Ernest Adankwah
49 Publications23 Research Themes34 Open Access
Research Overview & Focus
The researcher's work is centered on the intersection of immunology, cytokine signaling, viral infections, and their treatments across diverse health sciences. They employ advanced analytical techniques to diagnose conditions such as TB, COPD, uterine cancer, and vector-borne diseases. Their research encompasses immune cell functions, cytokine pathways, infectious disease studies, and applications of proteomics in diagnosing these issues, all while addressing specific themes like viral defense mechanisms in infections and immunopathology in various pathologies.
Faculty Biography
Dr. Ernest Adankwah is a research scientist and lecturer at the Department of Medical Diagnostics, Faculty of Allied Health Sciences, KNUST-Kumasi, Ghana. He is a trained Biomedical Scientist with extensive experience in laboratory-based research and clinical practice. He has collaborated extensively with international and local researchers in several translational studies. His competence is in the use of both immunological (i.e., Multi-colour flow cytometry, ELISA, CBA, immunofluorescence, in vitro assays, cell cultures, immunohistochemistry & phosphorylation assays) and molecular (i.e., Real-time PCR, Fluorescence in situ Hybridisation (FISH), western blot, Lentiviral transduction systems & o gene expression assays) tools in the discovery of novel biomarkers in infectious diseases and cancers. He is currently involved in a translational study to identify novel biomarkers and develop improved diagnostics for Mycobacterium (M.) tuberculosis infection detection in Ghana. Dr. Adankwah is an active researcher and has published in notable peer-reviews journals.
Key Research Themes (23)
Physical Sciences
Advanced Proteomics Techniques and Applications
Health Sciences
Autophagy in Disease and Therapy
Health Sciences
Bladder and Urothelial Cancer Treatments
Health Sciences
Cervical Cancer and HPV Research
Health Sciences
Chronic Obstructive Pulmonary Disease (COPD) Research
Health Sciences
Colorectal Cancer Surgical Treatments
Health Sciences
Cytokine Signaling Pathways and Interactions
Life Sciences
Gene expression and cancer classification
Life Sciences
Glycosylation and Glycoproteins Research
Health Sciences
Head and Neck Cancer Studies
Health Sciences
Hepatitis B Virus Studies
Health Sciences
Hepatitis C virus research
Life Sciences
Immune Cell Function and Interaction
Life Sciences
Immune Response and Inflammation
Life Sciences
Immune responses and vaccinations
Health Sciences
Malaria Research and Control
Health Sciences
Mycobacterium research and diagnosis
Health Sciences
Parasitic Diseases Research and Treatment
Health Sciences
SARS-CoV-2 detection and testing
Health Sciences
Thyroid Disorders and Treatments
Health Sciences
Tuberculosis Research and Epidemiology
Life Sciences
Vector-Borne Animal Diseases
Health Sciences
Viral Infections and Vectors
Publications (49)
Non-invasive saliva cytokine profiling for asthma and respiratory disease using machine learning: observational study (Preprint)
Open AccessHeterogeneity in clinically diagnosed type 1 diabetes: characterising a unique cohort with maintained C-peptide secretion in Ghana
Open AccessPerceptions of barriers and facilitators for cervical cancer screening from women and healthcare workers in Ghana: Applying the Dynamic Sustainability Framework
Open AccessPrecision Breathing: Asthma Phenotyping via Machine Learning
Open AccessExploring Self-Sampling for Hpv-Based Cervical Cancer Screening Among Ghanaian Women: A Pilot Study on Preferences, Experiences, and Clinical Utility
Open AccessMonocyte transcriptome signatures of inflammation and enhanced neutrophil recruitment characterize immunopathology in the blood of tuberculosis patients
Open AccessConcomitant parasite infections influence tuberculosis immunopathology and favor rapid sputum conversion of pulmonary tuberculosis patients
Open AccessBCG Vaccination-Associated Lower HbA1c and Increased CD25 Expression on CD8+ T Cells in Patients with Type 1 Diabetes in Ghana
Open AccessClinical Validation of Nuclear Factor Kappa B (p65) Among Head and Neck Cancer Patients at One Institution
Diversity of Culicoides in the middle belt of Ghana with Implications on the transmission of Mansonella perstans; a molecular approach
Open AccessPerceptions of barriers and facilitators for cervical cancer screening from women and healthcare workers in Ghana: Applying the Dynamic Sustainability Framework
Open AccessImmunopathology in human pulmonary tuberculosis: Inflammatory changes in the plasma milieu and impaired host immune cell functions
Open AccessDifferences in PPD- and mitogen-induced T-cell activation marker expression characterize immunopathology in acute tuberculosis patients
Open AccessCorrection to: Biomarker Development Against Infections Using Proteomics
Biomarker Development Against Infections Using Proteomics
Seroconversion and prevalence of Hepatitis B surface antigen among vaccinated health care workers in Ashanti Region, Ghana
Open AccessSeroconversion and Prevalence of Hepatitis B Surface Antigen among Vaccinated Health Care Workers in Ashanti Region, Ghana
Open AccessSeroconversion and prevalence of Hepatitis B surface antigen among vaccinated health care workers in Ashanti Region, Ghana
Open AccessDiminished Interleukin-7 receptor expression on T-cell subsets in tuberculosis patients
Memory B-cells are enriched in the blood of patients with acute Buruli ulcer disease: a prospective observational study
Open AccessMonocyte pathology in human tuberculosis is due to plasma milieu changes and aberrant <scp>STAT</scp> signalling
Open AccessBCG-Vaccinated Children with Contact to Tuberculosis Patients Show Delayed Conversion of Mycobacterium tuberculosis-Specific IFN-γ Release
Open AccessImpaired T-cell response to phytohemagglutinin (PHA) in tuberculosis patients is associated with high IL-6 plasma levels and normalizes early during anti-mycobacterial treatment
Open AccessProlonged Duration of Air-Dry Fixation of Cervical Smears Produces Superior Cytomorphological Staining Quality over Conventional Wet-Fixed Smears
T-Cell Responses Against <i>Mycobacterium ulcerans</i> and <i>Mycobacterium tuberculosis</i> Protein Extracts Identify Children With Buruli Ulcer Disease
Transcriptomic profiling identifies host-derived biomarker panels for assessing cerebral malaria
Plasma cytokine levels characterize disease pathogenesis and treatment response in tuberculosis patients
Open AccessDoxycycline Treatment of <i>Mansonella perstans</i>–Infected Individuals Affects Immune Cell Activation and Causes Long-term T-cell Polarization
Cytokine‐induced transient monocyte IL‐7Ra expression and the serum milieu in tuberculosis
Open AccessAuthor response for "Cytokine‐induced transient monocyte IL‐7Ra expression and the serum milieu in tuberculosis"
Aberrant cytokine milieu and signaling affect immune cell phenotypes and functions in tuberculosis pathology: What can we learn from this phenomenon for application to inflammatory syndromes?
Open AccessLower IL-7 Receptor Expression of Monocytes Impairs Antimycobacterial Effector Functions in Patients with Tuberculosis
Immune response against TB and non-tuberculous mycobacterial pulmonary disease
Interleukin-6 and Mycobacterium tuberculosis dormancy antigens improve diagnosis of tuberculosis
Knowledge, perception and screening of local dye workers regarding urinary bladder cancer in Ghana
Open AccessThe use of special stains in the detection of vascular invasion in cases of colon cancer in resource-limited settings in Africa
Lower Monocyte Interleukin-7 Receptor Expression Impairs Anti-Mycobacterial Effector Functions in Tuberculosis Patients
Open AccessSuppressor of cytokine signalling 3 is crucial for interleukin‐7 receptor re‐expression after T‐cell activation and interleukin‐7 dependent proliferation
Open AccessAuthor response for "Suppressor of cytokine signaling 3 is crucial for interleukin‐7 receptor re‐expression after T‐cell activation and interleukin‐7 dependent proliferation"
Open AccessCD27 expression of T-cells discriminates IGRA-negative TB patients from healthy contacts in Ghana
Two-Hit in vitro T-Cell Stimulation Detects Mycobacterium tuberculosis Infection in QuantiFERON Negative Tuberculosis Patients and Healthy Contacts From Ghana
Open AccessAssessment of proliferative index in different grades of breast cancers using AgNOR (Agyrophilic Nuclear Organizer Region) expression
Open AccessUrinary iodine concentration and thyroid volume of pregnant women attending antenatal care in two selected hospitals in Ashanti Region, Ghana: a comparative cross-sectional study
Open AccessConstitutive STAT3 phosphorylation and IL-6/IL-10 co-expression are associated with impaired T-cell function in tuberculosis patients
Open AccessNuclear Localisation of Autophagic p62 and Associated Cytoplasmic Beclin-1 and Bcl-2 Expressions in Adenomas and Adenocarcinomas of the Colorectal Regions
Aberrant plasma IL-7 and soluble IL-7 receptor levels indicate impaired T-cell response to IL-7 in human tuberculosis
Open AccessMucin expression patterns in histological grades of colonic cancers in Ghanaian population
Open AccessHighly Divergent Hepaciviruses from African Cattle
Open AccessA Novel Rhabdovirus Isolated from the Straw-Colored Fruit Bat Eidolon helvum, with Signs of Antibodies in Swine and Humans
Open AccessAcademic Metrics
DepartmentDepartment of Medical Diagnostics
Total Publications49
Research Themes23
Open Access Papers34
Department of Medical Diagnostics
Kwame Nkrumah University of Science and Technology