Michael Konney Laryea
Department of ChemistryLife SciencesPhysical SciencesHealth Sciences

Michael Konney Laryea

28 Publications16 Research Themes21 Open Access
Research Overview & Focus

The researcher's research is centered around the exploration of natural products derived from plants used in traditional medicine, with a primary focus on understanding their biological activities, potential applications in disease control, and their ethical implications. Their work spans multiple themes, including the chemical synthesis of alkaloids, the study of biofilms and quorum sensing mechanisms in bacteria, and the investigation of essential oils for antimicrobial properties. The researcher employs computational methods and molecular biology approaches to analyze these natural products, examining their effectiveness in preventing vector-borne diseases such as malaria and leishmaniasis. Their research also delves into plant biochemistry and synthesizes compounds that could inhibit or enhance processes like trans-sialidase enzymes. Additionally, they address environmental impacts of pharmaceuticals, the role of essential oils in health, and the ethical considerations surrounding natural product use. This integrated approach underscores a multidisciplinary study that bridges natural products, their chemical properties, and their health applications, aiming to inform both therapeutic strategies and sustainable practices in public health.

Faculty Biography

Michael Konney Laryea is a dedicated and innovative chemist with a profound interest in exploring Africa's rich biodiversity for novel therapeutics. Currently serving as a Lecturer in the Department of Chemistry at Kwame Nkrumah University of Science and Technology (KNUST) in Kumasi, Ghana, Michael has made significant contributions to the field of organic and natural products chemistry. Michael's academic journey began with a B.Sc. in Chemistry from KNUST, where he investigated the contamination of herbal medicines with formaldehyde and pathogens. He continued his studies at KNUST, earning an MPhil in Organic and Natural Products Chemistry, focusing on the in vitro anti-plasmodial activity of selected Ghanaian plants. His PhD research further delved into the isolation and characterization of anti-plasmodial agents from Ghanaian medicinal plants, under the guidance of Dr. Edmund Ekuadzi and Dr. Lawrence Sheringham Borquaye. Throughout his career, Michael has been actively involved in various research projects and has presented his findings at numerous conferences and workshops. His work has been published in reputable journals, showcasing his expertise in the field. Notable publications include studies on the antimicrobial and antibiofilm properties of plant extracts, as well as the antimalarial efficacy and toxicological assessment of Ghanaian medicinal plants. Michael's professional experience extends beyond academia. He has participated in the Next Generation Scientist Program by Novartis, where he received training in drug discovery and development, leadership, and professional communication. He has also attended the Phytochemistry Summer School at Egerton University in Kenya, gaining invaluable skills in the separation and structural elucidation of plant-derived compounds. In addition to his research and teaching responsibilities, Michael is committed to mentoring undergraduate and MPhil students, helping them navigate their research challenges. He is an active member of several professional organizations, including the Ghana Chemical Society and the Ghana Science Association, where he contributes to various initiatives aimed at advancing scientific research and education in Ghana. Michael's dedication to his field is further demonstrated by his involvement in developing and maintaining websites for research groups and projects, as well as his role in organizing and moderating journal club meetings and other academic events. With a strong foundation in chemistry and a passion for scientific discovery, Michael Konney Laryea continues to strive for excellence in his research, teaching, and professional endeavors, aiming to make a lasting impact on the scientific community and contribute to the development of a self-sustaining science base in Africa.

Key Research Themes (16)
Life Sciences

Alkaloids: synthesis and pharmacology

Life Sciences

Antimicrobial Peptides and Activities

Life Sciences

Bacterial biofilms and quorum sensing

Physical Sciences

Chemical synthesis and alkaloids

Health Sciences

Child Nutrition and Water Access

Life Sciences

Essential Oils and Antimicrobial Activity

Life Sciences

Ethnobotanical and Medicinal Plants Studies

Life Sciences

Insect Pest Control Strategies

Health Sciences

Malaria Research and Control

Life Sciences

Marine Sponges and Natural Products

Life Sciences

Moringa oleifera research and applications

Physical Sciences

Pharmaceutical and Antibiotic Environmental Impacts

Life Sciences

Phytochemistry and biological activity of medicinal plants

Life Sciences

Plant biochemistry and biosynthesis

Health Sciences

Research on Leishmaniasis Studies

Life Sciences

Traditional and Medicinal Uses of Annonaceae

Publications (28)

Antifungal potential of Salacia debilis extracts and compounds against Candida albicans: Biofilm inhibition, synergistic effects and computational studies

Nanoemulsion encapsulation improves the stability and antibacterial efficacy of orange (Citrus x sinensis) peel essential oil

Open Access

Pharmaceutical Waste Disposal: A Cross‐Sectional Survey of Disposal Practices and Awareness in Sefwi Wiawso Municipality, Ghana

Open Access
2025Pharmaceutical and Antibiotic Environmental ImpactsDOI: 10.1002/hsr2.71320

Descriptive analysis of pharmaceutical disposal practices in Sekondi-Takoradi: implications for environmental and public health safety in Ghana

Open Access
2025Child Nutrition and Water AccessDOI: 10.1186/s12982-025-00962-3

Essential Oil Emulsions from Xylopia Villosa and Hyparrhena Rufa as Potent Antimicrobial and Antibiofilm Agents

2025Traditional and Medicinal Uses of AnnonaceaeDOI: 10.1007/s42250-025-01459-x

Computational elucidation of Plasmodium falciparum enoyl-ACP reductase inhibition by Salacia debilis compounds: adaptive ligand binding drives antimalarial activity

2025Malaria Research and ControlDOI: 10.1007/s40203-025-00413-6

Synergistic action of phytoconstituents drives the anthelmintic potential of Croton penduliflorus stem bark extracts

Open Access
2025Insect Pest Control StrategiesDOI: 10.1007/s44371-025-00265-1

Chemical characterization, biological activities, and molecular docking studies of essential oils from <i>Annona reticulata</i> L (Annonaceae)

Open Access
2025Traditional and Medicinal Uses of AnnonaceaeDOI: 10.1080/28378083.2025.2540327

Occurrence and ecological risk assessment of commonly used pharmaceuticals in water and soil of Sefwi Wiawso, Ghana

Open Access
2025Pharmaceutical and Antibiotic Environmental ImpactsDOI: 10.1007/s44371-025-00146-7

Pharmaceutical residues in environment matrices in the Sekondi-Takoradi metropolis of Ghana present potential ecotoxicological risks

2025Pharmaceutical and Antibiotic Environmental ImpactsDOI: 10.1007/s13762-025-06471-9

Antiplasmodial and anti-trypanosomial monoterpene indole alkaloids from <i>Picralima nitida</i>

2024Alkaloids: synthesis and pharmacologyDOI: 10.1080/14786419.2024.2434710

Ecological risk assessment of selected pharmaceuticals in major rivers within Kumasi, Ghana

Open Access
2024Pharmaceutical and Antibiotic Environmental ImpactsDOI: 10.1080/28378083.2024.2421861

Molecular insights into the inhibition of Leishmania donovani O-acetylserine sulfhydrylase by cyclopropane carboxylic acid derivatives: a computational study

Open Access
2024Research on Leishmaniasis StudiesDOI: 10.1007/s44371-024-00032-8

Environmental impact of pharmaceutical contaminants in dumpsites: a study from Ejisu-Juaben municipality, Ghana

Open Access
2024Pharmaceutical and Antibiotic Environmental ImpactsDOI: 10.1007/s44378-024-00007-2

Peptide Extract from Red Kidney Beans, Phaseolus vulgaris (Fabaceae), Shows Promising Antimicrobial, Antibiofilm, and Quorum Sensing Inhibitory Effects

Open Access
2024Antimicrobial Peptides and ActivitiesDOI: 10.1155/2024/4667379

Abstract 2266 Amaryllidaceae Alkaloids as Potential Inhibitors of the Trypanosoma cruzi Trans-sialidase Enzyme: Unique Insights from Computational Studies

Open Access
2024Chemical synthesis and alkaloidsDOI: 10.1016/j.jbc.2024.106232

Targeting Quorum Sensing in <i>Pseudomonas aeruginosa</i> Using Marine‐Derived Metabolites—An <i>In Silico</i> Approach

Open Access
2024Bacterial biofilms and quorum sensingDOI: 10.1155/joch/2172452

Marine-Derived Furanones Targeting Quorum-Sensing Receptors in <i>Pseudomonas aeruginosa</i>: Molecular Insights and Potential Mechanisms of Inhibition

Open Access
2024Bacterial biofilms and quorum sensingDOI: 10.1177/11779322241275843

Molecular insights into the differential membrane targeting of maximin 1 in prokaryotic and eukaryotic cells

2023Antimicrobial Peptides and ActivitiesDOI: 10.1080/07391102.2023.2292297

Antimalarial compounds from the climbing stems of <i>salacia debilis</i>

2023Plant biochemistry and biosynthesisDOI: 10.1080/14786419.2023.2272288

De novo peptides as potential antimicrobial agents

Open Access
2023Antimicrobial Peptides and ActivitiesDOI: 10.1016/j.heliyon.2023.e19641

Antioxidant, antimicrobial, and antibiofilm properties of essential oils extracted from <i>Dialium guineense</i>

Open Access
2023Essential Oils and Antimicrobial ActivityDOI: 10.1080/10942912.2023.2236322

Antimalarial, Antioxidant, and Toxicological Evaluation of Extracts of Celtis africana, Grosseria vignei, Physalis micrantha, and Stachytarpheta angustifolia

Open Access
2021Ethnobotanical and Medicinal Plants StudiesDOI: 10.1155/2021/9971857

Biological Efficacy and Toxicological Evaluation of Ethanolic Extract of <i>Cassia nodosa</i> Buch.-Ham<i>.</i> (Leguminosae)

Open Access
2020Phytochemistry and biological activity of medicinal plantsDOI: 10.1155/2020/3983491

Anti-inflammatory and antioxidant activities of extracts of<i>Reissantia indica, Cissus cornifolia</i>and<i>Grosseria vignei</i>

Open Access
2020Ethnobotanical and Medicinal Plants StudiesDOI: 10.1080/23312025.2020.1785755

Antimalarial Efficacy and Toxicological Assessment of Extracts of Some Ghanaian Medicinal Plants

Open Access
2019Malaria Research and ControlDOI: 10.1155/2019/1630405

Nutritional and anti-nutrient profiles of some Ghanaian spices

Open Access
2017Moringa oleifera research and applicationsDOI: 10.1080/23311932.2017.1348185

Anti-inflammatory activities of extracts from<i>Oliva sp., Patella rustica</i>, and<i>Littorina littorea</i>collected from Ghana’s coastal shorelines

Open Access
2017Marine Sponges and Natural ProductsDOI: 10.1080/23312025.2017.1364063
Academic Metrics
DepartmentDepartment of Chemistry
Total Publications28
Research Themes16
Open Access Papers21

Department of Chemistry

Kwame Nkrumah University of Science and Technology

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