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John Nii Adotey Addotey

Pharmaceutical Chemistry

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About

Dr. John Addotey is a pharmacist by training and is a member of the Pharmaceutical Society of Ghana since 2007. He obtained a Master of Philosophy in Pharmaceutical Chemistry at the Kwame Nkrumah University of Science and Technology, Ghana in 2010 after which he was employed as an assistant lecturer at the same university. He was promoted to the rank of lecturer in 2014. In 2015, he won a scholarship by the DAAD/Ghana Government to study for a Ph.D. at the University of Muenster, Germany. He graduated cum Laude in 2019 and has since returned to Ghana where he is a senior lecturer at the Department of Pharmaceutical Chemistry, Kwame Nkrumah University of Science and Technology. John does research in Phytochemistry, Pharmaceutical, and Medicinal Chemistry. His focus is on the bioassay-guided isolation, characterization, and quantification of bioactive compounds. Dr. Addotey is a member of a number of organizations including the American Chemical Society and the Society for Medicinal Plants and Natural Products Research.

Research Summary

(inferred from publications by AI)

The researcher's research is centered around the study of bioactive compounds, focusing on alkaloids, phytochemicals, and antimalarials. Their work encompasses a wide range of areas, including their pharmacological activity, synthesis, interaction studies with natural products, and applications in disease management. Key contributions include the investigation of root extracts from Ononis spinosa for ant-inflammatory effects, triazoles for antimalarial agents, and the pharmacological properties of compounds like 5-HTP. The researcher also employs advanced techniques such as UV-Vis spectroscopy and chemometric strategies to classify herbal products and predict their behavior in various environments. Their work highlights a comprehensive approach to understanding bioactive compounds' roles across health sciences and pharmacology.

Research Themes

All Papers

Isoflavonoids with inhibiting effects on human hyaluronidase-1 and norneolignan clitorienolactone B from Ononis spinosa L. root extract(2018)
Root Extracts From Ononis spinosa Inhibit IL-8 Release via Interactions With Toll-Like Receptor 4 and Lipopolysaccharide(2020)
Hyal-1 inhibitors from the leaves of Phyllanthus muellerianus (Kuntze) Excell(2019)
Synthesis, molecular docking studies and ADME prediction of some new triazoles as potential antimalarial agents(2021)
Unlocking chemical markers for the standardization of antimalarial medicinal plants and products: Application of the herbal marker ranking system (Herb MaRS)(2025)
Preliminary pharmacological investigation of the ischuretic property and safety of a hydro-ethanolic extract of Amaranthus spinosis (Fam: Amaranthaceae)(2013)
Ultraviolet-Visible Spectroscopy and Chemometric Strategy Enable the Classification and Detection of Expired Antimalarial Herbal Medicinal Product in Ghana(2021)
Anti-biofilm Formation Activities of 4-hydroxyindole Azo Compounds against Pseudomonas aeruginosa and Staphylococcus aureus(2022)
A comparative study of Ghanaian propolis extracts: Chemometric analysis of the chromatographic profile, antioxidant, and hypoglycemic potential and identification of active constituents(2023)
A Comparative Study of Ghanaian Propolis Extracts: Chemometric Analysis of the Chromatographic Profile, Antioxidant, and Hypoglycaemic Potential and Identification of Active Constituents(2023)
Alstoboonine, an Ulean-Type Indole Alkaloid from <i>Alstonia boonei</i> Leaves(2023)
Quality Assessment of Tomato Paste Products on the Ghanaian Market: An Insight Into Their Possible Adulteration(2024)
The impact of cluster resolution feature selection on pattern recognition and classification for detecting Sudan dye adulteration in palm oil(2024)
A Systematic Review of Medicinal Plants and Their Compounds Validated as Agents for the Management of Sickle Cell Disease(2024)
Quality characteristics and HPLC detection of phosphodiesterase inhibitors in some herbal capsules indicated for male sexual disorders in Ghana(2024)
Local production of 5-HTP from the seeds of griffonia simplicifolia(2009)
Naturstoffe als Inhibitoren der humanen Hyaluronidase-1(2017)
Preliminary structure activity studies on Hyal1 inhibitors(2019)
Antiinflammatorische Wurzelextrakte aus Ononis spinosa L. inhibieren die LPS-induzierte IL-8- und TNF-α-Sekretion über Toll-like Rezeptor 4(2019)
Root extracts from Ononis spinosa exert anti-inflammatory activity in vitro on IL-8 and TNF-α release by inhibition of TLR-4 receptor(2019)
HPLC-HRESI-MSn Characterization of Polyphenolic Compounds in the Stem Bark of Chlorophora regia A. Chev (Moraceae)(2022)
Flash Talk 1 “Quality control of extracts and herbal products containing Anthocleista nobilis G. Don. via a validated RP-HPLC method”(2022)
A systematic review of validated medicinal plants and their compounds as agents for the management of sickle cell disease(2024)
Unlocking Chemical Markers for the Standardization of Antimalarial Medicinal Plants and Products: Application of the Herbal Marker Ranking System (Herb Mars)(2024)
In vivo anti-plasmodial activity of alpha-onocerin and artesunate combination against Plasmodium berghei infected mice(2025)

Collaboration Network

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About This Profile

This profile is generated from publicly available publication metadata and is intended for research discovery purposes. Themes, summaries, and trajectories are inferred computationally and may not capture the full scope of the lecturer's work. For authoritative information, please refer to the official KNUST profile.