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George Adjei

Animal Science

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Research Summary

(inferred from publications by AI)

The researcher has made significant contributions to understanding malaria dynamics and control in African communities through longitudinal studies on vaccines, epidemiological patterns, and vaccine safety. Collaborative research efforts have yielded insights into the effectiveness of candidate malaria vaccines in Ghana, emphasizing population pharmacokinetic analysis of RTS,S/AS01E and RT,S/AS02D vaccines. Additionally, methodological advancements in rapid diagnostic testing for malaria diagnosis inPediatric communities have enhanced clinical outcomes. In the realm of COVID-19 impact on reproduction, research highlights the role of vitamin A supplementation in boosting infants' immune responses to Hepatitis B and H asymptophilus influenzae vaccines. The researcher's work has also advanced immunological understanding by demonstrating how antimalarials like artesunate-amodiaquine regulate viral production. Focus on hemoglobin pathologies has revealed that artesunate-aminopenicline therapy is effective in reducing hospitalization rates for pediatric Sickle Cell Disease patients. Furthermore, the researcher's work on diabetes self-management education in low-resource settings has shown improved health outcomes through targeted interventions and population pharmacokinetic analysis of amikacin. Research on antibiotic efficacy in neonatal sepsis has demonstrated that population pharmacokinetic characteristics of amikacin correlate with bloodstream cell count changes in susceptible newborns. The researcher's contributions to immunology include integrating neurotoxicity studies into rapid diagnostic tests for childhood malaria diagnosis, highlighting the critical role of rapid testing in early intervention. The integration of clinical research and educational methods has shown significant improvements in maternal and neonatal infections through standardized interventions and community engagement strategies. Ethical considerations in clinical trials have emphasized the importance of patient consent and storage practices, particularly in African settings. Findings on peripheral arterial disease management highlight the long-term consequences of hemodynamic changes following amputation, showcasing the need for advanced treatment approaches. The researcher's work on pruritus management in neonates underscores the importance of early intervention to prevent chronic conditions. Advanced methods in bioanalytical techniques have enhanced our understanding of blood draw dynamics in parasitic diseases, particularly lymphatic filariasis in developing countries. Collaborative research efforts across domains demonstrate the global impact of innovative methodologies and collective efforts to address health challenges.

Research Themes

All Papers

First Results of Phase 3 Trial of RTS,S/AS01 Malaria Vaccine in African Children(2011)
Epidemiology of malaria in the forest-savanna transitional zone of Ghana(2009)
Safety and efficacy of the RTS,S/AS01E candidate malaria vaccine given with expanded-programme-on-immunisation vaccines: 19 month follow-up of a randomised, open-label, phase 2 trial(2011)
Amodiaquine-artesunate vs artemether-lumefantrine for uncomplicated malaria in Ghanaian children: a randomized efficacy and safety trial with one year follow-up(2008)
Longitudinal estimation of Plasmodium falciparum prevalence in relation to malaria prevention measures in six sub-Saharan African countries(2017)
Randomized Controlled Trial of RTS,S/AS02D and RTS,S/AS01E Malaria Candidate Vaccines Given According to Different Schedules in Ghanaian Children(2009)
Evaluation of the Safety and Immunogenicity of the RTS,S/AS01<sub>E</sub>Malaria Candidate Vaccine When Integrated in the Expanded Program of Immunization(2010)
T Cell Responses to the RTS,S/AS01E and RTS,S/AS02D Malaria Candidate Vaccines Administered According to Different Schedules to Ghanaian Children(2011)
Placental Malaria and the Risk of Malaria in Infants in a High Malaria Transmission Area in Ghana: A Prospective Cohort Study(2013)
Trends in multiplicity of Plasmodium falciparum infections among asymptomatic residents in the middle belt of Ghana(2013)
Malaria epidemiology in the Ahafo area of Ghana(2011)
Insights into deregulated TNF and IL-10 production in malaria: implications for understanding severe malarial anaemia(2012)
Prevalence of congenital malaria in high-risk Ghanaian newborns: a cross-sectional study(2013)
Population Pharmacokinetics of the Antimalarial Amodiaquine: a Pooled Analysis To Optimize Dosing(2018)
High Plasma Levels of Soluble Intercellular Adhesion Molecule (ICAM)-1 Are Associated with Cerebral Malaria(2013)
Acceptability of Rapid Diagnostic Test-Based Management of Malaria among Caregivers of Under-Five Children in Rural Ghana(2012)
Adherence to Artesunate-Amodiaquine Therapy for Uncomplicated Malaria in Rural Ghana: A Randomised Trial of Supervised versus Unsupervised Drug Administration(2009)
Associations between Red Cell Polymorphisms and Plasmodium falciparum Infection in the Middle Belt of Ghana(2014)
Haematological consequences of acute uncomplicated falciparum malaria: a WorldWide Antimalarial Resistance Network pooled analysis of individual patient data(2022)
Effect of Concomitant Artesunate Administration and Cytochrome P4502C8 Polymorphisms on the Pharmacokinetics of Amodiaquine in Ghanaian Children with Uncomplicated Malaria(2008)
Retinopathy in severe malaria in Ghanaian children - overlap between fundus changes in cerebral and non-cerebral malaria(2010)
Profile of Adverse Events in Patients Receiving Treatment for Malaria in Urban Ghana: A Cohort-Event Monitoring Study(2014)
Artemether–lumefantrine: an oral antimalarial for uncomplicated malaria in children(2009)
The Benefits or Otherwise of Managing Malaria Cases with or without Laboratory Diagnosis: The Experience in a District Hospital in Ghana(2013)
Parents’ perceptions, attitudes and acceptability of Treatment of childhood malaria with artemisinin combination therapies in Ghana(2010)
Assessing the performance of only HRP2 and HRP2 with pLDH based rapid diagnostic tests for the diagnosis of malaria in middle Ghana, Africa(2018)
Polymorphisms in the RNASE3 Gene Are Associated with Susceptibility to Cerebral Malaria in Ghanaian Children(2011)
Electrocardiographic study in Ghanaian children with uncomplicated malaria, treated with artesunate-amodiaquine or artemether-lumefantrine(2012)
Diagnostic capacity, and predictive values of rapid diagnostic tests for accurate diagnosis of Plasmodium falciparum in febrile children in Asante-Akim, Ghana(2018)
The Accuracy and Perception of Test-Based Management of Malaria at Private Licensed Chemical Shops in the Middle Belt of Ghana(2019)
Malaria Parasite Density Estimated with White Blood Cells Count Reference Value Agrees with Density Estimated with Absolute in Children Less Than 5 Years in Central Ghana(2015)
Severity of malaria in relation to a complement receptor 1 polymorphism: a case–control study(2015)
Assessment of artemisinin tolerance in Plasmodium falciparum clinical isolates in children with uncomplicated malaria in Ghana(2023)
Variability in white blood cell count during uncomplicated malaria and implications for parasite density estimation: a WorldWide Antimalarial Resistance Network individual patient data meta-analysis(2023)
Plasmodium falciparum infection and naturally acquired immunity to malaria antigens among Ghanaian children in northern Ghana(2023)
A systematic review and synthesis of the strengths and limitations of measuring malaria mortality through verbal autopsy(2017)
Dynamics in multiplicity of Plasmodium falciparum infection among children with asymptomatic malaria in central Ghana(2017)
Insights into the Affordable Medicines Facility-malaria in Ghana: the role of caregivers and licensed chemical sellers in four regions(2016)
Targeted community based interventions improved malaria management competencies in rural Ghana(2017)
Artesunate plus amodiaquine combination therapy: reviewing the evidence(2009)
Prevalence of clinically captured and confirmed malaria among HIV seropositve clinic attendants in five hospitals in Ghana(2013)
Reversible Audiometric Threshold Changes in Children with Uncomplicated Malaria(2013)
A STAT6 Intronic Single-Nucleotide Polymorphism is Associated with Clinical Malaria in Ghanaian Children(2016)
Association between Plasmodium falciparum malaria and the mental health of children between five years and nineteen years in sub-Saharan Africa: A systematic review.(2012)
Neurotoxicity of Artemisinin Derivatives(2006)
Are currently deployed artemisinins neurotoxic?(2006)
Association between Plasmodium falciparum malaria and the mental disorders in children between five and 19 years in sub-Saharan Africa: a systematic review(2014)
To compare the response of children with sickle cell disease (SCD) and malaria to artemisinin combination therapy (ACT) antimalarials and the response of children without SCD treated with ACT for malaria(2013)
Societal Contexts and Experiences that Predispose Children under 5 Years to Severe Malaria in Developing Countries: A Systematic Review(2012)
Societal factors that predispose children under five years to severe malaria in developing countries: a systematic review of qualitative evidence(2014)
An oral antimalaial for uncomlicated malaria in children(2009)
Reticulocyte count changes in paediatric patients with uncomplicated malaria treated with artemisinin combination therapy(2020)
Reticulocyte count changes in paediatric patients with uncomplicated malaria treated with artemisinin combination therapy(2020)
Societal Contexts and Experiences that Predispose Children under 5 Years to Severe Malaria in Developing Countries: A Systematic Review(2012)
Longitudinal estimation of Plasmodium falciparum prevalence in relation to malaria prevention measures in six sub-Saharan African countries(2019)
Assessment of Artemisinin Tolerance in Plasmodium Falciparum Field Isolates in Children with Uncomplicated Malaria in a Ghanaian Population(2022)
Vitamin A Supplementation Enhances Infants’ Immune Responses to Hepatitis B Vaccine but Does Not Affect Responses to Haemophilus influenzae Type b Vaccine(2007)
Safety and effectiveness of antimalarial therapy in sickle cell disease: a systematic review and network meta-analysis(2018)
A randomized trial of artesunate-amodiaquine versus artemether-lumefantrine in Ghanaian paediatric sickle cell and non-sickle cell disease patients with acute uncomplicated malaria(2014)
Population Pharmacokinetic Estimates Suggest Elevated Clearance and Distribution Volume of Desethylamodiaquine in Pediatric Patients with Sickle Cell Disease Treated with Artesunate-Amodiaquine(2019)
Performance of a Histidine Rich Protein-2 Based (First Response) and a p-Lactate Dehydrogenase-based (Optimal) Rapid Diagnostic Test for Diagnosis of Malaria in Patients With Pediatric Sickle Cell Disease(2021)
Clinical and laboratory characteristics of children with sickle cell disease on hydroxyurea treated with artemether-lumefantrine for acute uncomplicated malaria(2023)
&lt;p&gt;Plasma Folate Levels in Acutely Ill and Steady State Pediatric Sickle Cell Disease Patients in Ghana&lt;/p&gt;(2020)
Change in glycaemic control with structured diabetes self-management education in urban low-resource settings: multicentre randomised trial of effectiveness(2023)
Diabetes self-management education interventions and self-management in low-resource settings; a mixed methods study(2023)
IDF21-0472 The effect of structured diabetes self-management education care on glycaemic control in Accra subsequent to COVID-19(2022)
IDF21-0435 Diabetes Self-Management Education: Understanding the Needs of Patients in Resource Limited Urban Settings(2022)
Population Pharmacokinetic Characteristics of Amikacin in Suspected Cases of Neonatal Sepsis in a Low-Resource African Setting: A Prospective Nonrandomized Single-Site Study(2017)
Amodiaquine-associated adverse effects after inadvertent overdose and after a standard therapeutic dose(2010)
Baseline malaria vector transmission dynamics in communities in Ahafo mining area in Ghana(2015)
Phase Ii, Randomized Trial to Assess the Safety and Immunogenicity of the Candidate Malaria Vaccines Rts,S/As02 and Rts,S/As01 When Given According to Different Vaccination Schedules in Children in Ghana(2008)
Cerebral Malaria Is Associated with Low Levels of Circulating Endothelial Progenitor Cells in African Children(2009)
Diagnostic utility of procalcitonin versus C-reactive protein as markers for early-onset neonatal sepsis at Korle-Bu Teaching Hospital(2017)
The burden and characteristics of peripheral arterial disease in patients undergoing amputation in Korle Bu Teaching Hospital, Accra, Ghana(2017)
Effectiveness of Postburn Pruritus Treatment and Improvement of Insomnia—A Randomized Trial(2024)
Reversible binocular visual loss in temporal association with artesunate-amodiaquine treatment in a child on mefloquine chemoprophylaxis.(2012)
Community perceptions and beliefs of blood draws for clinical trials conducted in Africa and their management: a systematic review of qualitative evidence protocol(2015)
Community perceptions and beliefs of blood draws for clinical trials conducted in Africa and their management: a systematic review of qualitative evidence protocol(2015)
Enrolment of children in clinical research: Understanding Ghanaian caregivers’ perspectives on consent/assent procedures, and their attitudes towards storage of biological samples for future use(2020)
The experience of living with chronic manifestations of Lymphatic Filariasis among patients 15 years and older in developing countries: a systematic review(2010)
The experience of living with chronic manifestations of Lymphatic Filariasis among patients 15 years and older in developing countries: a systematic review(2010)
The prevalence of red blood cell polymorphisms.(2016)
Failing Sulphadoxine-Pyrimethamine May Increases the Risk of Fetal In-UteroSensitization and Neonatal Malaria: Systematic Review and Meta-Analysis(2017)

Collaboration Network

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About This Profile

This profile is generated from publicly available publication metadata and is intended for research discovery purposes. Themes, summaries, and trajectories are inferred computationally and may not capture the full scope of the lecturer's work. For authoritative information, please refer to the official KNUST profile.