Priscilla Kolibea Mante
The researcher investigates the effects of specific plant and alkaloid extracts on mental health and body chemistry in animal models, focusing on neurotransmission, antidepressant-like properties, neuroinflammation, and antipsychiatry. They employ extracts such asmallotus oppositifolius, Pseudospondias microcarpa hydroethanolic leaf extract, and Xylopic acid to study their roles in extended-brain axis modulation, axon effects, antidepressant activity, and cognitive dysfunction. The research bridges pharmacology, neuroscience, and biochemistry, using animal models like zebrafish and rabbits for extended-brain axis studies and clinical trials. The findings aim to advance understanding of mental health treatments through novel chemical approaches and provide insights for developing antipsychiatry strategies.
Faculty Biography
Prof. Priscilla Kolibea Mante is a Professor of Pharmacology at the Department of Pharmacology, Kwame Nkrumah University of Science and Technology (KNUST) and Research Faculty at the Center for Applied Research and Innovation in Supply Chain–Africa (CARISCA). A leading African neuroscientist, she has developed an extensive research portfolio on the neurobiology and pharmacotherapy of mental and neurological disorders, particularly epilepsy, depression, anxiety, and neuroinflammation. Her work explores the therapeutic potential of African medicinal plants and the molecular mechanisms underlying drug-resistant epilepsy, integrating metabolomics, gut–brain axis research, and neuroinflammatory biomarkers. She holds a PhD (Pharmacology), B.Pharm (Hons) from KNUST and is a Fellow (Mental and Behavioural Health subspecialty) of the West African Postgraduate College of Pharmacists.She has authored over 50 peer-reviewed publications that contribute vital insights into novel therapeutic pathways for central nervous system disorders. Her research leadership spans several high-impact projects, including the GIZ PharmaVax SirraScale Project on scalable phytomedicine manufacturing, the ECOWAS PARI DIABETOX Projecton toxicological and antidiabetic properties of medicinal plants, the USAID BRIDGE-Train Project on strengthening pharmaceutical supply chain systems and OWSD Early Career Award. She has supervised and mentored numerous PhD, MPhil, and undergraduate students in pharmacology and neuroscience. She serves as Deputy Editor-in-Chief of the Ghana Pharmaceutical Journal, Associate Editor of the African Brain Journal, and Review Editor for Frontiers in Pharmacology (Experimental Pharmacology and Drug Discovery). She also reviews for leading journals such as Scientific Reports and BMC Neurology.Prof. Mante has served as an Expert Advisor to the UN Secretary-General’s High-Level Advisory Body on Artificial Intelligence and as an expert representative of the network of institutions affiliated with the UN Secretary-General’s Scientific Advisory Board, contributing to global frameworks on strengthening science systems, ethical AI, equitable innovation, and responsible research. She also serves on UNESCO’s Global Advisory Committee for Women and Girls in Science as well as Springer Nature’s Africa Advisory Council, advancing gender equity and research integrity.She is an active member of several professional societies, including the Society for Neuroscience (SfN), International Society for Neurochemistry (ISN), Society of Neuroscientists of Africa (SONA), Ghana Neuroscience Society (GNS), Organization for Women in Science for the Developing World (OWSD), and the Pharmaceutical Society of Ghana (PSGH). She is the current Chair (2023–present) of the Academic, Social and Research Pharmacists’ Association of Ghana and a member of the Governing Board of the PSGH.Prof. Mante previously served as Co-Chair (LMIC) of the Global Young Academy (2022–2024) and Chair of the Ghana Young Academy (2019-2022), advancing the inclusion of young scientists in global policy and research dialogues. She serrved on the World Science Forum Steering Committee and served as an ex-officio member of the InterAcademy Partnership (IAP) Global Council for Science Education Programme. She currently sits on the Steering Committee of the Africa Science Leadership Programme and is a member of the InterAcademy Partnership IAP Communication, Education and Outreach Committee.An accomplished communicator, Prof. Mante has been a speaker and panelist at major international events, including the World Science Forum, the UN General Assembly Science Summit, the STS Forum (Japan), and Science Forum South Africa. In addition to her research and policy work, Prof. Mante founded WriteShop Ghana, a national science communication initiative that builds writing and publication skills among students and researchers. She coordinates national science engagement programmes including Brain Bee Ghana, 2-Minute Thesis, and STEM Elevate, all aimed at inspiring scientific literacy, mentorship, and innovation among young Ghanaians.
Acupuncture Treatment Research Studies
Alkaloids: synthesis and pharmacology
Animal testing and alternatives
Biochemical Acid Research Studies
Biological and pharmacological studies of plants
Chemical synthesis and alkaloids
COVID-19 Clinical Research Studies
Diet and metabolism studies
Drug Solubulity and Delivery Systems
Epilepsy research and treatment
Ethnobotanical and Medicinal Plants Studies
Food Allergy and Anaphylaxis Research
Genomics and Rare Diseases
Gut microbiota and health
HIV-related health complications and treatments
Intensive Care Unit Cognitive Disorders
Long-Term Effects of COVID-19
Medicinal Plant Extracts Effects
Medicinal Plants and Bioactive Compounds
Menopause: Health Impacts and Treatments
Natural Antidiabetic Agents Studies
Natural Compound Pharmacology Studies
Neuroendocrine regulation and behavior
Neuroinflammation and Neurodegeneration Mechanisms
Neuropeptides and Animal Physiology
Neuroscience and Neuropharmacology Research
Pain Mechanisms and Treatments
Papaya Research and Applications
Parasitic infections in humans and animals
Pharmaceutical and Antibiotic Environmental Impacts
Phytochemistry and Biological Activities
Rabbits: Nutrition, Reproduction, Health
Respiratory and Cough-Related Research
SARS-CoV-2 and COVID-19 Research
SARS-CoV-2 detection and testing
Synthesis and bioactivity of alkaloids
Traditional and Medicinal Uses of Annonaceae
Treatment of Major Depression
Tryptophan and brain disorders
Zebrafish Biomedical Research Applications
Isolation and characterization of antimicrobial compounds from Picralima nitida (Apocynaceae)
Bridging genomics and digital health for paediatric epilepsy in Africa
Harnessing phytochemicals for neuroprotection
Aqueous extract of Antiaris toxicaria alleviates LPS-induced neuroinflammation by modulating NF-κB signalling
Aframomum melegueta mitigates seizure severity and neuroinflammation via gut-brain axis modulation in PTZ-induced kindling
Open AccessEvidence for the anxiolytic- and antidepressant-like effects of three semi-synthetic derivatives of xylopic acid in mice
Antidepressant-like effect of picralima nitida total crude alkaloidal fraction in mice
Open AccessHydroethanolic Extract of <i>Salvia officinalis</i> L. Leaves Improves Memory and Alleviates Neuroinflammation in ICR Mice
Open AccessAnti-implantation and uterotonic properties of Mentha pulegium L. in female Sprague-Dawley rats
Open AccessAntimicrobial resistance modifying effects and molecular docking studies of Affinine, derived from Tabernaemontana crassa
Open AccessEditorial: Model organisms in experimental pharmacology and drug discovery 2023: rodent, worm and zebrafish models
Open AccessAntiaris africana aqueous extract inhibits chronic demyelination and seizures in mice
Open AccessInvestigation of Herb-Drug Interactions between <i>Xylopia aethiopica</i>, Its Principal Constituent Xylopic Acid, and Antidepressants
Open AccessSynergistic antidepressant-like effect of xylopic acid co-administered with selected antidepressants
Open AccessGut-Brain-axis: effect of basil oil on the gut microbiota and its contribution to the anticonvulsant properties
Open AccessAnxiolytic-like effects of Pseudospondias microcarpa hydroethanolic leaf extract in zebrafish: Possible involvement of GABAergic and serotonergic pathways
Open AccessBrain-gut-microbiota axis: effect of basil oil on the gut microbiota and its contribution to the anticonvulsant properties
Open AccessRisk factors and outcomes of delirium in hospitalized older Ghanaians
Fast-onset effects of Pseudospondias microcarpa (A. Rich) Engl. (Anacardiaceae) hydroethanolic leaf extract on behavioral alterations induced by chronic mild stress in mice
Open AccessSynergistic Antidepressant-Like Effect of Xylopic Acid Co-Administered with Selected Antidepressants
Open AccessDrug Disposal and Ecopharmacovigilance Practices in the Krowor Municipality, Ghana
Open AccessAssessment of renal function in HIV patients on tenofovir-containing antiretroviral therapy in Ghana: a longitudinal study
Open AccessPost-illness anxiety, depression and PTSD symptoms in COVID-19 survivors
Eugenol inhibits veratridine-induced non-convulsive seizures and wet dog shakes via blockage of sodium and calcium influx in rat cerebrocortical synaptosomes
Open AccessXylopic acid from Xylopia aethiopica (Annonaceae) inhibits morphine tolerance in rats
Open AccessSex Hormones as Risk Factors for Dementia
Implications of WHO COVID-19 interim guideline 2020.5 on the comprehensive care for infected persons in Africa Before, during and after clinical management of cases
Open AccessPharmacological management of seizures in patients with COVID-19: a systematic review
Cutaneous and systemic anti-allergic potential of xylopic acid in rodents
SARS-CoV-2 Viral Shedding and Transmission Dynamics: Implications of WHO COVID-19 Discharge Guidelines
Open AccessInvestigating the Anticonvulsant Properties of Aqueous Ethanolic Extracts of the Leaves, Roots, and Fruits of Jatropha gossypifolia L. (Euphorbiaceae)
Open AccessPharmacological management of seizures in patients with COVID-19: a systematic review
Open AccessSolid-lipid nanoparticle formulation improves antiseizure action of cryptolepine
Open AccessCorrelating WHO COVID-19 interim guideline 2020.5 and testing capacity, accuracy, and logistical challenges in Africa
Open AccessChronic administration of cryptolepine nanoparticle formulation alleviates seizures in a neurocysticercosis model
Open AccessFormulation and evaluation of sustained release matrix tablets of capparis erythrocarpos roots extract to improve patient compliance in management of arthritis
Open AccessLeaves and stems of Capparis erythrocarpos, more sustainable than roots, show antiarthritic effects
Pharmacognostic Studies of the Leaves, Stem and Root of Capparis erythrocarpos Isert (Capparaceae)
Open AccessAnxiolytic and Antidepressant Effects of<i>Maerua angolensis</i>DC. Stem Bark Extract in Mice
Open AccessToxicological Assessment of<i> Pseudospondias microcarpa</i> (A. Rich.) Engl. Hydroethanolic Leaf Extract in Rats: Haematological, Biochemical, and Histopathological Studies
Open AccessXylopic acid prevents the development of tolerance and physical dependence to morphine in rats
Open AccessMaerua angolensis stem bark extract reverses anxiety and related behaviours in zebrafish—Involvement of GABAergic and 5-HT systems
Anticonvulsant activity of Pseudospondias microcarpa (A. Rich) Engl. hydroethanolic leaf extract in mice: The role of excitatory/inhibitory neurotransmission and nitric oxide pathway
Anticonvulsant effects of antiaris toxicaria aqueous extract: investigation using animal models of temporal lobe epilepsy
Open AccessMOESM1 of Anticonvulsant effects of antiaris toxicaria aqueous extract: investigation using animal models of temporal lobe epilepsy
Open AccessThe possible mode of antitussive and expectorant activity of the ethanol seed extracts of Picralima nitida ((Stapf) Th. & H. Durand)
Open AccessAnalgesic properties of aqueous leaf extract of <i>Haematostaphis barteri:</i> involvement of ATP-sensitive potassium channels, adrenergic, opioidergic, muscarinic, adenosinergic and serotoninergic pathways
Antitussive, expectorant and analgesic effects of the ethanol seed extract of Picralima nitida (Stapf) Th. & H. Durand.
Open AccessAnxiolytic-like effect of the leaves of <i>Pseudospondias microcarpa</i> (A. Rich.) Engl. in mice
Scientific evidence of plant with a rapid-onset and sustained antidepressant effect in a chronic model of depression: <i>Mallotus oppositifolius</i>
AQUEOUS LEAF EXTRACT OF CARICA PAPAYA (CARICACEAE) LINN. CAUSES LIVER INJURY AND REDUCED FERTILITY IN RATS
Open AccessEnhancement of inhibitory neurotransmission and inhibition of excitatory mechanisms underlie the anticonvulsant effects of Mallotus oppositifolius
Open AccessPreclinical evidence of a rapid-onset antidepressant-like effect of Pseudospondias microcarpa hydroethanolic leaf extract in a chronic depression model
Open AccessAntidepressant-Like Effect of the Leaves of<i>Pseudospondias microcarpa</i>in Mice: Evidence for the Involvement of the Serotoninergic System, NMDA Receptor Complex, and Nitric Oxide Pathway
Open AccessAntidepressant-like properties of Antiaris toxicaria aqueous extract
Open AccessEffects of hyrdroethanolic leaf extract of Pseudospondias microcarpa (A. Rich.) Engl. (Anacardiaceae) on the central nervous system in mice
Open AccessAntidepressant Effects of<i>Mallotus oppositifolius</i>in Acute Murine Models
Open AccessNeuropharmacological effects of an ethanolic fruit extract of Xylopia aethiopica and xylopic acid, a kaurene diterpene isolate, in mice.
Anticonvulsant Effect of<i>Antiaris toxicaria</i>(Pers.) Lesch. (Moraceae) Aqueous Extract in Rodents
Open AccessScreening of Central Effects of the Leaves of Mallotus oppositifolius (Geiseler) Mull. Arg. in Mice
NEUROPHARMACOLOGICAL ASSESSMENT OF AN AQUEOUS BARK EXTRACT OF <i>ANTIARIS TOXICARIA</i> (PERS.) LESCH. (MORACEAE) IN RODENTS
Open AccessDepartment of Pharmacology
Kwame Nkrumah University of Science and Technology