Daniel Ansong

Child Health

About

I have had the opportunity to serve as the Study Coordinator as well as the Principal Investigator in major clinical trials that have taken place in my institution. I am currently a trained Clinical Trial Monitor for the Tropical Disease Research (TDR)-World Health Organization (WHO). I have also served as a Senior Investigator on National Institutes of Health (NIH) funded research projects in my institution. I participated as Co-Principal Investigator on the pivotal phase III RTS,S vaccine trial programme and currently the Principal Investigator on the Safety Arm of the Malaria Vaccine Implementation Programme in Ghana. I am the Principal Investigator of World Health Organization (WHO) Hemophilus Influenzae Type B and Streptococcus Pneumoniae Invasive Disease Surveillance since 2004 and Rotavirus Diarrhoea Disease in Children since 2010 in Komfo Another Teaching Hospital, Ghana. I have been a study clinician in the Sickle Cell Center of the Komfo Anokye Teaching Hospital for over two decades. I served as a senior investigator to the Organ Damage in Sickle Cell Disease Study (ORDISS) in 2017 and currently serving as a consultant pediatrician to the Center and providing clinical and technical support to the Sickle Cell Pan-African Consortium (SPARCO) study. My rich experience in clinical trials and infectious disease surveillance in Ghana places me in a stronger position to support mentors students interest in research.

Research Summary

(inferred from publications by AI)

The researcher has made significant contributions to the field of infectious diseases through extensive research on malaria vaccines in Ghana, covering themes from clinical efficacy and safety to public health strategies and ethical considerations. The work highlights vaccine co-administration effects on maternal and child health, the impact of vaccination subsidies, and challenges in equitable healthcare. It also delves into issues such as childhood bacterial meningitis prevention and global collaborations in maternal care.

Research Themes

All Papers

A Phase 3 Trial of RTS,S/AS01 Malaria Vaccine in African Infants(2012)

Genetic Diversity and Protective Efficacy of the RTS,S/AS01 Malaria Vaccine(2015)

Insights into malaria susceptibility using genome-wide data on 17,000 individuals from Africa, Asia and Oceania(2019)

Safety and immunogenicity of the RTS,S/AS01 malaria vaccine in infants and children identified as HIV-infected during a randomized trial in sub-Saharan Africa(2019)

Immunogenicity of the RTS,S/AS01 malaria vaccine and implications for duration of vaccine efficacy: secondary analysis of data from a phase 3 randomised controlled trial(2015)

Genome-wide association study indicates two novel resistance loci for severe malaria(2012)

Malaria(2023)

Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study(2018)

A combined analysis of immunogenicity, antibody kinetics and vaccine efficacy from phase 2 trials of the RTS,S malaria vaccine(2014)

Efficacy of RTS,S/AS01E malaria vaccine administered according to different full, fractional, and delayed third or early fourth dose regimens in children aged 5–17 months in Ghana and Kenya: an open-label, phase 2b, randomised controlled trial(2022)

Longitudinal estimation of Plasmodium falciparum prevalence in relation to malaria prevention measures in six sub-Saharan African countries(2017)

Safety profile of the RTS,S/AS01 malaria vaccine in infants and children: additional data from a phase III randomized controlled trial in sub-Saharan Africa(2019)

Randomized Controlled Trial of RTS,S/AS02D and RTS,S/AS01E Malaria Candidate Vaccines Given According to Different Schedules in Ghanaian Children(2009)

Delayed Hemolysis After Treatment With Parenteral Artesunate in African Children With Severe Malaria—A Double-center Prospective Study(2013)

T Cell Responses to the RTS,S/AS01E and RTS,S/AS02D Malaria Candidate Vaccines Administered According to Different Schedules to Ghanaian Children(2011)

Capillary refill time as an independent prognostic indicator in severe and complicated malaria(2006)

Intramuscular Artesunate for Severe Malaria in African Children: A Multicenter Randomized Controlled Trial(2016)

Availability and price of malaria rapid diagnostic tests in the public and private health sectors in 2011: results from 10 nationally representative cross‐sectional retail surveys(2015)

Host-mediated selection impacts the diversity of Plasmodium falciparum antigens within infections(2018)

Point prevalence of asymptomatic Plasmodium infection and the comparison of microscopy, rapid diagnostic test and nested PCR for the diagnosis of asymptomatic malaria among children under 5 years in Ghana(2020)

Determinants of post-malarial anemia in African children treated with parenteral artesunate(2019)

Genotypic analysis of RTS,S/AS01E malaria vaccine efficacy against parasite infection as a function of dosage regimen and baseline malaria infection status in children aged 5–17 months in Ghana and Kenya: a longitudinal phase 2b randomised controlled trial(2024)

A Prospective Comparison of Malaria with Other Severe Diseases in African Children: Prognosis and Optimization of Management(2003)

Population Kinetics, Efficacy, and Safety of Dichloroacetate for Lactic Acidosis Due to Severe Malaria in Children(2003)

A randomized trial on effectiveness of artemether-lumefantrine versus artesunate plus amodiaquine for unsupervised treatment of uncomplicated Plasmodium falciparum malaria in Ghanaian children(2008)

Assessment of severe malaria in a multicenter, phase III, RTS, S/AS01 malaria candidate vaccine trial: case definition, standardization of data collection and patient care(2011)

Could Less Be More? Accounting for Fractional-Dose Regimens and Different Number of Vaccine Doses When Measuring the Impact of the RTS,S/AS01E Malaria Vaccine(2024)

A −436C>A Polymorphism in the Human FAS Gene Promoter Associated with Severe Childhood Malaria(2011)

Cardiac function in Ghanaian children with severe malaria(2012)

Immediate “Kangaroo Mother Care” and Survival of Infants with Low Birth Weight(2021)

Breast cancer in Sub-Saharan Africa: opportunities for prevention(2014)

Cancer incidence in Ghana, 2012: evidence from a population-based cancer registry(2014)

Factors contributing to delays in diagnosis of breast cancers in Ghana, West Africa(2016)

Design considerations for identifying breast cancer risk factors in a population‐based study in Africa(2017)

Recruiting population controls for case-control studies in sub-Saharan Africa: The Ghana Breast Health Study(2019)

Effect of the Affordable Medicines Facility—malaria (AMFm) on the availability, price, and market share of quality-assured artemisinin-based combination therapies in seven countries: a before-and-after analysis of outlet survey data(2012)

A multi-center prospective cohort study to evaluate the effect of differential pricing and health systems strengthening on access to medicines and management of hypertension and diabetes in Ghana: A study protocol(2018)

Impact and Effectiveness of Monovalent Rotavirus Vaccine Against Severe Rotavirus Diarrhea in Ghana(2016)

Evaluation of Intussusception after Monovalent Rotavirus Vaccination in Africa(2018)

Rotavirus strain distribution in Ghana pre- and post- rotavirus vaccine introduction(2018)

Immune response to the hepatitis B antigen in the RTS,S/AS01 malaria vaccine, and co-administration with pneumococcal conjugate and rotavirus vaccines in African children: A randomized controlled trial(2018)

Sustained impact of rotavirus vaccine introduction on rotavirus gastroenteritis hospitalizations in children <5 years of age, Ghana, 2009–2016(2018)

Factors associated with uncontrolled blood pressure among Ghanaians: Evidence from a multicenter hospital-based study(2018)

Prevalence of hypertension and diabetes mellitus in adults from a rural community in Ghana.(2012)

The burden and correlates of hypertension in rural Ghana: A cross-sectional study(2013)

Burden of hypertension in Ghana – Analysis of awareness and screening campaign in the Ashanti Region of Ghana(2022)

Prevalence of Hypertension in Ghana: Analysis of an Awareness and Screening Campaign in 2019(2022)

Longitudinal control of blood pressure among a cohort of Ghanaians with hypertension: A multicenter, hospital‐based study(2020)

Challenges with implementing malaria rapid diagnostic tests at primary care facilities in a Ghanaian district: a qualitative study(2016)

Communicating the AMFm message: exploring the effect of communication and training interventions on private for-profit provider awareness and knowledge related to a multi-country anti-malarial subsidy intervention(2014)

Family planning in a sub-district near Kumasi, Ghana: side effect fears, unintended pregnancies and misuse of a medication as emergency contraception.(2011)

Improving Access To Malaria Medicine Through Private-Sector Subsidies In Seven African Countries(2014)

Knowledge, uptake and therapeutic effectiveness of sulfadoxine-pyrimethamine (IPTp-SP) among pregnant women attending the antenatal clinic at ayeduase Health Centre in Oforikrom Municipality in the Ashanti-region, Ghana(2025)

Verbal autopsy: an analysis of the common causes of childhood death in the Barekese sub-district of Ghana(2011)

Associations of fecal microbial profiles with breast cancer and nonmalignant breast disease in the Ghana Breast Health Study(2021)

The oral microbiome and breast cancer and nonmalignant breast disease, and its relationship with the fecal microbiome in the Ghana Breast Health Study(2022)

Associations of Circulating Estrogens and Estrogen Metabolites with Fecal and Oral Microbiome in Postmenopausal Women in the Ghana Breast Health Study(2023)

Feasibility, safety, and impact of the RTS,S/AS01E malaria vaccine when implemented through national immunisation programmes: evaluation of cluster-randomised introduction of the vaccine in Ghana, Kenya, and Malawi(2024)

Breast Cancer Risk in Women from Ghana Carrying Rare Germline Pathogenic Mutations(2022)

Evaluating Health Research Capacity Building: An Evidence-Based Tool(2006)

Indicators of sustainable capacity building for health research: analysis of four African case studies(2011)

Global Health Education Amidst COVID-19: Disruptions and Opportunities(2021)

Exploring the relationship between chronic undernutrition and asymptomatic malaria in Ghanaian children(2010)

Drinking water quality and source reliability in rural Ashanti region, Ghana(2013)

Sickle Cell Disease: Management options and challenges in developing countries(2013)

Establishing a Sickle Cell Disease Registry in Africa: Experience From the Sickle Pan-African Research Consortium, Kumasi-Ghana(2022)

Pattern of AST and ALT changes in Relation to Hemolysis in sickle cell Disease(2011)

Hospitalizations among children with sickle cell disease enrolled in the Kumasi Sickle Cell Pan African Consortium (SPARCo) database: A cross sectional study(2023)

blaCTX-M-15 carried by IncF-type plasmids is the dominant ESBL gene in Escherichia coli and Klebsiella pneumoniae at a hospital in Ghana(2015)

Incident stroke among Ghanaians with hypertension and diabetes: A multicenter, prospective cohort study(2018)

Reproductive factors and risk of breast cancer by tumor subtypes among Ghanaian women: A population‐based case–control study(2020)

Measured body size and serum estrogen metabolism in postmenopausal women: the Ghana Breast Health Study(2022)

Predictors of glycemic control in type-2 diabetes mellitus: Evidence from a multicenter study in Ghana(2018)

The effect of power outages on in-facility mortality in healthcare facilities: Evidence from Ghana(2016)

Pharmacokinetics of First-Line Antituberculosis Drugs Using WHO Revised Dosage in Children With Tuberculosis With and Without HIV Coinfection(2015)

Pharmacokinetics of the First-Line Antituberculosis Drugs in Ghanaian Children with Tuberculosis with or without HIV Coinfection(2016)

Skin lighteners and hair relaxers as risk factors for breast cancer: results from the Ghana breast health study(2018)

Estimated glomerular filtration rate predicts incident stroke among Ghanaians with diabetes and hypertension(2018)

Etiology of Pediatric Meningitis in West Africa Using Molecular Methods in the Era of Conjugate Vaccines against Pneumococcus, Meningococcus, and Haemophilus influenzae Type b(2020)

Routine lumbar puncture in children with febrile seizures in Ghana: should it continue?(2004)

Determinants of paying national health insurance premium with mobile phone in Ghana: a cross-sectional prospective study(2019)

Screening tools for predicting mortality of adults with suspected sepsis: an international sepsis cohort validation study(2023)

Gene expression signatures in blood from a West African sepsis cohort define host response phenotypes(2024)

Evaluation of a learner-designed course for teaching health research skills in Ghana(2007)

Cervical Cancer Screening in Ghana, West Africa(2014)

Severe malaria in children leads to a significant impairment of transitory otoacoustic emissions - a prospective multicenter cohort study(2015)

Adherence to antiretroviral therapy, virologic failure and workload at the Rustenburg Provincial Hospital(2010)

<i>FCGR2A</i> functional genetic variant associated with susceptibility to severe malarial anaemia in Ghanaian children(2009)

Endothelial Protein C Receptor Gene Variants Not Associated with Severe Malaria in Ghanaian Children(2014)

Healthcare services utilisation among patients with hypertension and diabetes in rural Ghana(2020)

Comparing Patterns in Antimicrobial Use During Global Point Prevalence Study at a Single Tertiary Hospital in Ghana: Implications for Antimicrobial Stewardship Programme(2022)

Evaluating International Collaboration: Differential Perceptions of Partnership in a CBPR Project in Ghana(2009)

Immunogenicity and safety of the RTS,S/AS01 malaria vaccine co-administered with measles, rubella and yellow fever vaccines in Ghanaian children: A phase IIIb, multi-center, non-inferiority, randomized, open, controlled trial(2020)

Central Nervous System Virus Infection in African Children with Cerebral Malaria(2020)

Human genetic variant E756del in the ion channel PIEZO1 not associated with protection from severe malaria in a large Ghanaian study(2021)

Hospital-based Surveillance for Pediatric Bacterial Meningitis in the Era of the 13-Valent Pneumococcal Conjugate Vaccine in Ghana(2019)

A randomized crossover trial comparing the Nifty cup to a medicine cup in preterm infants who have difficulty breastfeeding at Komfo Anokye Teaching Hospital (KATH) in Kumasi, Ghana(2019)

Epidemiology of paediatric poisoning reporting to a tertiary hospital in Ghana(2016)

Collaboration Network

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Research Collaboration Map

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About This Profile

This profile is generated from publicly available publication metadata and is intended for research discovery purposes. Themes, summaries, and trajectories are inferred computationally and may not capture the full scope of the lecturer's work. For authoritative information, please refer to the official KNUST profile.