Caleb Kesse Firempong
58 Publications36 Research Themes23 Open Access
Research Overview & Focus
The researcher's work is concentrated across multiple thematic areas within health sciences, with a focus on bioavailability, nanotechnology applications, and systemic effects without significant overlap with other domains. Their research includes capsaicin derivatives via liposomal nanoformulation, ergosterol loading for antitumor activity, lipid nanoparticles in biocharaction studies, and the effects of chemicals like CCl4 and Hura crepitans on liver injury. However, these areas are distinct and not directly linked to other domains such as thermal therapy or systemic drugs.
Faculty Biography
Caleb Kesse Firempong is a PhD holder in Medical Science and Clinical Laboratory Diagnostics from Jiangsu University, China. He doubles as a lecturer and laboratory manager at Department of Biochemistry and Biotechnology, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi-Ghana, and Clinical Analysis Laboratory (CAn-Lab), KNUST, respectively. Currently, he is also the Head of Department of Biochemistry and Biotechnology, KNUST-Kumasi. He is an expert in Medicinal Plant Biochemistry with special emphasis on the discovery, formulation and bioavailability of drugs from natural sources which can be used to treat non-communicable diseases (Cancers, Liver disorders and Hypertension). By dint of hard work he has contributed immensely to the progress of society and the knowledge of Natural Product Science both locally and at the international level. His professional mission is to improve health and well-being in Ghana and the international community as a whole, through biomedical research, education, clinical services and consulting.
Key Research Themes (36)
Life Sciences
Advanced Biosensing Techniques and Applications
Physical Sciences
Advanced Chemical Sensor Technologies
Life Sciences
Advanced Drug Delivery Systems
Life Sciences
Advancements in Transdermal Drug Delivery
Life Sciences
African Botany and Ecology Studies
Physical Sciences
Analytical Chemistry and Chromatography
Life Sciences
Curcumin's Biomedical Applications
Health Sciences
Diet and metabolism studies
Health Sciences
Diverse Scientific Research Studies
Life Sciences
Drug Solubulity and Delivery Systems
Health Sciences
Drug Transport and Resistance Mechanisms
Life Sciences
Drug-Induced Hepatotoxicity and Protection
Life Sciences
Ethnobotanical and Medicinal Plants Studies
Health Sciences
Food composition and properties
Life Sciences
Ginger and Zingiberaceae research
Physical Sciences
Heavy metals in environment
Health Sciences
Inflammatory mediators and NSAID effects
Physical Sciences
Innovative Microfluidic and Catalytic Techniques Innovation
Health Sciences
Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Health Sciences
Medicinal Plants and Neuroprotection
Physical Sciences
Nanoparticle-Based Drug Delivery
Health Sciences
Natural Antidiabetic Agents Studies
Life Sciences
Natural product bioactivities and synthesis
Health Sciences
PARP inhibition in cancer therapy
Life Sciences
Pesticide Exposure and Toxicity
Life Sciences
Phytochemical compounds biological activities
Life Sciences
Phytochemical Studies and Bioactivities
Health Sciences
Phytochemicals and Antioxidant Activities
Physical Sciences
Phytochemistry and Bioactive Compounds
Health Sciences
Pomegranate: compositions and health benefits
Life Sciences
Proteoglycans and glycosaminoglycans research
Health Sciences
Silymarin and Mushroom Poisoning
Physical Sciences
Surfactants and Colloidal Systems
Life Sciences
Synthesis and bioactivity of alkaloids
Physical Sciences
Toxic Organic Pollutants Impact
Life Sciences
Venomous Animal Envenomation and Studies
Publications (58)
Health risk assessment of arsenic and metals (Cd, Cu, Fe, Ni, and Pb) consumed in meat singed with different fuel types from some selected cities in Ghana
Open AccessEvaluation of azithromycin–resin suspension designed for taste-masking and sustained-release
Open AccessA bioactive fraction from the leaves of Ceiba pentandra (L.) Gaertn. exhibits antiproliferative activity via cell cycle arrest at the G1/S checkpoint and initiation of apoptosis via poly [ADP-ribose] polymerase 1 (PARP1) cleavage in HeLa cells.
Polycyclic Aromatic Hydrocarbons Burden of Meats Singed with Different Fuel Sources from Abattoirs in Ghana and Associated Cancer Risk Assessment
Open AccessConstruction And In Vitro/ In Vivo Evaluations Of Pulse Sustained Release Of Verapamil Hydrochloride Delivery System
Open AccessIn vitro cytotoxic activity of five Ghanaian plants on human cancer cell lines
Open AccessFabrication of core-shell quantum dots microbeads with high stability, enhanced sensitivity and potential application in C-reactive protein (CRP) and procalcitonin (PCT) immunochromatography in vitro diagnostic reagents
Open AccessIn vitro antiproliferative activities of some Ghanaian medicinal plants
Open AccessConstruction and <i>in vitro</i> / <i>in vivo</i> evaluation of menantine hydrochloride oral liquid sustained-release drug delivery system
Development and in vitro/in vivo evaluation of famotidine hydrochloride bioadhesive sustained release suspension.
2024Advanced Drug Delivery Systems
In Vitro Cytotoxic Activity of Five Ghanaian Plants on Human Cancer Cell Lines
Open AccessA review of preclinical evidence of Cryptolepis nigrescens (Wennberg) L. Joubert. and Bruyns., Prosopsis africana (Guill. and Perr.) Taub. and Pterygota macrocarpa K. Schum. traditionally used to manage tumours in Ghana
Preparation and evaluation of sustained release pirfenidone-loaded microsphere dry powder inhalation for treatment of idiopathic pulmonary fibrosis
Open AccessProduction and evaluation of monovalent anti-snake immunoglobulins from chicken egg yolk using Ghanaian puff adder (Bitis arietans) Venom: Isolation, purification, and neutralization efficacy
Development, optimization, and in vitro/in vivo evaluation of ranitidine hydrochloride resinate sustained release suspension
Open AccessEthnobotanical study of medicinal plants used to treat HIV, cancer and diabetes in some communities of Ashanti Region, Ghana
Fabrication of ticagrelor bioadhesive solid dispersion based on coaxial electrostatic spray to improve drug release and enhance oral bioavailability.
2023Innovative Microfluidic and Catalytic Techniques Innovation
Improving the Oral Absorption of Celecoxib via Solid Self-Microemulsion Drug Delivery System: Preparation and In Vitro/In Vivo Evaluation
Open AccessConstruction and Evaluation of Traceable rhES-QDs-M-MS Protein Delivery System: Sustained-Release Properties, Targeted Effect, and Antitumor Activity
Preparation and Evaluation of rhINF-α-2b Sodium Hyaluronate Cross-Linked Porous Microspheres: Characterization, Sustained-Release Properties, and Antitumor Activity
Hura crepitans stem bark extract: A potential remedy to sub-acute liver damage
Preparation and <i>in vitro/in vivo</i> evaluation of a clonidine hydrochloride drug–resin suspension as a sustained-release formulation
Glycemic index of different varieties of yam as influenced by boiling, frying and roasting
Open AccessExtracts of Hura crepitans L. stem bark attenuate liver injury and inflammation induced by CCl4 in rats
Phytochemical, Antioxidant and Safety Evaluation of Hura crepitans (L.) Stem Bark Hydroethanolic Extract in Animals
Open AccessHepatoprotective Potential of Hura crepitans L.: A Review of Ethnomedical, Phytochemical and Pharmacological Studies
Open AccessModulation of Oxidative Stress and Inflammatory Cytokines as Therapeutic Mechanisms of<i>Ocimum americanum</i>L Extract in Carbon Tetrachloride and Acetaminophen-Induced Toxicity in Rats
Open AccessNovel cuminaldehyde self-emulsified nanoemulsion for enhanced antihepatotoxicity in carbon tetrachloride-treated mice
Anti-hyperuricemic property of 6-shogaol via self-micro emulsifying drug delivery system in model rats: formulation design, <i>in vitro</i> and <i>in vivo</i> evaluation
Open AccessSelf-microemulsifying Drug Delivery System for Improved Oral Delivery of Limonene: Preparation, Characterization, in vitro and in vivo Evaluation
In Vitro Metabolic Profiling of Periplogenin in Rat Liver Microsomes and its Associated Enzyme-kinetic Evaluation
Preparation and <i>in vitro/in vivo</i> evaluation of 6-Gingerol TPGS/PEG-PCL polymeric micelles
Preparation, optimization, and pharmacokinetic study of nanoliposomes loaded with triacylglycerol‐bound punicic acid for increased antihepatotoxic activity
Enhanced oral bioavailability and anti-gout activity of [6]-shogaol-loaded solid lipid nanoparticles
Enhanced oral bioavailability, reduced irritation and increased hypolipidemic activity of self-assembled capsaicin prodrug nanoparticles
Open AccessEnhanced oral bioavailability of [6]-Gingerol-SMEDDS: Preparation, in vitro and in vivo evaluation
Open AccessTissue distribution and enhanced in vivo anti-hyperlipidemic-antioxidant effects of perillaldehyde-loaded liposomal nanoformulation against Poloxamer 407-induced hyperlipidemia
Segetoside I, a plant-derived bisdesmosidic saponin, induces apoptosis in human hepatoma cells in vitro and inhibits tumor growth in vivo
Enhanced Solubility and Bioavailability of Naringenin via Liposomal Nanoformulation: Preparation and In Vitro and In Vivo Evaluations
Ergosterol-loaded poly(lactide-co-glycolide) nanoparticles with enhanced in vitro antitumor activity and oral bioavailability
Open AccessPreparation, characterization and pharmacokinetic studies of linalool-loaded nanostructured lipid carriers
Open AccessEnhanced oral bioavailability and in vivo antioxidant activity of chlorogenic acid via liposomal formulation
Hypolipidemic potential of perillaldehyde-loaded self-nanoemulsifying delivery system in high-fat diet induced hyperlipidemic mice: Formulation, in vitro and in vivo evaluation
Lipid raft biomaterial as a mass screening affinity tool for rapid identification of potential antitumor Chinese herbal medicine
Preparation, characterization, and pharmacokinetics study of capsaicin via hydroxypropyl-beta-cyclodextrin encapsulation
Prospects for multitarget lipid-raft-coated silica beads: a remarkable online biomaterial for discovering multitarget antitumor lead compounds
<i>In vitro</i> and <i>in vivo</i> evaluation of capsaicin‐loaded microemulsion for enhanced oral bioavailability
Improved oral bioavailability of capsaicin via liposomal nanoformulation: preparation, in vitro drug release and pharmacokinetics in rats
Enhanced oral bioavailability of capsaicin in mixed polymeric micelles: Preparation, in vitro and in vivo evaluation
Open AccessSimultaneous Measurement of Titratable Acidity and Fermentation Index in Cocoa Beans by Electronic Tongue Together with Linear and Non-linear Multivariate Technique
Development and thermodynamic evaluation of novel lipid raft stationary phase chromatography for screening potential antitumor agents
Lipid Raft Stationary Phase Chromatography for Screening Anti-tumor Components from Galla chinensis
Simultaneous HPLC determination of ergosterol and 22,23‐dihydroergosterol in <i>Flammulina velutipes</i> sterol‐loaded microemulsion
Enhanced Oral Bioavailability and Tissue Distribution of a New Potential Anticancer Agent, Flammulina velutipes Sterols, through Liposomal Encapsulation
Cytotoxic effect of novel Flammulina velutipes sterols and its oral bioavailability via mixed micellar nanoformulation
Chemical characteristics of toilet soap prepared from neem (Azadirachta indica A. Juss) seed oil
2011African Botany and Ecology Studies
Some Anthropometric, Biochemical and Haematogical Studies of Rats Fed on Different Composite Diets Prepared from Maize, Groundnut and Soybean
Open AccessAcademic Metrics
DepartmentDepartment of Biochemistry and Biotechnology
Total Publications58
Research Themes36
Open Access Papers23
Department of Biochemistry and Biotechnology
Kwame Nkrumah University of Science and Technology