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Patrick Williams Narkwa

Clinical Microbiology

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About

Patrick Williams Narkwa is a lecturer in Virology, Immunology and Molecular Techniques at the Department of Clinical Microbiology at the Kwame Nkrumah University of Science and Technology (KNUST), Kumasi-Ghana. Patrick's research focuses on the 'interaction between aflatoxin B1 and hepatitis B virus: effects on type I interferon signalling pathway". Patrick received his PhD in Clinical Microbiology from KNUST where he worked on understanding the role of aflatoxin B1 in modulating the type I interferon response. Prior to being appointed as a lecturer, Patrick was a Leverhulme Royal Society Africa Postdoctoral Fellow at the Department of Clinical Microbiology.

Research Summary

(inferred from publications by AI)

The researcher's work spans multiple domains within health sciences, with a central focus on the interplay between alkaloids like cryptolepine and their biological roles. This includes its role in anti-cancer mechanisms by modulating pathways such as STAT3 and interleukin signaling, particularly in the context of hepatocellular carcinoma growth. The study also explores its pathobiology, highlighting how it consolidates anticancer properties while counteracting anti-cancer pathways. Additionally, the researcher investigates emerging challenges in environmental hazards affecting health sciences through studies on viral gastroenteritis, mycotoxins, and SARS-CoV-2. This work integrates diverse themes to advance understanding of alkaloid-derived compounds' pharmacological versatility across cancer prevention, food safety, and global health crises.

Research Themes

All Papers

Aflatoxin B1 inhibits the type 1 interferon response pathway via STAT1 suggesting another mechanism of hepatocellular carcinoma(2017)
Risk factors associated with hepatitis B exposure and the reliability of five rapid kits commonly used for screening blood donors in Ghana(2014)
Sero-prevalence of Hepatitis B and C viral co-infections among HIV-1 infected ART-naïve individuals in Kumasi, Ghana(2019)
Immunosurveillance and molecular detection of hepatitis B virus infection amongst vaccinated children in the West Gonja District in Savanna Region of Ghana(2021)
Cryptolepine and Nibima inhibit hepatitis B virus replication(2021)
Evaluation of inflammatory and liver injury biomarkers among drug-naive viral hepatitis B patients: A study in a referral laboratory, Ghana(2022)
Evidence of chikungunya virus infections among febrile patients at three secondary health facilities in the Ashanti and the Bono Regions of Ghana(2021)
Dengue virus exposure among blood donors in Ghana(2016)
Cryptolepine inhibits hepatocellular carcinoma growth through inhibiting interleukin-6/STAT3 signalling(2021)
Cryptolepine consolidates its anticancer potential by increasing the anti-cancer pathway genes and decreasing that of pro-cancer pathway genes(2021)
Cryptolepine consolidates its anticancer potential by increasing the anti-cancer pathway genes and decreasing that of pro-cancer pathway genes(2021)
Cryptolepine consolidates its anticancer property by increasing the anti-cancer pathway genes and decreasing that of pro-cancer pathway genes(2020)
Cryptolepine, a plant-derived alkaloid, differentially regulates signal transduction pathways in human embryonic kidney (HEK293) cells(2023)
Aflatoxin B<sub>1</sub>: An Immunomodulator and Cancer Agent(2022)
Antifungal and Anti-Proliferative Effects of Zeolites A and X on Yeast Pathogenic and Cancer Cells <i>In Vitro</i>(2017)
Microbial pathogens associated with acute childhood diarrhoea in Kumasi, Ghana(2017)
Seroprevalence of Rubella Virus, Cytomegalovirus and Herpes Simplex Virus–2 among Pregnant Women at the Komfo Anokye Teaching Hospital, Ghana(2015)
Performance of First Response® and CareStart™ Malaria Rapid Diagnostic Tests for the Detection of Plasmodium falciparum in a Tertiary Hospital in Ghana(2017)
The Pharmacologically Active Alkaloid Cryptolepine Activates a Type 1 Interferon Response That Is Independent of MAVS and STING Pathways(2022)
Phased Multi-Country Seroepidemiology Study of Over 20000 Individuals&amp;nbsp;In West Africa Reveals the Dynamics of SARS-CoV-2 Exposure Driven by Delta, Omicron and Omicron Waves(2023)
In Vitro Cytotoxic Activity of Five Ghanaian Plants on Human Cancer Cell Lines(2024)
In vitro cytotoxic activity of five Ghanaian plants on human cancer cell lines(2024)

Collaboration Network

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About This Profile

This profile is generated from publicly available publication metadata and is intended for research discovery purposes. Themes, summaries, and trajectories are inferred computationally and may not capture the full scope of the lecturer's work. For authoritative information, please refer to the official KNUST profile.