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Isaac Ayensu

Pharmaceutical Chemistry

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About

Profile of Professor Isaac AyensuProfessor Isaac Ayensu, a distinguished alumnus of Mfantsipim School (Cape Coast), has been appointed as a Full Professor in Pharmaceutical Chemistry at the Kwame Nkrumah University of Science and Technology (KNUST), marking the first such promotion since  1988. This prestigiousnappointment, effective August 1,  2023,  was  formally communicated in a letter dated June 24, 2024, signed by the Registrar of KNUST.Professor Ayensu holds a Bachelor of Pharmacy degree (First Class Honors,  2000) and a Master of Science in Pharmaceutical Analysis and Quality Control (2003) from KNUST. He began his academic career as a lecturer in the Department of Pharmaceutical Chemistry at KNUST in  2003. He furthered his education through a Commonwealth Scholarship, earning a PhD from the University of Greenwich, UK, between  2009 and  2013. Additionally, he holds a Commonwealth Executive Masters in Public Administration (CEMPA) from the Institute of Distance Learning (IDL), KNUST, which he completed in  2015. Professor  Ayensu  is a fellow of the Ghana College of Pharmacist and has  held  several  leadership  roles,  including  three  terms  as  Head  of  the Department  of  Pharmaceutical  Chemistry  (2014-2017),  and  most  recently,  as  Head  of  the Department of Herbal Medicine (2020-2022). He currently serves as the Head of the Department of Pharmaceutical Chemistry. His leadership extends beyond academia; he is the immediate past Chairman of the Academic, Social, and Research Pharmacists Association (ASRPA) and served on the Governing Board of the Pharmaceutical Society of Ghana from  2019 to 2023. He was also a member  of  the  Governing  Board  of  the  Traditional  Medicine  Practice  Council.With a robust research portfolio, Professor Ayensu has published extensively and presented at numerous national and international conferences. He is a respected reviewer for several peer-reviewed international journals. His research interests include pharmacokinetics, bioavailability, stability evaluation of allopathic and plant medicines, pharmaceutical analysis, drug regulation, quality control, and the development of novel drug formulations. Since returning to Ghana after his PhD, Professor Ayensu has been instrumental in bridging academia and  industry,  significantly  enhancing  the quality  of training  for PharmD,  Human Biology, Dental Surgery, Veterinary Medicine, MPhil, and PhD students. He has trained countless pharmacists,  doctors,  dentists,  physician  assistants,  veterinary  doctors,  medical  herbalists, pharmacologists, and pharmaceutical analysts in Ghana, Nigeria, and China. Since  2019, he has supervised and graduated seven (7) PhD candidates who are now academics and leaders in various institutions globally. He is also a visiting professor at Madonna University (Nigeria) and China Pharmaceutical University (Nanjing, China). Professor  Ayensu  is  a  Commonwealth  Fellow  (2017)  and  a  recipient  of  the  Seeding  Labs Instrumental  Access  Award  (2018).  His  expertise  is  pivotal  in  advancing  the  Ghanaian Pharmaceutical Industry's research and development (R&D) capabilities, fostering strong collaborations between academia and industry. His work in medicine quality control has significantly improved the quality of herbal products on the Ghanaian market, addressing the critical issue of substandard medicines that pose risks to vulnerable populations such as children and pregnant women.Professor Ayensu is married to Mrs. Olivia Ayensu, and they are blessed with four children.

Research Summary

(inferred from publications by AI)

The researcher has a diverse research focus centered around innovative approaches in drug delivery systems and biochemical analysis techniques. Their work encompasses the development of chitosan-based films for protein delivery via both buccal and wafers, as well as the functional characterization of lyophilized materials like thiolated chitosan wafers. The researcher employs computational methods and bioactive compound studies to evaluate their efficacy and biological properties. Their research also extends into health sciences, particularly in treatments related to malaria, wound healing, hemp-based interventions, and natural antidiabetic agents. This work highlights a comprehensive exploration of delivery mechanisms, biochemical characterization, and computational tools, aiming to advance therapeutic applications in various domains.

Research Themes

All Papers

Development and characterisation of chitosan films impregnated with insulin loaded PEG-b-PLA nanoparticles (NPs): A potential approach for buccal delivery of macromolecules(2012)
An integrated buccal delivery system combining chitosan films impregnated with peptide loaded PEG-b-PLA nanoparticles(2013)
Development and physico-mechanical characterisation of lyophilised chitosan wafers as potential protein drug delivery systems via the buccal mucosa(2011)
Development and physico-mechanical characterization of carrageenan and poloxamer-based lyophilized matrix as a potential buccal drug delivery system(2013)
In vitro characterisation of chitosan based xerogels for potential buccal delivery of proteins(2012)
Functional Characterisation and Permeation Studies of Lyophilised Thiolated Chitosan Xerogels for Buccal Delivery of Insulin(2014)
Effect of membrane dialysis on characteristics of lyophilised chitosan wafers for potential buccal delivery of proteins(2012)
Preparation and characterization of laminated thiolated chitosan-based freeze-dried wafers for potential buccal delivery of macromolecules(2014)
Development and Evaluation of Lyophilized Thiolated-Chitosan Wafers for Buccal Delivery of Protein(2012)
Chitosan(2014)
Development of novel formulations for mucosal delivery of protein based drugs(2012)
Novel lyophilization cycle development of chitosan based formulation for buccal delivery using paracetamol as a model drug(2010)
Multifunctional Medicated Lyophilised Wafer Dressing for Effective Chronic Wound Healing(2014)
Oral Thin Films As a Remedy for Noncompliance in Pediatric and Geriatric Patients(2019)
Evaluation of acid neutralizing and buffering capacities of selected antacids in Ghana(2020)
Synthesis and Antimicrobial Resistant Modulatory Activity of 2,4-Dinitrophenylhydrazone Derivatives as Agents against Some ESKAPE Human Pathogens(2020)
Assessing metal contaminants in milled maize products available on the Ghanaian market with Atomic Absorption Spectrometry and Instrumental Neutron Activation Analyser techniques(2019)
Trace Metals in Cannabis Seized by Law Enforcement in Ghana and Multivariate Analysis to Distinguish among Different Cannabis Farms(2022)
Preliminary Phytochemical Screening and Scientific Validation of the Anti-Diabetic Effect of the Dried Husk of Zea mays L. (Corn, Poaceae)(2017)
Hydroethanolic stem bark extract of Vernonia amygdalina Del. (Asteraceae) suppresses yeast-induced pyrexia and Plasmodium berghei malaria in murine models(2020)
In-vivo anti-inflammatory activity of different parts of Adansonia Digitata(2021)
Phytochemical screening and antimicrobial activities of the stem bark of Allanblackia parviflora Chev. (Clusiaceae)(2016)
The Challenges and Knowledge Gaps in Malaria Therapy: A Stakeholder Approach to Improving Oral Quinine Use in the Treatment of Childhood Malaria in Ghana(2018)
Antiplasmodial activity and toxicity of the leaves, stem and roots of Parinari robusta Oliv [CHRYSOBALANACEAE] in animal model(2024)
Ultraviolet-Visible Spectroscopy and Chemometric Strategy Enable the Classification and Detection of Expired Antimalarial Herbal Medicinal Product in Ghana(2021)
Acid-Base Indicator Properties of Synthesized Phenylhydrazones: 4-(2-(2,4-Dinitrophenyl) Hydrazono) Methyl)-2 Methoxy Phenol and 4-(2-(2,4-Dinitrophenylhydrazono) Methyl) Benzene-1,3-diol(2022)
Pharmacokinetics and in vitro liver microsomal enzyme metabolism of Xylopic acid(2022)
Forced Degradation Studies, Elucidation of Degradation Pathways and Degradation Kinetics of Xylopic Acid via LC and LC-MS/MS Analyses(2023)
Synergistic in-vitro anthelmintic potentials of Vernonia amygdalina Delile stem and Carica papaya Lin. seeds(2017)
Determination of the antimicrobial and antitussive activities of the leaves of Solanum torvum(2016)
CHARACTERIZATION AND RP-HPLC METHOD DEVELOPMENT OF A BIOMARKER (BERGENIN) FROM THE ROOTS OF Securinega virosa(2019)
Forced Degradation Studies, Elucidation of Degradation Pathways and Degradation Kinetics of Xylopic Acid via LC and LC-MS/MS Analyses(2022)
Assessment of bioequivalence profile of locally produced flucloxacillin sodium capsules via urinary excretory rates(2016)
Bioavailability studies on a locally manufactured paracetamol tablet.(2002)
Pharmacokinetics and in Vitro Liver Microsomal Enzyme Metabolism of Xylopic Acid(2022)
The Effect of Storage Time on the Levels of Phthalates in Extemporaneous Preparations in Ghana(2024)
The Editor-in-Chief May 31, 2024 the Journal of Chemical Thermodynamicslow-Temperature Heat Capacity and Other Thermodynamic Characteristics of Xylopic Acid Crystals(2024)
Low-temperature Heat Capacity and Other Thermodynamic Characteristics of Xylopic Acid Crystals(2025)
Phytochemical constituents from corn silk and antimicrobial activity of the isolates(2024)
A proteomics–metabolomics approach and mineral content analysis reveal inherent differences in the quality of <scp>Bambara</scp> groundnuts from two geographic regions(2025)

Collaboration Network

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Research Collaboration Map
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About This Profile

This profile is generated from publicly available publication metadata and is intended for research discovery purposes. Themes, summaries, and trajectories are inferred computationally and may not capture the full scope of the lecturer's work. For authoritative information, please refer to the official KNUST profile.