Josephine Adams

Human Resource and Organisational Development

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Research Summary

(inferred from publications by AI)

The researcher investigates diverse aspects of cell adhesion, extracellular matrix interactions, cancer development, connective tissue disorders, proteoglycans, nuclear physics, genetics, muscle physiology, and more. These studies collectively advance our understanding of extracellular matrix roles across health and disease contexts, integrating findings that significantly contribute to advancing knowledge in interconnected biological fields.

Research Themes

All Papers

Regulation of development and differentiation by the extracellular matrix(1993)

Changes in keratinocyte adhesion during terminal differentiation: Reduction in fibronectin binding precedes α5β1 integrin loss from the cell surface(1990)

Fibronectin inhibits the terminal differentiation of human keratinocytes(1989)

Cell-matrix contact structures(2001)

Formation of stable microspikes containing actin and the 55 kDa actin bundling protein, fascin, is a consequence of cell adhesion to thrombospondin-1: implications for the anti-adhesive activities of thrombospondin-1(1995)

Phylogenetic analysis of the tenascin gene family: evidence of origin early in the chordate lineage.(2006)

Diverse mechanisms for cell attachment to platelet thrombospondin(1993)

The evolution of tenascins and fibronectin(2014)

Insider trading: Extracellular matrix proteins and their non‐canonical intracellular roles(2015)

Expression of beta 1, beta 3, beta 4, and beta 5 integrins by human epidermal keratinocytes and non-differentiating keratinocytes.(1991)

Regulation of keratinocyte terminal differentiation by integrin-extracellular matrix interactions(1993)

Molecular organisation of cell–matrix contacts: essential multiprotein assemblies in cell and tissue function(2002)

The kelch repeat superfamily of proteins: propellers of cell function(2000)

Directional control of lamellipodia extension by constraining cell shape and orienting cell tractional forces(2002)

Roles of fascin in cell adhesion and motility(2004)

Fascins, and their roles in cell structure and function(2002)

The RickA protein of Rickettsia conorii activates the Arp2/3 complex(2004)

Roles of fascin in human carcinoma motility and signaling: Prospects for a novel biomarker?(2005)

Association of fascin-1 with mortality, disease progression and metastasis in carcinomas: a systematic review and meta-analysis(2013)

The roles of fascins in health and disease(2011)

The Expression of Fascin, an Actin-Bundling Motility Protein, Correlates with Hormone Receptor–Negative Breast Cancer and a More Aggressive Clinical Course(2005)

Fascin, an Actin-Bundling Protein, Modulates Colonic Epithelial Cell Invasiveness and Differentiation in Vitro(2003)

Interaction of fascin and protein kinase C : a novel intersection in cell adhesion and motility(2003)

Stimulation of Fascin Spikes by Thrombospondin-1 Is Mediated by the Gtpases Rac and Cdc42(2000)

Dual Actin-bundling and Protein Kinase C-binding Activities of Fascin Regulate Carcinoma Cell Migration Downstream of Rac and Contribute to Metastasis(2007)

Cell-Matrix Adhesions Differentially Regulate Fascin Phosphorylation(1999)

Expression of fascin-1, the gene encoding the actin-bundling protein fascin-1, during mouse embryogenesis(2004)

Rac regulates the interaction of fascin with protein kinase C in cell migration(2008)

Fascin Protrusions in Cell Interactions(2004)

Fascin-1 Promoter Activity Is Regulated by CREB and the Aryl Hydrocarbon Receptor in Human Carcinoma Cells(2009)

A novel Rho-dependent pathway that drives interaction of fascin-1 with p-Lin-11/Isl-1/Mec-3 kinase (LIMK) 1/2 to promote fascin-1/actin binding and filopodia stability(2012)

Fascin-1 as a biomarker and prospective therapeutic target in colorectal cancer(2014)

Induction of fascin spikes in breast cancer cells by activation of the insulin-like growth factor-I receptor(2002)

Characterization of Cell–Matrix Adhesion Requirements for the Formation of Fascin Microspikes(1997)

Analysis of Fascin-1 in Relation to Gleason Risk Classification and Nuclear ETS-Related Gene Status of Human Prostate Carcinomas: An Immunohistochemical Study of Clinically Annotated Tumours From the Wales Cancer Bank(2017)

The Thrombospondins(2011)

The thrombospondin type 1 repeat (TSR) superfamily: Diverse proteins with related roles in neuronal development(2000)

Thrombospondins: Multifunctional Regulators of Cell Interactions(2001)

The thrombospondins(2004)

Structure of a thrombospondin C‐terminal fragment reveals a novel calcium core in the type 3 repeats(2004)

The Evolution of Thrombospondins and Their Ligand-Binding Activities(2010)

Muskelin, a novel intracellular mediator of cell adhesive and cytoskeletal responses to thrombospondin-1(1998)

In the balance: how do thrombospondins contribute to the cellular pathophysiology of cardiovascular disease?(2021)

Identification and characterization of thrombospondin-4, a new member of the thrombospondin gene family.(1993)

The thrombospondin family(1993)

Thrombospondin-1(1997)

Functions of the conserved thrombospondin carboxy-terminal cassette in cell–extracellular matrix interactions and signaling(2004)

Thrombospondin‐4 is expressed by early osteogenic tissues in the chick embryo(1995)

Extracellular matrix retention of thrombospondin 1 is controlled by its conserved C-terminal region(2008)

Intermolecular interactions of thrombospondins drive their accumulation in extracellular matrix(2015)

The Thrombospondin Gene Family(1995)

Characterisation of Drosophila Thrombospondin Defines an Early Origin of Pentameric Thrombospondins(2003)

Trimeric assembly of the C-terminal region of Thrombospondin-1 or Thrombospondin-2 is necessary for cell spreading and fascin spike organisation(2002)

Coronary artery disease and the thrombospondin single nucleotide polymorphisms(2004)

Phylogenomic analysis of vertebrate thrombospondins reveals fish-specific paralogues, ancestral gene relationships and a tetrapod innovation(2006)

Modulation of the extracellular matrix patterning of thrombospondins by actin dynamics and thrombospondin oligomer state(2015)

The Evolution of Extracellular Matrix(2010)

The predicted secretomes of Monosiga brevicollis and Capsaspora owczarzaki, close unicellular relatives of metazoans, reveal new insights into the evolution of the metazoan extracellular matrix(2014)

Molecular phylogeny of the kelch-repeat superfamily reveals an expansion of BTB/kelch proteins in animals(2003)

Prognostic significance of fascin expression in advanced colorectal cancer: an immunohistochemical study of colorectal adenomas and adenocarcinomas(2006)

Thrombospondin-1 promotes matrix homeostasis by interacting with collagen and lysyl oxidase precursors and collagen cross-linking sites(2018)

Adhesion-modulating/matricellular ECM protein families: A structural, functional and evolutionary appraisal(2012)

Matricellular Proteins: Functional Insights From Non-mammalian Animal Models(2018)

PDIA3/ERp57 promotes a matrix-rich secretome that stimulates fibroblast adhesion through CCN2(2022)

Association of loss of epithelial syndecan-1 with stage and local metastasis of colorectal adenocarcinomas: An immunohistochemical study of clinically annotated tumors(2008)

Comparative genomics of the syndecans defines an ancestral genomic context associated with matrilins in vertebrates(2006)

A Role for Syndecan-1 in Coupling Fascin Spike Formation by Thrombospondin-1(2001)

Functional Role of Syndecan-1 Cytoplasmic V Region in Lamellipodial Spreading, Actin Bundling, and Cell Migration(2005)

Molecular Phylogeny of a RING E3 Ubiquitin Ligase, Conserved in Eukaryotic Cells and Dominated by Homologous Components, the Muskelin/RanBPM/CTLH Complex(2013)

Novel role of the muskelin–RanBP9 complex as a nucleocytoplasmic mediator of cell morphology regulation(2008)

Correction: Molecular Phylogeny of a RING E3 Ubiquitin Ligase, Conserved in Eukaryotic Cells and Dominated by Homologous Components, the Muskelin/RanBPM/CTLH Complex(2013)

Membrane-associated collagens with interrupted triple-helices (MACITs): evolution from a bilaterian common ancestor and functional conservation in C. elegans(2015)

Hydra Mesoglea Proteome Identifies Thrombospondin as a Conserved Component Active in Head Organizer Restriction(2018)

A thrombospondin in the anthozoan Nematostella vectensis is associated with the nervous system and upregulated during regeneration(2012)

Modelling the early evolution of extracellular matrix from modern Ctenophores and Sponges(2019)

Adhesion Networks of Cnidarians(2014)

Extracellular Matrix Evolution: An Overview(2013)

Emergence of a Thrombospondin Superfamily at the Origin of Metazoans(2019)

A Rapid, Scalable Method for the Isolation, Functional Study, and Analysis of Cell-derived Extracellular Matrix(2017)

The evolution of the dystroglycan complex, a major mediator of muscle integrity(2015)

The superficial circumflex iliac artery perforator flap in intra-oral reconstruction(2013)

Physiological roles of non-coding RNAs(2019)

Combined digital imaging of mixed-field radioactivity with a single detector(2011)

Analysis of α-Dystroglycan/LG Domain Binding Modes: Investigating Protein Motifs That Regulate the Affinity of Isolated LG Domains(2019)

Revised guidelines to enhance the rigor and reproducibility of research published in American Physiological Society journals(2018)

Passing the post: roles of posttranslational modifications in the form and function of extracellular matrix(2023)

Impairment of cell adhesion and migration by inhibition of protein disulphide isomerases in three breast cancer cell lines(2020)

Protein disulfide isomerase A3 activity promotes extracellular accumulation of proteins relevant to basal breast cancer outcomes in human MDA-MB-A231 breast cancer cells(2022)

Integrin expression during human epidermal development in vivo and in vitro(1991)

Functional role of α-actinin, PI 3-kinase and MEK1/2 in insulin-like growth factor I receptor kinase regulated motility of human breast carcinoma cells(2002)

Neuronal expression of muskelin in the rodent central nervous system(2007)

Prediction and analysis of higher-order coiled-coils: Insights from proteins of the extracellular matrix, tenascins and thrombospondins(2013)

Sharpey‐Schafer, Langley and Sherrington: ‘swordsmen’ of physiology. A historical look to the future(2023)

Studies of recombinant TWA1 reveal constitutive dimerization(2016)

A new initiative for AJP-Cell Physiology: “Making Cell Culture More Physiological”(2019)

Molecular analysis of muskelin identifies a conserved discoidin-like domain that contributes to protein self-association(2004)

Clinicopathological features of squamous cell carcinoma of the oral cavity and oropharynx in young patients(2018)

St. Martin's Uncovered: Investigations in the churchyard of St. Martin's-in-the-Bull Ring(2006)

An American Physiological Society cross-journal Call for Papers on “Deconstructing Organs: Single-Cell Analyses, Decellularized Organs, Organoids, and Organ-on-a-Chip Models”(2020)

Collaboration Network

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About This Profile

This profile is generated from publicly available publication metadata and is intended for research discovery purposes. Themes, summaries, and trajectories are inferred computationally and may not capture the full scope of the lecturer's work. For authoritative information, please refer to the official KNUST profile.