Jibira Yakubu

Pharmacology

About

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Research Summary

(inferred from publications by AI)

The researcher's work focuses on synthesizing and studying natural compounds to address a wide range of health issues, including inflammation, pain, cardiovascular disease, prostate cancer, heart disease, hyperinflammation, mental health, and bone health. The approach integrates chemical synthesis, in vitro experiments, and therapeutic activities across diverse biological pathways, leveraging natural products like curcumin and ethylene glycol for anti-prostatic activity and anti-inflammatory effects.

Research Themes

All Papers

Non-steroidal CYP17A1 Inhibitors: Discovery and Assessment(2023)

Pyridine indole hybrids as novel potent CYP17A1 inhibitors(2025)

Essential oil terpenes may inhibit steroidogenic cytochrome P450 activities(2023)

Nanoencapsulation of Curcumin-Piperine Complex for Targeting CYP17A1 in Castration-Resistant Prostate Cancer(2024)

Curcumin and Piperine Nanoparticles inhibit CYP17A1 activity to Regulate Steroid Biosynthesis in Prostate Cancer(2024)

Design and Evaluation of Novel CYP17A1 Inhibitors: Potential Therapeutic Agents for Castration-Resistant Prostate Cancer (Abstract ID: 190110)(2025)

Resistance Modulation Action, Time-Kill Kinetics Assay, and Inhibition of Biofilm Formation Effects of Plumbagin from Plumbago zeylanica Linn(2019)

Innovative Delivery Systems for Curcumin: Exploring Nanosized and Conventional Formulations(2024)

Nanoparticles with curcumin and piperine modulate steroid biosynthesis in prostate cancer(2025)

Nano‐Delivery Systems for Curcumin(2024)

7906 Nanoencapsulated Curcumin-Piperine Complex: A Breakthrough in Targeting CYP17A1 for Castration Resistant Prostate Cancer Therapy(2024)

7906 Nanoencapsulated Curcumin-Piperine Complex: A Breakthrough In Targeting CYP17A1 For Castration Resistant Prostate Cancer Therapy(2024)

Nanoparticles with Curcumin and Piperine Modulate Steroid Biosynthesis in Prostate Cancer(2024)

Evaluation of the anti-inflammatory and antioxidant potential of the stem bark extract and some constituents of Aidia genipiflora (DC.) dandy (rubiaceae)(2022)

Pharmacognostic study, anti-inflammatory and, antioxidant activities of Loeseneriella africana(2023)

Amphimas pterocarpoides Harms: An Evaluation of Flavonoid and Phenolic Contents, Wound Healing, Anthelmintic and Antioxidant Activities of the Leaves and Stem Bark(2021)

Antimicrobial Qualities of Senna Alata(2014)

Pharmacognostic studies of the leaves and seeds of Cassia occidentalis (Linn.) (Leguminosae)(2016)

Lantana camara leaf extract ameliorates memory deficit and the neuroinflammation associated with scopolamine-induced Alzheimer’s-like cognitive impairment in zebrafish and mice(2023)

Hypotensive and Antihypertensive Properties and Safety for Use of Annona muricata and Persea americana and Their Combination Products(2020)

“Hydroethanol extract and triterpenoids of Senegalia ataxacantha show antiplasmodial activity and the compounds are predicted to inhibit parasite lactate dehydrogenase (pfLDH) as indicated by molecular docking studies”(2024)

Methanolic extract of Nauclea diderrichii (stem-bark) show anti-microbial, anti-oxidant and anti-inflammatory bioactivities(2022)

Antimicrobial, antioxidant and wound healing activities of methanol leaf extract of Bridelia micrantha (Hochst.) Baill.(2021)

Wound Management Property of a Hydroethanolic Leaf Extract of Cnestis ferruginea DC(2021)

Effect of Essential Oil Components on the Activity of Steroidogenic Cytochrome P450(2024)

Effect of Essential oil Components on the Activity of Steroidogenic Cytochromes P450(2024)

Essential Oil Components May Act as Antiandrogen Compounds in Prostate Cancer by Inhibition of Steroidogenic Cytochrome P450 Activities(2023)

Amphimas pterocarpoides harms.: An Evaluation of flavonoid and phenolic contents, wound healing, anthelmintic and antioxidant activities of the leaves and stem bark(2021)

Evaluation of the Anti-inflammatory, Antimicrobial and Antioxidant activities of the stem bark extract of Croton penduliflorus Hutch (Euphorbiaceae)(2017)

Anti-microbial, anti-inflammatory and anti-oxidant bioactivities of the methanolic extract of Alafia zambesiaca (stem-bark)(2022)

Exploring the Potential of Sulfur Moieties in Compounds Inhibiting Steroidogenesis(2023)

Co-extract mixture from Strophanthus hispidus (roots) and Aframomum meleguta (seeds) show phytochemical synergy in its anti-inflammatory activity(2019)

Hydroethanolic stem bark extract of Vernonia amygdalina Del. (Asteraceae) suppresses yeast-induced pyrexia and Plasmodium berghei malaria in murine models(2020)

Evaluation of the Anti-Inflammatory and Antioxidant Potential of the Stem Bark Extract and Some Constituents of Aidia Genipiflora (Dc.) Dandy (Rubiaceae)(2022)

Macaranga barteri stem bark extract exerts anti-inflammatory and anti-hyperalgesia activity in murine models(2019)

Antioxidant and Hepatoprotective properties of Helianthus annuus seed extract against paracetamol-induced liver toxicity(2020)

In-vivo anti-inflammatory activity of different parts of Adansonia Digitata(2021)

Review of: "Toxicity of Olea africana in Artemia Salina and Mice"(2023)

Hydroethanolic Stem Bark Extract of Burkea africana Attenuates Vincristine-Induced Peripheral Neuropathy in Rats(2020)

Neuro-therapeutic effect of ursolic acid in a murine model of vincristine-induced neuropathic pain(2025)

Physicochemical, Phytochemical, Heavy Metal and Microbiological Analysis of Moringa oleifera Lam. Leaves(2020)

Purchase of Aphrodisiacs; A Descriptive Cross-sectional Study in the Kumasi Metropolis of Ghana(2021)

Antinociceptive effects of a hydroethanolic stem bark extract of Burkea africana(2022)

Antimicrobial, Antioxidant, and Anti-inflammatory Evaluation of Synthesised Azo Compounds based on β-naphthol, Catechol and Quinol Nucleus(2022)

The Effectiveness of Varying Combination Ratios of A. cordifolia and M. indica against Field and Laboratory Strains of P. falciparum In Vitro(2020)

Phytochemistry, proximate and antioxidant properties of some indigenous leafy vegetables(2019)

Sensory Perception of Bioactive Peptides and Debittering Techniques Employed for Taste Improvement(2021)

Pharmacological Role of Biosynthetic Products(2021)

Anti-arthritic activity of solvent extracts of the bulbs of Crinum pedunculatum R.Br.(2022)

Review of: "In-Vitro Antibacterial Activity of some Ganoderma Species: A Review"(2024)

In vitro antioxidant and antiarthritic effects of Persicaria lanigera R. Br. Soják (Polygonaceae) leaf extract in complete Freund’s Adjuvant-induced rheumatoid arthritis model via immunomodulatory regulation of NF-κB, IL-1β, TNF-α, and COX-2 signaling pathways(2025)

Steroidogenesis and CYP17A1 inhibition: development of potent inhibitors for adrenal and gonadal steroid biosynthesis(2025)

Anti-Prostatic Carcinoma Activity of Entandrophragma angolense and Methyl Angolensate: In Vitro and In Silico Analyses(2025)

SAT-317 Design and Evaluation of novel CYP17A1 Inhibitors: Potential Therapeutic Agents for Castration-Resistant Prostate Cancer(2025)

Collaboration Network

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Research Collaboration Map

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About This Profile

This profile is generated from publicly available publication metadata and is intended for research discovery purposes. Themes, summaries, and trajectories are inferred computationally and may not capture the full scope of the lecturer's work. For authoritative information, please refer to the official KNUST profile.