Priscilla Kolibea Mante
Department of PharmacologyHealth SciencesLife SciencesPhysical SciencesSocial Sciences

Priscilla Kolibea Mante

61 Publications40 Research Themes43 Open Access
Research Overview & Focus

The researcher investigates the effects of specific plant and alkaloid extracts on mental health and body chemistry in animal models, focusing on neurotransmission, antidepressant-like properties, neuroinflammation, and antipsychiatry. They employ extracts such asmallotus oppositifolius, Pseudospondias microcarpa hydroethanolic leaf extract, and Xylopic acid to study their roles in extended-brain axis modulation, axon effects, antidepressant activity, and cognitive dysfunction. The research bridges pharmacology, neuroscience, and biochemistry, using animal models like zebrafish and rabbits for extended-brain axis studies and clinical trials. The findings aim to advance understanding of mental health treatments through novel chemical approaches and provide insights for developing antipsychiatry strategies.

Faculty Biography

Prof. Priscilla Kolibea Mante is a Professor of Pharmacology at the Department of Pharmacology, Kwame Nkrumah University of Science and Technology (KNUST) and Research Faculty at the Center for Applied Research and Innovation in Supply Chain–Africa (CARISCA). A leading African neuroscientist, she has developed an extensive research portfolio on the neurobiology and pharmacotherapy of mental and neurological disorders, particularly epilepsy, depression, anxiety, and neuroinflammation. Her work explores the therapeutic potential of African medicinal plants and the molecular mechanisms underlying drug-resistant epilepsy, integrating metabolomics, gut–brain axis research, and neuroinflammatory biomarkers. She holds a PhD (Pharmacology), B.Pharm (Hons) from KNUST and is a Fellow (Mental and Behavioural Health subspecialty) of the West African Postgraduate College of Pharmacists.She has authored over 50 peer-reviewed publications that contribute vital insights into novel therapeutic pathways for central nervous system disorders. Her research leadership spans several high-impact projects, including the GIZ PharmaVax SirraScale Project on scalable phytomedicine manufacturing, the ECOWAS PARI DIABETOX Projecton toxicological and antidiabetic properties of medicinal plants, the USAID BRIDGE-Train Project on strengthening pharmaceutical supply chain systems and OWSD Early Career Award. She has supervised and mentored numerous PhD, MPhil, and undergraduate students in pharmacology and neuroscience. She serves as Deputy Editor-in-Chief of the Ghana Pharmaceutical Journal, Associate Editor of the African Brain Journal, and Review Editor for Frontiers in Pharmacology (Experimental Pharmacology and Drug Discovery). She also reviews for leading journals such as Scientific Reports and BMC Neurology.Prof. Mante has served as an Expert Advisor to the UN Secretary-General’s High-Level Advisory Body on Artificial Intelligence and as an expert representative of the network of institutions affiliated with the UN Secretary-General’s Scientific Advisory Board, contributing to global frameworks on strengthening science systems, ethical AI, equitable innovation, and responsible research. She also serves on UNESCO’s Global Advisory Committee for Women and Girls in Science as well as Springer Nature’s Africa Advisory Council, advancing gender equity and research integrity.She is an active member of several professional societies, including the Society for Neuroscience (SfN), International Society for Neurochemistry (ISN), Society of Neuroscientists of Africa (SONA), Ghana Neuroscience Society (GNS), Organization for Women in Science for the Developing World (OWSD), and the Pharmaceutical Society of Ghana (PSGH). She is the current Chair (2023–present) of the Academic, Social and Research Pharmacists’ Association of Ghana and a member of the Governing Board of the PSGH.Prof. Mante previously served as Co-Chair (LMIC) of the Global Young Academy (2022–2024) and Chair of the Ghana Young Academy (2019-2022), advancing the inclusion of young scientists in global policy and research dialogues. She serrved on the World Science Forum Steering Committee and served as an ex-officio member of the InterAcademy Partnership (IAP) Global Council for Science Education Programme. She currently sits on the Steering Committee of the Africa Science Leadership Programme and is a member of the InterAcademy Partnership IAP Communication, Education and Outreach Committee.An accomplished communicator, Prof. Mante has been a speaker and panelist at major international events, including the World Science Forum, the UN General Assembly Science Summit, the STS Forum (Japan), and Science Forum South Africa. In addition to her research and policy work, Prof. Mante founded WriteShop Ghana, a national science communication initiative that builds writing and publication skills among students and researchers. She coordinates national science engagement programmes including Brain Bee Ghana, 2-Minute Thesis, and STEM Elevate, all aimed at inspiring scientific literacy, mentorship, and innovation among young Ghanaians.

Key Research Themes (40)
Health Sciences

Acupuncture Treatment Research Studies

Life Sciences

Alkaloids: synthesis and pharmacology

Health Sciences

Animal testing and alternatives

Life Sciences

Biochemical Acid Research Studies

Health Sciences

Biological and pharmacological studies of plants

Physical Sciences

Chemical synthesis and alkaloids

Health Sciences

COVID-19 Clinical Research Studies

Health Sciences

Diet and metabolism studies

Life Sciences

Drug Solubulity and Delivery Systems

Health Sciences

Epilepsy research and treatment

Life Sciences

Ethnobotanical and Medicinal Plants Studies

Health Sciences

Food Allergy and Anaphylaxis Research

Life Sciences

Genomics and Rare Diseases

Life Sciences

Gut microbiota and health

Health Sciences

HIV-related health complications and treatments

Health Sciences

Intensive Care Unit Cognitive Disorders

Health Sciences

Long-Term Effects of COVID-19

Health Sciences

Medicinal Plant Extracts Effects

Life Sciences

Medicinal Plants and Bioactive Compounds

Health Sciences

Menopause: Health Impacts and Treatments

Health Sciences

Natural Antidiabetic Agents Studies

Life Sciences

Natural Compound Pharmacology Studies

Social Sciences

Neuroendocrine regulation and behavior

Life Sciences

Neuroinflammation and Neurodegeneration Mechanisms

Life Sciences

Neuropeptides and Animal Physiology

Life Sciences

Neuroscience and Neuropharmacology Research

Health Sciences

Pain Mechanisms and Treatments

Health Sciences

Papaya Research and Applications

Health Sciences

Parasitic infections in humans and animals

Physical Sciences

Pharmaceutical and Antibiotic Environmental Impacts

Life Sciences

Phytochemistry and Biological Activities

Life Sciences

Rabbits: Nutrition, Reproduction, Health

Health Sciences

Respiratory and Cough-Related Research

Health Sciences

SARS-CoV-2 and COVID-19 Research

Health Sciences

SARS-CoV-2 detection and testing

Life Sciences

Synthesis and bioactivity of alkaloids

Life Sciences

Traditional and Medicinal Uses of Annonaceae

Health Sciences

Treatment of Major Depression

Life Sciences

Tryptophan and brain disorders

Life Sciences

Zebrafish Biomedical Research Applications

Publications (61)

Isolation and characterization of antimicrobial compounds from Picralima nitida (Apocynaceae)

Bridging genomics and digital health for paediatric epilepsy in Africa

2025Genomics and Rare DiseasesDOI: 10.1111/dmcn.16507

Harnessing phytochemicals for neuroprotection

2025Medicinal Plants and Bioactive CompoundsDOI: 10.1016/j.neuroscience.2025.05.093

Aqueous extract of Antiaris toxicaria alleviates LPS-induced neuroinflammation by modulating NF-κB signalling

2025Neuroinflammation and Neurodegeneration MechanismsDOI: 10.1186/s41110-025-00340-8

Aframomum melegueta mitigates seizure severity and neuroinflammation via gut-brain axis modulation in PTZ-induced kindling

Open Access
2025Acupuncture Treatment Research StudiesDOI: 10.1186/s40816-025-00393-2

Evidence for the anxiolytic- and antidepressant-like effects of three semi-synthetic derivatives of xylopic acid in mice

2025Natural Compound Pharmacology StudiesDOI: 10.1007/s00210-025-03814-8

Antidepressant-like effect of picralima nitida total crude alkaloidal fraction in mice

Open Access
2025Diet and metabolism studiesDOI: 10.1016/j.sciaf.2025.e02548

Hydroethanolic Extract of <i>Salvia officinalis</i> L. Leaves Improves Memory and Alleviates Neuroinflammation in ICR Mice

Open Access
2025Neuroinflammation and Neurodegeneration MechanismsDOI: 10.1155/tswj/2198542

Anti-implantation and uterotonic properties of Mentha pulegium L. in female Sprague-Dawley rats

Open Access
2024Rabbits: Nutrition, Reproduction, HealthDOI: 10.18203/issn.2454-2156.intjscirep20242693

Antimicrobial resistance modifying effects and molecular docking studies of Affinine, derived from Tabernaemontana crassa

Open Access
2024Alkaloids: synthesis and pharmacologyDOI: 10.1016/j.sciaf.2024.e02382

Editorial: Model organisms in experimental pharmacology and drug discovery 2023: rodent, worm and zebrafish models

Open Access
2024Animal testing and alternativesDOI: 10.3389/fphar.2024.1462972

Antiaris africana aqueous extract inhibits chronic demyelination and seizures in mice

Open Access
2024Natural Antidiabetic Agents StudiesDOI: 10.1016/j.heliyon.2024.e34296

Investigation of Herb-Drug Interactions between <i>Xylopia aethiopica</i>, Its Principal Constituent Xylopic Acid, and Antidepressants

Open Access
2024Traditional and Medicinal Uses of AnnonaceaeDOI: 10.1155/2024/9923801

Synergistic antidepressant-like effect of xylopic acid co-administered with selected antidepressants

Open Access
2024Neuroendocrine regulation and behaviorDOI: 10.1016/j.ibneur.2024.01.011

Gut-Brain-axis: effect of basil oil on the gut microbiota and its contribution to the anticonvulsant properties

Open Access
2023Epilepsy research and treatmentDOI: 10.1186/s12906-023-04211-5

Anxiolytic-like effects of Pseudospondias microcarpa hydroethanolic leaf extract in zebrafish: Possible involvement of GABAergic and serotonergic pathways

Open Access
2023Zebrafish Biomedical Research ApplicationsDOI: 10.1007/s13659-023-00399-8

Brain-gut-microbiota axis: effect of basil oil on the gut microbiota and its contribution to the anticonvulsant properties

Open Access
2023Gut microbiota and healthDOI: 10.21203/rs.3.rs-2775005/v1

Risk factors and outcomes of delirium in hospitalized older Ghanaians

2023Intensive Care Unit Cognitive DisordersDOI: 10.1002/gps.5912

Fast-onset effects of Pseudospondias microcarpa (A. Rich) Engl. (Anacardiaceae) hydroethanolic leaf extract on behavioral alterations induced by chronic mild stress in mice

Open Access
2023Tryptophan and brain disordersDOI: 10.1371/journal.pone.0278231

Synergistic Antidepressant-Like Effect of Xylopic Acid Co-Administered with Selected Antidepressants

Open Access
2023Biochemical Acid Research StudiesDOI: 10.2139/ssrn.4442394

Drug Disposal and Ecopharmacovigilance Practices in the Krowor Municipality, Ghana

Open Access
2022Pharmaceutical and Antibiotic Environmental ImpactsDOI: 10.1155/2022/7674701

Assessment of renal function in HIV patients on tenofovir-containing antiretroviral therapy in Ghana: a longitudinal study

Open Access
2022HIV-related health complications and treatmentsDOI: 10.5281/zenodo.6382806

Post-illness anxiety, depression and PTSD symptoms in COVID-19 survivors

2022Long-Term Effects of COVID-19DOI: 10.1080/00207411.2022.2028057

Eugenol inhibits veratridine-induced non-convulsive seizures and wet dog shakes via blockage of sodium and calcium influx in rat cerebrocortical synaptosomes

Open Access
2022Neuroscience and Neuropharmacology ResearchDOI: 10.7324/japs.2021.120117

Xylopic acid from Xylopia aethiopica (Annonaceae) inhibits morphine tolerance in rats

Open Access
2022Traditional and Medicinal Uses of AnnonaceaeDOI: 10.29090/psa.2022.02.21.124

Sex Hormones as Risk Factors for Dementia

2022Menopause: Health Impacts and TreatmentsDOI: 10.1007/978-981-16-7606-2_4

Implications of WHO COVID-19 interim guideline 2020.5 on the comprehensive care for infected persons in Africa Before, during and after clinical management of cases

Open Access
2021COVID-19 Clinical Research StudiesDOI: 10.1016/j.sciaf.2021.e01083

Pharmacological management of seizures in patients with COVID-19: a systematic review

2021Long-Term Effects of COVID-19DOI: 10.12688/aasopenres.13224.2

Cutaneous and systemic anti-allergic potential of xylopic acid in rodents

2021Food Allergy and Anaphylaxis ResearchDOI: 10.1007/s13596-021-00595-2

SARS-CoV-2 Viral Shedding and Transmission Dynamics: Implications of WHO COVID-19 Discharge Guidelines

Open Access
2021SARS-CoV-2 and COVID-19 ResearchDOI: 10.3389/fmed.2021.648660

Investigating the Anticonvulsant Properties of Aqueous Ethanolic Extracts of the Leaves, Roots, and Fruits of Jatropha gossypifolia L. (Euphorbiaceae)

Open Access
2021Epilepsy research and treatmentDOI: 10.1155/2021/5547353

Pharmacological management of seizures in patients with COVID-19: a systematic review

Open Access
2021Long-Term Effects of COVID-19DOI: 10.12688/aasopenres.13224.1

Solid-lipid nanoparticle formulation improves antiseizure action of cryptolepine

Open Access
2021Synthesis and bioactivity of alkaloidsDOI: 10.1016/j.biopha.2021.111354

Correlating WHO COVID-19 interim guideline 2020.5 and testing capacity, accuracy, and logistical challenges in Africa

Open Access
2021SARS-CoV-2 detection and testingDOI: 10.11604/pamj.2021.39.89.27522

Chronic administration of cryptolepine nanoparticle formulation alleviates seizures in a neurocysticercosis model

Open Access
2021Parasitic infections in humans and animalsDOI: 10.1016/j.crphar.2021.100040

Formulation and evaluation of sustained release matrix tablets of capparis erythrocarpos roots extract to improve patient compliance in management of arthritis

Open Access
2019Drug Solubulity and Delivery SystemsDOI: 10.1016/j.sciaf.2019.e00172

Leaves and stems of Capparis erythrocarpos, more sustainable than roots, show antiarthritic effects

2019Phytochemistry and Biological ActivitiesDOI: 10.1016/j.jep.2019.111890

Pharmacognostic Studies of the Leaves, Stem and Root of Capparis erythrocarpos Isert (Capparaceae)

Open Access
2019Phytochemistry and Biological ActivitiesDOI: 10.5530/pj.2019.1.19

Anxiolytic and Antidepressant Effects of<i>Maerua angolensis</i>DC. Stem Bark Extract in Mice

Open Access
2018Phytochemistry and Biological ActivitiesDOI: 10.1155/2018/1537371

Toxicological Assessment of<i> Pseudospondias microcarpa</i> (A. Rich.) Engl. Hydroethanolic Leaf Extract in Rats: Haematological, Biochemical, and Histopathological Studies

Open Access
2018Ethnobotanical and Medicinal Plants StudiesDOI: 10.1155/2018/4256782

Xylopic acid prevents the development of tolerance and physical dependence to morphine in rats

Open Access
2018Traditional and Medicinal Uses of AnnonaceaeDOI: 10.1254/jpssuppl.wcp2018.0_po1-1-87

Maerua angolensis stem bark extract reverses anxiety and related behaviours in zebrafish—Involvement of GABAergic and 5-HT systems

2017Zebrafish Biomedical Research ApplicationsDOI: 10.1016/j.jep.2017.06.012

Anticonvulsant activity of Pseudospondias microcarpa (A. Rich) Engl. hydroethanolic leaf extract in mice: The role of excitatory/inhibitory neurotransmission and nitric oxide pathway

2017Neuroscience and Neuropharmacology ResearchDOI: 10.1016/j.jep.2017.05.017

Anticonvulsant effects of antiaris toxicaria aqueous extract: investigation using animal models of temporal lobe epilepsy

Open Access
2017Neuroscience and Neuropharmacology ResearchDOI: 10.1186/s13104-017-2488-x

MOESM1 of Anticonvulsant effects of antiaris toxicaria aqueous extract: investigation using animal models of temporal lobe epilepsy

Open Access
2017Alkaloids: synthesis and pharmacologyDOI: 10.6084/m9.figshare.c.3756962_d1

The possible mode of antitussive and expectorant activity of the ethanol seed extracts of Picralima nitida ((Stapf) Th. &amp; H. Durand)

Open Access
2016Natural Compound Pharmacology StudiesDOI: 10.1016/j.jtcme.2016.05.003

Analgesic properties of aqueous leaf extract of <i>Haematostaphis barteri:</i> involvement of ATP-sensitive potassium channels, adrenergic, opioidergic, muscarinic, adenosinergic and serotoninergic pathways

2016Pain Mechanisms and TreatmentsDOI: 10.1515/jbcpp-2015-0108

Antitussive, expectorant and analgesic effects of the ethanol seed extract of Picralima nitida (Stapf) Th. & H. Durand.

Open Access
2016Respiratory and Cough-Related Research

Anxiolytic-like effect of the leaves of <i>Pseudospondias microcarpa</i> (A. Rich.) Engl. in mice

2016Medicinal Plant Extracts EffectsDOI: 10.1515/jbcpp-2015-0067

Scientific evidence of plant with a rapid-onset and sustained antidepressant effect in a chronic model of depression: <i>Mallotus oppositifolius</i>

2016Biological and pharmacological studies of plantsDOI: 10.1515/jbcpp-2015-0029

AQUEOUS LEAF EXTRACT OF CARICA PAPAYA (CARICACEAE) LINN. CAUSES LIVER INJURY AND REDUCED FERTILITY IN RATS

Open Access
2016Papaya Research and Applications

Enhancement of inhibitory neurotransmission and inhibition of excitatory mechanisms underlie the anticonvulsant effects of Mallotus oppositifolius

Open Access
2016Chemical synthesis and alkaloidsDOI: 10.4103/0975-7406.183226

Preclinical evidence of a rapid-onset antidepressant-like effect of Pseudospondias microcarpa hydroethanolic leaf extract in a chronic depression model

Open Access
2016Tryptophan and brain disordersDOI: 10.18203/2319-2003.ijbcp20162426

Antidepressant-Like Effect of the Leaves of<i>Pseudospondias microcarpa</i>in Mice: Evidence for the Involvement of the Serotoninergic System, NMDA Receptor Complex, and Nitric Oxide Pathway

Open Access
2015Neuropeptides and Animal PhysiologyDOI: 10.1155/2015/397943

Antidepressant-like properties of Antiaris toxicaria aqueous extract

Open Access
2015Neuroscience and Neuropharmacology ResearchDOI: 10.5455/2319-2003.ijbcp20150220

Effects of hyrdroethanolic leaf extract of Pseudospondias microcarpa (A. Rich.) Engl. (Anacardiaceae) on the central nervous system in mice

Open Access
2014Medicinal Plant Extracts EffectsDOI: 10.31254/phyto.2014.3607

Antidepressant Effects of<i>Mallotus oppositifolius</i>in Acute Murine Models

Open Access
2014Treatment of Major DepressionDOI: 10.1155/2014/324063

Neuropharmacological effects of an ethanolic fruit extract of Xylopia aethiopica and xylopic acid, a kaurene diterpene isolate, in mice.

2014Traditional and Medicinal Uses of Annonaceae

Anticonvulsant Effect of<i>Antiaris toxicaria</i>(Pers.) Lesch. (Moraceae) Aqueous Extract in Rodents

Open Access
2013Neuroscience and Neuropharmacology ResearchDOI: 10.1155/2013/519208

Screening of Central Effects of the Leaves of Mallotus oppositifolius (Geiseler) Mull. Arg. in Mice

2012Phytochemistry and Biological ActivitiesDOI: 10.5567/pharmacologia.2012.683.692

NEUROPHARMACOLOGICAL ASSESSMENT OF AN AQUEOUS BARK EXTRACT OF &lt;i&gt;ANTIARIS TOXICARIA&lt;/i&gt; (PERS.) LESCH. (MORACEAE) IN RODENTS

Open Access
2012Neuroscience and Neuropharmacology ResearchDOI: 10.3844/ajptsp.2012.123.134
Academic Metrics
DepartmentDepartment of Pharmacology
Total Publications61
Research Themes40
Open Access Papers43

Department of Pharmacology

Kwame Nkrumah University of Science and Technology

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