George Kwaw Ainooson

Pharmacology

About

George Ainooson is an Associate Professor at the Department of Pharmacology, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana.He completed his Bachelor of Pharmacy (BPharm) and Master of Philosophy (MPhil. Pharmacology) degrees in the Faculty of Pharmacy and Pharmaceutical Sciences (FPPS), KNUST, in 2003 and 2007 respectively, and a PhD in Molecular Biology from the Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany.He started his teaching and research career in 2007 as a lecturer in the Department of Pharmacology, KNUST, in natural product pharmacology, with a keen interest in inflammatory disorders. He served in this position for 5 years before his promotion to the rank of of a Senior Lecturer in 2013 and subsequent award of a DAAD scholarship in the same year for a PhD in Molecular Biology at the Institute of Toxicology and Genetics (ITG), now the Institute of Biological and Chemical Systems (IBCS) in the KIT.His PhD thesis titled 'Pest-Domain-Enriched Tyrosine Phosphatase and Glucocorticoids as Regulators of Mast Cell Signalling', sought to employ transcriptomics to deepen our understanding of the molecular mechanisms responsible for the beneficial and toxic effects of glucocorticoids, to facilitate the design of newer drugs with equipotent anti-inflammatory effect as glucocorticoids, but minimal toxic effects.Having trained in a steroid hormone lab that specialises in the molecular endocrinology of the steroid hormone pathway in anaphylaxis and hormone-dependent malignancy (prostate and breast cancer) at KIT and as a postdoctoral research fellow in Cancer Immunology at the Center for Medical Innovation, Nagasaki University, his current research work covers the use of rodent, zebrafish and cell-based models in elucidating the mechanism of natural products in inflammatory disorders and steroid hormone-dependent malignancies such as prostate cancer. Through his research work and headship period at the Department of Pharmacology, KNUST, he secured support from the GIZ and his alma mater KIT, to run molecular pharmacology and zebrafish labs at the KNUST.

Research Summary

(inferred from publications by AI)

The researcher's work integrates comprehensive studies across various biological domains, focusing on understanding phytocannabinoid systems, mast cell signaling, neuroinflammation mechanisms, and anthocyanins in plants. Their research underscores the role of these components in both therapeutic applications and fundamental biological processes. Through systematic investigations, they have elucidated the pharmacological effects of natural compounds and explored their potential therapeutic uses across diverse health contexts, from inflammatory diseases to neurodegenerative conditions.

Research Themes

All (31 Papers)

Life Sciences (20 Papers)

Health Sciences (11 Papers)

All Papers

Acetic Acid-Induced Ulcerative Colitis in Sprague Dawley Rats Is Suppressed by Hydroethanolic Extract ofCordia vigneiLeaves through Reduced Serum Levels of TNF-αand IL-6(2020)

Regulation of the pleiotropic effects of tissue-resident mast cells(2019)

Identification of Biological and Pharmaceutical Mast Cell‐ and Basophil‐Related Targets(2016)

An Evaluation of the Anti-inflammatory, Antipyretic and Antinociceptive Effects of Ficus exasperata (Vahl) Leaf Extract(2009)

Lantana camara leaf extract ameliorates memory deficit and the neuroinflammation associated with scopolamine-induced Alzheimer’s-like cognitive impairment in zebrafish and mice(2023)

Antiarthritic and antioxidant effects of the leaf extract ofFicus exasperataP. Beauv. (Moraceae)(2010)

Analgesic effects of stem bark extracts of Trichilia monadelpha (Thonn.) JJ De Wilde(2012)

Trichilia monadelpha Bark Extracts Inhibit Carrageenan-Induced Foot-Oedema in the 7-Day Old Chick and the Oedema Associated with Adjuvant-Induced Arthritis in Rats(2011)

Analgesic Effects of an Ethanol Extract of the Fruits of Xylopia aethiopica and Xylopic Acid in Murine Models of Pain: Possible Mechanism(s)(2013)

Anti-Inflammatory and antipyretic effects of an ethanolic extract of Palisota hirsuta K. Schum roots(2008)

Anti-Inflammatory and Antioxidant Effects of an Ethanolic Extract of the Aerial Parts of Hilleria latifolia (Lam.) H. Walt. (Phytolaccaceae)(2011)

Anti-Nociceptive Effects and the Mechanism of Palisota hirsuta K. Schum. Leaf Extract in Murine Models(2009)

ANTI.INFLAMMATORYANDANTIOXIDANTPROPERTIESOFTHE ROOTEXTRACTOFCARISSAEDULIS(FORSK.)VAHL (APOCYNACEAE)(2007)

Anti-inflammatory and antioxidant properties of the root extract of Carissa edulis (forsk.) Vahl (apocynaceae)(2008)

Anti-arthritic and antioxidant properties of the ethanolic stem bark extract of Newbouldia laevis (P. Beauv.) Seaman ex Bureau (Bignoniaceae)(2008)

Antinociceptive Effects of Newbouldia laevis (P. Beauv.) Stem Bark Extract in a Rat Model(2009)

Hydroethanolic Leaf Extract of Cordia vignei Hutch and Dalziel Inhibits Carrageenan‐Induced Foot Oedema in Chicks, Prostaglandin E2‐Induced Paw Oedema in Mice, and Bradykinin‐Induced Paw Oedema in Mice(2023)

Antinociceptive Effects of an Ethanolic Extract of Capparis erythrocarpos Isert Roots in the Mice Formalin Test(2009)

Formulation of Suppositories of Alum Produced from Bauxite Waste in Ghana for the Treatment of Hemorrhoid(2021)

Coadministration of Stigmasterol and Dexamethasone (STIG+DEX) Modulates Steroid-Resistant Asthma(2022)

Preliminary pharmacological investigation of the ischuretic property and safety of a hydro-ethanolic extract of Amaranthus spinosis (Fam: Amaranthaceae)(2013)

Myorelaxant Effect of an Alcoholic Extract of Sphenocentrum jollyanum Roots in Rabbit Aortic Strip and Corpus Cavernosum(2013)

Transcriptomic data on the role of PEST-domain-enriched tyrosine phosphatase in the regulation of antigen-mediated activation and antiallergic action of glucocorticoids in mast cells(2018)

Ratios of Prostate-Specific Antigen to Albumin, C-reactive Protein, and Haemoglobin Concentration are Valuable Markers to Predict Patients with Either Prostate Cancer or Benign Prostate Hyperplasia(2024)

PEST-domain-enriched tyrosine phosphatase and glucocorticoids as regulators of mast cell signalling(2017)

Cannabinoid Receptor and Inflammation(2020)

Association Between Green Tea Drinking with Body Mass Index, Serum Lipid Profile and Prostate Specific-Antigen in a Ghanaian Population: A Cross- Sectional Study(2024)

Associations between green tea drinking and body mass index, serum lipid profile and prostate-specific antigen in a Ghanaian population: a cross-sectional study(2025)

Effect of Dietary Patterns on Testosterone-Induced Prostatic Hyperplasia in Rats(2025)

The impact of zinc and testosterone co-treatment on tumourigenesis in prostate cancer: a novel model(2025)

Antiangiogenic effects of the hydroethanolic root extract of Croton membranaceus in chick chorioallantoic membrane(2025)

Collaboration Network

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About This Profile

This profile is generated from publicly available publication metadata and is intended for research discovery purposes. Themes, summaries, and trajectories are inferred computationally and may not capture the full scope of the lecturer's work. For authoritative information, please refer to the official KNUST profile.