Ernest Adankwah

Medical Diagnostics

About

Dr. Ernest Adankwah is a research scientist and lecturer at the Department of Medical Diagnostics, Faculty of Allied Health Sciences, KNUST-Kumasi, Ghana. He is a trained Biomedical Scientist with extensive experience in laboratory-based research and clinical practice. He has collaborated extensively with international and local researchers in several translational studies. His competence is in the use of both immunological (i.e., Multi-colour flow cytometry, ELISA, CBA, immunofluorescence, in vitro assays, cell cultures, immunohistochemistry & phosphorylation assays) and molecular (i.e., Real-time PCR, Fluorescence in situ Hybridisation (FISH), western blot, Lentiviral transduction systems & o gene expression assays) tools in the discovery of novel biomarkers in infectious diseases and cancers. He is currently involved in a translational study to identify novel biomarkers and develop improved diagnostics for Mycobacterium (M.) tuberculosis infection detection in Ghana. Dr. Adankwah is an active researcher and has published in notable peer-reviews journals.

Research Summary

(inferred from publications by AI)

The researcher's work is centered on the intersection of immunology, cytokine signaling, viral infections, and their treatments across diverse health sciences. They employ advanced analytical techniques to diagnose conditions such as TB, COPD, uterine cancer, and vector-borne diseases. Their research encompasses immune cell functions, cytokine pathways, infectious disease studies, and applications of proteomics in diagnosing these issues, all while addressing specific themes like viral defense mechanisms in infections and immunopathology in various pathologies.

Research Themes

All (47 Papers)

Health Sciences (39 Papers)

Life Sciences (7 Papers)

Physical Sciences (1 Papers)

All Papers

Highly Divergent Hepaciviruses from African Cattle(2015)

Constitutive STAT3 phosphorylation and IL-6/IL-10 co-expression are associated with impaired T-cell function in tuberculosis patients(2018)

Suppressor of cytokine signalling 3 is crucial for interleukin‐7 receptor re‐expression after T‐cell activation and interleukin‐7 dependent proliferation(2019)

Author response for "Suppressor of cytokine signaling 3 is crucial for interleukin‐7 receptor re‐expression after T‐cell activation and interleukin‐7 dependent proliferation"(2019)

Aberrant plasma IL-7 and soluble IL-7 receptor levels indicate impaired T-cell response to IL-7 in human tuberculosis(2017)

A Novel Rhabdovirus Isolated from the Straw-Colored Fruit Bat Eidolon helvum, with Signs of Antibodies in Swine and Humans(2015)

Interleukin-6 and Mycobacterium tuberculosis dormancy antigens improve diagnosis of tuberculosis(2020)

Plasma cytokine levels characterize disease pathogenesis and treatment response in tuberculosis patients(2022)

Impaired T-cell response to phytohemagglutinin (PHA) in tuberculosis patients is associated with high IL-6 plasma levels and normalizes early during anti-mycobacterial treatment(2023)

Lower IL-7 Receptor Expression of Monocytes Impairs Antimycobacterial Effector Functions in Patients with Tuberculosis(2021)

Two-Hit in vitro T-Cell Stimulation Detects Mycobacterium tuberculosis Infection in QuantiFERON Negative Tuberculosis Patients and Healthy Contacts From Ghana(2019)

Aberrant cytokine milieu and signaling affect immune cell phenotypes and functions in tuberculosis pathology: What can we learn from this phenomenon for application to inflammatory syndromes?(2021)

CD27 expression of T-cells discriminates IGRA-negative TB patients from healthy contacts in Ghana(2019)

Diminished Interleukin-7 receptor expression on T-cell subsets in tuberculosis patients(2023)

Immunopathology in human pulmonary tuberculosis: Inflammatory changes in the plasma milieu and impaired host immune cell functions(2024)

Monocyte pathology in human tuberculosis is due to plasma milieu changes and aberrant <scp>STAT</scp> signalling(2023)

Differences in PPD- and mitogen-induced T-cell activation marker expression characterize immunopathology in acute tuberculosis patients(2024)

Monocyte transcriptome signatures of inflammation and enhanced neutrophil recruitment characterize immunopathology in the blood of tuberculosis patients(2024)

Author response for "Cytokine‐induced transient monocyte IL‐7Ra expression and the serum milieu in tuberculosis"(2022)

Concomitant parasite infections influence tuberculosis immunopathology and favor rapid sputum conversion of pulmonary tuberculosis patients(2024)

Urinary iodine concentration and thyroid volume of pregnant women attending antenatal care in two selected hospitals in Ashanti Region, Ghana: a comparative cross-sectional study(2018)

Mucin expression patterns in histological grades of colonic cancers in Ghanaian population(2017)

Assessment of proliferative index in different grades of breast cancers using AgNOR (Agyrophilic Nuclear Organizer Region) expression(2018)

Perceptions of barriers and facilitators for cervical cancer screening from women and healthcare workers in Ghana: Applying the Dynamic Sustainability Framework(2025)

Prolonged Duration of Air-Dry Fixation of Cervical Smears Produces Superior Cytomorphological Staining Quality over Conventional Wet-Fixed Smears(2023)

Perceptions of barriers and facilitators for cervical cancer screening from women and healthcare workers in Ghana: Applying the Dynamic Sustainability Framework(2024)

Exploring Self-Sampling for Hpv-Based Cervical Cancer Screening Among Ghanaian Women: A Pilot Study on Preferences, Experiences, and Clinical Utility(2025)

Seroconversion and Prevalence of Hepatitis B Surface Antigen among Vaccinated Health Care Workers in Ashanti Region, Ghana(2023)

Seroconversion and prevalence of Hepatitis B surface antigen among vaccinated health care workers in Ashanti Region, Ghana(2023)

Diversity of Culicoides in the middle belt of Ghana with Implications on the transmission of Mansonella perstans; a molecular approach(2024)

Cytokine‐induced transient monocyte IL‐7Ra expression and the serum milieu in tuberculosis(2022)

BCG-Vaccinated Children with Contact to Tuberculosis Patients Show Delayed Conversion of Mycobacterium tuberculosis-Specific IFN-γ Release(2023)

BCG Vaccination-Associated Lower HbA1c and Increased CD25 Expression on CD8+ T Cells in Patients with Type 1 Diabetes in Ghana(2024)

Doxycycline Treatment of Mansonella perstans–Infected Individuals Affects Immune Cell Activation and Causes Long-term T-cell Polarization(2022)

The use of special stains in the detection of vascular invasion in cases of colon cancer in resource-limited settings in Africa(2020)

Knowledge, perception and screening of local dye workers regarding urinary bladder cancer in Ghana(2020)

Immune response against TB and non-tuberculous mycobacterial pulmonary disease(2021)

Lower Monocyte Interleukin-7 Receptor Expression Impairs Anti-Mycobacterial Effector Functions in Tuberculosis Patients(2020)

T-Cell Responses Against Mycobacterium ulcerans and Mycobacterium tuberculosis Protein Extracts Identify Children With Buruli Ulcer Disease(2022)

Memory B-cells are enriched in the blood of patients with acute Buruli ulcer disease: a prospective observational study(2023)

Transcriptomic profiling identifies host-derived biomarker panels for assessing cerebral malaria(2022)

Nuclear Localisation of Autophagic p62 and Associated Cytoplasmic Beclin-1 and Bcl-2 Expressions in Adenomas and Adenocarcinomas of the Colorectal Regions(2018)

Clinical Validation of Nuclear Factor Kappa B (p65) Among Head and Neck Cancer Patients at One Institution(2024)

Biomarker Development Against Infections Using Proteomics(2024)

Correction to: Biomarker Development Against Infections Using Proteomics(2024)

Precision Breathing: Asthma Phenotyping via Machine Learning(2025)

Collaboration Network

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Research Collaboration Map

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About This Profile

This profile is generated from publicly available publication metadata and is intended for research discovery purposes. Themes, summaries, and trajectories are inferred computationally and may not capture the full scope of the lecturer's work. For authoritative information, please refer to the official KNUST profile.