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Alex Kwame Owusu-Ofori

Clinical Microbiology

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About

I currently spend my time in academia lecturing clinical microbiology to a wide range of students including Medical, Nursing, Midwifery, Medical Imaging, Medical Laboaratory and Physician assistant students. I have been supervising undergraduate and post graduates, including masters and PhD students. The core areas that I worked in with my recent PhD and masters students include Nasopharyngeal carriage of Streptococcus pneumoniae in the community and among sickle cell patients attending their clinic and Methicillin Resistant Staphylococcus aureus where I evaluated carriage rates among healthworkers and patients and the disease burden of MRSA.  Epidemiology of Extended spectrum beta lactamase (ESBL) producing Gram negative organisms is another area that I have worked diligently over the past few years.In the hospital, I lead the Infection Prevention and Control Committee and run the the clinical microbiology laboratory of the 2nd biggest teaching hospital in Ghana. The lab is responsible for bacteriological cultures of all body fluids including blood, urine, CSF etc. In a currently on-going observational sepsis study in KATH, I serve as the co-investigator.I am interested in transfusion-transmitted infections as a component of infections that patients acquired in hospitals. I pursued a PhD on transfusion-transmitted infections with a focus on malaria, syphilis and other bacteria. Subsequently I have remained active in the area of improving blood safety. My work demonstrated the transmissibility of infections and as a follow up to my research activities; our research team partnered a private company and our collaborator from University of Cambridge to successfully evaluate pathogen reduction technology in whole blood.

Research Summary

(inferred from publications by AI)

The researcher's work focuses primarily on several key areas within public health and infectious diseases. These include antibiotic resistance and antimicrobial stewardship across diverse settings such as African hospitals, with a particular emphasis on understanding the mechanisms of resistance acquisition and evaluating the effectiveness of antibiotic use. The researcher also investigates transfusion-transmitted infections like malaria and sepsis, employing various diagnostic tools to assess infection severity and patient outcomes. Their studies cover a wide range of topics within this domain, from identifying bacterial agents responsible for infections to improving the accuracy of rapid diagnostic tests. Additionally, the researcher examines Salmonella and Campylobacter infections, focusing on molecular characterization and their impact on human health. The research also delves into global challenges related to maternal and child health, including blood donation practices and infection control measures, aiming to enhance safety and efficiency in healthcare settings. The work highlights the importance of understanding antimicrobial resistance as a global threat and evaluates interventions for reducing hospitalization rates associated with these issues.

Research Themes

All Papers

Effect of carbapenem resistance on outcomes of bloodstream infection caused by Enterobacteriaceae in low-income and middle-income countries (PANORAMA): a multinational prospective cohort study(2019)
Multidrug-resistant gram-negative bacterial infections in a teaching hospital in Ghana(2018)
Multidrug-resistant Acinetobacter baumannii in healthcare settings in Africa(2023)
Genomic characterization of multidrug-resistant ESBL-producing Klebsiella pneumoniae isolated from a Ghanaian teaching hospital(2019)
Prevalence of carbapenem-resistant and extended-spectrum beta-lactamase-producing Enterobacteriaceae in a teaching hospital in Ghana(2023)
Genomic characterization of multi drug resistant ESBL-producing Escherichia coli isolates from patients and patient environments in a teaching hospital in Ghana(2024)
Carbapenem Resistance Determinants Acquired through Novel Chromosomal Integrations in Extensively Drug-Resistant Pseudomonas aeruginosa(2021)
Multidrug-resistant Gram-negative bacterial colonization in patients, carriage by healthcare workers and contamination of hospital environments in Ghana(2023)
Impact of antibiotic intake on the incidence of extended-spectrum β-lactamase–producing Enterobacterales in sub-Saharan Africa: results from a community-based longitudinal study(2022)
Genomic characterization of multi drug resistant ESBL-producing Escherichia coli isolates from patients and patient environments in a teaching hospital in Ghana(2024)
Multidrug-resistant Gram-negative bacterial colonization in patients, carriage by healthcare workers and contamination of hospital environments in Ghana(2023)
Whole-Genome Sequencing and Bioinformatics Analysis of ESBL- producing Klebsiella pneumoniae in a Ghanaian teaching hospital(2025)
Whole-Genome Sequences of Two Multidrug-Resistant Acinetobacter baumannii Strains Isolated from Patients with Urinary Tract Infection in Ghana(2019)
Prevalence of carbapenem-resistant and extended-spectrum beta-lactamase-producing Enterobacteriaceae in a teaching hospital in Ghana(2022)
Effect of Plasmodium inactivation in whole blood on the incidence of blood transfusion-transmitted malaria in endemic regions: the African Investigation of the Mirasol System (AIMS) randomised controlled trial(2016)
Transfusion‐Transmitted Malaria in Countries Where Malaria Is Endemic: A Review of the Literature from Sub‐Saharan Africa(2010)
Transfusion-Transmitted Malaria in Ghana(2013)
Bioavailability and Preliminary Clinical Efficacy of Intrarectal Artesunate in Ghanaian Children with Moderate Malaria(2001)
Capillary refill time as an independent prognostic indicator in severe and complicated malaria(2006)
Treatment of Whole Blood With Riboflavin and UV Light(2014)
Transfusion-transmitted malaria: donor prevalence of parasitaemia and a survey of healthcare workers knowledge and practices in a district hospital in Ghana(2016)
Impact of Inconsistent Policies for Transfusion-Transmitted Malaria on Clinical Practice in Ghana(2012)
Point prevalence of asymptomatic Plasmodium infection and the comparison of microscopy, rapid diagnostic test and nested PCR for the diagnosis of asymptomatic malaria among children under 5 years in Ghana(2020)
A Prospective Comparison of Malaria with Other Severe Diseases in African Children: Prognosis and Optimization of Management(2003)
Population Kinetics, Efficacy, and Safety of Dichloroacetate for Lactic Acidosis Due to Severe Malaria in Children(2003)
Prevalence of Plasmodium parasitaemia in blood donors and a survey of the knowledge, attitude and practices of transfusion malaria among health workers in a hospital in Kumasi, Ghana(2018)
Characterization of posttransfusion <i>Plasmodium falciparum</i> infection in semi‐immune nonparasitemic patients(2016)
Population Pharmacokinetics of Intramuscular Quinine in Children with Severe Malaria(2001)
Prevention of Transfusion-Transmitted Malaria By Treatment of Whole Blood with the Mirasol® PRT System(2015)
Diagnostic Performance of Blood Film Microscopy and PfHRP2-based RDT in a Routine Clinical Setting of a Secondary Health Facility in Ghana(2019)
Prevention of transfusion‐transmitted malaria(2016)
Transfusion‐transmitted Malaria in Sub‐Saharan Africa(2015)
Global challenges of malaria risk – perspectives from transfusion‐transmitted malaria(2016)
Malaria in the blood supply in Africa: Is it a problem?(2011)
Determining the Potential Value of Salivary Plasmodium Falciparum Hisditine-Rich Protein 2 and Lactate Dehydrogenase as a Non-Invasive Test for Malaria(2020)
Determining The Potential Value Of Salivary Plasmodium Falciparum Hisditine-Rich Protein 2 And Lactate Dehydrogenase As A Non-Invasive Test For Malaria(2020)
Prevalence of plasmodium parasitaemia in blood donors and a survey of the knowledge and practices of transfusion malaria among health workers in a hospital in kumasi, ghana. v1(2018)
Prevalence of vulvovaginal candidiasis, bacterial vaginosis and trichomoniasis in pregnant women attending antenatal clinic in the middle belt of Ghana(2019)
Multicenter Surveillance of Antimicrobial Resistance among Gram-Negative Bacteria Isolated from Bloodstream Infections in Ghana(2023)
Point prevalence survey of antibiotic consumption across three hospitals in Ghana(2021)
Self-Medication and Antimicrobial Resistance: A Survey of Students Studying Healthcare Programmes at a Tertiary Institution in Ghana(2021)
Assessing the impact of antimicrobial stewardship implementation at a district hospital in Ghana using a health partnership model(2023)
Antimicrobial stewardship capacity and infection prevention and control assessment of three health facilities in the Ashanti Region of Ghana(2022)
Knowledge, attitudes and practices regarding antimicrobial use and resistance among healthcare seekers in two tertiary hospitals in Ghana: a quasi-experimental study(2023)
A cross-sectional study on the prevalence of antibiotic use prior to laboratory tests at two Ghanaian hospitals(2019)
Microbiology testing capacity and antimicrobial drug resistance in surgical-site infections: a post-hoc, prospective, secondary analysis of the FALCON randomised trial in seven low-income and middle-income countries(2024)
Use what you have: leveraging microbiology support to develop a cumulative antibiotic susceptibility report for antimicrobial stewardship at a district hospital in Ghana(2024)
Antimicrobial resistance and self-medication: A survey among first-year health students at a tertiary institution in Ghana(2020)
Public perceptions on the use of antibiotics at a market place in Kumasi, Ghana: A cross-sectional study(2020)
Antibiotic Use in an Accident and Emergency Department in a Teaching Hospital in Ghana(2017)
Implementation of Antimicrobial Stewardship in a District Hospital in the Ashanti Region of Ghana Using a Health Partnership Model(2022)
Tackling Antimicrobial Resistance: The AMR Surveillance Toolkit(2021)
Sepsis endotypes identified by host gene expression across global cohorts(2024)
Screening tools for predicting mortality of adults with suspected sepsis: an international sepsis cohort validation study(2023)
Gene expression signatures in blood from a West African sepsis cohort define host response phenotypes(2024)
The performance of screening tools for predicting mortality across multi-site international sepsis cohorts(2022)
1169. Derivation And Validation of an International Clinical Prognostication Model for 28-day Sepsis Mortality.(2022)
LABORATORY USE IN GHANA: PHYSICIAN PERCEPTION AND PRACTICE(2006)
Treatment of Salmonella meningitis: two case reports and a review of the literature(2003)
Chromosomal and plasmid-mediated fluoroquinolone resistance in human Salmonella enterica infection in Ghana(2019)
Identification of Multidrug-resistant Salmonella Plasmid Variants Using Polymerase Chain Reaction (PCR) Based Replicon Typing Technique in Ghana(2019)
Bloodborne Pathogen Exposure Risk Among Surgeons in Sub-Saharan Africa(2007)
Assessing Hand Hygiene Resources and Practices at a Large African Teaching Hospital(2010)
A nationwide cross-sectional review of in-hospital hepatitis B virus testing and disease burden estimation in Ghana, 2016 - 2021(2022)
Evaluation of two formulations of adjuvanted RTS, S malaria vaccine in children aged 3 to 5 years living in a malaria-endemic region of Mozambique: a Phase I/IIb randomized double-blind bridging trial(2007)
Hepatitis C virus seroprevalence, testing, and treatment capacity in public health facilities in Ghana, 2016–2021; A multi-centre cross-sectional study(2023)
Cost‐effectiveness and budget impact of whole blood pathogen reduction in Ghana(2021)
Detection of adverse events of transfusion in a teaching hospital in Ghana(2017)
Bacterial contamination of blood products in Africa(2021)
Bacterial contamination of donated blood in a teaching hospital in Ghana(2010)
Transfusion practices in a teaching hospital in Kumasi, Ghana(2010)
Blood Bank Screening(2014)
Transfusion-transmitted Syphilis in Teaching Hospital, Ghana(2011)
A novel strategy for screening blood donors for syphilis at Komfo Anokye Teaching Hospital, Ghana(2016)
Prevalence of yaws and syphilis in the Ashanti region of Ghana and occurrence of H. ducreyi, herpes simplex virus 1 and herpes simplex virus 2 in skin lesions associated with treponematoses(2024)
Improving the screening of blood donors with syphilis rapid diagnostic test (<scp>RDT</scp>) and rapid plasma reagin (<scp>RPR</scp>) in low‐ and middle‐income countries (<scp>LMIC</scp>)(2016)
Transfusion-transmitted Syphilis in Teaching Hospital, Ghana [Letter](2011)
Syphilis testing and cross reactions for syphilis in Ghanaian blood donors(2013)
Prevalence of yaws and syphilis in the Ashanti region of Ghana and occurrence of H. ducreyi, herpes simplex virus 1 and herpes simplex virus 2 in skin lesions associated with treponematoses(2024)
Routine lumbar puncture in children with febrile seizures in Ghana: should it continue?(2004)
Routine lumbar puncture in children with febrile seizures in Ghana: should it continue?(2004)
Nasopharyngeal carriage of Streptococcus pneumoniae among healthy children in Kassena-Nankana districts of Northern Ghana(2021)
Diagnosis and treatment of urinary tract infections in hospitalized adults in Ghana: The role of the clinical microbiology laboratory in improving antimicrobial stewardship(2020)
Plasma glutamine levels and falciparum malaria(1999)
Molecular characterization of methicillin-resistant &lt;i&gt;Staphylococcus aureus&lt;/i&gt; isolates from a hospital in Ghana(2019)
Methicillin-resistant Staphylococcus aureus among patients in a teaching hospital in Ghana(2017)
On the Environmental Presence of Burkholderia pseudomallei in South-Central Ghana(2022)
Phylogenetic and phenotypic characterization of Burkholderia pseudomallei isolates from Ghana reveals a novel sequence type and common phenotypes(2024)
Rapid, Low-Complexity, Simultaneous Bacterial Group Identification and Antimicrobial Susceptibility Testing Performed Directly on Positive Blood Culture Bottles Using Chromogenic Agar(2022)
Transfusion-transmitted malaria and bacterial infections in a malaria endemic region(2012)
Transfusionssicherheit – Plasmodium-Inaktivierung in Vollblut: neue Methode(2016)
Safety and yield of sputum induction for diagnosis of pulmonary tuberculosis in children in a tertiary hospital in Ghana(2024)
PROTOCOLS FOR PREPARATION OF BLOOD SMEARS, REPORTING OF MALARIA PARASITES, PROCESSING OF BLOOD SAMPLES USING MALARIA RDT (HRP-2), BLOOD GROUPING AND DESIGN OF QUESTIONNAIRE v1(2018)
Transfusion-transmitted malaria in countries where malaria is endemic(2012)
Syphilis screening of donated blood in a teaching hospital in Ghana(2010)
Gene Expression Signatures in Blood that Predict Mortality in a West African Sepsis Cohort Define Host Response Phenotypes(2024)
1039Urinary Tract Infections in an African Teaching Hospital, a Comparison of Antimicrobial Susceptibility of Inpatient and Outpatient and Catheter Associated Risks.(2014)
PROTOCCOLS FOR PREPARATION OF BLOOD FILMS, REPORTING OF MALARIA PARASITES, BLOOD GROUPING AND QUESTIONNAIRE DESIGN v1(2018)
Seroprevalence of Cryptococcus Sp. Infection Among HIV Patients in a Tertiary Hospital in Ghana(2024)

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About This Profile

This profile is generated from publicly available publication metadata and is intended for research discovery purposes. Themes, summaries, and trajectories are inferred computationally and may not capture the full scope of the lecturer's work. For authoritative information, please refer to the official KNUST profile.