Isaac Donkor

Painting and Sculpture

About

Staff has not updated content!

Research Summary

(inferred from publications by AI)

This researcher has focused on synthesizing novel heterocyclic compounds and exploring their roles in understanding chiral centers, biological activity, and reactivity. Their work encompasses the development of synthetic frameworks for calpain inhibitors, quinazolines, bisbenzamidines, and dihydrophenoxiamides, which have significant applications in treating conditions such as Alzheimer's disease, Leishmaniasis, and pseudomonas species resistance. The research also investigates the role of these compounds in cognitive function, neurodegenerative diseases, and the impact of anti-Pneumocystis carinii activity in preventing pneumonia. Additionally, their studies highlight the importance of molecular modeling and chiral properties in elucidating the mechanisms behind disease progression and drug efficacy.

Research Themes

All (72 Papers)

Life Sciences (32 Papers)

Health Sciences (22 Papers)

Physical Sciences (18 Papers)

All Papers

Calpain inhibitors: a survey of compounds reported in the patent and scientific literature(2011)

A Survey of Calpain Inhibitors(2000)

An updated patent review of calpain inhibitors (2012 – 2014)(2014)

An update on the therapeutic potential of calpain inhibitors: a patent review(2020)

Synthesis, Calpain Inhibitory Activity, and Cytotoxicity of P2-Substituted Proline and Thiaproline Peptidyl Aldehydes and Peptidyl α-Ketoamides(2006)

Apoptosis induced by novel aldehyde calpain inhibitors in human tumor cell lines(2006)

Synthesis of a reported calpain inhibitor isolated from Streptomyces griseus(2001)

Synthesis and calpain inhibitory activity of α-ketoamides with 2,3-methanoleucine stereoisomers at the P2 position(2000)

Structural Basis for the Potent Calpain Inhibitory Activity of Peptidyl α-Ketoacids(2008)

Synthesis and antiproliferative activity of sulfonamide-based peptidomimetic calpain inhibitors(2020)

Peptidyl aldehyde inhibitors of calpain incorporating P2-proline mimetics(2003)

Significance of Hydrogen Bonding at the S1′ Subsite of Calpain I(2001)

Design, Synthesis, Molecular Modeling Studies, and Calpain Inhibitory Activity of Novel α-Ketoamides Incorporating Polar Residues at the P1‘-Position(2003)

A novel series of urea-based peptidomimetic calpain inhibitors(2006)

Asymmetric synthesis of 2,3-methanoleucine stereoisomers from common intermediates(2000)

Synthesis and calpain inhibitory activity of peptidomimetic compounds with constrained amino acids at the P2 position(2008)

Asymmetric synthesis of 2,3-methanoleucine stereoisomers from common intermediates(2000)

A Novel Series of Urea‐Based Peptidomimetic Calpain Inhibitors.(2006)

ChemInform Abstract: Synthesis of a Reported Calpain Inhibitor Isolated from Streptomyces griseus.(2002)

ChemInform Abstract: Significance of Hydrogen Bonding at the S1′ Subsite of Calpain I.(2001)

ChemInform Abstract: Synthesis and Calpain Inhibitory Activity of α‐Ketoamides with 2,3‐Methanoleucine Stereoisomers at the P2 Position.(2001)

Peptidomimetic Probes and Molecular Modeling Suggest That Alzheimer's γ-Secretase Is an Intramembrane-Cleaving Aspartyl Protease(1999)

ChemInform Abstract: A Substrate‐Based Difluoro Ketone Selectively Inhibits Alzheimer′s γ‐Secretase Activity.(1998)

A Substrate-Based Difluoro Ketone Selectively Inhibits Alzheimer's γ-Secretase Activity(1998)

Structure, DNA minor groove binding, and base pair specificity of alkyl- and aryl-linked bis(amidinobenzimidazoles) and bis(amidinoindoles)(1993)

Synthesis and Antimicrobial Activity of 6,7-Annulated Pyrid0[2,3-d]pyrimidine(1995)

Synthesis and biological activities of substituted dihydrobenzo[h]‐pyrimido[4,5‐b]quinolines as tetracyclic 5‐deaza nonclassical folates(1991)

Antitumor and Anti-Pneumocystis Carinii Activities of Novel Bisbenzamidines(2005)

Synthesis of substituted tetrahydropyrimido‐[4, 5‐b][1, 7]naphthyridines as potential antitumor agents(1989)

Synthesis and DHFR Inhibitory Activity of a Series of 6‐Substituted 2,4‐Diaminothieno[2,3‐d]pyrimidines (VI).(2003)

Synthesis and radioprotective effects of adamantyl substituted 1,4-dihydropyridine derivatives(1998)

Trypanocidal Activity of Conformationally Restricted Pentamidine Congeners(2003)

Trypanocidal activity of piperazine-linked bisbenzamidines and bisbenzamidoxime, an orally active prodrug(2007)

Trypanocidal activity of dicationic compounds related to pentamidine(2001)

ChemInform Abstract: Trypanocidal Activity of Dicationic Compounds Related to Pentamidine.(2002)

Novel piperazine induces apoptosis in U937 cells.(2011)

Synthesis and DHFR inhibitory activity of a series of 6-substituted-2,4-diaminothieno[2,3-d]pyrimidines(2003)

Synthesis and anti-Pneumocystis carinii activity of conformationally restricted analogues of pentamidine(1999)

N,N′-Bis[4-(N-alkylamidino)phenyl]homopiperazines as anti-Pneumocystis carinii agents(2001)

In vitro antimicrobial activity of aromatic diamidines and diimidazolines related to pentamidine(1999)

Pentamidine Congeners. 2. 2-Butene-Bridged Aromatic Diamidines and Diimidazolines as Potential Anti-Pneumocystis carinii Pneumonia Agents(1994)

Synthesis and anti-pneumocystis carinii activity of piperidine-linked aromatic diimidazolines(1996)

Sequence-selective binding to DNA of cis- and trans- butamidine analogues of the anti-Pneumocystis carinii pneumonia drug pentamidine.(1994)

Pentamidine congeners 1: Synthesis of Cis- and Trans-butamidine analogues as anti-Pneumocystis carinii pneumonia agents.(1993)

Pentamidine congeners. 4. DNA binding affinity and anti-Pneumocystis carinii activity of butamidine analogues(1996)

ChemInform Abstract: Synthesis and Anti‐Pneumocystis carinii Activity of Piperidine‐Linked Aromatic Diimidazolines.(1996)

ChemInform Abstract: Synthesis and Anti‐Pneumocystis carinii Activity of Conformationally Restricted Analogues of Pentamidine.(1999)

ChemInform Abstract: N,N′‐Bis[4‐(N‐Alkylamidino)phenyl]homopiperazines as Anti‐Pneumocystis carinii Agents.(2002)

Pentamidine congeners 1: Synthesis of Cis- and Trans-butamidine analogues as anti-Pneumocystis carinii pneumonia agents.(2020)

Anti-plasmodial and anti-leishmanial activity of conformationally restricted pentamidine congeners(2006)

Synthesis and biological activities of aldose reductase inhibitors bearing acyl benzenesulfonamides as carboxylic acid surrogates(1998)

Phenylsulfonylnitromethanes as potent irreversible inhibitors of aldose reductase(1999)

Synthesis and biological activity of aldose reductase inhibitors with Michael acceptor substituents(1999)

ChemInform Abstract: Synthesis and Biological Activities of Aldose Reductase Inhibitors Bearing Acyl Benzenesulfonamides as Carboxylic Acid Surrogates.(1998)

ChemInform Abstract: Synthesis and Biological Activity of Aldose Reductase Inhibitors with Michael Acceptor Substituents.(1999)

ChemInform Abstract: Phenylsulfonylnitromethanes as Potent Irreversible Inhibitors of Aldose Reductase.(2000)

Novel bisbenzamidines and bisbenzimidazolines as noncompetitive NMDA receptor antagonists(1999)

Synthesis of substituted dihydrobenzo[f]pyrimido[4,5‐b]‐quinolines as tetracyclic 5‐deaza nonclassical folates(1990)

Synthesis and biological activity of 5,11-methylenetetrahydro-5-deazahomofolic acid(1991)

ChemInform Abstract: Synthesis of Substituted Dihydrobenzo(f)pyrimido(4,5‐b)quinolines as Tetracyclic 5‐Deaza Nonclassical Folates(1990)

Synthesis of a series of diaminobenzo[f]‐ and diaminobenzo[h]pyrimido[4,5‐b]quinolines as 5‐deaza tetracyclic nonclassical antifolates(1996)

ChemInform Abstract: Synthesis of a Series of Diaminobenzo(f)‐ and Diaminobenzo(h)pyrimido( 4,5‐b)quinolines as 5‐Deaza Tetracyclic Nonclassical Antifolates.(1997)

THE SYNTHESIS OF A SERIES OF 3,5-DISUBSTITUTED TETRAHYDRO- 1H-IMIDAZOLE-2,4-DIONES UTILIZING LITHIUM ALUMINUM HYDRIDE(2002)

ChemInform Abstract: The Synthesis of a Series of 3,5‐Disubstituted Tetrahydro‐1H‐imidazole‐2,4‐diones Utilizing Lithium Aluminum Hydride.(2002)

Inhibitory effects of pentamidine analogues on spermine stimulated ligand binding to the NMDA receptor complex(1997)

ChemInform Abstract: Novel Bisbenzamidines and Bisbenzimidazolines as Noncompetitive NMDA Receptor Antagonists.(1999)

Unprecedented crystallization and X-ray crystal structure of racemicN?-(t-butyloxycarbonyl)-L-L-phenylalanineN-methoxy-N-methylamide(2000)

Pentamidine Congeners. 3. Crystal Structure and Molecular Modeling Studies of trans-1,4-Bis( 4-amidinphenoxy)-2-butene(1995)

ChemInform Abstract: Synthesis and Biological Activities of Substituted Dihydrobenzo(h) pyrimido(4,5‐b)quinolines as Tetracyclic 5‐Deaza Nonclassical Folates.(1992)

The Impact of Alzheimer’s Disease and Related Dementias on Dental Care Utilization and Costs in Older Adults(2020)

ChemInform Abstract: Synthesis of Substituted Tetrahydropyrimido(4,5‐b) (1,7)naphthyridines as Potential Antitumor Agents.(1989)

Asymmetric synthesis of 2,3‐methanoleucine stereoisomers from common intermediates(2000)

Collaboration Network

No collaborations found in the dataset.

About This Profile

This profile is generated from publicly available publication metadata and is intended for research discovery purposes. Themes, summaries, and trajectories are inferred computationally and may not capture the full scope of the lecturer's work. For authoritative information, please refer to the official KNUST profile.