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Priscilla Kolibea Mante

Pharmacology

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About

Prof. Priscilla Kolibea Mante is a Professor of Pharmacology at the Department of Pharmacology, Kwame Nkrumah University of Science and Technology (KNUST) and Research Faculty at the Center for Applied Research and Innovation in Supply Chain–Africa (CARISCA). A leading African neuroscientist, she has developed an extensive research portfolio on the neurobiology and pharmacotherapy of mental and neurological disorders, particularly epilepsy, depression, anxiety, and neuroinflammation. Her work explores the therapeutic potential of African medicinal plants and the molecular mechanisms underlying drug-resistant epilepsy, integrating metabolomics, gut–brain axis research, and neuroinflammatory biomarkers. She holds a PhD (Pharmacology), B.Pharm (Hons) from KNUST and is a Fellow (Mental and Behavioural Health subspecialty) of the West African Postgraduate College of Pharmacists.She has authored over 50 peer-reviewed publications that contribute vital insights into novel therapeutic pathways for central nervous system disorders. Her research leadership spans several high-impact projects, including the GIZ PharmaVax SirraScale Project on scalable phytomedicine manufacturing, the ECOWAS PARI DIABETOX Projecton toxicological and antidiabetic properties of medicinal plants, the USAID BRIDGE-Train Project on strengthening pharmaceutical supply chain systems and OWSD Early Career Award. She has supervised and mentored numerous PhD, MPhil, and undergraduate students in pharmacology and neuroscience. She serves as Deputy Editor-in-Chief of the Ghana Pharmaceutical Journal, Associate Editor of the African Brain Journal, and Review Editor for Frontiers in Pharmacology (Experimental Pharmacology and Drug Discovery). She also reviews for leading journals such as Scientific Reports and BMC Neurology.Prof. Mante has served as an Expert Advisor to the UN Secretary-General’s High-Level Advisory Body on Artificial Intelligence and as an expert representative of the network of institutions affiliated with the UN Secretary-General’s Scientific Advisory Board, contributing to global frameworks on strengthening science systems, ethical AI, equitable innovation, and responsible research. She also serves on UNESCO’s Global Advisory Committee for Women and Girls in Science as well as Springer Nature’s Africa Advisory Council, advancing gender equity and research integrity.She is an active member of several professional societies, including the Society for Neuroscience (SfN), International Society for Neurochemistry (ISN), Society of Neuroscientists of Africa (SONA), Ghana Neuroscience Society (GNS), Organization for Women in Science for the Developing World (OWSD), and the Pharmaceutical Society of Ghana (PSGH). She is the current Chair (2023–present) of the Academic, Social and Research Pharmacists’ Association of Ghana and a member of the Governing Board of the PSGH.Prof. Mante previously served as Co-Chair (LMIC) of the Global Young Academy (2022–2024) and Chair of the Ghana Young Academy (2019-2022), advancing the inclusion of young scientists in global policy and research dialogues. She serrved on the World Science Forum Steering Committee and served as an ex-officio member of the InterAcademy Partnership (IAP) Global Council for Science Education Programme. She currently sits on the Steering Committee of the Africa Science Leadership Programme and is a member of the InterAcademy Partnership IAP Communication, Education and Outreach Committee.An accomplished communicator, Prof. Mante has been a speaker and panelist at major international events, including the World Science Forum, the UN General Assembly Science Summit, the STS Forum (Japan), and Science Forum South Africa. In addition to her research and policy work, Prof. Mante founded WriteShop Ghana, a national science communication initiative that builds writing and publication skills among students and researchers. She coordinates national science engagement programmes including Brain Bee Ghana, 2-Minute Thesis, and STEM Elevate, all aimed at inspiring scientific literacy, mentorship, and innovation among young Ghanaians.

Research Summary

(inferred from publications by AI)

The researcher investigates the effects of specific plant and alkaloid extracts on mental health and body chemistry in animal models, focusing on neurotransmission, antidepressant-like properties, neuroinflammation, and antipsychiatry. They employ extracts such asmallotus oppositifolius, Pseudospondias microcarpa hydroethanolic leaf extract, and Xylopic acid to study their roles in extended-brain axis modulation, axon effects, antidepressant activity, and cognitive dysfunction. The research bridges pharmacology, neuroscience, and biochemistry, using animal models like zebrafish and rabbits for extended-brain axis studies and clinical trials. The findings aim to advance understanding of mental health treatments through novel chemical approaches and provide insights for developing antipsychiatry strategies.

Research Themes

All Papers

Maerua angolensis stem bark extract reverses anxiety and related behaviours in zebrafish—Involvement of GABAergic and 5-HT systems(2017)
Anxiolytic-like effects of Pseudospondias microcarpa hydroethanolic leaf extract in zebrafish: Possible involvement of GABAergic and serotonergic pathways(2023)
SARS-CoV-2 Viral Shedding and Transmission Dynamics: Implications of WHO COVID-19 Discharge Guidelines(2021)
Solid-lipid nanoparticle formulation improves antiseizure action of cryptolepine(2021)
Antidepressant-Like Effect of the Leaves of<i>Pseudospondias microcarpa</i>in Mice: Evidence for the Involvement of the Serotoninergic System, NMDA Receptor Complex, and Nitric Oxide Pathway(2015)
Anticonvulsant activity of Pseudospondias microcarpa (A. Rich) Engl. hydroethanolic leaf extract in mice: The role of excitatory/inhibitory neurotransmission and nitric oxide pathway(2017)
Anticonvulsant Effect of<i>Antiaris toxicaria</i>(Pers.) Lesch. (Moraceae) Aqueous Extract in Rodents(2013)
Anticonvulsant effects of antiaris toxicaria aqueous extract: investigation using animal models of temporal lobe epilepsy(2017)
NEUROPHARMACOLOGICAL ASSESSMENT OF AN AQUEOUS BARK EXTRACT OF &lt;i&gt;ANTIARIS TOXICARIA&lt;/i&gt; (PERS.) LESCH. (MORACEAE) IN RODENTS(2012)
Antidepressant-like properties of Antiaris toxicaria aqueous extract(2015)
Eugenol inhibits veratridine-induced non-convulsive seizures and wet dog shakes via blockage of sodium and calcium influx in rat cerebrocortical synaptosomes(2022)
Antimicrobial resistance modifying effects and molecular docking studies of Affinine, derived from Tabernaemontana crassa(2024)
MOESM1 of Anticonvulsant effects of antiaris toxicaria aqueous extract: investigation using animal models of temporal lobe epilepsy(2017)
Enhancement of inhibitory neurotransmission and inhibition of excitatory mechanisms underlie the anticonvulsant effects of Mallotus oppositifolius(2016)
Formulation and evaluation of sustained release matrix tablets of capparis erythrocarpos roots extract to improve patient compliance in management of arthritis(2019)
Antidepressant Effects of<i>Mallotus oppositifolius</i>in Acute Murine Models(2014)
Antitussive, expectorant and analgesic effects of the ethanol seed extract of Picralima nitida (Stapf) Th. & H. Durand.(2016)
Correlating WHO COVID-19 interim guideline 2020.5 and testing capacity, accuracy, and logistical challenges in Africa(2021)
AQUEOUS LEAF EXTRACT OF CARICA PAPAYA (CARICACEAE) LINN. CAUSES LIVER INJURY AND REDUCED FERTILITY IN RATS(2016)
Fast-onset effects of Pseudospondias microcarpa (A. Rich) Engl. (Anacardiaceae) hydroethanolic leaf extract on behavioral alterations induced by chronic mild stress in mice(2023)
Preclinical evidence of a rapid-onset antidepressant-like effect of Pseudospondias microcarpa hydroethanolic leaf extract in a chronic depression model(2016)
Neuropharmacological effects of an ethanolic fruit extract of Xylopia aethiopica and xylopic acid, a kaurene diterpene isolate, in mice.(2014)
Xylopic acid prevents the development of tolerance and physical dependence to morphine in rats(2018)
Xylopic acid from Xylopia aethiopica (Annonaceae) inhibits morphine tolerance in rats(2022)
Investigation of Herb-Drug Interactions between <i>Xylopia aethiopica</i>, Its Principal Constituent Xylopic Acid, and Antidepressants(2024)
Anxiolytic and Antidepressant Effects of<i>Maerua angolensis</i>DC. Stem Bark Extract in Mice(2018)
Leaves and stems of Capparis erythrocarpos, more sustainable than roots, show antiarthritic effects(2019)
Screening of Central Effects of the Leaves of Mallotus oppositifolius (Geiseler) Mull. Arg. in Mice(2012)
Pharmacognostic Studies of the Leaves, Stem and Root of Capparis erythrocarpos Isert (Capparaceae)(2019)
Investigating the Anticonvulsant Properties of Aqueous Ethanolic Extracts of the Leaves, Roots, and Fruits of Jatropha gossypifolia L. (Euphorbiaceae)(2021)
Gut-Brain-axis: effect of basil oil on the gut microbiota and its contribution to the anticonvulsant properties(2023)
Implications of WHO COVID-19 interim guideline 2020.5 on the comprehensive care for infected persons in Africa Before, during and after clinical management of cases(2021)
The possible mode of antitussive and expectorant activity of the ethanol seed extracts of Picralima nitida ((Stapf) Th. &amp; H. Durand)(2016)
Evidence for the anxiolytic- and antidepressant-like effects of three semi-synthetic derivatives of xylopic acid in mice(2025)
Drug Disposal and Ecopharmacovigilance Practices in the Krowor Municipality, Ghana(2022)
Post-illness anxiety, depression and PTSD symptoms in COVID-19 survivors(2022)
Pharmacological management of seizures in patients with COVID-19: a systematic review(2021)
Pharmacological management of seizures in patients with COVID-19: a systematic review(2021)
Risk factors and outcomes of delirium in hospitalized older Ghanaians(2023)
Chronic administration of cryptolepine nanoparticle formulation alleviates seizures in a neurocysticercosis model(2021)
Scientific evidence of plant with a rapid-onset and sustained antidepressant effect in a chronic model of depression: <i>Mallotus oppositifolius</i>(2016)
Effects of hyrdroethanolic leaf extract of Pseudospondias microcarpa (A. Rich.) Engl. (Anacardiaceae) on the central nervous system in mice(2014)
Anxiolytic-like effect of the leaves of <i>Pseudospondias microcarpa</i> (A. Rich.) Engl. in mice(2016)
Analgesic properties of aqueous leaf extract of <i>Haematostaphis barteri:</i> involvement of ATP-sensitive potassium channels, adrenergic, opioidergic, muscarinic, adenosinergic and serotoninergic pathways(2016)
Cutaneous and systemic anti-allergic potential of xylopic acid in rodents(2021)
Synergistic antidepressant-like effect of xylopic acid co-administered with selected antidepressants(2024)
Antiaris africana aqueous extract inhibits chronic demyelination and seizures in mice(2024)
Aqueous extract of Antiaris toxicaria alleviates LPS-induced neuroinflammation by modulating NF-κB signalling(2025)
Hydroethanolic Extract of <i>Salvia officinalis</i> L. Leaves Improves Memory and Alleviates Neuroinflammation in ICR Mice(2025)
Toxicological Assessment of<i> Pseudospondias microcarpa</i> (A. Rich.) Engl. Hydroethanolic Leaf Extract in Rats: Haematological, Biochemical, and Histopathological Studies(2018)
Assessment of renal function in HIV patients on tenofovir-containing antiretroviral therapy in Ghana: a longitudinal study(2022)
Sex Hormones as Risk Factors for Dementia(2022)
Synergistic Antidepressant-Like Effect of Xylopic Acid Co-Administered with Selected Antidepressants(2023)
Brain-gut-microbiota axis: effect of basil oil on the gut microbiota and its contribution to the anticonvulsant properties(2023)
Editorial: Model organisms in experimental pharmacology and drug discovery 2023: rodent, worm and zebrafish models(2024)
Anti-implantation and uterotonic properties of Mentha pulegium L. in female Sprague-Dawley rats(2024)
Antidepressant-like effect of picralima nitida total crude alkaloidal fraction in mice(2025)
Aframomum melegueta mitigates seizure severity and neuroinflammation via gut-brain axis modulation in PTZ-induced kindling(2025)
Harnessing phytochemicals for neuroprotection(2025)
Bridging genomics and digital health for paediatric epilepsy in Africa(2025)

Collaboration Network

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About This Profile

This profile is generated from publicly available publication metadata and is intended for research discovery purposes. Themes, summaries, and trajectories are inferred computationally and may not capture the full scope of the lecturer's work. For authoritative information, please refer to the official KNUST profile.