water and soil of Sefwi Wiawso, Ghana
Open AccessPharmaceutical residues in environment matrices in the Sekondi-Takoradi metropolis of Ghana present potential ecotoxicological risks
Antiplasmodial and anti-trypanosomial monoterpene indole alkaloids from <i>Picralima nitida</i>
Ecological risk assessment of selected pharmaceuticals in major rivers within Kumasi, Ghana
Open AccessMolecular insights into the inhibition of Leishmania donovani O-acetylserine sulfhydrylase by cyclopropane carboxylic acid derivatives: a computational study
Open AccessEnvironmental impact of pharmaceutical contaminants in dumpsites: a study from Ejisu-Juaben municipality, Ghana
Open AccessPeptide Extract from Red Kidney Beans, Phaseolus vulgaris (Fabaceae), Shows Promising Antimicrobial, Antibiofilm, and Quorum Sensing Inhibitory Effects
Open AccessAbstract 2266 Amaryllidaceae Alkaloids as Potential Inhibitors of the Trypanosoma cruzi Trans-sialidase Enzyme: Unique Insights from Computational Studies
Open AccessTargeting Quorum Sensing in <i>Pseudomonas aeruginosa</i> Using Marine‐Derived Metabolites—An <i>In Silico</i> Approach
Open AccessMarine-Derived Furanones Targeting Quorum-Sensing Receptors in <i>Pseudomonas aeruginosa</i>: Molecular Insights and Potential Mechanisms of Inhibition
Open AccessMolecular insights into the differential membrane targeting of maximin 1 in prokaryotic and eukaryotic cells
Antimalarial compounds from the climbing stems of <i>salacia debilis</i>
De novo peptides as potential antimicrobial agents
Open AccessAntioxidant, antimicrobial, and antibiofilm properties of essential oils extracted from <i>Dialium guineense</i>
Open AccessAntimalarial, Antioxidant, and Toxicological Evaluation of Extracts of Celtis africana, Grosseria vignei, Physalis micrantha, and Stachytarpheta angustifolia
Open AccessBiological Efficacy and Toxicological Evaluation of Ethanolic Extract of <i>Cassia nodosa</i> Buch.-Ham<i>.</i> (Leguminosae)
Open AccessAnti-inflammatory and antioxidant activities of extracts of<i>Reissantia indica, Cissus cornifolia</i>and<i>Grosseria vignei</i>
Open AccessAntimalarial Efficacy and Toxicological Assessment of Extracts of Some Ghanaian Medicinal Plants
Open AccessNutritional and anti-nutrient profiles of some Ghanaian spices
Open AccessAnti-inflammatory activities of extracts from<i>Oliva sp., Patella rustica</i>, and<i>Littorina littorea</i>collected from Ghana’s coastal shorelines
Open AccessDepartment of Chemistry
Kwame Nkrumah University of Science and Technology