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Aaron Opoku Antwi

Pharmacology

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About

Dr. Aaron Opoku Antwi is a lecturer at the Department of Pharmacology, KNUST, Kumasi, Ghana. He obtained both his Bachelor of Pharmacy (BPharm) and PhD (Pharmacology) degrees in Kwame Nkrumah University of Science and Technology (KNUST), in 2011 and 2018 respectively. Dr. Antwi’s research interest is mainly the immunopharmacology of medicinal plants and plant-derived compounds. His research focuses on investigating the effect of these compounds on modulatory pathways, cytokine profiles and inflammatory cell involvement in allergy and inflammation.Dr. Antwi is currently a member of the Pharmaceutical Society of Ghana (PSGH) and the Society for Medicinal Plants and Natural Product Research.

Research Summary

(inferred from publications by AI)

The researcher's work is centered on the study of asthma and related inflammatory conditions, focusing particularly on the modulation of allergic and inflammatory responses through compounds like Stigmasterol. Their research integrates multiple domains such as immunology, pharmacology, phytochemistry, and traditional medicine applications. Key themes include the use of Stigmasterol in modulating airway inflammation in guinea pigs induced by ovalbumin, its therapeutic potential in asthma treatment, and its broader relevance to inflammatory diseases across various biological systems. The researcher also explores the biological mechanisms underlying these effects, applying findings to both animal models and human conditions, highlighting a holistic approach to understanding and addressing respiratory health challenges.

Research Themes

All Papers

Stigmasterol Modulates Allergic Airway Inflammation in Guinea Pig Model of Ovalbumin-Induced Asthma(2017)
Allergic Airway-Induced Hypersensitivity Is Attenuated by Bergapten in Murine Models of Inflammation(2019)
Coadministration of Stigmasterol and Dexamethasone (STIG+DEX) Modulates Steroid-Resistant Asthma(2022)
Pseudocedrela kotschyi limits airway inflammation in ovalbumin-induced asthma in guinea pigs(2021)
Hydro-ethanol extract of Holarrhena floribunda stem bark exhibits anti-anaphylactic and anti-oedematogenic effects in murine models of acute inflammation(2022)
Eleusine indica inhibits airway inflammation and ICAM-1 expression in ovalbumin-induced asthma in guinea pigs(2025)
Acetic Acid-Induced Ulcerative Colitis in Sprague Dawley Rats Is Suppressed by Hydroethanolic Extract of<i>Cordia vignei</i>Leaves through Reduced Serum Levels of TNF-<i>α</i>and IL-6(2020)
Anti-IBD activity of Eleusine indica through inhibition of TNF-alpha and p38 MAPK expression(2025)
Xylopia aethiopica (Annonaceae) fruit extract suppresses Freund׳s adjuvant-induced arthritis in Sprague-Dawley rats(2014)
The acute anti-inflammatory action of xylopic acid isolated from <i>Xylopia aethiopica</i>(2018)
Voacanga africana-artesunate and Voacanga africana-amodiaquine combinations as effective anti-plasmodial agents in mice(2025)
Stigmasterol inhibits lipopolysaccharide-induced innate immune responses in murine models(2017)
Stigmasterol Alleviates Cutaneous Allergic Responses in Rodents(2018)
Potential effects of xylopic acid on acetic acid-induced ulcerative colitis in rats(2019)
Hydro ethanol extract of Holarrhena floribunda stem bark exhibits anti-anaphylactic and anti-oedematogenic effects in murine models of acute inflammation(2020)
Endocannabinoid system and its modulation of brain, gut, joint and skin inflammation(2021)
Cannabinoid Receptor and Inflammation(2020)
The Ethanolic Stem-Bark Extract of<i>Antrocaryon micraster</i>Inhibits Carrageenan-Induced Pleurisy and Pedal Oedema in Murine Models of Inflammation(2017)
Antiplasmodial and Antipyretic Activity and Safety Evaluation of the Methanolic Leaf Extract of <i>Murraya exotica (L.)</i>(2020)
Methanolic Leaf Extract of Dissotis Rotundifolia Alleviates Acetic Acid-Induced Ulcerative Colitis in Rats(2021)
Cryptolepine, the major alkaloid of Cryptolepis sanguinolenta (Lindl.) Schlechter (Apocynaceae), attenuates early and late-phase symptoms of asthma(2020)
Cutaneous and systemic anti-allergic potential of xylopic acid in rodents(2021)
Aurantio-obtusin alleviates allergic responses in ovalbumin-induced rhinitis(2023)
Pharmacovigilance of herbal medicines in Ghana- Knowledge, perception and practice(2025)
Effects of a Hydro-ethanolic Extract of Scoparia dulcis on Systemic Inflammation and Cachexia in an Allergic Asthma Model(2016)
Oxidative Stress and Neurodegeneration(2018)
Xylopic Acid Suppresses Adjuvant-induced Arthritis in Sprague DawleyRats via Reduction in Serum Levels of IL-6 and TNF-alpha(2021)
Effect of xylopic acid isolated from <i>Xylopia aethiopica</i> on acetic acid‐induced ulcerative colitis in rats(2018)
Acetic acid-induced ulcerative colitis alleviation by Xylopia aethiopica (Dunal) A. Rich in Sprague Dawley rats(2025)
Antiangiogenic effects of the hydroethanolic root extract of Croton membranaceus in chick chorioallantoic membrane(2025)
In vivo anti-plasmodial activity of alpha-onocerin and artesunate combination against Plasmodium berghei infected mice(2025)
Aurantio‐Obtusin Suppresses Airway Inflammation and Serum ICAM‐1 Expression in Guinea Pig Allergic Asthma Model(2025)
Antidepressant-like potential of stigmasterol against lipopolysaccharide-induced depression-like behaviors in mice(2025)
Evaluating the potential of stigmasterol as a scaffold for novel antidepressants(2025)
Exploring the antidepressant-like effects of stigmasterol using network pharmacology with molecular docking and in vivo experimental validation: Involvement of serotonin modulation(2025)

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About This Profile

This profile is generated from publicly available publication metadata and is intended for research discovery purposes. Themes, summaries, and trajectories are inferred computationally and may not capture the full scope of the lecturer's work. For authoritative information, please refer to the official KNUST profile.