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Newman Osafo

Pharmacology

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About

Newman Osafo teaches pharmacology, and supervises postgraduate research at the Department of Pharmacology, KNUST. He holds a PhD in Pharmacology from KNUST, with expertise in natural products pharmacology, inflammation, cancer, neurodegenerative disorders, and drug discovery. Newman has published extensively, with more than eighty peer-reviewed journal articles, book chapters, and conference abstracts to his credit. He serves on the editorial boards of several international journals, including Frontiers in Pharmacology, Scientific Reports, and the International Journal of Inflammation. A fellow of the Africa Science Leadership Programme (ASLP), his professional affiliations span the American Society for Pharmacology and Experimental Therapeutics (ASPET), the International Society of Pharmacovigilance (ISoP), Society for Medicinal Plant and Natural Product Research (GA), and the Pharmaceutical Society of Ghana (PSGh).

Research Summary

(inferred from publications by AI)

The researcher's research focuses on the study of systemic immune responses, particularly those involving inflammation, chronic inflammation, and systemic autoimmunity. Their work spans diverse biological pathways, including allergic inflammation, immune response modulation by natural compounds like pleuromycin and hydroethanol, and systemic inflammation mechanisms such as Allergic asthma and inflammatory bowel disease. The researcher's studies utilize a combination of pharmacological agents, synthetic extracts, and functional biopsies to investigate the role of natural molecules in modulating systemic inflammation and their potential therapeutic applications.

Research Themes

All Papers

Stigmasterol Modulates Allergic Airway Inflammation in Guinea Pig Model of Ovalbumin-Induced Asthma(2017)
Allergic Airway-Induced Hypersensitivity Is Attenuated by Bergapten in Murine Models of Inflammation(2019)
Coadministration of Stigmasterol and Dexamethasone (STIG+DEX) Modulates Steroid-Resistant Asthma(2022)
Hydro-ethanol extract of Holarrhena floribunda stem bark exhibits anti-anaphylactic and anti-oedematogenic effects in murine models of acute inflammation(2022)
Eleusine indica inhibits airway inflammation and ICAM-1 expression in ovalbumin-induced asthma in guinea pigs(2025)
Acetic Acid-Induced Ulcerative Colitis in Sprague Dawley Rats Is Suppressed by Hydroethanolic Extract of<i>Cordia vignei</i>Leaves through Reduced Serum Levels of TNF-<i>α</i>and IL-6(2020)
Acetic acid‐induced colitis modulating potential of total crude alkaloidal extract of <i>Picralima nitida</i> seeds in rats(2023)
The crude alkaloidal extract of Picralima nitida seeds alleviates TNBS-induced inflammatory bowel disease through reduced serum expression of TNF-α, IL-1β and p38 MAPK(2024)
Ulcerative colitis induced with acetic acid is ameliorated by Antrocaryon micraster through reduced serum levels of tumor necrosis factor alpha and interleukin-6 in sprague dawley rats(2020)
Anti-IBD activity of Eleusine indica through inhibition of TNF-alpha and p38 MAPK expression(2025)
Phytochemical and Pharmacological Review of<i> Cryptolepis sanguinolenta</i> (Lindl.) Schlechter(2017)
Solid-lipid nanoparticle formulation improves antiseizure action of cryptolepine(2021)
Mechanism of Action of Nonsteroidal Anti-Inflammatory Drugs(2017)
Xylopia aethiopica (Annonaceae) fruit extract suppresses Freund׳s adjuvant-induced arthritis in Sprague-Dawley rats(2014)
The acute anti-inflammatory action of xylopic acid isolated from <i>Xylopia aethiopica</i>(2018)
Anti-inflammatory and anti-anaphylactic activity of xylopic acid isolated from the dried fruit of Xylopia aethiopica in mice(2016)
In vivo inhibitory effect of hydro-ethanol extract of xylopia aethiopica fruits on mediators of acute inflammation(2022)
Xylopic acid from Xylopia aethiopica (Annonaceae) inhibits morphine tolerance in rats(2022)
Stigmasterol inhibits lipopolysaccharide-induced innate immune responses in murine models(2017)
Aqueous ethanol extract of the fruit of Xylopia aethiopica (Annonaceae) exhibits anti-anaphylactic and anti-inflammatory actions in mice(2013)
Stigmasterol Alleviates Cutaneous Allergic Responses in Rodents(2018)
Antiallergic and Antiarthritic Effects of Stem Bark Extract of<i>Glyphaea brevis</i>(Spreng) Monachino (Tiliaceae) in Murine Models(2013)
Anti-Inflammatory and Analgesic Activities of African Medicinal Plants(2013)
Margaritaria discoidea (Euphorbiaceae) stem bark extract attenuates allergy and Freund′s adjuvant-induced arthritis in rodents(2014)
Anti-inflammatory and wound healing properties of methanol leaf extract of Physalis angulata L.(2020)
Potential effects of xylopic acid on acetic acid-induced ulcerative colitis in rats(2019)
Hydro ethanol extract of Holarrhena floribunda stem bark exhibits anti-anaphylactic and anti-oedematogenic effects in murine models of acute inflammation(2020)
Endocannabinoid system and its modulation of brain, gut, joint and skin inflammation(2021)
Cannabinoid Receptor and Inflammation(2020)
Antimicrobial Agents: Antibacterial Agents, Anti-biofilm Agents, Antibacterial Natural Compounds, and Antibacterial Chemicals(2019)
Biomarkers of Wound Healing(2019)
Aqueous Ethanol Fruit Extract of Xylopia aethiopica and Xylopic Acid Exhibit Anti-inflammatory Activity Through Inhibition of the Arachidonic Acid Pathway(2016)
The Ethanolic Stem-Bark Extract of<i>Antrocaryon micraster</i>Inhibits Carrageenan-Induced Pleurisy and Pedal Oedema in Murine Models of Inflammation(2017)
Regulation of Nrf2 and NF-κB activities may contribute to the anti-inflammatory mechanism of xylopic acid(2022)
Nrf2 and VCAM-1 regulation may play a role in the anti-inflammatory mechanism of xylopic acid(2022)
African Plants with Antiproliferative Properties(2017)
Methanolic Leaf Extract of Dissotis Rotundifolia Alleviates Acetic Acid-Induced Ulcerative Colitis in Rats(2021)
A Review: Ethnomedicinal, Phytochemical and Pharmacological Investigations of Lannea welwitschii (Hiern) Engl.(2016)
Glyphaea brevis (Spreng.) Monach.: A Review of the Ethno-medical, Phytochemical and Pharmacological Investigations(2016)
Natural Products as Therapeutic Option for Echinococcossis(2023)
Informed but Unvaccinated: A Cross-Sectional Study Among University Students in Ghana(2025)
Antipleuritic and Vascular Permeability Inhibition of the Ethyl Acetate-Petroleum Ether Stem Bark Extract of<i>Maerua angolensis</i>DC (Capparaceae) in Murine(2018)
ANTI-ALLERGIC, ANTI-INFLAMMATORY AND ANALGESIC ACTIONS OF STEM BARK EXTRACT OF LANNEA WELWITSCHII (ANARCADIACEAE) IN MICE(2013)
Anti-Arthritic Effect of the Hydroethanolic Root Extract of Psydrax subcordata in Rats(2022)
Review of the Ethno-medical, Phytochemical, Pharmacological and Toxicological Studies on Dissotis rotundifolia (Sm.) Triana(2017)
In vivo anti-inflammatory and antioxidant properties of Albizia zygia D. C. Macbr.(2016)
Inflammation Modulating Activity of the Hydroethanol Stem Bark Extract of Bombax costatum in Murine Models(2022)
Cutaneous and systemic anti-allergic potential of xylopic acid in rodents(2021)
The hydroethanolic root extract of Psydrax subcordata (DC.) Bridson exhibits antinociceptive and anti-inflammatory effects in animal models(2022)
Hydroethanolic Leaf Extract of <i>Cordia vignei</i> Hutch and Dalziel Inhibits Carrageenan‐Induced Foot Oedema in Chicks, Prostaglandin E<sub>2</sub>‐Induced Paw Oedema in Mice, and Bradykinin‐Induced Paw Oedema in Mice(2023)
Antiinflammatory, modulatory and analgesic activities of African medicinal plants and their derivatives(2025)
Anticataract Effect of the Aqueous Extract of the Flowers of Aspilia africana in Murine Model of Diabetic and Age-Related Cataracts(2023)
The Aqueous Stem Bark Extract of Alstonia boonei Exhibits Anticataract Activity in Sprague Dawley Rat(2023)
Prevalence and Predictors of Mother-to-Child Transmission of Human Immunodeficiency Virus (HIV) among HIV-exposed Infants(2025)
Pharmacological Management of Parkinson’s Disease(2020)
Palmatine Modulates Triple Negative Mammary Carcinoma by Regulating the Endogenous Function of p53, p21 and Mdm2(2021)
Amyotrophic Lateral Sclerosis(2018)
Oxidative Stress and Neurodegeneration(2018)
Palmatine sensitizes chemoresistant triple negative breast cancer cells via efflux inhibition of multidrug resistant protein 1.(2021)
Xylopic Acid Suppresses Adjuvant-induced Arthritis in Sprague DawleyRats via Reduction in Serum Levels of IL-6 and TNF-alpha(2021)
Anti‐inflammatory activity of xylopic acid may be attributed to the modulation of Nrf2 and NF‐kB activities(2022)
Microglial Mitophagy and Neurodegenerative Disorders(2020)
Infection-Induced Systemic Inflammation and Dementia(2022)
Hydroethanolic Extract of <i>Salvia officinalis</i> L. Leaves Improves Memory and Alleviates Neuroinflammation in ICR Mice(2025)
Effect of xylopic acid isolated from <i>Xylopia aethiopica</i> on acetic acid‐induced ulcerative colitis in rats(2018)
Acetic acid-induced ulcerative colitis alleviation by Xylopia aethiopica (Dunal) A. Rich in Sprague Dawley rats(2025)
Antiangiogenic effects of the hydroethanolic root extract of Croton membranaceus in chick chorioallantoic membrane(2025)
Interferon Signature Analysis(2021)
Neurogenesis in the Embryonic and Adult Brain(2023)
Therapeutic Targets and Neurochemical Signaling in Huntington's Disease(2023)
Aurantio‐Obtusin Suppresses Airway Inflammation and Serum ICAM‐1 Expression in Guinea Pig Allergic Asthma Model(2025)
The hepatoprotective effects of hydroethanolic stem bark extract of <i>cleistopholis patens</i> in paracetamol-induced hepatotoxicity in rats(2025)
Neuro-therapeutic effect of ursolic acid in a murine model of vincristine-induced neuropathic pain(2025)
The impact of zinc and testosterone co-treatment on tumourigenesis in prostate cancer: a novel model(2025)

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About This Profile

This profile is generated from publicly available publication metadata and is intended for research discovery purposes. Themes, summaries, and trajectories are inferred computationally and may not capture the full scope of the lecturer's work. For authoritative information, please refer to the official KNUST profile.