Newman Osafo
76 Publications44 Research Themes43 Open Access
Research Overview & Focus
The researcher's research focuses on the study of systemic immune responses, particularly those involving inflammation, chronic inflammation, and systemic autoimmunity. Their work spans diverse biological pathways, including allergic inflammation, immune response modulation by natural compounds like pleuromycin and hydroethanol, and systemic inflammation mechanisms such as Allergic asthma and inflammatory bowel disease. The researcher's studies utilize a combination of pharmacological agents, synthetic extracts, and functional biopsies to investigate the role of natural molecules in modulating systemic inflammation and their potential therapeutic applications.
Faculty Biography
Newman Osafo teaches pharmacology, and supervises postgraduate research at the Department of Pharmacology, KNUST. He holds a PhD in Pharmacology from KNUST, with expertise in natural products pharmacology, inflammation, cancer, neurodegenerative disorders, and drug discovery. Newman has published extensively, with more than eighty peer-reviewed journal articles, book chapters, and conference abstracts to his credit. He serves on the editorial boards of several international journals, including Frontiers in Pharmacology, Scientific Reports, and the International Journal of Inflammation. A fellow of the Africa Science Leadership Programme (ASLP), his professional affiliations span the American Society for Pharmacology and Experimental Therapeutics (ASPET), the International Society of Pharmacovigilance (ISoP), Society for Medicinal Plant and Natural Product Research (GA), and the Pharmaceutical Society of Ghana (PSGh).
Key Research Themes (44)
Health Sciences
Amyotrophic Lateral Sclerosis Research
Health Sciences
Asthma and respiratory diseases
Health Sciences
Cancer-related Molecular Pathways
Health Sciences
Cannabis and Cannabinoid Research
Life Sciences
Connexins and lens biology
Health Sciences
Dermatology and Skin Diseases
Health Sciences
Diverse Scientific Research Studies
Health Sciences
Drug Transport and Resistance Mechanisms
Life Sciences
Drug-Induced Hepatotoxicity and Protection
Life Sciences
Echinoderm biology and ecology
Life Sciences
Essential Oils and Antimicrobial Activity
Life Sciences
Ethnobotanical and Medicinal Plants Studies
Health Sciences
Food Allergy and Anaphylaxis Research
Health Sciences
Gastrointestinal motility and disorders
Life Sciences
Genetic Neurodegenerative Diseases
Life Sciences
Genomics, phytochemicals, and oxidative stress
Health Sciences
HIV/AIDS Research and Interventions
Life Sciences
Immune Response and Inflammation
Life Sciences
Inflammatory Bowel Disease
Health Sciences
Inflammatory mediators and NSAID effects
Health Sciences
Mangiferin and Mango Extracts
Life Sciences
Mast cells and histamine
Life Sciences
Mitochondrial Function and Pathology
Life Sciences
Moringa oleifera research and applications
Health Sciences
Natural Antidiabetic Agents Studies
Life Sciences
Natural product bioactivities and synthesis
Life Sciences
Neurogenesis and neuroplasticity mechanisms
Life Sciences
Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences
Pain Mechanisms and Treatments
Health Sciences
Parasitic infections in humans and animals
Health Sciences
Parkinson's Disease Mechanisms and Treatments
Life Sciences
Pharmacological Effects of Natural Compounds
Health Sciences
Phytochemicals and Medicinal Plants
Physical Sciences
Phytochemistry and Bioactive Compounds
Life Sciences
Phytochemistry and Bioactivity Studies
Life Sciences
Phytochemistry and Biological Activities
Life Sciences
Piperaceae Chemical and Biological Studies
Life Sciences
Sulfur Compounds in Biology
Life Sciences
Synthesis and bioactivity of alkaloids
Health Sciences
Systemic Lupus Erythematosus Research
Health Sciences
Trace Elements in Health
Life Sciences
Traditional and Medicinal Uses of Annonaceae
Social Sciences
Vaccine Coverage and Hesitancy
Health Sciences
Wound Healing and Treatments
Publications (76)
Antiangiogenic effects of the hydroethanolic root extract of Croton membranaceus in chick chorioallantoic membrane
Open AccessThe impact of zinc and testosterone co-treatment on tumourigenesis in prostate cancer: a novel model
Open AccessAnti-IBD activity of Eleusine indica through inhibition of TNF-alpha and p38 MAPK expression
Neuro-therapeutic effect of ursolic acid in a murine model of vincristine-induced neuropathic pain
Prevalence and Predictors of Mother-to-Child Transmission of Human Immunodeficiency Virus (HIV) among HIV-exposed Infants
Open AccessAcetic acid-induced ulcerative colitis alleviation by Xylopia aethiopica (Dunal) A. Rich in Sprague Dawley rats
The hepatoprotective effects of hydroethanolic stem bark extract of <i>cleistopholis patens</i> in paracetamol-induced hepatotoxicity in rats
Informed but Unvaccinated: A Cross-Sectional Study Among University Students in Ghana
Open AccessAurantio‐Obtusin Suppresses Airway Inflammation and Serum ICAM‐1 Expression in Guinea Pig Allergic Asthma Model
Open AccessEleusine indica inhibits airway inflammation and ICAM-1 expression in ovalbumin-induced asthma in guinea pigs
Contributors
Antiinflammatory, modulatory and analgesic activities of African medicinal plants and their derivatives
Hydroethanolic Extract of <i>Salvia officinalis</i> L. Leaves Improves Memory and Alleviates Neuroinflammation in ICR Mice
Open AccessThe crude alkaloidal extract of Picralima nitida seeds alleviates TNBS-induced inflammatory bowel disease through reduced serum expression of TNF-α, IL-1β and p38 MAPK
The Aqueous Stem Bark Extract of Alstonia boonei Exhibits Anticataract Activity in Sprague Dawley Rat
Open AccessTherapeutic Targets and Neurochemical Signaling in Huntington's Disease
Neurogenesis in the Embryonic and Adult Brain
Acetic acid‐induced colitis modulating potential of total crude alkaloidal extract of <i>Picralima nitida</i> seeds in rats
Open AccessAnticataract Effect of the Aqueous Extract of the Flowers of Aspilia africana in Murine Model of Diabetic and Age-Related Cataracts
Open AccessNatural Products as Therapeutic Option for Echinococcossis
Open AccessHydroethanolic Leaf Extract of <i>Cordia vignei</i> Hutch and Dalziel Inhibits Carrageenan‐Induced Foot Oedema in Chicks, Prostaglandin E<sub>2</sub>‐Induced Paw Oedema in Mice, and Bradykinin‐Induced Paw Oedema in Mice
Open AccessNrf2 and VCAM-1 regulation may play a role in the anti-inflammatory mechanism of xylopic acid
The hydroethanolic root extract of Psydrax subcordata (DC.) Bridson exhibits antinociceptive and anti-inflammatory effects in animal models
Open AccessCoadministration of Stigmasterol and Dexamethasone (STIG+DEX) Modulates Steroid-Resistant Asthma
Open AccessAnti-Arthritic Effect of the Hydroethanolic Root Extract of Psydrax subcordata in Rats
Open AccessInflammation Modulating Activity of the Hydroethanol Stem Bark Extract of Bombax costatum in Murine Models
Open AccessAnti‐inflammatory activity of xylopic acid may be attributed to the modulation of Nrf2 and NF‐kB activities
Hydro-ethanol extract of Holarrhena floribunda stem bark exhibits anti-anaphylactic and anti-oedematogenic effects in murine models of acute inflammation
Open AccessRegulation of Nrf2 and NF-κB activities may contribute to the anti-inflammatory mechanism of xylopic acid
In vivo inhibitory effect of hydro-ethanol extract of xylopia aethiopica fruits on mediators of acute inflammation
Open AccessInfection-Induced Systemic Inflammation and Dementia
Xylopic acid from Xylopia aethiopica (Annonaceae) inhibits morphine tolerance in rats
Open AccessPalmatine sensitizes chemoresistant triple negative breast cancer cells via efflux inhibition of multidrug resistant protein 1.
Open AccessMethanolic Leaf Extract of Dissotis Rotundifolia Alleviates Acetic Acid-Induced Ulcerative Colitis in Rats
Open AccessInterferon Signature Analysis
Cutaneous and systemic anti-allergic potential of xylopic acid in rodents
Palmatine Modulates Triple Negative Mammary Carcinoma by Regulating the Endogenous Function of p53, p21 and Mdm2
Open AccessEndocannabinoid system and its modulation of brain, gut, joint and skin inflammation
Xylopic Acid Suppresses Adjuvant-induced Arthritis in Sprague DawleyRats via Reduction in Serum Levels of IL-6 and TNF-alpha
Solid-lipid nanoparticle formulation improves antiseizure action of cryptolepine
Open AccessHydro ethanol extract of Holarrhena floribunda stem bark exhibits anti-anaphylactic and anti-oedematogenic effects in murine models of acute inflammation
Open AccessCannabinoid Receptor and Inflammation
Open AccessAnti-inflammatory and wound healing properties of methanol leaf extract of Physalis angulata L.
Open AccessAcetic Acid-Induced Ulcerative Colitis in Sprague Dawley Rats Is Suppressed by Hydroethanolic Extract of<i>Cordia vignei</i>Leaves through Reduced Serum Levels of TNF-<i>α</i>and IL-6
Open AccessPharmacological Management of Parkinson’s Disease
Ulcerative colitis induced with acetic acid is ameliorated by Antrocaryon micraster through reduced serum levels of tumor necrosis factor alpha and interleukin-6 in sprague dawley rats
Open AccessMicroglial Mitophagy and Neurodegenerative Disorders
Potential effects of xylopic acid on acetic acid-induced ulcerative colitis in rats
Open AccessAntimicrobial Agents: Antibacterial Agents, Anti-biofilm Agents, Antibacterial Natural Compounds, and Antibacterial Chemicals
Open AccessBiomarkers of Wound Healing
Open AccessAllergic Airway-Induced Hypersensitivity Is Attenuated by Bergapten in Murine Models of Inflammation
Open AccessThe acute anti-inflammatory action of xylopic acid isolated from <i>Xylopia aethiopica</i>
Stigmasterol Alleviates Cutaneous Allergic Responses in Rodents
Open AccessAntipleuritic and Vascular Permeability Inhibition of the Ethyl Acetate-Petroleum Ether Stem Bark Extract of<i>Maerua angolensis</i>DC (Capparaceae) in Murine
Open AccessOxidative Stress and Neurodegeneration
Amyotrophic Lateral Sclerosis
Effect of xylopic acid isolated from <i>Xylopia aethiopica</i> on acetic acid‐induced ulcerative colitis in rats
Stigmasterol inhibits lipopolysaccharide-induced innate immune responses in murine models
Mechanism of Action of Nonsteroidal Anti-Inflammatory Drugs
Open AccessThe Ethanolic Stem-Bark Extract of<i>Antrocaryon micraster</i>Inhibits Carrageenan-Induced Pleurisy and Pedal Oedema in Murine Models of Inflammation
Open AccessAfrican Plants with Antiproliferative Properties
Open AccessReview of the Ethno-medical, Phytochemical, Pharmacological and Toxicological Studies on Dissotis rotundifolia (Sm.) Triana
Open AccessStigmasterol Modulates Allergic Airway Inflammation in Guinea Pig Model of Ovalbumin-Induced Asthma
Open AccessPhytochemical and Pharmacological Review of<i> Cryptolepis sanguinolenta</i> (Lindl.) Schlechter
Open AccessAqueous Ethanol Fruit Extract of Xylopia aethiopica and Xylopic Acid Exhibit Anti-inflammatory Activity Through Inhibition of the Arachidonic Acid Pathway
Open AccessAnti-inflammatory and anti-anaphylactic activity of xylopic acid isolated from the dried fruit of Xylopia aethiopica in mice
In vivo anti-inflammatory and antioxidant properties of Albizia zygia D. C. Macbr.
A Review: Ethnomedicinal, Phytochemical and Pharmacological Investigations of Lannea welwitschii (Hiern) Engl.
Open AccessGlyphaea brevis (Spreng.) Monach.: A Review of the Ethno-medical, Phytochemical and Pharmacological Investigations
Xylopia aethiopica (Annonaceae) fruit extract suppresses Freund׳s adjuvant-induced arthritis in Sprague-Dawley rats
Margaritaria discoidea (Euphorbiaceae) stem bark extract attenuates allergy and Freund′s adjuvant-induced arthritis in rodents
Open AccessAntiallergic and Antiarthritic Effects of Stem Bark Extract of<i>Glyphaea brevis</i>(Spreng) Monachino (Tiliaceae) in Murine Models
Open AccessAqueous ethanol extract of the fruit of Xylopia aethiopica (Annonaceae) exhibits anti-anaphylactic and anti-inflammatory actions in mice
Anti-Inflammatory and Analgesic Activities of African Medicinal Plants
List of Contributors
ANTI-ALLERGIC, ANTI-INFLAMMATORY AND ANALGESIC ACTIONS OF STEM BARK EXTRACT OF LANNEA WELWITSCHII (ANARCADIACEAE) IN MICE
2013Phytochemistry and Biological Activities
Academic Metrics
DepartmentDepartment of Pharmacology
Total Publications76
Research Themes44
Open Access Papers43
Department of Pharmacology
Kwame Nkrumah University of Science and Technology